dbPTM

F120A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	F120A_HUMAN
UniProt AC	Q9NZB2
Protein Name	Constitutive coactivator of PPAR-gamma-like protein 1
Gene Name	FAM120A
Organism	Homo sapiens (Human).
Sequence Length	1118
Subcellular Localization	Cytoplasm . Cell membrane Peripheral membrane protein Cytoplasmic side . Translocates to plasma membrane upon ultraviolet exposure.
Protein Description	May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses..
Protein Sequence	MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHVPPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDSAYFPGSSTSSSSDNDEGSGGATNHISGNKIGWEKTGSHSEPQARGDPGDQTKAEGSSTASSGSQLAEGKGSQMGTVQPIPCLLSMPTRNHMDITTPPLPPVAPEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEANKDLPPAALLYRPVRQYVYGVLFSLAESRKKTERLAFRKNRLPPEFSPVIIKEWAAYKGKSPQTPELVEALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQSVLEGLSFSRQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRGRGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRTSKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKPAPQMNGSTGDARAPSHSESALNNDSKTCNTNPHLNALSTDSACRREAALEAAVLNKEE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GVQGFQDYIEKHCPS CCCHHHHHHHHHCCC	10.53	-
12	Acetylation	GFQDYIEKHCPSAVV HHHHHHHHHCCCCEE	40.73	21466224
12	Ubiquitination	GFQDYIEKHCPSAVV HHHHHHHHHCCCCEE	40.73	29967540
12 (in isoform 6)	Ubiquitination	-	40.73	-
14	S-nitrosylation	QDYIEKHCPSAVVPV HHHHHHHCCCCEEEH	4.16	2212679
25	Ubiquitination	VVPVELQKLARGSLV EEEHHHHHHHCCCCC	57.65	33845483
25 (in isoform 6)	Ubiquitination	-	57.65	-
30	Phosphorylation	LQKLARGSLVGGGRQ HHHHHCCCCCCCCCC	17.83	26699800
42	Phosphorylation	GRQRPPQTPLRLLVD CCCCCCCCCHHHEEC	30.02	-
110	Ubiquitination	ARLHEWVKRQGNERQ HHHHHHHHHCCCCHH	39.82	29967540
110 (in isoform 6)	Ubiquitination	-	39.82	-
118	Phosphorylation	RQGNERQTAQQIVSH HCCCCHHHHHHHHHH	32.43	21406692
124	Phosphorylation	QTAQQIVSHVQNKGT HHHHHHHHHHHHCCC	21.41	21406692
129	Ubiquitination	IVSHVQNKGTPPPKV HHHHHHHCCCCCCCC	47.25	29967540
131	Phosphorylation	SHVQNKGTPPPKVWF HHHHHCCCCCCCCCC	33.94	24719451
210	Ubiquitination	LKLSRNGKSLTTSQY HHHCCCCCCCCHHHH	45.93	-
210 (in isoform 6)	Ubiquitination	-	45.93	-
211	Phosphorylation	KLSRNGKSLTTSQYL HHCCCCCCCCHHHHH	32.14	22210691
284	Acetylation	PPCDVVIKAVADYVR CCHHHHHHHHHHHHH	25.79	26051181
289	Phosphorylation	VIKAVADYVRNIQDT HHHHHHHHHHHCCCC	7.50	25690035
297	Phosphorylation	VRNIQDTSDLDAIAK HHHCCCCCCHHHHHH	44.45	-
304	Ubiquitination	SDLDAIAKDVFQHSQ CCHHHHHHHHHHHHC	48.59	22817900
304 (in isoform 1)	Ubiquitination	-	48.59	21890473
304 (in isoform 2)	Ubiquitination	-	48.59	21890473
304 (in isoform 4)	Ubiquitination	-	48.59	21890473
304 (in isoform 5)	Ubiquitination	-	48.59	21890473
304 (in isoform 6)	Ubiquitination	-	48.59	21890473
327	Phosphorylation	RFKRAIGYYSATSKP HHHHHHCCCCCCCCC	6.53	-
328	Phosphorylation	FKRAIGYYSATSKPM HHHHHCCCCCCCCCC	6.14	-
336	Phosphorylation	SATSKPMSFHPPHYL CCCCCCCCCCCCCCC	29.00	23312004
342	Phosphorylation	MSFHPPHYLAARPGP CCCCCCCCCCCCCCC	12.10	-
370	Phosphorylation	QMLNIPQTSLQAKPV HHHCCCCCCCCCCCC	26.50	24043423
371	Phosphorylation	MLNIPQTSLQAKPVA HHCCCCCCCCCCCCC	17.15	24043423
382	Phosphorylation	KPVAPQVPSPGGAPG CCCCCCCCCCCCCCC	29.56	32142685
383	Phosphorylation	PVAPQVPSPGGAPGQ CCCCCCCCCCCCCCC	37.00	28355574
393	Phosphorylation	GAPGQGPYPYSLSEP CCCCCCCCCCCCCCC	22.94	28102081
395	Phosphorylation	PGQGPYPYSLSEPAP CCCCCCCCCCCCCCC	19.19	25159151
396	Phosphorylation	GQGPYPYSLSEPAPL CCCCCCCCCCCCCCC	22.40	26657352
398	Phosphorylation	GPYPYSLSEPAPLTL CCCCCCCCCCCCCEE	35.28	29978859
404	Phosphorylation	LSEPAPLTLDTSGKN CCCCCCCEECCCCCC	22.87	29978859
407	Phosphorylation	PAPLTLDTSGKNLTE CCCCEECCCCCCCCC	42.35	20639409
408	Phosphorylation	APLTLDTSGKNLTEQ CCCEECCCCCCCCCC	47.65	20639409
413	Phosphorylation	DTSGKNLTEQNSYSN CCCCCCCCCCCCCCC	44.94	21945579
417	Phosphorylation	KNLTEQNSYSNIPHE CCCCCCCCCCCCCCC	29.63	21945579
417 (in isoform 6)	Phosphorylation	-	29.63	27642862
418	Phosphorylation	NLTEQNSYSNIPHEG CCCCCCCCCCCCCCC	17.18	21945579
418 (in isoform 6)	Phosphorylation	-	17.18	27642862
419	Phosphorylation	LTEQNSYSNIPHEGK CCCCCCCCCCCCCCC	28.27	21945579
419 (in isoform 6)	Phosphorylation	-	28.27	27642862
425	Ubiquitination	YSNIPHEGKHTPLYE CCCCCCCCCCCCCCC	24.82	29967540
426	Ubiquitination	SNIPHEGKHTPLYER CCCCCCCCCCCCCCC	41.12	29967540
426 (in isoform 6)	Malonylation	-	41.12	30639696
428	Phosphorylation	IPHEGKHTPLYERSS CCCCCCCCCCCCCCC	20.62	22167270
428 (in isoform 6)	Phosphorylation	-	20.62	27642862
431	Phosphorylation	EGKHTPLYERSSPIN CCCCCCCCCCCCCCC	15.53	27273156
431 (in isoform 6)	Phosphorylation	-	15.53	27642862
434	Phosphorylation	HTPLYERSSPINPAQ CCCCCCCCCCCCHHH	28.64	23927012
435	Phosphorylation	TPLYERSSPINPAQS CCCCCCCCCCCHHHC	35.70	30278072
442	Phosphorylation	SPINPAQSGSPNHVD CCCCHHHCCCCCCCC	43.26	30278072
444	Phosphorylation	INPAQSGSPNHVDSA CCHHHCCCCCCCCCC	27.98	23927012
450	Phosphorylation	GSPNHVDSAYFPGSS CCCCCCCCCCCCCCC	24.63	23927012
452	Phosphorylation	PNHVDSAYFPGSSTS CCCCCCCCCCCCCCC	17.79	23663014
456	Phosphorylation	DSAYFPGSSTSSSSD CCCCCCCCCCCCCCC	30.58	23927012
457	Phosphorylation	SAYFPGSSTSSSSDN CCCCCCCCCCCCCCC	37.92	23927012
458	Phosphorylation	AYFPGSSTSSSSDND CCCCCCCCCCCCCCC	34.03	23663014
459	Phosphorylation	YFPGSSTSSSSDNDE CCCCCCCCCCCCCCC	30.12	25159151
460	Phosphorylation	FPGSSTSSSSDNDEG CCCCCCCCCCCCCCC	33.67	25159151
461	Phosphorylation	PGSSTSSSSDNDEGS CCCCCCCCCCCCCCC	41.29	23927012
462	Phosphorylation	GSSTSSSSDNDEGSG CCCCCCCCCCCCCCC	42.24	25159151
468	Phosphorylation	SSDNDEGSGGATNHI CCCCCCCCCCCCCCC	31.82	23663014
472	Phosphorylation	DEGSGGATNHISGNK CCCCCCCCCCCCCCC	30.51	23663014
476	Phosphorylation	GGATNHISGNKIGWE CCCCCCCCCCCCCCE	28.85	23663014
478 (in isoform 6)	Phosphorylation	-	26.44	25159151
483	Ubiquitination	SGNKIGWEKTGSHSE CCCCCCCEECCCCCC	35.21	29967540
484	Ubiquitination	GNKIGWEKTGSHSEP CCCCCCEECCCCCCC	52.24	29967540
485	Phosphorylation	NKIGWEKTGSHSEPQ CCCCCEECCCCCCCC	32.19	26699800
487	Phosphorylation	IGWEKTGSHSEPQAR CCCEECCCCCCCCCC	29.13	25849741
489	Phosphorylation	WEKTGSHSEPQARGD CEECCCCCCCCCCCC	53.31	28985074
501	Phosphorylation	RGDPGDQTKAEGSST CCCCCCCCCCCCCCC	36.64	23312004
501	Ubiquitination	RGDPGDQTKAEGSST CCCCCCCCCCCCCCC	36.64	21963094
502	Acetylation	GDPGDQTKAEGSSTA CCCCCCCCCCCCCCC	38.52	26051181
502	Ubiquitination	GDPGDQTKAEGSSTA CCCCCCCCCCCCCCC	38.52	21906983
502 (in isoform 1)	Ubiquitination	-	38.52	21890473
502 (in isoform 2)	Ubiquitination	-	38.52	21890473
502 (in isoform 4)	Ubiquitination	-	38.52	21890473
502 (in isoform 5)	Ubiquitination	-	38.52	21890473
504 (in isoform 6)	Phosphorylation	-	62.25	24275569
506	Phosphorylation	DQTKAEGSSTASSGS CCCCCCCCCCCCCCC	18.93	29255136
507	Phosphorylation	QTKAEGSSTASSGSQ CCCCCCCCCCCCCCC	38.56	29255136
508	Phosphorylation	TKAEGSSTASSGSQL CCCCCCCCCCCCCCC	32.05	29255136
510	Phosphorylation	AEGSSTASSGSQLAE CCCCCCCCCCCCCCC	35.01	29255136
511	Phosphorylation	EGSSTASSGSQLAEG CCCCCCCCCCCCCCC	39.74	29255136
513	Phosphorylation	SSTASSGSQLAEGKG CCCCCCCCCCCCCCC	24.78	29255136
521	Phosphorylation	QLAEGKGSQMGTVQP CCCCCCCCCCCCCCC	22.08	22210691
525	Phosphorylation	GKGSQMGTVQPIPCL CCCCCCCCCCCCCEE	15.60	28348404
529	Ubiquitination	QMGTVQPIPCLLSMP CCCCCCCCCEEECCC	1.79	21963094
530	Ubiquitination	MGTVQPIPCLLSMPT CCCCCCCCEEECCCC	14.91	21963094
530 (in isoform 6)	Ubiquitination	-	14.91	21890473
534	Phosphorylation	QPIPCLLSMPTRNHM CCCCEEECCCCCCCC	15.12	27251275
537	Phosphorylation	PCLLSMPTRNHMDIT CEEECCCCCCCCCCC	35.15	22210691
545	Phosphorylation	RNHMDITTPPLPPVA CCCCCCCCCCCCCCC	24.20	22210691
619	Phosphorylation	VLFSLAESRKKTERL HHHHHHHHHHHHHHH	43.74	29083192
638	Phosphorylation	NRLPPEFSPVIIKEW CCCCCCCCHHHHHHH	19.32	27050516
650	Ubiquitination	KEWAAYKGKSPQTPE HHHHHHCCCCCCCHH	24.01	29967540
651	Ubiquitination	EWAAYKGKSPQTPEL HHHHHCCCCCCCHHH	55.61	29967540
652	Phosphorylation	WAAYKGKSPQTPELV HHHHCCCCCCCHHHH	30.79	25850435
655	Phosphorylation	YKGKSPQTPELVEAL HCCCCCCCHHHHHHH	23.32	29255136
673	Acetylation	EWTCPNLKRLWLGKA CCCCCCCHHHHCCHH	52.68	25953088
673	Ubiquitination	EWTCPNLKRLWLGKA CCCCCCCHHHHCCHH	52.68	-
678	Ubiquitination	NLKRLWLGKAVEDKN CCHHHHCCHHHHCHH	12.32	29967540
679	Ubiquitination	LKRLWLGKAVEDKNR CHHHHCCHHHHCHHH	47.27	29967540
701 (in isoform 6)	Ubiquitination	-	19.72	-
721	Phosphorylation	VLCCVLRYMVQWPGA HHHHHHHHHHHCCCH	9.47	-
745	Phosphorylation	AFLAQALSPKLYEPD HHHHHHHCCCCCCHH	24.01	24719451
757	Ubiquitination	EPDQLQELKIENLDP CHHHHHHHCCCCCCC	4.34	33845483
758	Ubiquitination	PDQLQELKIENLDPR HHHHHHHCCCCCCCC	47.42	21906983
758 (in isoform 1)	Ubiquitination	-	47.42	21890473
758 (in isoform 4)	Ubiquitination	-	47.42	21890473
777 (in isoform 6)	Phosphorylation	-	3.40	27642862
786 (in isoform 6)	Ubiquitination	-	10.11	21890473
810	Acetylation	DGKLFQSKLLKASRE CCHHHHHHHHHHHHC	47.24	25953088
810	Ubiquitination	DGKLFQSKLLKASRE CCHHHHHHHHHHHHC	47.24	-
817	Ubiquitination	KLLKASREKTPLIDL HHHHHHHCCCCCHHC	59.80	32015554
818	Ubiquitination	LLKASREKTPLIDLC HHHHHHCCCCCHHCC	55.09	33845483
833	Ubiquitination	DGQADQAAKVEKMRQ CCCHHHHHHHHHHHH	15.70	29967540
834	Acetylation	GQADQAAKVEKMRQS CCHHHHHHHHHHHHH	54.68	26051181
834	Ubiquitination	GQADQAAKVEKMRQS CCHHHHHHHHHHHHH	54.68	29967540
838 (in isoform 6)	Ubiquitination	-	2.74	-
841	Phosphorylation	KVEKMRQSVLEGLSF HHHHHHHHHHHHHCC	20.50	20068231
845	Ubiquitination	MRQSVLEGLSFSRQS HHHHHHHHHCCCCCC	23.59	24816145
846	Ubiquitination	RQSVLEGLSFSRQSH HHHHHHHHCCCCCCC	3.22	24816145
846 (in isoform 6)	Ubiquitination	-	3.22	-
847	Phosphorylation	QSVLEGLSFSRQSHT HHHHHHHCCCCCCCC	31.84	20068231
849	Phosphorylation	VLEGLSFSRQSHTLP HHHHHCCCCCCCCCC	26.49	20068231
852	Phosphorylation	GLSFSRQSHTLPFPP HHCCCCCCCCCCCCC	19.82	-
854	Phosphorylation	SFSRQSHTLPFPPPP CCCCCCCCCCCCCCC	41.18	-
873	Methylation	YPASAYPRHFGPVPP CCCCCCCCCCCCCCC	25.70	24129315
884	Dimethylation	PVPPSQGRGRGFAGV CCCCCCCCCCCCCCC	24.81	-
884	Methylation	PVPPSQGRGRGFAGV CCCCCCCCCCCCCCC	24.81	24129315
886	Dimethylation	PPSQGRGRGFAGVCG CCCCCCCCCCCCCCC	35.38	-
886	Methylation	PPSQGRGRGFAGVCG CCCCCCCCCCCCCCC	35.38	24129315
916	Phosphorylation	AFRVAAASGHCGAFS HHHHHHCCCCCCCCC	25.09	23312004
923	Phosphorylation	SGHCGAFSGSDSSRT CCCCCCCCCCCCCCC	36.53	25850435
925	Phosphorylation	HCGAFSGSDSSRTSK CCCCCCCCCCCCCCC	32.87	25850435
927	Phosphorylation	GAFSGSDSSRTSKSQ CCCCCCCCCCCCCCC	24.34	30576142
928	Phosphorylation	AFSGSDSSRTSKSQG CCCCCCCCCCCCCCC	44.56	30576142
930	Phosphorylation	SGSDSSRTSKSQGGV CCCCCCCCCCCCCCC	42.32	26434776
931	Phosphorylation	GSDSSRTSKSQGGVQ CCCCCCCCCCCCCCC	29.24	26434776
931	Ubiquitination	GSDSSRTSKSQGGVQ CCCCCCCCCCCCCCC	29.24	27667366
932	Acetylation	SDSSRTSKSQGGVQP CCCCCCCCCCCCCCC	46.30	-
932	Ubiquitination	SDSSRTSKSQGGVQP CCCCCCCCCCCCCCC	46.30	27667366
932 (in isoform 1)	Ubiquitination	-	46.30	21890473
933	Phosphorylation	DSSRTSKSQGGVQPI CCCCCCCCCCCCCCC	33.55	26055452
942	Phosphorylation	GGVQPIPSQGGKLEI CCCCCCCCCCCEEEE	42.02	-
952	Phosphorylation	GKLEIAGTVVGHWAG CEEEEECEEEECCCC	11.73	-
959	Ubiquitination	TVVGHWAGSRRGRGG EEEECCCCCCCCCCC	19.25	27667366
960	Phosphorylation	VVGHWAGSRRGRGGR EEECCCCCCCCCCCC	15.85	28857561
960	Ubiquitination	VVGHWAGSRRGRGGR EEECCCCCCCCCCCC	15.85	27667366
960 (in isoform 6)	Ubiquitination	-	15.85	21890473
964	Methylation	WAGSRRGRGGRGPFP CCCCCCCCCCCCCCC	42.45	-
967	Methylation	SRRGRGGRGPFPLQV CCCCCCCCCCCCEEE	53.05	-
976	Phosphorylation	PFPLQVVSVGGPARG CCCEEEEEECCCCCC	19.05	28857561
981	Methylation	VVSVGGPARGRPRGV EEEECCCCCCCCCCC	29.81	15782174
982	Dimethylation	VSVGGPARGRPRGVI EEECCCCCCCCCCCC	44.80	-
982	Methylation	VSVGGPARGRPRGVI EEECCCCCCCCCCCC	44.80	24129315
984	Methylation	VGGPARGRPRGVIST ECCCCCCCCCCCCCC	16.52	-
986	Methylation	GPARGRPRGVISTPV CCCCCCCCCCCCCHH	51.12	24129315
990	Phosphorylation	GRPRGVISTPVIRTF CCCCCCCCCHHHCCC	25.01	29978859
991	Phosphorylation	RPRGVISTPVIRTFG CCCCCCCCHHHCCCC	15.51	16964243
995	Methylation	VISTPVIRTFGRGGR CCCCHHHCCCCCCCC	25.00	-
996	Phosphorylation	ISTPVIRTFGRGGRY CCCHHHCCCCCCCCC	21.22	21406692
999	Methylation	PVIRTFGRGGRYYGR HHHCCCCCCCCCCCC	39.95	-
1002	Methylation	RTFGRGGRYYGRGYK CCCCCCCCCCCCCCC	25.07	-
1003	Phosphorylation	TFGRGGRYYGRGYKN CCCCCCCCCCCCCCC	17.34	-
1004	Phosphorylation	FGRGGRYYGRGYKNQ CCCCCCCCCCCCCCC	10.05	-
1006	Dimethylation	RGGRYYGRGYKNQAA CCCCCCCCCCCCCHH	29.19	-
1006	Methylation	RGGRYYGRGYKNQAA CCCCCCCCCCCCCHH	29.19	-
1020	Phosphorylation	AIQGRPPYAASAEEV HHCCCCCCCCCHHHH	19.92	29255136
1023	Phosphorylation	GRPPYAASAEEVAKE CCCCCCCCHHHHHHH	28.21	23401153
1029	Acetylation	ASAEEVAKELKSKSG CCHHHHHHHHHHCCC	69.61	26051181
1033	Phosphorylation	EVAKELKSKSGESKS HHHHHHHHCCCCCHH	44.68	-
1035	Phosphorylation	AKELKSKSGESKSSA HHHHHHCCCCCHHHC	55.68	25954137
1038	Phosphorylation	LKSKSGESKSSAMSS HHHCCCCCHHHCCCC	41.17	-
1040	Phosphorylation	SKSGESKSSAMSSDG HCCCCCHHHCCCCCC	32.39	23927012
1041	Phosphorylation	KSGESKSSAMSSDGS CCCCCHHHCCCCCCC	31.56	23927012
1044	Phosphorylation	ESKSSAMSSDGSLAE CCHHHCCCCCCCHHH	25.62	23401153
1045	Phosphorylation	SKSSAMSSDGSLAEN CHHHCCCCCCCHHHC	32.67	23927012
1048	Phosphorylation	SAMSSDGSLAENGVM HCCCCCCCHHHCCCC	29.42	23927012
1067	Phosphorylation	PAPQMNGSTGDARAP CCCCCCCCCCCCCCC	24.98	25159151
1068	Phosphorylation	APQMNGSTGDARAPS CCCCCCCCCCCCCCC	40.24	23927012
1075	Phosphorylation	TGDARAPSHSESALN CCCCCCCCCCHHHHC	38.36	29255136
1077	Phosphorylation	DARAPSHSESALNND CCCCCCCCHHHHCCC	37.27	26657352
1079	Phosphorylation	RAPSHSESALNNDSK CCCCCCHHHHCCCCC	40.86	25627689
1085	Ubiquitination	ESALNNDSKTCNTNP HHHHCCCCCCCCCCC	31.80	29967540
1086	Ubiquitination	SALNNDSKTCNTNPH HHHCCCCCCCCCCCC	61.02	29967540
1098	Phosphorylation	NPHLNALSTDSACRR CCCHHHCCCCHHHHH	27.97	28348404
1099	Phosphorylation	PHLNALSTDSACRRE CCHHHCCCCHHHHHH	34.52	28348404
1101	Phosphorylation	LNALSTDSACRREAA HHHCCCCHHHHHHHH	29.38	28857561
1115	Ubiquitination	ALEAAVLNKEE---- HHHHHHHCCCC----	42.99	24816145
1116	Ubiquitination	LEAAVLNKEE----- HHHHHHCCCC-----	60.09	24816145
1143	Ubiquitination	-------------------------------- --------------------------------		24816145
1144	Ubiquitination	--------------------------------- ---------------------------------		24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of F120A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
982	R	Methylation		24129315
Arg-982 is dimethylated, probably to asymmetric dimethylarginine.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of F120A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of F120A_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of F120A_HUMAN

Related Literatures of Post-Translational Modification

Methylation
Reference	PubMed
"Identifying and quantifying in vivo methylation sites by heavy methylSILAC."; Ong S.E., Mittler G., Mann M.; Nat. Methods 1:119-126(2004). Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-982, AND MASS SPECTROMETRY.	15782174 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044; SER-1045 ANDSER-1048, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1023, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383, AND MASSSPECTROMETRY.	17081983 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-991, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-393 AND TYR-395, ANDMASS SPECTROMETRY.	15592455 [Abstract]

show