MIEN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIEN1_HUMAN
• UniProt AC: Q9BRT3
• Protein Name: Migration and invasion enhancer 1
• Gene Name: MIEN1
• Organism: Homo sapiens (Human).
• Sequence Length: 115
• Subcellular Localization: Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
• Protein Description: Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process..
• Protein Sequence: MSGEPGQTSVAPPPEEVEPGSGVRIVVEYCEPCGFEATYLELASAVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRRASNGETLEKITNSRPPCVIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGEPGQTS ------CCCCCCCCC	52.44	22814378
2	Phosphorylation	------MSGEPGQTS ------CCCCCCCCC	52.44	24505115
39	Phosphorylation	PCGFEATYLELASAV CCCCCHHHHHHHHHH	12.77	-
50	Phosphorylation	ASAVKEQYPGIEIES HHHHHHHCCCCEEEE	12.43	-
85	Phosphorylation	LENGGFPYEKDLIEA CCCCCCCCHHHHHHH	33.09	28102081
87	Ubiquitination	NGGFPYEKDLIEAIR CCCCCCHHHHHHHHH	52.57	-
97	Phosphorylation	IEAIRRASNGETLEK HHHHHHHHCCCHHHH	43.48	28102081
101	Phosphorylation	RRASNGETLEKITNS HHHHCCCHHHHHHCC	41.43	28102081
112	Geranylgeranylation	ITNSRPPCVIL---- HHCCCCCEEEC----	3.09	19503095
112	Geranylgeranylation	ITNSRPPCVIL---- HHCCCCCEEEC----	3.09	19503095

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIEN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIEN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIEN1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MIEN1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Prenylation

"Prenylated c17orf37 induces filopodia formation to promote cellmigration and metastasis.";
Dasgupta S., Cushman I., Kpetemey M., Casey P.J., Vishwanatha J.K.;
J. Biol. Chem. 286:25935-25946(2011).
Cited for: FUNCTION, SUBCELLULAR LOCATION, ISOPRENYLATION AT CYS-112, ANDMUTAGENESIS OF CYS-112 AND 112-CYS--LEU-115.
PubMed: 21628459

"Novel gene C17orf37 in 17q12 amplicon promotes migration and invasionof prostate cancer cells.";
Dasgupta S., Wasson L.M., Rauniyar N., Prokai L., Borejdo J.,Vishwanatha J.K.;
Oncogene 28:2860-2872(2009).
Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND PROBABLEISOPRENYLATION AT CYS-112.
PubMed: 19503095

"C35 (C17orf37) is a novel tumor biomarker abundantly expressed inbreast cancer.";
Evans E.E., Henn A.D., Jonason A., Paris M.J., Schiffhauer L.M.,Borrello M.A., Smith E.S., Sahasrabudhe D.M., Zauderer M.;
Mol. Cancer Ther. 5:2919-2930(2006).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION,AND PROBABLE ISOPRENYLATION.
PubMed: 17121940