CCR10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCR10_HUMAN
• UniProt AC: P46092
• Protein Name: C-C chemokine receptor type 10
• Gene Name: CCR10
• Organism: Homo sapiens (Human).
• Sequence Length: 362
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line..
• Protein Sequence: MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGTEATEQVS -----CCCCCCCCCC	22.58	24043423
6	Phosphorylation	--MGTEATEQVSWGH --CCCCCCCCCCCCC	22.25	24043423
10	Phosphorylation	TEATEQVSWGHYSGD CCCCCCCCCCCCCCC	27.34	24043423
14	Phosphorylation	EQVSWGHYSGDEEDA CCCCCCCCCCCHHHC	15.48	24043423
15	Phosphorylation	QVSWGHYSGDEEDAY CCCCCCCCCCHHHCC	33.81	24043423
22	Phosphorylation	SGDEEDAYSAEPLPE CCCHHHCCCCCCCHH	22.27	24043423
23	Phosphorylation	GDEEDAYSAEPLPEL CCHHHCCCCCCCHHH	28.07	24043423
32	Phosphorylation	EPLPELCYKADVQAF CCCHHHHHHHHHHHH	23.10	24043423
286	Acetylation	ERSCPASKRKDVALL HCCCCHHHCHHHHHH	66.62	12431323
295	Phosphorylation	KDVALLVTSGLALAR HHHHHHHHHHHHHHH	19.62	22817900
296	Phosphorylation	DVALLVTSGLALARC HHHHHHHHHHHHHHC	25.08	22817900
329	Phosphorylation	RRLLRGGSCPSGPQP HHHHCCCCCCCCCCC	26.19	23312004
332	Phosphorylation	LRGGSCPSGPQPRRG HCCCCCCCCCCCCCC	68.39	24706070
347	Phosphorylation	CPRRPRLSSCSAPTE CCCCCCCCCCCCCCC	30.49	30108239
348	Phosphorylation	PRRPRLSSCSAPTET CCCCCCCCCCCCCCC	19.38	30108239
350	Phosphorylation	RPRLSSCSAPTETHS CCCCCCCCCCCCCCC	38.95	30108239
353	Phosphorylation	LSSCSAPTETHSLSW CCCCCCCCCCCCCCC	53.91	30108239
355	Phosphorylation	SCSAPTETHSLSWDN CCCCCCCCCCCCCCC	21.17	30108239
357	Phosphorylation	SAPTETHSLSWDN-- CCCCCCCCCCCCC--	31.36	30108239
359	Phosphorylation	PTETHSLSWDN---- CCCCCCCCCCC----	35.08	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCR10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCR10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCR10_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CCR10_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-295 AND SER-296, ANDMASS SPECTROMETRY.
PubMed: 18187866