CELR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CELR2_HUMAN
• UniProt AC: Q9HCU4
• Protein Name: Cadherin EGF LAG seven-pass G-type receptor 2
• Gene Name: CELSR2
• Organism: Homo sapiens (Human).
• Sequence Length: 2923
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor that may have an important role in cell/cell signaling during nervous system formation..
• Protein Sequence: MRSPATGVPLPTPPPPLLLLLLLLLPPPLLGDQVGPCRSLGSRGRGSSGACAPMGWLCPSSASNLWLYTSRCRDAGTELTGHLVPHHDGLRVWCPESEAHIPLPPAPEGCPWSCRLLGIGGHLSPQGKLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGERSPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQLALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSALLDTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNFAGAKLPRYEALRGEQPPDLETTVILPESVFRETPPVVRPAGPGEAQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTLLRILRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLALLSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLACSRKPSPDPALTTKSTLTSSYNCPSPYADGRLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGLGDPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQGWDSLLGPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEERLRENGDALSREGSLGPLPGSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGPPPRPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
166	Phosphorylation	GERSPEESLGGRRKR CCCCHHHHCCCCCCC	30.56	28787133
363	Phosphorylation	DREEVESYQLTVEAS CHHHHEEEEEEEEHH	8.27	22210691
380	Phosphorylation	GRDPGPRSTTAAVFL CCCCCCCCCEEEEEE	32.99	30576142
388	Phosphorylation	TTAAVFLSVEDDNDN CEEEEEEEEECCCCC	16.40	30576142
468	Ubiquitination	PLDYETTKEYTLRVR CCCCCCCCEEEEEEE	57.02	21963094
471	Phosphorylation	YETTKEYTLRVRAQD CCCCCEEEEEEEECC	14.80	24719451
486	N-linked_Glycosylation	GGRPPLSNVSGLVTV CCCCCCCCCCCEEEE	39.39	UniProtKB CARBOHYD
557	N-linked_Glycosylation	DFPFTINNGTGWISV CCCEEEECCCCEEEE	45.62	UniProtKB CARBOHYD
662	Phosphorylation	RFSITSQSGGGLVSL CEEEEEECCCCEEEE	38.89	22210691
668	Phosphorylation	QSGGGLVSLALPLDY ECCCCEEEEEEECCC	16.99	22210691
676	Ubiquitination	LALPLDYKLERQYVL EEEECCCCCEEEEEE	43.47	-
681	Phosphorylation	DYKLERQYVLAVTAS CCCCEEEEEEEEECC	12.03	24043423
686	Phosphorylation	RQYVLAVTASDGTRQ EEEEEEEECCCCCCC	18.16	28985074
688	Phosphorylation	YVLAVTASDGTRQDT EEEEEECCCCCCCCE	27.49	24043423
691	Phosphorylation	AVTASDGTRQDTAQI EEECCCCCCCCEEEE	30.10	24043423
701	N-linked_Glycosylation	DTAQIVVNVTDANTH CEEEEEEEECCCCCC	21.78	UniProtKB CARBOHYD
1033	Phosphorylation	FEILFNNYVTNRSSS EEEEECCCCCCCCCC	15.12	-
1035	Phosphorylation	ILFNNYVTNRSSSFP EEECCCCCCCCCCCC	17.98	-
1036	N-linked_Glycosylation	LFNNYVTNRSSSFPG EECCCCCCCCCCCCC	31.62	UniProtKB CARBOHYD
1076	N-linked_Glycosylation	ELSLVLLNASTGELK EEEEEEEECCCCCEE	27.90	UniProtKB CARBOHYD
1103	Phosphorylation	AIMSVLVSDGVHSVT HHHHHHHCCCCCHHH	25.20	22210691
1121	Phosphorylation	ALRVTIITDEMLTHS EEEEEEECHHHHCCE	23.27	20068231
1128	Phosphorylation	TDEMLTHSITLRLED CHHHHCCEEEEEHHH	16.42	26074081
1130	Phosphorylation	EMLTHSITLRLEDMS HHHCCEEEEEHHHCC	14.61	26074081
1182	N-linked_Glycosylation	APGGHILNVSLSVGQ CCCCEEEEEEEEECC	22.26	UniProtKB CARBOHYD
1212	N-linked_Glycosylation	LQERLYLNRSLLTAI HHHHHHCCHHHHHHH	20.24	UniProtKB CARBOHYD
1214	Phosphorylation	ERLYLNRSLLTAISA HHHHCCHHHHHHHHH	27.02	-
1281	Phosphorylation	CRCPPGFTGDYCETE ECCCCCCCCCCCCEE	34.75	30576142
1284	Phosphorylation	PPGFTGDYCETEVDL CCCCCCCCCCEEEEE	8.11	30576142
1287	Phosphorylation	FTGDYCETEVDLCYS CCCCCCCEEEEEEEC	37.43	30576142
1293	Phosphorylation	ETEVDLCYSRPCGPH CEEEEEEECCCCCCC	18.27	30576142
1294	Phosphorylation	TEVDLCYSRPCGPHG EEEEEEECCCCCCCC	28.84	30576142
1305	Phosphorylation	GPHGRCRSREGGYTC CCCCCCCCCCCCEEE	38.01	22964224
1311	Phosphorylation	RSREGGYTCLCRDGY CCCCCCEEEEECCCC	11.41	22964224
1376	Phosphorylation	TRSFPAHSFITFRGL CCCCCCCEEEEECCH	22.05	24719451
1379	Phosphorylation	FPAHSFITFRGLRQR CCCCEEEEECCHHHH	12.79	24719451
1406	Phosphorylation	ERDGLLLYNGRFNEK CCCEEEEECCCCCCC	18.62	23403867
1459	Phosphorylation	WHTVQLKYYNKPLLG EEEEEEEECCCCCCC	22.36	22817900
1460	Phosphorylation	HTVQLKYYNKPLLGQ EEEEEEECCCCCCCC	18.34	22817900
1462	Ubiquitination	VQLKYYNKPLLGQTG EEEEECCCCCCCCCC	22.41	29967540
1497	Phosphorylation	GVALRFGSVLGNYSC CHHHCCHHCCCCCCH	16.08	25262027
1501	N-linked_Glycosylation	RFGSVLGNYSCAAQG CCHHCCCCCCHHCCC	22.76	UniProtKB CARBOHYD
1502	Phosphorylation	FGSVLGNYSCAAQGT CHHCCCCCCHHCCCC	11.88	25262027
1503	Phosphorylation	GSVLGNYSCAAQGTQ HHCCCCCCHHCCCCC	10.98	25262027
1509	Phosphorylation	YSCAAQGTQGGSKKS CCHHCCCCCCCCCCC	16.38	25262027
1513	Phosphorylation	AQGTQGGSKKSLDLT CCCCCCCCCCCCCCC	43.67	25262027
1565	N-linked_Glycosylation	MADFIANNGTVPGCP HHHHHHCCCCCCCCC	38.19	UniProtKB CARBOHYD
1591	Hydroxylation	HNGGTCVNQWDAFSC CCCCCCCCCCCCEEC	39.10	-
1641	Phosphorylation	ISQPWYLSLMFRTRQ CCCCHHHHHHEEECC	11.33	24719451
1685	Phosphorylation	EGTGLQASSLRLEPG ECCCCCEEEEEECCC	19.56	29507054
1741	N-linked_Glycosylation	LHGLHLSNITVGGIP CCEEECCCEEECCCC	40.07	UniProtKB CARBOHYD
1810	Hydroxylation	PANSYCSNDWDSYSC CCCCCCCCCCCCCCC	51.32	-
1827	N-linked_Glycosylation	DPGYYGDNCTNVCDL CCCCCCCCCCCCCCC	30.10	UniProtKB CARBOHYD
1848	Phosphorylation	SVCTRKPSAPHGYTC CCCCCCCCCCCCEEC	58.42	24043423
1853	Phosphorylation	KPSAPHGYTCECPPN CCCCCCCEECCCCCC	12.75	24043423
1854	Phosphorylation	PSAPHGYTCECPPNY CCCCCCEECCCCCCC	13.35	24043423
1861	Phosphorylation	TCECPPNYLGPYCET ECCCCCCCCCCCCCE	20.86	24043423
1865	Phosphorylation	PPNYLGPYCETRIDQ CCCCCCCCCCEECCC	10.91	24043423
1868	Phosphorylation	YLGPYCETRIDQPCP CCCCCCCEECCCCCC	29.39	24043423
1900	N-linked_Glycosylation	KGFDPDCNKTSGECH CCCCCCCCCCCCCCC	59.00	UniProtKB CARBOHYD
1927	Phosphorylation	TCLLCDCYPTGSLSR EEEEEECCCCCCCCC	7.20	28634298
1929	Phosphorylation	LLCDCYPTGSLSRVC EEEECCCCCCCCCCC	16.96	28634298
1931	Phosphorylation	CDCYPTGSLSRVCDP EECCCCCCCCCCCCC	26.16	28634298
1933	Phosphorylation	CYPTGSLSRVCDPED CCCCCCCCCCCCCCC	25.10	28634298
2024	N-linked_Glycosylation	WLPPNLFNCTSITFS CCCCCCCCCCCCCHH	31.18	UniProtKB CARBOHYD
2043	N-linked_Glycosylation	FAERLQRNESGLDSG HHHHHHHCCCCCCCC	34.52	UniProtKB CARBOHYD
2052	Phosphorylation	SGLDSGRSQQLALLL CCCCCCHHHHHHHHH	26.29	27174698
2061	N-linked_Glycosylation	QLALLLRNATQHTAG HHHHHHHHHCCCCCC	47.51	UniProtKB CARBOHYD
2063	Phosphorylation	ALLLRNATQHTAGYF HHHHHHHCCCCCCCC	25.16	27174698
2066	Phosphorylation	LRNATQHTAGYFGSD HHHHCCCCCCCCCCH	16.38	27174698
2069	Phosphorylation	ATQHTAGYFGSDVKV HCCCCCCCCCCHHHH	11.42	27174698
2072	Phosphorylation	HTAGYFGSDVKVAYQ CCCCCCCCHHHHHHH	29.36	27174698
2121	Ubiquitination	ALLDTANKRHWELIQ HHHHHCCHHHHHHHH	43.08	22817900
2212	O-linked_Glycosylation	PESVFRETPPVVRPA CHHHHCCCCCCCCCC	28.74	OGP
2323	N-linked_Glycosylation	KPICVFWNHSILVSG CCEEEEECCCEEEEC	13.94	UniProtKB CARBOHYD
2345	N-linked_Glycosylation	GCEVVFRNESHVSCQ CEEEEEECCCCEEEE	43.59	UniProtKB CARBOHYD
2380	Phosphorylation	ILPLKTLTYVALGVT CCCCCHHHHHHHHHH	22.60	30576142
2494	Phosphorylation	WGVPAFITGLAVGLD CCCCCHHHHHHCCCC	21.49	26074081
2505	Phosphorylation	VGLDPEGYGNPDFCW CCCCCCCCCCCCCEE	16.45	26074081
2514	Phosphorylation	NPDFCWLSIYDTLIW CCCCEEEEHHHHHHH	8.46	26074081
2516	Phosphorylation	DFCWLSIYDTLIWSF CCEEEEHHHHHHHHH	10.25	26074081
2518	Phosphorylation	CWLSIYDTLIWSFAG EEEEHHHHHHHHHHH	11.81	26074081
2637	Ubiquitination	PDPALTTKSTLTSSY CCCCCCCCCEECCCC	35.89	21963094
2638	Phosphorylation	DPALTTKSTLTSSYN CCCCCCCCEECCCCC	26.93	21945579
2639	Phosphorylation	PALTTKSTLTSSYNC CCCCCCCEECCCCCC	35.29	21945579
2641	Phosphorylation	LTTKSTLTSSYNCPS CCCCCEECCCCCCCC	18.73	21945579
2642	Phosphorylation	TTKSTLTSSYNCPSP CCCCEECCCCCCCCC	33.66	21945579
2643	Phosphorylation	TKSTLTSSYNCPSPY CCCEECCCCCCCCCC	18.35	21945579
2644	Phosphorylation	KSTLTSSYNCPSPYA CCEECCCCCCCCCCC	22.13	21945579
2648	Phosphorylation	TSSYNCPSPYADGRL CCCCCCCCCCCCCCE	32.51	21945579
2650	Phosphorylation	SYNCPSPYADGRLYQ CCCCCCCCCCCCEEC	22.97	21945579
2656	Phosphorylation	PYADGRLYQPYGDSA CCCCCCEECCCCCCC	13.19	21945579
2659	Phosphorylation	DGRLYQPYGDSAGSL CCCEECCCCCCCCCC	20.31	21945579
2662	Phosphorylation	LYQPYGDSAGSLHST EECCCCCCCCCCCCC	30.11	21945579
2665	Phosphorylation	PYGDSAGSLHSTSRS CCCCCCCCCCCCCCC	23.72	21945579
2668	Phosphorylation	DSAGSLHSTSRSGKS CCCCCCCCCCCCCCC	33.11	21945579
2669	Phosphorylation	SAGSLHSTSRSGKSQ CCCCCCCCCCCCCCC	19.88	21945579
2670	Phosphorylation	AGSLHSTSRSGKSQP CCCCCCCCCCCCCCC	27.71	21945579
2672	Phosphorylation	SLHSTSRSGKSQPSY CCCCCCCCCCCCCCC	50.79	24719451
2674	Ubiquitination	HSTSRSGKSQPSYIP CCCCCCCCCCCCCCC	47.35	-
2675	Phosphorylation	STSRSGKSQPSYIPF CCCCCCCCCCCCCCH	51.34	24719451
2679	Phosphorylation	SGKSQPSYIPFLLRE CCCCCCCCCCHHCCC	21.21	25106551
2776	Phosphorylation	AERLPLHSTPKDGGP CCCCCCCCCCCCCCC	54.83	27251275
2777	Phosphorylation	ERLPLHSTPKDGGPG CCCCCCCCCCCCCCC	24.49	27251275
2787	Ubiquitination	DGGPGPGKAPWPGDF CCCCCCCCCCCCCCC	55.18	29967540
2823	Phosphorylation	DALSREGSLGPLPGS CCCCCCCCCCCCCCC	25.96	25849741
2830	Phosphorylation	SLGPLPGSSAQPHKG CCCCCCCCCCCCCCC	22.14	22210691
2831	Phosphorylation	LGPLPGSSAQPHKGI CCCCCCCCCCCCCCC	36.52	22210691
2852	Phosphorylation	PTISEKSSLLRLPLE CCCCCCCCCCCCCHH	42.35	24719451
2868	Phosphorylation	CTGSSRGSSASEGSR CCCCCCCCCCCCCCC	22.94	18669648
2869	Phosphorylation	TGSSRGSSASEGSRG CCCCCCCCCCCCCCC	38.34	18669648
2871	Phosphorylation	SSRGSSASEGSRGGP CCCCCCCCCCCCCCC	44.42	18669648

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CELR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CELR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CELR2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CELR2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.