BRI3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRI3B_HUMAN
• UniProt AC: Q8WY22
• Protein Name: BRI3-binding protein
• Gene Name: BRI3BP {ECO:0000312|EMBL:AAL54382.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 251
• Subcellular Localization: Mitochondrion outer membrane ; Multi-pass membrane protein .
• Protein Description: Involved in tumorigenesis and may function by stabilizing p53/TP53..
• Protein Sequence: MGARASGGPLARAGLLLLLLLLLLLGLLAPGAQGARGRGGAEKNSYRRTVNTFSQSVSSLFGEDNVRAAQKFLARLTERFVLGVDMFVETLWKVWTELLDVLGLDVSNLSQYFSPASVSSSPARALLLVGVVLLAYWFLSLTLGFTFSVLHVVFGRFFWIVRVVLFSMSCVYILHKYEGEPENAVLPLCFVVAVYFMTGPMGFYWRSSPSGPSNPSNPSVEEKLEHLEKQVRLLNIRLNRVLESLDRSKDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	EKNSYRRTVNTFSQS CCCCHHHHHHHHHHH	14.76	27251275
71	Ubiquitination	DNVRAAQKFLARLTE HHHHHHHHHHHHHHH	37.30	21890473
210	Phosphorylation	FYWRSSPSGPSNPSN CCEECCCCCCCCCCC	66.34	28985074
229	Acetylation	EKLEHLEKQVRLLNI HHHHHHHHHHHHHHH	61.53	19608861
229	Ubiquitination	EKLEHLEKQVRLLNI HHHHHHHHHHHHHHH	61.53	33845483
244	Phosphorylation	RLNRVLESLDRSKDK HHHHHHHHHHHCCCC	31.26	30266825
248	Phosphorylation	VLESLDRSKDK---- HHHHHHHCCCC----	44.89	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRI3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRI3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRI3B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of BRI3B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-229, AND MASS SPECTROMETRY.
PubMed: 19608861