ZBT17_HUMAN - dbPTM
ZBT17_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZBT17_HUMAN
UniProt AC Q13105
Protein Name Zinc finger and BTB domain-containing protein 17
Gene Name ZBTB17
Organism Homo sapiens (Human).
Sequence Length 803
Subcellular Localization Nucleus .
Protein Description Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1. [PubMed: 25245946]
Protein Sequence MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
113PhosphorylationTACHALKSLAEPATS
HHHHHHHHHCCCCCC		33.3929255136
119PhosphorylationKSLAEPATSPGGNAE
HHHCCCCCCCCCCHH		46.2823401153
120PhosphorylationSLAEPATSPGGNAEA
HHCCCCCCCCCCHHH		24.5329255136
130PhosphorylationGNAEALATEGGDKRA
CCHHHHHCCCCCHHH		35.6930278072
135 (in isoform 2)Ubiquitination-58.4921906983
135 (in isoform 1)Ubiquitination-58.4921906983
135UbiquitinationLATEGGDKRAKEEKV
HHCCCCCHHHHHHHH		58.4921906983
156PhosphorylationRLEQAGRSTPIGPSR
HHHHCCCCCCCCCCC		37.3030624053
157PhosphorylationLEQAGRSTPIGPSRD
HHHCCCCCCCCCCCC		19.9825849741
162PhosphorylationRSTPIGPSRDLKEER
CCCCCCCCCCCCHHH		32.96-
169MethylationSRDLKEERGGQAQSA
CCCCCHHHCCCHHHH		56.48115920305
175PhosphorylationERGGQAQSAASGAEQ
HHCCCHHHHHCCHHH		28.90-
178PhosphorylationGQAQSAASGAEQTEK
CCHHHHHCCHHHHHC		37.95-
202PhosphorylationVELKPDPTSGMAAAE
CCCCCCCCCHHHHHH		45.3429449344
203PhosphorylationELKPDPTSGMAAAEA
CCCCCCCCHHHHHHH		31.7722210691
215PhosphorylationAEAEAALSESSEQEM
HHHHHHHCCCCHHHH		30.6129449344
217PhosphorylationAEAALSESSEQEMEV
HHHHHCCCCHHHHCC		35.4822210691
218PhosphorylationEAALSESSEQEMEVE
HHHHCCCCHHHHCCC		38.9722210691
255PhosphorylationAEVKEEGSQLENGEA
HHHHHHCCCCCCCCC		34.5721406692
271 (in isoform 2)Phosphorylation-26.3121406692
271PhosphorylationEENENEESAGTDSGQ
CCCCCCCCCCCCCHH		26.3130576142
274PhosphorylationENEESAGTDSGQELG
CCCCCCCCCCHHHHH		27.0630576142
274 (in isoform 2)Phosphorylation-27.0621406692
276PhosphorylationEESAGTDSGQELGSE
CCCCCCCCHHHHHHH		42.0621406692
276 (in isoform 2)Phosphorylation-42.0621406692
282PhosphorylationDSGQELGSEARGLRS
CCHHHHHHHHHCCCC		40.4821406692
291PhosphorylationARGLRSGTYGDRTES
HHCCCCCCCCCCCCC		26.10-
292PhosphorylationRGLRSGTYGDRTESK
HCCCCCCCCCCCCCC		22.13-
301 (in isoform 2)Phosphorylation-17.4227642862
329PhosphorylationKRHIRIHTGEKPFSC
EEEEEEECCCCCCCH		44.67-
332UbiquitinationIRIHTGEKPFSCREC
EEEECCCCCCCHHHH		53.3521906983
332 (in isoform 2)Ubiquitination-53.3521906983
332 (in isoform 1)Ubiquitination-53.3521906983
341UbiquitinationFSCRECSKAFSDPAA
CCHHHHHHHHCCHHH		66.1721906983
341 (in isoform 1)Ubiquitination-66.1721906983
341 (in isoform 2)Ubiquitination-66.1721906983
350 (in isoform 1)Ubiquitination-48.3121906983
350 (in isoform 2)Ubiquitination-48.3121906983
350UbiquitinationFSDPAACKAHEKTHS
HCCHHHHHHCCCCCC		48.312190698
355PhosphorylationACKAHEKTHSPLKPY
HHHHCCCCCCCCCCC		25.3028387310
357PhosphorylationKAHEKTHSPLKPYGC
HHCCCCCCCCCCCCC		36.8423401153
360UbiquitinationEKTHSPLKPYGCEEC
CCCCCCCCCCCCCCC		39.31-
362PhosphorylationTHSPLKPYGCEECGK
CCCCCCCCCCCCCCC		32.5918083107
371PhosphorylationCEECGKSYRLISLLN
CCCCCCHHHHHHHHC		16.9618083107
406UbiquitinationFTTSGNLKRHQLVHS
EECCCCCCEEEEECC		52.41-
413PhosphorylationKRHQLVHSGEKPYQC
CEEEEECCCCCCEEC		40.96-
426PhosphorylationQCDYCGRSFSDPTSK
ECCCCCCCCCCCCHH		17.8729052541
428PhosphorylationDYCGRSFSDPTSKMR
CCCCCCCCCCCHHCC		43.8829052541
431PhosphorylationGRSFSDPTSKMRHLE
CCCCCCCCHHCCCCC		46.0729052541
432PhosphorylationRSFSDPTSKMRHLET
CCCCCCCHHCCCCCC		29.8229052541
433AcetylationSFSDPTSKMRHLETH
CCCCCCHHCCCCCCC		42.2920167786
462UbiquitinationFNQVGNLKAHLKIHI
CCCCCCHHHEEEEEE		37.45-
497PhosphorylationKRHLRIHSGEKPYVC
HHEEEEECCCCCEEE		46.4029214152
525PhosphorylationQRHVRIHTGEKPCQC
HHCEEEECCCCCEEE		44.67-
570PhosphorylationCGKRFVQSSQLANHI
CCCCHHHHHHHHHHH		18.10-
609PhosphorylationSKHIIIHTGEKPYLC
HCEEEEECCCCCCCC		36.3129214152
791PhosphorylationGQPALAETSPTAPEC
CCCCCCCCCCCCCCC		34.1126074081
792PhosphorylationQPALAETSPTAPECP
CCCCCCCCCCCCCCC		16.2630576142
794PhosphorylationALAETSPTAPECPPP
CCCCCCCCCCCCCCC		55.3930576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseHUWE1Q7Z6Z7
PMID:26212014
-KUbiquitinationE3 ubiquitin ligaseTRAF2Q12933
PMID:20577214
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
397Kubiquitylation

-
481Kubiquitylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZBT17_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TOPB1_HUMANTOPBP1physical
12408820
MYC_HUMANMYCphysical
11283613
MAX_HUMANMAXphysical
11283613
MYC_HUMANMYCphysical
9312026
HCFC1_HUMANHCFC1physical
12244100
IRF8_HUMANIRF8physical
12904288
ZBT17_HUMANZBTB17physical
17880999
MYCN_HUMANMYCNphysical
21908575
KLF5_HUMANKLF5physical
19419955
MYC_HUMANMYCphysical
18923429
MYC_HUMANMYCphysical
20426839
MYC_HUMANMYCphysical
17418410
1433T_HUMANYWHAQphysical
19786833
DNM3A_HUMANDNMT3Aphysical
19786833
MYC_HUMANMYCphysical
19786833
MYC_HUMANMYCphysical
16352593
HXK2_RATHk2physical
11068878
HXK3_RATHk3physical
11068878
ZBT49_HUMANZBTB49physical
25245946
ZBTB4_HUMANZBTB4physical
18451802
GFI1_HUMANGFI1physical
19164764
MYCN_HUMANMYCNphysical
21123453
TOPB1_HUMANTOPBP1physical
17006541
TOPB1_HUMANTOPBP1physical
18923429
CDN2A_HUMANCDKN2Aphysical
19901969
ARF_HUMANCDKN2Aphysical
19901969
P53_HUMANTP53physical
19901969
BCL6_HUMANBCL6physical
16142238
MAGA4_HUMANMAGEA4physical
14739298
DACT1_HUMANDACT1physical
25558878
DVL2_HUMANDVL2physical
25558878
MYC_HUMANMYCphysical
26766587
ZBT7C_HUMANZBTB7Cphysical
21804610
BCL6_HUMANBCL6physical
21804610
ZBT17_HUMANZBTB17physical
21804610
P53_HUMANTP53physical
21804610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZBT17_HUMAN

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Related Literatures of Post-Translational Modification

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