ZBT7C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT7C_HUMAN
• UniProt AC: A1YPR0
• Protein Name: Zinc finger and BTB domain-containing protein 7C
• Gene Name: ZBTB7C
• Organism: Homo sapiens (Human).
• Sequence Length: 619
• Protein Description: May be a tumor suppressor gene..
• Protein Sequence: MANDIDELIGIPFPNHSSEVLCSLNEQRHDGLLCDVLLVVQEQEYRTHRSVLAACSKYFKKLFTAGTLASQPYVYEIDFVQPEALAAILEFAYTSTLTITAGNVKHILNAARMLEIQCIVNVCLEIMEPGGDGGEEDDKEDDDDDEDDDDEEDEEEEEEEEEDDDDDTEDFADQENLPDPQDISCHQSPSKTDHLTEKAYSDTPRDFPDSFQAGSPGHLGVIRDFSIESLLRENLYPKANIPDRRPSLSPFAPDFFPHLWPGDFGAFAQLPEQPMDSGPLDLVIKNRKIKEEEKEELPPPPPPPFPNDFFKDMFPDLPGGPLGPIKAENDYGAYLNFLSATHLGGLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRTHTGEKPYMCTICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVRPYQCEFCYKSFTRSDHLHRHIKRQSCRMARPRRGRKPAAWRAASLLFGPGGPAPDKAAFVMPPALGEVGGHLGGAAVCLPGPSPAKHFLAAPKGALSLQELERQFEETQMKLFGRAQLEAERNAGGLLAFALAENVAAARPYFPLPDPWAAGLAGLPGLAGLNHVASMSEANN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	VLAACSKYFKKLFTA HHHHHHHHHHHHHCH	12.34	-
73	Phosphorylation	GTLASQPYVYEIDFV HHHCCCCEEEEEEEC	14.18	-
75	Phosphorylation	LASQPYVYEIDFVQP HCCCCEEEEEEECCH	11.00	-
201	Phosphorylation	HLTEKAYSDTPRDFP CCCHHHHCCCCCCCC	39.61	24719451
215	Phosphorylation	PDSFQAGSPGHLGVI CCHHCCCCCCCCEEE	30.62	26657352
226	Phosphorylation	LGVIRDFSIESLLRE CEEECCCCHHHHHHC	29.72	27251275
229	Phosphorylation	IRDFSIESLLRENLY ECCCCHHHHHHCCCC	30.91	28348404
331	Phosphorylation	PIKAENDYGAYLNFL CCCCCCCHHHHHHHH	18.42	22817900
385	Phosphorylation	KLPRHMRTHTGEKPY CCCCCCCCCCCCCCE	19.06	-
387	Phosphorylation	PRHMRTHTGEKPYMC CCCCCCCCCCCCEEE	46.56	-
529	Phosphorylation	AVCLPGPSPAKHFLA EEECCCCCHHHHHHH	43.32	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBT7C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBT7C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT7C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRBP1_HUMAN	SREBF1	physical	22331133
JUN_HUMAN	JUN	physical	27646874
ZBT17_HUMAN	ZBTB17	physical	21804610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-331, AND MASSSPECTROMETRY.
PubMed: 18083107