| UniProt ID | ZBT49_HUMAN | |
|---|---|---|
| UniProt AC | Q6ZSB9 | |
| Protein Name | Zinc finger and BTB domain-containing protein 49 | |
| Gene Name | ZBTB49 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 765 | |
| Subcellular Localization |
Isoform 1: Cytoplasm . Nucleus . Predominantly located in the nucleus. Isoform 3: Cytoplasm . Nucleus . |
|
| Protein Description | Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.; Isoform 1: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).; Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.. | |
| Protein Sequence | MDPVATHSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDVKNVSGIGQILDFMYTSHLDLNQDNIQVMLDTAQCLQVQNVLSLCHTFLKSATVVQPPGMPCNSTLSLQSTLTPDATCVISENYPPHLLQECSADAQQNKTLDESHPHASPSVNRHHSAGEISKQAPDTSDGSCTELPFKQPNYYYKLRNFYSKQYHKHAAGPSQERVVEQPFAFSTSTDLTTVESQPCAVSHSECILESPEHLPSNFLAQPVNDSAPHPESDATCQQPVKQMRLKKAIHLKKLNFLKSQKYAEQVSEPKSDDGLTKRLESASKNTLEKASSQSAEEKESEEVVSCENFNCISETERPEDPAALEDQSQTLQSQRQYACELCGKPFKHPSNLELHKRSHTGEKPFECNICGKHFSQAGNLQTHLRRHSGEKPYICEICGKRFAASGDVQRHIIIHSGEKPHLCDICGRGFSNFSNLKEHKKTHTADKVFTCDECGKSFNMQRKLVKHRIRHTGERPYSCSACGKCFGGSGDLRRHVRTHTGEKPYTCEICNKCFTRSAVLRRHKKMHCKAGDESPDVLEELSQAIETSDLEKSQSSDSFSQDTSVTLMPVSVKLPVHPVENSVAEFDSHSGGSYCKLRSMIQPHGVSDQEKLSLDPGKLAKPQMQQTQPQAYAYSDVDTPAGGEPLQADGMAMIRSSLAALDNHGGDPLGSRASSTTYRNSEGQFFSSMTLWGLAMKTLQNENELDQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 173 | Phosphorylation | QNKTLDESHPHASPS HCCCCCCCCCCCCCC | 41.82 | 23186163 | |
| 178 | Phosphorylation | DESHPHASPSVNRHH CCCCCCCCCCCCCCC | 18.05 | 25159151 | |
| 180 | Phosphorylation | SHPHASPSVNRHHSA CCCCCCCCCCCCCCC | 29.54 | 23186163 | |
| 316 | Methylation | LKKLNFLKSQKYAEQ HHHHHHHHCHHHHHH | 46.86 | 115978181 | |
| 325 | Phosphorylation | QKYAEQVSEPKSDDG HHHHHHCCCCCCCCC | 48.12 | 30576142 | |
| 329 | Phosphorylation | EQVSEPKSDDGLTKR HHCCCCCCCCCHHHH | 52.21 | 30576142 | |
| 334 | Phosphorylation | PKSDDGLTKRLESAS CCCCCCHHHHHHHHC | 21.46 | 30576142 | |
| 339 | Phosphorylation | GLTKRLESASKNTLE CHHHHHHHHCHHHHH | 42.29 | - | |
| 344 | Phosphorylation | LESASKNTLEKASSQ HHHHCHHHHHHHHHC | 39.78 | - | |
| 352 | Phosphorylation | LEKASSQSAEEKESE HHHHHHCCHHHHHCC | 39.33 | 28985074 | |
| 440 | Phosphorylation | SQAGNLQTHLRRHSG HHCCCHHHHHHHHCC | 26.50 | 17494752 | |
| 459 | Methylation | ICEICGKRFAASGDV EEEECCCEECCCCCC | 16.24 | 115372861 | |
| 459 | Dimethylation | ICEICGKRFAASGDV EEEECCCEECCCCCC | 16.24 | - | |
| 556 | Phosphorylation | DLRRHVRTHTGEKPY CHHHHHHCCCCCCCE | 23.77 | - | |
| 558 | Phosphorylation | RRHVRTHTGEKPYTC HHHHHCCCCCCCEEE | 46.56 | - | |
| 575 | Phosphorylation | CNKCFTRSAVLRRHK CCCCCCHHHHHHHHH | 21.48 | 23532336 | |
| 592 | Phosphorylation | HCKAGDESPDVLEEL CCCCCCCCHHHHHHH | 31.01 | 28387310 | |
| 600 | Phosphorylation | PDVLEELSQAIETSD HHHHHHHHHHHHHHH | 22.35 | 28634120 | |
| 605 | Phosphorylation | ELSQAIETSDLEKSQ HHHHHHHHHHHHHHH | 22.79 | 28102081 | |
| 606 | Phosphorylation | LSQAIETSDLEKSQS HHHHHHHHHHHHHHC | 27.66 | - | |
| 652 | Phosphorylation | DSHSGGSYCKLRSMI CCCCCCCCEEHHHCC | 9.25 | 17053785 | |
| 714 | Phosphorylation | DGMAMIRSSLAALDN CHHHHHHHHHHHHHC | 20.83 | 22210691 | |
| 715 | Phosphorylation | GMAMIRSSLAALDNH HHHHHHHHHHHHHCC | 16.51 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZBT49_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZBT49_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZBT49_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZBT8A_HUMAN | ZBTB8A | physical | 25416956 | |
| KAT5_HUMAN | KAT5 | physical | 25245946 | |
| EP300_HUMAN | EP300 | physical | 25245946 | |
| ZBT17_HUMAN | ZBTB17 | physical | 25245946 | |
| HINFP_HUMAN | HINFP | physical | 25245946 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-652, AND MASSSPECTROMETRY. | |
