| UniProt ID | HINFP_HUMAN | |
|---|---|---|
| UniProt AC | Q9BQA5 | |
| Protein Name | Histone H4 transcription factor | |
| Gene Name | HINFP | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 517 | |
| Subcellular Localization | Nucleus . Associated with discrete nuclear foci. | |
| Protein Description | Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.. | |
| Protein Sequence | MPPPGKVPRKENLWLQCEWGSCSFVCSTMEKFFEHVTQHLQQHLHGSGEEEEEEEEDDPLEEEFSCLWQECGFCSLDSSADLIRHVYFHCYHTKLKQWGLQALQSQADLGPCILDFQSRNVIPDIPDHFLCLWEHCENSFDNPEWFYRHVEAHSLCCEYEAVGKDNPVVLCGWKGCTCTFKDRSKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQTSLDQQHFQCSHCSKRFATERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSEDRPFKCDCCDYSCKNLIDLQKHLDTHSEEPAYRCDFENCTFSARSLCSIKSHYRKVHEGDSEPRYKCHVCDKCFTRGNNLTVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQLVRYESVELTQQLLRQPQEGSGLGTSLNESSLQGIILETVPGEPGRKEEEEEGKGSEGTALSASQDNPSSVIHVVNQTNAQGQQEIVYYVLSEAPGEPPPAPEPPSGGIMEKLQGIAEEPEIQMV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 184 | Phosphorylation | TCTFKDRSKLREHLR CCEECCHHHHHHHHH | 46.29 | 26657352 | |
| 192 | Phosphorylation | KLREHLRSHTQEKVV HHHHHHHHCCCCCEE | 36.93 | 26657352 | |
| 194 | Phosphorylation | REHLRSHTQEKVVAC HHHHHHCCCCCEEEC | 39.40 | 26657352 | |
| 240 | Phosphorylation | HCSKRFATERLLRDH HHHHHHHHHHHHHHH | 20.94 | - | |
| 279 | Phosphorylation | NHMRFRHSEDRPFKC HHCCCCCCCCCCCCC | 36.62 | 28555341 | |
| 301 | Ubiquitination | KNLIDLQKHLDTHSE HHHHHHHHHHHCCCC | 54.13 | - | |
| 330 | Ubiquitination | ARSLCSIKSHYRKVH HHHHHHHHHHEEECC | 18.19 | - | |
| 333 | Phosphorylation | LCSIKSHYRKVHEGD HHHHHHHEEECCCCC | 21.15 | - | |
| 345 | Phosphorylation | EGDSEPRYKCHVCDK CCCCCCCCEEEECCC | 28.78 | - | |
| 396 | Phosphorylation | MRLQLVRYESVELTQ EEEEEEEEEHHHHHH | 12.70 | 25690035 | |
| 398 | Phosphorylation | LQLVRYESVELTQQL EEEEEEEHHHHHHHH | 16.38 | 30624053 | |
| 402 | Phosphorylation | RYESVELTQQLLRQP EEEHHHHHHHHHHCC | 10.77 | 25690035 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HINFP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HINFP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HINFP_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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