TRI44_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI44_HUMAN
• UniProt AC: Q96DX7
• Protein Name: Tripartite motif-containing protein 44
• Gene Name: TRIM44
• Organism: Homo sapiens (Human).
• Sequence Length: 344
• Protein Description: May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression. [PubMed: 26394807]
• Protein Sequence: MASGVGAAFEELPHDGTCDECEPDEAPGAEEVCRECGFCYCRRHAEAHRQKFLSHHLAEYVHGSQAWTPPADGEGAGKEEAEVKVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPEIEMEAERVAKRKCPDHGLDLSTYCQEDRQLICVLCPVIGAHQGHQLSTLDEAFEELRSKDSGGLKAAMIELVERLKFKSSDPKVTRDQMKMFIQQEFKKVQKVIADEEQKALHLVDIQEAMATAHVTEILADIQSHMDRLMTQMAQAKEQLDTSNESAEPKAEGDEEGPSGASEEEDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASGVGAAFE -----CCCCCCHHHH	32.48	24043423
17	Phosphorylation	EELPHDGTCDECEPD HCCCCCCCCCCCCCC	23.88	24043423
40	Phosphorylation	CRECGFCYCRRHAEA HHHCCCEEHHHHHHH	6.17	24043423
64	Phosphorylation	LAEYVHGSQAWTPPA HHHHHHCCCCCCCCC	11.22	29523821
68	Phosphorylation	VHGSQAWTPPADGEG HHCCCCCCCCCCCCC	23.55	29523821
178	Ubiquitination	AERVAKRKCPDHGLD HHHHHHHHCCCCCCC	49.79	33845483
225	Ubiquitination	AFEELRSKDSGGLKA HHHHHHCCCCCCHHH	49.86	23000965
231	Ubiquitination	SKDSGGLKAAMIELV CCCCCCHHHHHHHHH	37.06	23000965
244	Ubiquitination	LVERLKFKSSDPKVT HHHHHCCCCCCCCCC	47.68	33845483
249	Ubiquitination	KFKSSDPKVTRDQMK CCCCCCCCCCHHHHH	62.32	29967540
256	Ubiquitination	KVTRDQMKMFIQQEF CCCHHHHHHHHHHHH	25.65	23000965
264	Ubiquitination	MFIQQEFKKVQKVIA HHHHHHHHHHHHHHC	51.81	23000965
265	Ubiquitination	FIQQEFKKVQKVIAD HHHHHHHHHHHHHCC	56.04	23000965
268	Ubiquitination	QEFKKVQKVIADEEQ HHHHHHHHHHCCHHH	38.30	23000965
314	Ubiquitination	MTQMAQAKEQLDTSN HHHHHHHHHHHHCCC	33.63	23000965
319	Phosphorylation	QAKEQLDTSNESAEP HHHHHHHCCCCCCCC	41.88	25159151
320	Phosphorylation	AKEQLDTSNESAEPK HHHHHHCCCCCCCCC	37.96	25159151
323	Phosphorylation	QLDTSNESAEPKAEG HHHCCCCCCCCCCCC	42.03	25159151
327	Ubiquitination	SNESAEPKAEGDEEG CCCCCCCCCCCCCCC	51.04	23503661
336	Phosphorylation	EGDEEGPSGASEEED CCCCCCCCCCCCCCC	58.82	25159151
339	Phosphorylation	EEGPSGASEEEDT-- CCCCCCCCCCCCC--	49.41	25159151
344	Phosphorylation	GASEEEDT------- CCCCCCCC-------	43.73	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRI44_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI44_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI44_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI17_HUMAN	TRIM17	physical	19358823
A4_HUMAN	APP	physical	21832049
TRI69_HUMAN	TRIM69	physical	25416956
ZN254_HUMAN	ZNF254	physical	28514442
DACH1_HUMAN	DACH1	physical	28514442
RN187_HUMAN	RNF187	physical	28514442
TRI47_HUMAN	TRIM47	physical	28514442
BOREA_HUMAN	CDCA8	physical	28514442
SPS2L_HUMAN	SPATS2L	physical	28514442
CCD15_HUMAN	CCDC15	physical	28514442
FEM1B_HUMAN	FEM1B	physical	28514442
TRI11_HUMAN	TRIM11	physical	28514442
FGRL1_HUMAN	FGFRL1	physical	28514442
ZNF91_HUMAN	ZNF91	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
CC112_HUMAN	CCDC112	physical	28514442
TAF1B_HUMAN	TAF1B	physical	28514442
TAF1A_HUMAN	TAF1A	physical	28514442
SPAS2_HUMAN	SPATS2	physical	28514442
CC151_HUMAN	CCDC151	physical	28514442
GOGA2_HUMAN	GOLGA2	physical	28514442
MCRS1_HUMAN	MCRS1	physical	28514442
KANL2_HUMAN	KANSL2	physical	28514442
PTHB1_HUMAN	BBS9	physical	28514442
TAF1C_HUMAN	TAF1C	physical	28514442
NDUF7_HUMAN	NDUFAF7	physical	28514442
TAF1D_HUMAN	TAF1D	physical	28514442
TXLNG_HUMAN	TXLNG	physical	28514442
ZNF92_HUMAN	ZNF92	physical	28514442
SRBD1_HUMAN	SRBD1	physical	28514442
TXLNA_HUMAN	TXLNA	physical	28514442
DACH2_HUMAN	DACH2	physical	28514442
ZMYM1_HUMAN	ZMYM1	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442
CUL2_HUMAN	CUL2	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
MICU2_HUMAN	MICU2	physical	28514442
TSYL1_HUMAN	TSPYL1	physical	28514442
BAP18_HUMAN	C17orf49	physical	28514442
AN30B_HUMAN	ANKRD30B	physical	28514442
MICU1_HUMAN	MICU1	physical	28514442
BBX_HUMAN	BBX	physical	28514442
CK5P3_HUMAN	CDK5RAP3	physical	28514442
BBS2_HUMAN	BBS2	physical	28514442
ZN761_HUMAN	ZNF761	physical	28514442
BBS1_HUMAN	BBS1	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.