MICU2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MICU2_HUMAN
• UniProt AC: Q8IYU8
• Protein Name: Calcium uptake protein 2, mitochondrial
• Gene Name: MICU2
• Organism: Homo sapiens (Human).
• Sequence Length: 434
• Subcellular Localization: Mitochondrion intermembrane space .
• Protein Description: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. [PubMed: 24503055]
• Protein Sequence: MAAAAGSCARVAAWGGKLRRGLAVSRQAVRSPGPLAAAVAGAALAGAGAAWHHSRVSVAARDGSFTVSAQKNVEHGIIYIGKPSLRKQRFMQFSSLEHEGEYYMTPRDFLFSVMFEQMERKTSVKKLTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILTKPHSGFHVAFKMLDTDGNEMIEKREFFKLQKIISKQDDLMTVKTNETGYQEAIVKEPEINTTLQMRFFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSKGLSFMRKEDFAEWLLFFTNTENKDIYWKNVREKLSAGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKESIKGVKEVWKQAGKGLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAAAAGSCARVAAW -CCCCHHHHHHHHHC		20860994
25	Phosphorylation	LRRGLAVSRQAVRSP HHHCCHHHHHHHCCC		-
79	Phosphorylation	NVEHGIIYIGKPSLR CCCCEEEEECCHHHH		29496907
82	Ubiquitination	HGIIYIGKPSLRKQR CEEEEECCHHHHCCH		21890473
84	Phosphorylation	IIYIGKPSLRKQRFM EEEECCHHHHCCHHC		20873877
130	Ubiquitination	SVKKLTKKDIEDTLS CHHHHCHHHHHHHHH		-
194	Ubiquitination	DGNEMIEKREFFKLQ CCCHHHHHHHHHHHH		21890473
194	2-Hydroxyisobutyrylation	DGNEMIEKREFFKLQ CCCHHHHHHHHHHHH		-
199	Ubiquitination	IEKREFFKLQKIISK HHHHHHHHHHHHHHC		-
202	Ubiquitination	REFFKLQKIISKQDD HHHHHHHHHHHCCCC		-
205	Phosphorylation	FKLQKIISKQDDLMT HHHHHHHHCCCCCEE		29632367
206	Ubiquitination	KLQKIISKQDDLMTV HHHHHHHCCCCCEEE		21890473
212	Phosphorylation	SKQDDLMTVKTNETG HCCCCCEEEEECCCC		23612710
214	Ubiquitination	QDDLMTVKTNETGYQ CCCCEEEEECCCCCC		21890473
220	Phosphorylation	VKTNETGYQEAIVKE EEECCCCCCEEEECC		-
226	Ubiquitination	GYQEAIVKEPEINTT CCCEEEECCCCCCCE		21890473
355	Ubiquitination	AEFKRAVKVATGQEL HHHHHHHHHHCCCHH		-
392	Ubiquitination	EEFLGVLKNRMHRGL HHHHHHHHHCCCCCC		-
423	Ubiquitination	KESIKGVKEVWKQAG HHHCCCHHHHHHHHC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MICU2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MICU2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MICU2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASH2L_HUMAN	ASH2L	physical	26186194
MICU1_HUMAN	MICU1	physical	26186194
ACOX3_HUMAN	ACOX3	physical	26186194
KC1E_HUMAN	CSNK1E	physical	26186194
KC1D_HUMAN	CSNK1D	physical	26186194
GAPD1_HUMAN	GAPVD1	physical	26186194
SMAP1_HUMAN	SMAP1	physical	26186194
SKT_HUMAN	KIAA1217	physical	26186194
MICU1_HUMAN	MICU1	physical	28514442
ACOX3_HUMAN	ACOX3	physical	28514442
KLH22_HUMAN	KLHL22	physical	28514442
SMAP1_HUMAN	SMAP1	physical	28514442
KC1E_HUMAN	CSNK1E	physical	28514442
ASH2L_HUMAN	ASH2L	physical	28514442
GAPD1_HUMAN	GAPVD1	physical	28514442
TBB5_HUMAN	TUBB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.