KLH22_HUMAN - dbPTM
KLH22_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KLH22_HUMAN
UniProt AC Q53GT1
Protein Name Kelch-like protein 22
Gene Name KLHL22
Organism Homo sapiens (Human).
Sequence Length 634
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Lo
Protein Description Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation..
Protein Sequence MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGTPDRSQADPDFASEVMSVSDWEEFDNSSED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAEEQEFTQ
------CCCHHHHHH		29.0922223895
12UbiquitinationQEFTQLCKLPAQPSH
HHHHHHCCCCCCCCC		67.12-
18PhosphorylationCKLPAQPSHPHCVNN
CCCCCCCCCCCCCCC		37.2628857561
52UbiquitinationDSGILFDVVLVVEGR
HCCCEEEEEEEEECC		2.55-
117UbiquitinationTSELELSLSNVQETL
HCCCEEECCCHHHHH		7.26-
176UbiquitinationEQLDTYILKNFVAFS
HHHHHHHHHHHHHCC		2.33-
185PhosphorylationNFVAFSRTDKYRQLP
HHHHCCCCCCCCCCC		35.3322210691
186UbiquitinationFVAFSRTDKYRQLPL
HHHCCCCCCCCCCCH		44.90-
195UbiquitinationYRQLPLEKVYSLLSS
CCCCCHHHHHHHHHC		54.9030230243
260UbiquitinationVLQRLHDKLDPSPLR
HHHHHHHCCCCCCHH		44.0030230243
269PhosphorylationDPSPLRDTVASALMY
CCCCHHHHHHHHHHH		16.1329759185
272PhosphorylationPLRDTVASALMYHRN
CHHHHHHHHHHHHCC		20.0029759185
281PhosphorylationLMYHRNESLQPSLQS
HHHHCCCCCCHHHCC		35.5328857561
288PhosphorylationSLQPSLQSPQTELRS
CCCHHHCCCCCHHHH		25.0328555341
290UbiquitinationQPSLQSPQTELRSDF
CHHHCCCCCHHHHHC		53.51-
291PhosphorylationPSLQSPQTELRSDFQ
HHHCCCCCHHHHHCE		40.1322210691
319UbiquitinationTVLSDQAKYLNPLLG
CHHHHHHHHHHHHCC		44.64-
320PhosphorylationVLSDQAKYLNPLLGE
HHHHHHHHHHHHCCC		18.0924719451
329UbiquitinationNPLLGEWKHFTASLA
HHHCCCHHHHHHHHH		25.25-
334PhosphorylationEWKHFTASLAPRMSN
CHHHHHHHHHHHHCC		23.2324719451
356UbiquitinationNFVYLIGGDNNVQGF
CEEEEECCCCCCCCE		27.7221890473
393UbiquitinationQQEHADLSVCVVGRY
HHHCCCCEEEEHHHH		17.6421890473
399UbiquitinationLSVCVVGRYIYAVAG
CEEEEHHHHHEEECC		11.7621890473
415UbiquitinationDYHNDLNAVERYDPA
CCCCCCCHHHHCCCC		16.3121890473
433UbiquitinationWAYVAPLKREVYAHA
EEEEEECCCEEEECC		45.5121890473
433 (in isoform 1)Ubiquitination-45.5121890473
433UbiquitinationWAYVAPLKREVYAHA
EEEEEECCCEEEECC		45.5121890473
463PhosphorylationGEDYLKETHCYDPGS
CCCCCCCCEEECCCC		18.69-
465UbiquitinationDYLKETHCYDPGSNT
CCCCCCEEECCCCCC		5.5621890473
466PhosphorylationYLKETHCYDPGSNTW
CCCCCEEECCCCCCE		19.98-
475PhosphorylationPGSNTWHTLADGPVR
CCCCCEEECCCCCCC		18.40-
481UbiquitinationHTLADGPVRRAWHGM
EECCCCCCCHHHHHH		8.7121890473
494AcetylationGMATLLNKLYVIGGS
HHHHHHHCEEEECCC		40.9618603029
501UbiquitinationKLYVIGGSNNDAGYR
CEEEECCCCCCCCCC		27.5221890473
517PhosphorylationDVHQVACYSCTSGQW
CCEEEEEEECCCCCC		9.31-
592PhosphorylationGLAACVLTLPRSLLL
HHHHHHHHCCHHHHC		17.8324719451
596PhosphorylationCVLTLPRSLLLEPPR
HHHHCCHHHHCCCCC		22.7923403867
605PhosphorylationLLEPPRGTPDRSQAD
HCCCCCCCCCHHHCC		24.2423401153
609PhosphorylationPRGTPDRSQADPDFA
CCCCCCHHHCCCCHH		36.7826074081
617PhosphorylationQADPDFASEVMSVSD
HCCCCHHHHCCCHHH		30.6226074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KLH22_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KLH22_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KLH22_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLK1_HUMANPLK1physical
23455478
DHE4_HUMANGLUD2physical
28514442
SREC2_HUMANSCARF2physical
28514442
LYRM4_HUMANLYRM4physical
28514442
MET15_HUMANMETTL15physical
28514442
ATG4C_HUMANATG4Cphysical
28514442
SCAF8_HUMANSCAF8physical
28514442
NFS1_HUMANNFS1physical
28514442
FMC1_HUMANC7orf55physical
28514442
KLH26_HUMANKLHL26physical
28514442
MICU1_HUMANMICU1physical
28514442
NDUF5_HUMANNDUFAF5physical
28514442
NUDC3_HUMANNUDCD3physical
28514442
NDUB9_HUMANNDUFB9physical
28514442
TRM6_HUMANTRMT6physical
28514442
TM223_HUMANTMEM223physical
28514442
LYRM7_HUMANLYRM7physical
28514442
NOA1_HUMANNOA1physical
28514442
NIPS2_HUMANGBASphysical
28514442
ZBT34_HUMANZBTB34physical
28514442
CIZ1_HUMANCIZ1physical
28514442
KLH13_HUMANKLHL13physical
28514442
EMC7_HUMANEMC7physical
28514442
DHE3_HUMANGLUD1physical
28514442
ALR_HUMANGFERphysical
28514442
KAISO_HUMANZBTB33physical
28514442
KLHL9_HUMANKLHL9physical
28514442
CUL3_HUMANCUL3physical
27561354
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KLH22_HUMAN

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Related Literatures of Post-Translational Modification

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