SREC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SREC2_HUMAN
• UniProt AC: Q96GP6
• Protein Name: Scavenger receptor class F member 2
• Gene Name: SCARF2
• Organism: Homo sapiens (Human).
• Sequence Length: 870
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity)..
• Protein Sequence: MEGAGPRGAGPARRRGAGGPPSPLLPSLLLLLLLWMLPDTVAPQELNPRGRNVCRAPGSQVPTCCAGWRQQGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEPGWWGAQCASACYCSATSRCDPQTGACLCHAGWWGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYCQCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDPVTGACHLETNQRKGVMGAGALLVLLVCLLLSLLGCCCACRGKDPTRRPRPRRELSLGRKKAPHRLCGRFSRISMKLPRIPLRRQKLPKVVVAHHDLDNTLNCSFLEPPSGLEQPSPSWSSRASFSSFDTTDEGPVYCVPHEEAPAESRDPEVPTVPAEAPAPSPVPLTTPASAEEAIPLPASSDSERSASSVEGPGGALYARVARREARPARARGEIGGLSLSPSPERRKPPPPDPATKPKVSWIHGKHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPSDKSAHTVEHGSPRTRDPTPRPPGLPEEATALAAPSPPRARARAAPRPLGAHGRRRSPAKRAEAASMLAADVRGKTRSLGRAEVALGAQGPREKPAPPQKAKRSVPPASPARAPPATETPGPEKAATDLPAPETPRKKTPIQKPPRKKSREAAGELGRAGAPTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	N-linked_Glycosylation	GIAVCEGNSTCSENE EEEEECCCCCCCCCC	16.32	UniProtKB CARBOHYD
104	Phosphorylation	ECRCRHGYFGANCDT CEECCCCEECCCCCC	7.85	-
111	Phosphorylation	YFGANCDTKCPRQFW EECCCCCCCCCHHHC	36.42	-
127	Phosphorylation	PDCKELCSCHPHGQC CCHHHHHCCCCCCCC	28.25	-
138	Phosphorylation	HGQCEDVTGQCTCHA CCCCCCCCCEEEEEC	33.58	-
142	Phosphorylation	EDVTGQCTCHARRWG CCCCCEEEEECCCCC	10.23	-
210	Phosphorylation	HAGWWGRSCNNQCAC ECCCCCCCCCCCCCC	19.77	24114839
219	Phosphorylation	NNQCACNSSPCEQQS CCCCCCCCCHHHCCC	35.23	24114839
220	Phosphorylation	NQCACNSSPCEQQSG CCCCCCCCHHHCCCC	21.41	24114839
226	Phosphorylation	SSPCEQQSGRCQCRE CCHHHCCCCCCCCCC	28.09	24114839
310	N-linked_Glycosylation	LTCEPGWNGTKCDQP EECCCCCCCCCCCCC	54.92	UniProtKB CARBOHYD
365	N-linked_Glycosylation	RCETKCSNGTYGEDC CCCCCCCCCCCCCCC	57.19	UniProtKB CARBOHYD
367	Phosphorylation	ETKCSNGTYGEDCAF CCCCCCCCCCCCCEE	32.38	-
388	Phosphorylation	SGHCDFQSGRCLCSP CCCCCCCCCCEEECC	28.35	-
403	N-linked_Glycosylation	GVHGPHCNVTCPPGL CCCCCCCCCCCCCCC	29.15	UniProtKB CARBOHYD
474	Methylation	CRGKDPTRRPRPRRE HCCCCCCCCCCCCCH	52.58	30892187
478 (in isoform 2)	Phosphorylation	-	42.22	28842319
479	Methylation	PTRRPRPRRELSLGR CCCCCCCCCHHHCCC	46.08	46518869
483	Phosphorylation	PRPRRELSLGRKKAP CCCCCHHHCCCCCCC	24.83	24670416
498	Ubiquitination	HRLCGRFSRISMKLP HHHCCHHHHHHCCCC	27.61	23000965
498	Phosphorylation	HRLCGRFSRISMKLP HHHCCHHHHHHCCCC	27.61	29449344
501	Phosphorylation	CGRFSRISMKLPRIP CCHHHHHHCCCCCCC	14.57	24719451
503	Ubiquitination	RFSRISMKLPRIPLR HHHHHHCCCCCCCCC	48.85	23000965
527	Phosphorylation	AHHDLDNTLNCSFLE EECCCCCCCCCCCCC	21.00	28857561
531	Phosphorylation	LDNTLNCSFLEPPSG CCCCCCCCCCCCCCC	31.62	28857561
537	Phosphorylation	CSFLEPPSGLEQPSP CCCCCCCCCCCCCCC	67.72	27251275
543	Phosphorylation	PSGLEQPSPSWSSRA CCCCCCCCCCHHCCC	31.12	29978859
545	Phosphorylation	GLEQPSPSWSSRASF CCCCCCCCHHCCCCC	43.88	27251275
547	Phosphorylation	EQPSPSWSSRASFSS CCCCCCHHCCCCCCC	17.81	27251275
548	Phosphorylation	QPSPSWSSRASFSSF CCCCCHHCCCCCCCC	26.13	27251275
551	Phosphorylation	PSWSSRASFSSFDTT CCHHCCCCCCCCCCC	25.26	26657352
553	Phosphorylation	WSSRASFSSFDTTDE HHCCCCCCCCCCCCC	27.83	26657352
554	Phosphorylation	SSRASFSSFDTTDEG HCCCCCCCCCCCCCC	25.73	28192239
557	Phosphorylation	ASFSSFDTTDEGPVY CCCCCCCCCCCCCEE	33.85	26657352
558	Phosphorylation	SFSSFDTTDEGPVYC CCCCCCCCCCCCEEE	33.62	27732954
564	Phosphorylation	TTDEGPVYCVPHEEA CCCCCCEEEEECCCC	7.29	25884760
575	Phosphorylation	HEEAPAESRDPEVPT CCCCCHHHCCCCCCC	44.05	23312004
582	Phosphorylation	SRDPEVPTVPAEAPA HCCCCCCCCCCCCCC	44.27	25850435
591	Phosphorylation	PAEAPAPSPVPLTTP CCCCCCCCCCCCCCC	40.41	25850435
596	Phosphorylation	APSPVPLTTPASAEE CCCCCCCCCCCCHHH	25.35	25850435
597	Phosphorylation	PSPVPLTTPASAEEA CCCCCCCCCCCHHHC	25.25	25850435
600	Phosphorylation	VPLTTPASAEEAIPL CCCCCCCCHHHCCCC	37.10	25850435
610	Phosphorylation	EAIPLPASSDSERSA HCCCCCCCCCCCCCC	32.51	24275569
611	Phosphorylation	AIPLPASSDSERSAS CCCCCCCCCCCCCCC	47.46	24275569
613	Phosphorylation	PLPASSDSERSASSV CCCCCCCCCCCCCCC	36.54	24275569
616	Phosphorylation	ASSDSERSASSVEGP CCCCCCCCCCCCCCC	28.57	26356563
618	Phosphorylation	SDSERSASSVEGPGG CCCCCCCCCCCCCHH	35.84	26356563
619	Phosphorylation	DSERSASSVEGPGGA CCCCCCCCCCCCHHH	24.73	26356563
628	Phosphorylation	EGPGGALYARVARRE CCCHHHHHHHHHHHH	7.57	25884760
646	Phosphorylation	ARARGEIGGLSLSPS CHHCCCCCCCCCCCC	27.04	32142685
648	Phosphorylation	ARGEIGGLSLSPSPE HCCCCCCCCCCCCCC	3.82	32142685
649	Phosphorylation	RGEIGGLSLSPSPER CCCCCCCCCCCCCCC	30.03	29255136
651	Phosphorylation	EIGGLSLSPSPERRK CCCCCCCCCCCCCCC	21.69	30266825
653	Phosphorylation	GGLSLSPSPERRKPP CCCCCCCCCCCCCCC	35.70	30266825
667	Acetylation	PPPDPATKPKVSWIH CCCCCCCCCCEEEEC	44.97	24847299
682	Phosphorylation	GKHSAAAAGRAPSPP CCCCHHHCCCCCCCC	11.86	32142685
687	Phosphorylation	AAAGRAPSPPPPGSE HHCCCCCCCCCCCCC	49.40	30266825
693	Phosphorylation	PSPPPPGSEAAPSPS CCCCCCCCCCCCCCC	29.81	25219547
695	Phosphorylation	PPPPGSEAAPSPSKR CCCCCCCCCCCCCCC	26.77	32142685
698	Phosphorylation	PGSEAAPSPSKRKRT CCCCCCCCCCCCCCC	36.76	30266825
700	Phosphorylation	SEAAPSPSKRKRTPS CCCCCCCCCCCCCCC	49.80	30266825
705	Phosphorylation	SPSKRKRTPSDKSAH CCCCCCCCCCCHHCC	30.13	27732954
707	Phosphorylation	SKRKRTPSDKSAHTV CCCCCCCCCHHCCCC	57.99	28857561
710	Phosphorylation	KRTPSDKSAHTVEHG CCCCCCHHCCCCCCC	30.21	20363803
713	Phosphorylation	PSDKSAHTVEHGSPR CCCHHCCCCCCCCCC	27.57	26699800
718	Phosphorylation	AHTVEHGSPRTRDPT CCCCCCCCCCCCCCC	17.08	30266825
721	Phosphorylation	VEHGSPRTRDPTPRP CCCCCCCCCCCCCCC	42.69	26437602
725	Phosphorylation	SPRTRDPTPRPPGLP CCCCCCCCCCCCCCC	35.90	21902226
736	Phosphorylation	PGLPEEATALAAPSP CCCCHHHHHHCCCCC	26.03	21902226
737	Phosphorylation	GLPEEATALAAPSPP CCCHHHHHHCCCCCH	11.40	32142685
742	Phosphorylation	ATALAAPSPPRARAR HHHHCCCCCHHHHHH	42.69	30266825
784	Phosphorylation	DVRGKTRSLGRAEVA HHCCCCCCCCCHHHH	40.17	24719451
785	Phosphorylation	VRGKTRSLGRAEVAL HCCCCCCCCCHHHHC	4.92	27251275
815	Phosphorylation	KRSVPPASPARAPPA CCCCCCCCCCCCCCC	25.51	22985185
823	Phosphorylation	PARAPPATETPGPEK CCCCCCCCCCCCCCC	46.28	-
825	Phosphorylation	RAPPATETPGPEKAA CCCCCCCCCCCCCCC	29.23	-
833	Phosphorylation	PGPEKAATDLPAPET CCCCCCCCCCCCCCC	42.82	-
840	Phosphorylation	TDLPAPETPRKKTPI CCCCCCCCCCCCCCC	27.60	19664994
841	Phosphorylation	DLPAPETPRKKTPIQ CCCCCCCCCCCCCCC	44.42	27251275
855	Phosphorylation	QKPPRKKSREAAGEL CCCCCHHHHHHHHHH	38.09	20363803
856	Phosphorylation	KPPRKKSREAAGELG CCCCHHHHHHHHHHH	46.59	27251275
869	Phosphorylation	LGRAGAPTL------ HHHCCCCCC------	44.56	24670416

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SREC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SREC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SREC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SREC2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 600920: Van den Ende-Gupta syndrome (VDEGS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-651; SER-653; SER-687AND SER-698, AND MASS SPECTROMETRY.
PubMed: 19413330