MET15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MET15_HUMAN
• UniProt AC: A6NJ78
• Protein Name: Probable methyltransferase-like protein 15
• Gene Name: METTL15
• Organism: Homo sapiens (Human).
• Sequence Length: 407
• Protein Description: Probable S-adenosyl-L-methionine-dependent methyltransferase..
• Protein Sequence: MLRYPYFCRMYKECLSCWLESGIPNLGVWPNRIHTTAEKYREYEAREQTDQTQAQELHRSQDRDFETMAKLHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALASILRTYGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQRSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALSFHSLEDRIVKRFLLGISMTERFNLSVRQQVMKTSQLGSDHENTEEVSMRRAPLMWELIHKKVLSPQDQDVQDNPRGRSAKLRAAIKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	RIHTTAEKYREYEAR CCCCHHHHHHHHHHH	47.33	29967540
70	Methylation	RDFETMAKLHIPVMV CCHHHHHHCCCCEEH	29.76	-
85	Phosphorylation	DEVVHCLSPQKGQIF HHHHHHCCCCCCEEE	30.58	20873877
103	Phosphorylation	TFGSGGHTKAILQKE ECCCCHHHHHHEECC	25.99	20860994
147	Phosphorylation	RAMLGQFSQAEALLM HHHHCCCCHHHHHHH	22.16	22210691
162	Phosphorylation	KAGVQPGTFDGVLMD HCCCCCCCCCEEEEE	25.82	22210691
179	Phosphorylation	CSSMQLDTPERGFSL CCCCCCCCCCCCCCC	35.32	22210691
185	Phosphorylation	DTPERGFSLRKDGPL CCCCCCCCCCCCCCC	30.04	24719451
188	Ubiquitination	ERGFSLRKDGPLDMR CCCCCCCCCCCCCEE	72.78	-
211	Ubiquitination	MPTAADVVNALDQQA CCCHHHHHHHHHHHH	3.41	21890473
239	Ubiquitination	AKKIASAIVQARSIY HHHHHHHHHHHHCCC	1.87	21890473
240	Ubiquitination	KKIASAIVQARSIYP HHHHHHHHHHHCCCC	3.49	21890473
258	Ubiquitination	TQQLASIVAGAFPPS HHHHHHHHHCCCCHH	3.58	21890473
286	Ubiquitination	HIATKTFQALRIFVN HHHHHHHHHHHHHHC	44.72	21890473
287	Ubiquitination	IATKTFQALRIFVNN HHHHHHHHHHHHHCH	8.46	21890473
301	Phosphorylation	NELNELYTGLKTAQK HHHHHHHHHHHHHHH	48.97	24719451
315	Ubiquitination	KFLRPGGRLVALSFH HHHCCCCEEEEEEEC	31.72	21890473
316	Ubiquitination	FLRPGGRLVALSFHS HHCCCCEEEEEEECC	2.75	21890473
352	Ubiquitination	SVRQQVMKTSQLGSD HHHHHHHHHHHCCCC	46.28	21890473
352 (in isoform 1)	Ubiquitination	-	46.28	21890473
353	Phosphorylation	VRQQVMKTSQLGSDH HHHHHHHHHHCCCCC	12.01	28450419
354	Phosphorylation	RQQVMKTSQLGSDHE HHHHHHHHHCCCCCC	20.21	28450419
358	Phosphorylation	MKTSQLGSDHENTEE HHHHHCCCCCCCCHH	44.37	28348404
363	Phosphorylation	LGSDHENTEEVSMRR CCCCCCCCHHHHHHH	30.45	30108239
380	Ubiquitination	LMWELIHKKVLSPQD HHHHHHHHHCCCCCC	37.27	21890473
380 (in isoform 1)	Ubiquitination	-	37.27	21890473
381	Ubiquitination	MWELIHKKVLSPQDQ HHHHHHHHCCCCCCC	33.96	22817900
381 (in isoform 1)	Ubiquitination	-	33.96	21890473
395	Methylation	QDVQDNPRGRSAKLR CCCCCCCCCHHHHHH	60.45	30988091

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MET15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MET15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MET15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MB12B_HUMAN	MVB12B	physical	26186194
MB12B_HUMAN	MVB12B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.