EMC7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMC7_HUMAN
• UniProt AC: Q9NPA0
• Protein Name: ER membrane protein complex subunit 7
• Gene Name: EMC7
• Organism: Homo sapiens (Human).
• Sequence Length: 242
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MAAALWGFFPVLLLLLLSGDVQSSEVPGAAAEGSGGSGVGIGDRFKIEGRAVVPGVKPQDWISAARVLVDGEEHVGFLKTDGSFVVHDIPSGSYVVEVVSPAYRFDPVRVDITSKGKMRARYVNYIKTSEVVRLPYPLQMKSSGPPSYFIKRESWGWTDFLMNPMVMMMVLPLLIFVLLPKVVNTSDPDMRREMEQSMNMLNSNHELPDVSEFMTRLFSSKSSGKSSSGSSKTGKSGAGKRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Ubiquitination	RAVVPGVKPQDWISA EEECCCCCHHHEEEE	42.76	21906983
79	Ubiquitination	EEHVGFLKTDGSFVV CCCEEEEECCCCEEE	42.16	29967540
100	Phosphorylation	SYVVEVVSPAYRFDP CEEEEEECCCCCCCC	14.69	-
113	O-linked_Glycosylation	DPVRVDITSKGKMRA CCEEEEECCCCCEEE	21.66	55833161
115	Ubiquitination	VRVDITSKGKMRARY EEEEECCCCCEEEEE	54.63	27667366
117	Ubiquitination	VDITSKGKMRARYVN EEECCCCCEEEEEEE	29.02	22817900
122	Phosphorylation	KGKMRARYVNYIKTS CCCEEEEEEEEEECC	7.64	-
127	Ubiquitination	ARYVNYIKTSEVVRL EEEEEEEECCCEEEC	35.32	27667366
136	Phosphorylation	SEVVRLPYPLQMKSS CCEEECCCCEECCCC	22.59	-
141	Ubiquitination	LPYPLQMKSSGPPSY CCCCEECCCCCCCCE	28.63	23000965
142	Phosphorylation	PYPLQMKSSGPPSYF CCCEECCCCCCCCEE	34.87	27794612
143	Phosphorylation	YPLQMKSSGPPSYFI CCEECCCCCCCCEEE	50.21	27794612
147	Phosphorylation	MKSSGPPSYFIKRES CCCCCCCCEEEECHH	35.49	27794612
148	Phosphorylation	KSSGPPSYFIKRESW CCCCCCCEEEECHHC	18.33	27794612
151	Acetylation	GPPSYFIKRESWGWT CCCCEEEECHHCCCC	39.97	26051181
151	Ubiquitination	GPPSYFIKRESWGWT CCCCEEEECHHCCCC	39.97	21963094
203	Phosphorylation	QSMNMLNSNHELPDV HHHHHHHCCCCCCCH	35.29	20068231
215	Phosphorylation	PDVSEFMTRLFSSKS CCHHHHHHHHHCCCC	29.55	22468782
219	Phosphorylation	EFMTRLFSSKSSGKS HHHHHHHCCCCCCCC	41.26	30177828
220	Phosphorylation	FMTRLFSSKSSGKSS HHHHHHCCCCCCCCC	29.26	26434776
221	Ubiquitination	MTRLFSSKSSGKSSS HHHHHCCCCCCCCCC	47.66	27667366
222	Phosphorylation	TRLFSSKSSGKSSSG HHHHCCCCCCCCCCC	46.39	26434776
223	Phosphorylation	RLFSSKSSGKSSSGS HHHCCCCCCCCCCCC	54.71	26434776
225	Ubiquitination	FSSKSSGKSSSGSSK HCCCCCCCCCCCCCC	49.46	29967540
228	Phosphorylation	KSSGKSSSGSSKTGK CCCCCCCCCCCCCCC	50.19	-
230	Phosphorylation	SGKSSSGSSKTGKSG CCCCCCCCCCCCCCC	30.52	-
231	Phosphorylation	GKSSSGSSKTGKSGA CCCCCCCCCCCCCCC	37.45	22468782
232	Ubiquitination	KSSSGSSKTGKSGAG CCCCCCCCCCCCCCC	64.09	24816145
235	Ubiquitination	SGSSKTGKSGAGKRR CCCCCCCCCCCCCCC	51.45	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMC7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMC7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMC7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EMC9_HUMAN	EMC9	physical	22119785
UBQL2_HUMAN	UBQLN2	physical	22119785
EMC8_HUMAN	EMC8	physical	22119785
EMC2_HUMAN	EMC2	physical	22119785
EMC3_HUMAN	EMC3	physical	22119785
EMC10_HUMAN	EMC10	physical	22119785
CLP1L_HUMAN	CLPTM1L	physical	22119785
EMC6_HUMAN	EMC6	physical	22119785
MMGT1_HUMAN	MMGT1	physical	22119785
EMC1_HUMAN	EMC1	physical	22119785
EMC4_HUMAN	EMC4	physical	22119785
EMC8_HUMAN	EMC8	physical	28514442
EMC4_HUMAN	EMC4	physical	28514442
EMC10_HUMAN	EMC10	physical	28514442
EMC1_HUMAN	EMC1	physical	28514442
MMGT1_HUMAN	MMGT1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.