EMC8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMC8_HUMAN
• UniProt AC: O43402
• Protein Name: ER membrane protein complex subunit 8
• Gene Name: EMC8
• Organism: Homo sapiens (Human).
• Sequence Length: 210
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIMVDNTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRNDWTNPEINKAVLHLC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MPGVKLTTQAYC ---CCCCEEEHHHHH	46.13	-
5	Malonylation	---MPGVKLTTQAYC ---CCCCEEEHHHHH	46.13	26320211
7	Phosphorylation	-MPGVKLTTQAYCKM -CCCCEEEHHHHHHH	15.90	25072903
8	Phosphorylation	MPGVKLTTQAYCKMV CCCCEEEHHHHHHHH	22.95	25072903
11	Phosphorylation	VKLTTQAYCKMVLHG CEEEHHHHHHHHHCC	5.25	25072903
13	Ubiquitination	LTTQAYCKMVLHGAK EEHHHHHHHHHCCCC	21.26	-
20	Acetylation	KMVLHGAKYPHCAVN HHHHCCCCCCCEEEC	65.00	26051181
20	Ubiquitination	KMVLHGAKYPHCAVN HHHHCCCCCCCEEEC	65.00	-
34	Ubiquitination	NGLLVAEKQKPRKEH CCEEEEECCCCCCCC	54.61	-
100	Ubiquitination	YQANERVKDASPNQV EECCCHHCCCCHHHH	54.52	21906983
103	Phosphorylation	NERVKDASPNQVAEK CCHHCCCCHHHHHHH	34.22	25159151
110	Ubiquitination	SPNQVAEKVASRIAE CHHHHHHHHHHHHHC	33.10	21890473
110	Acetylation	SPNQVAEKVASRIAE CHHHHHHHHHHHHHC	33.10	26051181
110	Ubiquitination	SPNQVAEKVASRIAE CHHHHHHHHHHHHHC	33.10	21890473
173	Phosphorylation	EAQRISASLLDSRSY HHHHHCHHHHCCCCC	23.75	22617229
173	O-linked_Glycosylation	EAQRISASLLDSRSY HHHHHCHHHHCCCCC	23.75	29351928
177	O-linked_Glycosylation	ISASLLDSRSYETLV HCHHHHCCCCCEEEE	24.09	29351928
177	Phosphorylation	ISASLLDSRSYETLV HCHHHHCCCCCEEEE	24.09	27251275
179	Phosphorylation	ASLLDSRSYETLVDF HHHHCCCCCEEEEEC	31.13	26471730
180	Phosphorylation	SLLDSRSYETLVDFD HHHCCCCCEEEEECC	16.30	27642862
194	Methylation	DNHLDDIRNDWTNPE CCHHHHHHHCCCCHH	41.89	-
204	Acetylation	WTNPEINKAVLHLC- CCCHHHHHHHHHHC-	45.60	26051181
204	Ubiquitination	WTNPEINKAVLHLC- CCCHHHHHHHHHHC-	45.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMC8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMC8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMC8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UBQL2_HUMAN	UBQLN2	physical	22119785
EMC2_HUMAN	EMC2	physical	22119785
EMC3_HUMAN	EMC3	physical	22119785
EMC6_HUMAN	EMC6	physical	22119785
MMGT1_HUMAN	MMGT1	physical	22119785
EMC1_HUMAN	EMC1	physical	22119785
EMC7_HUMAN	EMC7	physical	22119785
EMC10_HUMAN	EMC10	physical	22119785
EMC4_HUMAN	EMC4	physical	22119785
K2C6A_HUMAN	KRT6A	physical	22119785
F186B_HUMAN	FAM186B	physical	22119785

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.