EMC1_HUMAN - dbPTM
EMC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EMC1_HUMAN
UniProt AC Q8N766
Protein Name ER membrane protein complex subunit 1
Gene Name EMC1
Organism Homo sapiens (Human).
Sequence Length 993
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description
Protein Sequence MAAEWASRFWLWATLLIPAAAVYEDQVGKFDWRQQYVGKVKFASLEFSPGSKKLVVATEKNVIAALNSRTGEILWRHVDKGTAEGAVDAMLLHGQDVITVSNGGRIMRSWETNIGGLNWEITLDSGSFQALGLVGLQESVRYIAVLKKTTLALHHLSSGHLKWVEHLPESDSIHYQMVYSYGSGVVWALGVVPFSHVNIVKFNVEDGEIVQQVRVSTPWLQHLSGACGVVDEAVLVCPDPSSRSLQTLALETEWELRQIPLQSLDLEFGSGFQPRVLPTQPNPVDASRAQFFLHLSPSHYALLQYHYGTLSLLKNFPQTALVSFATTGEKTVAAVMACRNEVQKSSSSEDGSMGSFSEKSSSKDSLACFNQTYTINLYLVETGRRLLDTTITFSLEQSGTRPERLYIQVFLKKDDSVGYRALVQTEDHLLLFLQQLAGKVVLWSREESLAEVVCLEMVDLPLTGAQAELEGEFGKKADGLLGMFLKRLSSQLILLQAWTSHLWKMFYDARKPRSQIKNEINIDTLARDEFNLQKMMVMVTASGKLFGIESSSGTILWKQYLPNVKPDSSFKLMVQRTTAHFPHPPQCTLLVKDKESGMSSLYVFNPIFGKWSQVAPPVLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTAFPATRNVLRQLHELAPSIFFYLVDAEQGRLCGYRLRKDLTTELSWELTIPPEVQRIVKVKGKRSSEHVHSQGRVMGDRSVLYKSLNPNLLAVVTESTDAHHERTFIGIFLIDGVTGRIIHSSVQKKAKGPVHIVHSENWVVYQYWNTKARRNEFTVLELYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSISAMEATITERGITSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQIHAERFINYNQTVSRMRGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLFGLVFATMITKRLAQVKLLNRAWR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39UbiquitinationWRQQYVGKVKFASLE
HHHHHCCEEEEEEEE		32.0127667366
41UbiquitinationQQYVGKVKFASLEFS
HHHCCEEEEEEEEEC		38.40-
48PhosphorylationKFASLEFSPGSKKLV
EEEEEEECCCCCEEE		20.9829214152
52UbiquitinationLEFSPGSKKLVVATE
EEECCCCCEEEEEEC		56.9221906983
52 (in isoform 1)Ubiquitination-56.9221890473
52 (in isoform 2)Ubiquitination-56.9221890473
52 (in isoform 3)Ubiquitination-56.9221890473
52 (in isoform 4)Ubiquitination-56.9221890473
53UbiquitinationEFSPGSKKLVVATEK
EECCCCCEEEEEECH		48.4922817900
60UbiquitinationKLVVATEKNVIAALN
EEEEEECHHHHHHHH		52.7622817900
60 (in isoform 1)Ubiquitination-52.7621890473
60 (in isoform 2)Ubiquitination-52.7621890473
60 (in isoform 3)Ubiquitination-52.7621890473
60 (in isoform 4)Ubiquitination-52.7621890473
68 (in isoform 4)Phosphorylation-31.8828842319
70 (in isoform 4)Phosphorylation-38.7028842319
77 (in isoform 4)Phosphorylation-22.1228842319
79 (in isoform 4)Phosphorylation-37.2328842319
82PhosphorylationWRHVDKGTAEGAVDA
EEECCCCCCCCHHHE		27.5525954137
125 (in isoform 4)Ubiquitination-39.1821890473
126UbiquitinationWEITLDSGSFQALGL
EEEEEECCCEEEEEE		31.9529967540
147UbiquitinationVRYIAVLKKTTLALH
HHHHHHHHHHHHHHH		41.2821906983
147 (in isoform 1)Ubiquitination-41.2821890473
147 (in isoform 2)Ubiquitination-41.2821890473
147 (in isoform 3)Ubiquitination-41.2821890473
148UbiquitinationRYIAVLKKTTLALHH
HHHHHHHHHHHHHHH		42.4529967540
149PhosphorylationYIAVLKKTTLALHHL
HHHHHHHHHHHHHHH		26.0020068231
150PhosphorylationIAVLKKTTLALHHLS
HHHHHHHHHHHHHHC		20.9320068231
157PhosphorylationTLALHHLSSGHLKWV
HHHHHHHCCCCCEEE		29.8920068231
201UbiquitinationFSHVNIVKFNVEDGE
CCCEEEEEEEECCCC		27.68-
252PhosphorylationLQTLALETEWELRQI
HHHHHHHCCEEEECC		47.45-
311PhosphorylationQYHYGTLSLLKNFPQ
HHHHHHHHHHHHCCC		31.3420860994
322UbiquitinationNFPQTALVSFATTGE
HCCCEEEEEEEECCH		4.0323503661
322 (in isoform 4)Ubiquitination-4.0321890473
337UbiquitinationKTVAAVMACRNEVQK
HHHHHHHHHCHHHHH		5.1923503661
337 (in isoform 4)Ubiquitination-5.1921890473
341UbiquitinationAVMACRNEVQKSSSS
HHHHHCHHHHHCCCC		27.2923503661
344UbiquitinationACRNEVQKSSSSEDG
HHCHHHHHCCCCCCC		58.4421906983
344 (in isoform 1)Ubiquitination-58.4421890473
344 (in isoform 3)Ubiquitination-58.4421890473
346PhosphorylationRNEVQKSSSSEDGSM
CHHHHHCCCCCCCCC		44.9429116813
347PhosphorylationNEVQKSSSSEDGSMG
HHHHHCCCCCCCCCC		44.8528857561
348PhosphorylationEVQKSSSSEDGSMGS
HHHHCCCCCCCCCCC		41.4728857561
352PhosphorylationSSSSEDGSMGSFSEK
CCCCCCCCCCCCCCC		32.0922210691
353SulfoxidationSSSEDGSMGSFSEKS
CCCCCCCCCCCCCCC		6.7921406390
355PhosphorylationSEDGSMGSFSEKSSS
CCCCCCCCCCCCCCC		19.56-
357PhosphorylationDGSMGSFSEKSSSKD
CCCCCCCCCCCCCCC		45.90-
358UbiquitinationGSMGSFSEKSSSKDS
CCCCCCCCCCCCCCC		55.7523503661
358 (in isoform 2)Ubiquitination-55.7521890473
359UbiquitinationSMGSFSEKSSSKDSL
CCCCCCCCCCCCCCE		55.2121906983
359 (in isoform 1)Ubiquitination-55.2121890473
359 (in isoform 3)Ubiquitination-55.2121890473
362PhosphorylationSFSEKSSSKDSLACF
CCCCCCCCCCCEECC		47.80-
362UbiquitinationSFSEKSSSKDSLACF
CCCCCCCCCCCEECC		47.8023503661
363UbiquitinationFSEKSSSKDSLACFN
CCCCCCCCCCEECCC		53.9723503661
370N-linked_GlycosylationKDSLACFNQTYTINL
CCCEECCCCCEEEEE		32.9232439656
389PhosphorylationTGRRLLDTTITFSLE
CCCCCCEEEEEEEEH		21.7726074081
390PhosphorylationGRRLLDTTITFSLEQ
CCCCCEEEEEEEEHH		20.0726074081
392PhosphorylationRLLDTTITFSLEQSG
CCCEEEEEEEEHHCC		12.7026074081
394PhosphorylationLDTTITFSLEQSGTR
CEEEEEEEEHHCCCC		23.5026074081
398PhosphorylationITFSLEQSGTRPERL
EEEEEHHCCCCCEEE		32.5326074081
400PhosphorylationFSLEQSGTRPERLYI
EEEHHCCCCCEEEEE		48.5826074081
406PhosphorylationGTRPERLYIQVFLKK
CCCCEEEEEEEEEEC		8.7726074081
4762-HydroxyisobutyrylationLEGEFGKKADGLLGM
HHCCHHHHHCHHHHH		52.68-
4862-HydroxyisobutyrylationGLLGMFLKRLSSQLI
HHHHHHHHHHHHHHH		39.77-
495UbiquitinationLSSQLILLQAWTSHL
HHHHHHHHHHHHHHH		2.3029967540
495 (in isoform 4)Ubiquitination-2.3021890473
516UbiquitinationARKPRSQIKNEINID
CCCCHHHCCCCCCHH		5.6529967540
516 (in isoform 2)Ubiquitination-5.6521890473
516 (in isoform 3)Ubiquitination-5.6521890473
517UbiquitinationRKPRSQIKNEINIDT
CCCHHHCCCCCCHHH		40.6721906983
517 (in isoform 1)Ubiquitination-40.6721890473
543UbiquitinationMVMVTASGKLFGIES
EEEEECCCCEEEEEC		28.3721890473
543 (in isoform 4)Ubiquitination-28.3721890473
550PhosphorylationGKLFGIESSSGTILW
CCEEEEECCCCEEEE		28.08-
564UbiquitinationWKQYLPNVKPDSSFK
EEEECCCCCCCCCCE		10.0721890473
564 (in isoform 2)Ubiquitination-10.0721890473
564 (in isoform 3)Ubiquitination-10.0721890473
565UbiquitinationKQYLPNVKPDSSFKL
EEECCCCCCCCCCEE		50.1522817900
565 (in isoform 1)Ubiquitination-50.1521890473
567UbiquitinationYLPNVKPDSSFKLMV
ECCCCCCCCCCEEEE		51.7221890473
568UbiquitinationLPNVKPDSSFKLMVQ
CCCCCCCCCCEEEEE		46.3221890473
596PhosphorylationLLVKDKESGMSSLYV
EEEEECCCCCCEEEE		45.6022199227
598UbiquitinationVKDKESGMSSLYVFN
EEECCCCCCEEEEEE		3.2421890473
598 (in isoform 4)Ubiquitination-3.2421890473
599PhosphorylationKDKESGMSSLYVFNP
EECCCCCCEEEEEEC		22.2522199227
600PhosphorylationDKESGMSSLYVFNPI
ECCCCCCEEEEEECC		18.1522199227
602PhosphorylationESGMSSLYVFNPIFG
CCCCCEEEEEECCCC		12.6322199227
619UbiquitinationSQVAPPVLKRPILQS
HHCCCHHHCCHHHHH		4.8621890473
619 (in isoform 2)Ubiquitination-4.8621890473
619 (in isoform 3)Ubiquitination-4.8621890473
6202-HydroxyisobutyrylationQVAPPVLKRPILQSL
HCCCHHHCCHHHHHH		57.26-
620UbiquitinationQVAPPVLKRPILQSL
HCCCHHHCCHHHHHH		57.2627667366
620 (in isoform 1)Ubiquitination-57.2621890473
622UbiquitinationAPPVLKRPILQSLLL
CCHHHCCHHHHHHHH		30.0121890473
623UbiquitinationPPVLKRPILQSLLLP
CHHHCCHHHHHHHHH		6.7621890473
626PhosphorylationLKRPILQSLLLPVMD
HCCHHHHHHHHHHCC		19.9622210691
626 (in isoform 4)Ubiquitination-19.9621890473
647PhosphorylationLLLIDDEYKVTAFPA
EEEECCCCCCCCCHH		20.11-
647 (in isoform 2)Ubiquitination-20.1121890473
647 (in isoform 3)Ubiquitination-20.1121890473
648UbiquitinationLLIDDEYKVTAFPAT
EEECCCCCCCCCHHH		30.9421906983
648 (in isoform 1)Ubiquitination-30.9421890473
712UbiquitinationQRIVKVKGKRSSEHV
HHEEEECCCCCCCCH		33.3321890473
712 (in isoform 4)Ubiquitination-33.3321890473
715PhosphorylationVKVKGKRSSEHVHSQ
EEECCCCCCCCHHHC		43.4926437602
721PhosphorylationRSSEHVHSQGRVMGD
CCCCCHHHCCCCCCC		32.9920860994
733PhosphorylationMGDRSVLYKSLNPNL
CCCHHHHHHCCCCCE		9.0720049867
733UbiquitinationMGDRSVLYKSLNPNL
CCCHHHHHHCCCCCE		9.0721890473
733 (in isoform 2)Ubiquitination-9.0721890473
733 (in isoform 3)Ubiquitination-9.0721890473
734UbiquitinationGDRSVLYKSLNPNLL
CCHHHHHHCCCCCEE		44.2822817900
734 (in isoform 1)Ubiquitination-44.2821890473
736UbiquitinationRSVLYKSLNPNLLAV
HHHHHHCCCCCEEEE		12.3521890473
737UbiquitinationSVLYKSLNPNLLAVV
HHHHHCCCCCEEEEE		30.4221890473
766PhosphorylationIFLIDGVTGRIIHSS
EEEEECCCCCCHHHH		26.69-
772PhosphorylationVTGRIIHSSVQKKAK
CCCCCHHHHHHHHCC		23.07-
773PhosphorylationTGRIIHSSVQKKAKG
CCCCHHHHHHHHCCC		17.88-
7762-HydroxyisobutyrylationIIHSSVQKKAKGPVH
CHHHHHHHHCCCCEE		53.17-
776UbiquitinationIIHSSVQKKAKGPVH
CHHHHHHHHCCCCEE		53.17-
818N-linked_GlycosylationYEGTEQYNATAFSSL
EECCCCCCCEECCCC		30.4332439656
845PhosphorylationYIFPSSISAMEATIT
CCCHHHHHHEECCCC		24.4222210691
850PhosphorylationSISAMEATITERGIT
HHHHEECCCCCCCCC		18.3522210691
852PhosphorylationSAMEATITERGITSR
HHEECCCCCCCCCCC		18.4422210691
853UbiquitinationAMEATITERGITSRH
HEECCCCCCCCCCCC		45.0933845483
853 (in isoform 4)Ubiquitination-45.0921890473
874UbiquitinationSGAILSLPKALLDPR
CCCHHCCCHHHCCCC		19.2533845483
874 (in isoform 2)Ubiquitination-19.2521890473
874 (in isoform 3)Ubiquitination-19.2521890473
875UbiquitinationGAILSLPKALLDPRR
CCHHCCCHHHCCCCC		57.8933845483
875 (in isoform 1)Ubiquitination-57.8921890473
887PhosphorylationPRRPEIPTEQSREEN
CCCCCCCCHHCCCCC		52.9320639409
890PhosphorylationPEIPTEQSREENLIP
CCCCCHHCCCCCCCC		35.1120639409
898PhosphorylationREENLIPYSPDVQIH
CCCCCCCCCCCCEEE		26.3320639409
899PhosphorylationEENLIPYSPDVQIHA
CCCCCCCCCCCEEEE		14.8520639409
913N-linked_GlycosylationAERFINYNQTVSRMR
EEHHCCCHHHHHHHC		26.9332439656
923PhosphorylationVSRMRGIYTAPSGLE
HHHHCCEEECCCCHH		10.32-
938PhosphorylationSTCLVVAYGLDIYQT
HHHEEEEECCCEEEC		13.45-
958UbiquitinationKQFDVLKDDYDYVLI
HHCCCCCCCCCHHHH		56.3823000965
960PhosphorylationFDVLKDDYDYVLISS
CCCCCCCCCHHHHHH		21.2120068231
962PhosphorylationVLKDDYDYVLISSVL
CCCCCCCHHHHHHHH		7.3020068231
964UbiquitinationKDDYDYVLISSVLFG
CCCCCHHHHHHHHHH		2.2723000965
966PhosphorylationDYDYVLISSVLFGLV
CCCHHHHHHHHHHHH		15.3820068231
967PhosphorylationYDYVLISSVLFGLVF
CCHHHHHHHHHHHHH		18.8220068231
976PhosphorylationLFGLVFATMITKRLA
HHHHHHHHHHHHHHH		9.5320068231
979PhosphorylationLVFATMITKRLAQVK
HHHHHHHHHHHHHHH		10.1720068231
979UbiquitinationLVFATMITKRLAQVK
HHHHHHHHHHHHHHH		10.1723000965
980UbiquitinationVFATMITKRLAQVKL
HHHHHHHHHHHHHHH		34.1923000965
982UbiquitinationATMITKRLAQVKLLN
HHHHHHHHHHHHHHH		4.1023000965
983UbiquitinationTMITKRLAQVKLLNR
HHHHHHHHHHHHHHH		19.0223000965
985UbiquitinationITKRLAQVKLLNRAW
HHHHHHHHHHHHHHC		3.8223000965
986UbiquitinationTKRLAQVKLLNRAWR
HHHHHHHHHHHHHCC		34.8723000965
988UbiquitinationRLAQVKLLNRAWR--
HHHHHHHHHHHCC--		3.1923000965
989UbiquitinationLAQVKLLNRAWR---
HHHHHHHHHHCC---		41.9023000965
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EMC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EMC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EMC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ENOA_HUMANENO1physical
22119785
EMC8_HUMANEMC8physical
22119785
EMC2_HUMANEMC2physical
22119785
CALX_HUMANCANXphysical
22119785
EMC3_HUMANEMC3physical
22119785
MMGT1_HUMANMMGT1physical
22119785
EMC7_HUMANEMC7physical
22119785
VDAC2_HUMANVDAC2physical
22119785
EMC4_HUMANEMC4physical
22119785
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EMC1_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-913, AND MASSSPECTROMETRY.

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