EMC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMC3_HUMAN
• UniProt AC: Q9P0I2
• Protein Name: ER membrane protein complex subunit 3
• Gene Name: EMC3
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMAKDLHFEGMFKKELQTSIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	GPELLLDSNIRLWVV CCCCCCCCCHHHHHH	33.84	22210691
33	Phosphorylation	FVGMIRHYVSILLQS HHHHHHHHHHHHHHC	6.00	22210691
35	Phosphorylation	GMIRHYVSILLQSDK HHHHHHHHHHHHCCC	10.60	24247654
40	Phosphorylation	YVSILLQSDKKLTQE HHHHHHHCCCCCCHH	51.90	24247654
43	Ubiquitination	ILLQSDKKLTQEQVS HHHHCCCCCCHHHCC	62.85	29967540
66	Ubiquitination	RVLRENGKYIPKQSF HHHHHCCCCCCCHHH	52.14	-
70	Ubiquitination	ENGKYIPKQSFLTRK HCCCCCCCHHHCCCC	49.36	29967540
77	Ubiquitination	KQSFLTRKYYFNNPE CHHHCCCCHHCCCCC	38.78	29967540
77	2-Hydroxyisobutyrylation	KQSFLTRKYYFNNPE CHHHCCCCHHCCCCC	38.78	-
77	Acetylation	KQSFLTRKYYFNNPE CHHHCCCCHHCCCCC	38.78	27452117
89	Acetylation	NPEDGFFKKTKRKVV CCCCCCCCCCCCCCC	58.22	27452117
89	2-Hydroxyisobutyrylation	NPEDGFFKKTKRKVV CCCCCCCCCCCCCCC	58.22	-
89	Ubiquitination	NPEDGFFKKTKRKVV CCCCCCCCCCCCCCC	58.22	23000965
90	Ubiquitination	PEDGFFKKTKRKVVP CCCCCCCCCCCCCCC	54.87	23000965
91	Phosphorylation	EDGFFKKTKRKVVPP CCCCCCCCCCCCCCC	36.35	22210691
92	Ubiquitination	DGFFKKTKRKVVPPS CCCCCCCCCCCCCCC	60.13	23000965
94	Ubiquitination	FFKKTKRKVVPPSPM CCCCCCCCCCCCCCC	49.49	23000965
99	Phosphorylation	KRKVVPPSPMTDPTM CCCCCCCCCCCCHHH	22.64	-
102	Phosphorylation	VVPPSPMTDPTMLTD CCCCCCCCCHHHHHH	42.06	22210691
108	Phosphorylation	MTDPTMLTDMMKGNV CCCHHHHHHHHHCCH	15.83	-
145	Phosphorylation	TKVPFPLTLRFKPML CCCCCCEEEECHHHH	19.00	20068231
198	Sulfoxidation	NAADQSRMMQEQMTG CHHHHHHHHHHHHHH	3.83	28465586
199	Sulfoxidation	AADQSRMMQEQMTGA HHHHHHHHHHHHHHH	3.74	28465586
203	Sulfoxidation	SRMMQEQMTGAAMAM HHHHHHHHHHHHHCC	3.52	28465586
204	Phosphorylation	RMMQEQMTGAAMAMP HHHHHHHHHHHHCCC	24.30	28176443
208	Sulfoxidation	EQMTGAAMAMPADTN HHHHHHHHCCCCCCC	3.05	28465586
210	Sulfoxidation	MTGAAMAMPADTNKA HHHHHHCCCCCCCHH	1.48	28465586
216	Ubiquitination	AMPADTNKAFKTEWE CCCCCCCHHHHHHHH	58.24	21963094
216	Methylation	AMPADTNKAFKTEWE CCCCCCCHHHHHHHH	58.24	-
219	Ubiquitination	ADTNKAFKTEWEALE CCCCHHHHHHHHHHH	50.85	22817900
253	2-Hydroxyisobutyrylation	LHFEGMFKKELQTSI CCHHHHHHHHHHHCC	36.12	-
253	Ubiquitination	LHFEGMFKKELQTSI CCHHHHHHHHHHHCC	36.12	29967540
253	Acetylation	LHFEGMFKKELQTSI CCHHHHHHHHHHHCC	36.12	25953088
254	Ubiquitination	HFEGMFKKELQTSIF CHHHHHHHHHHHCCC	53.01	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EMC9_HUMAN	EMC9	physical	22119785
UBQL2_HUMAN	UBQLN2	physical	22119785
EMC8_HUMAN	EMC8	physical	22119785
EMC2_HUMAN	EMC2	physical	22119785
EMC1_HUMAN	EMC1	physical	22119785
EMC7_HUMAN	EMC7	physical	22119785
EMC4_HUMAN	EMC4	physical	22119785
EMC10_HUMAN	EMC10	physical	22119785
MMGT1_HUMAN	MMGT1	physical	22119785
EMC7_HUMAN	EMC7	physical	28514442
EMC4_HUMAN	EMC4	physical	28514442
EMC10_HUMAN	EMC10	physical	28514442
EMC1_HUMAN	EMC1	physical	28514442
MMGT1_HUMAN	MMGT1	physical	28514442
PDIA4_HUMAN	PDIA4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.