| UniProt ID | EMC10_HUMAN | |
|---|---|---|
| UniProt AC | Q5UCC4 | |
| Protein Name | ER membrane protein complex subunit 10 | |
| Gene Name | EMC10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 262 | |
| Subcellular Localization |
Isoform 1: Membrane Single-pass type I membrane protein . Isoform 2: Secreted . |
|
| Protein Description | ||
| Protein Sequence | MAAASAGATRLLLLLLMAVAAPSRARGSGCRAGTGARGAGAEGREGEACGTVGLLLEHSFEIDDSANFRKRGSLLWNQQDGTLSLSQRQLSEEERGRLRDVAALNGLYRVRIPRRPGALDGLEAGGYVSSFVPACSLVESHLSDQLTLHVDVAGNVVGVSVVTHPGGCRGHEVEDVDLELFNTSVQLQPPTTAPGPETAAFIERLEMEQAQKAKNPQEQKSFFAKYWMYIIPVVLFLMMSGAPDTGGQGGGGGGGGGGGSGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 73 | Phosphorylation | ANFRKRGSLLWNQQD CCCHHCCCEEEECCC | 25.07 | - | |
| 86 | Phosphorylation | QDGTLSLSQRQLSEE CCCCEEEHHHHCCHH | 21.68 | - | |
| 91 | Phosphorylation | SLSQRQLSEEERGRL EEHHHHCCHHHHHHH | 34.32 | 21815630 | |
| 99 | Methylation | EEERGRLRDVAALNG HHHHHHHHHHHHHCC | 34.69 | - | |
| 182 | N-linked_Glycosylation | DVDLELFNTSVQLQP ECCCEEECEEEEECC | 44.03 | 32439656 | |
| 191 | O-linked_Glycosylation | SVQLQPPTTAPGPET EEEECCCCCCCCHHH | 42.12 | OGP | |
| 192 | O-linked_Glycosylation | VQLQPPTTAPGPETA EEECCCCCCCCHHHH | 36.31 | OGP | |
| 212 | Ubiquitination | LEMEQAQKAKNPQEQ HHHHHHHHCCCHHHH | 65.43 | 21906983 | |
| 212 (in isoform 1) | Ubiquitination | - | 65.43 | 21906983 | |
| 212 (in isoform 2) | Ubiquitination | - | 65.43 | 21906983 | |
| 214 | Ubiquitination | MEQAQKAKNPQEQKS HHHHHHCCCHHHHHH | 75.97 | 21906983 | |
| 214 (in isoform 1) | Ubiquitination | - | 75.97 | 21906983 | |
| 214 (in isoform 2) | Ubiquitination | - | 75.97 | 21906983 | |
| 220 | Ubiquitination | AKNPQEQKSFFAKYW CCCHHHHHHHHHHHH | 48.77 | 27667366 | |
| 220 (in isoform 1) | Ubiquitination | - | 48.77 | 21906983 | |
| 220 (in isoform 2) | Ubiquitination | - | 48.77 | 21906983 | |
| 225 | Ubiquitination | EQKSFFAKYWMYIIP HHHHHHHHHHHHHHH | 34.00 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EMC10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EMC10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EMC10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of EMC10_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182, AND MASSSPECTROMETRY. | |
