| UniProt ID | EMC4_HUMAN | |
|---|---|---|
| UniProt AC | Q5J8M3 | |
| Protein Name | ER membrane protein complex subunit 4 | |
| Gene Name | EMC4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 183 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | May mediate anti-apoptotic activity.. | |
| Protein Sequence | MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTAQGGLVA ------CCCCCCEEC | 27.91 | 20058876 | |
| 2 | Acetylation | ------MTAQGGLVA ------CCCCCCEEC | 27.91 | 20058876 | |
| 11 | Methylation | QGGLVANRGRRFKWA CCCEECCCCCCEEEE | 30.20 | 115918645 | |
| 16 | Ubiquitination | ANRGRRFKWAIELSG CCCCCCEEEEEEECC | 33.63 | - | |
| 22 | Phosphorylation | FKWAIELSGPGGGSR EEEEEEECCCCCCCC | 30.10 | 30108239 | |
| 28 | Phosphorylation | LSGPGGGSRGRSDRG ECCCCCCCCCCCCCC | 34.53 | 30108239 | |
| 32 | Phosphorylation | GGGSRGRSDRGSGQG CCCCCCCCCCCCCCC | 34.19 | 23401153 | |
| 36 | Phosphorylation | RGRSDRGSGQGDSLY CCCCCCCCCCCCCCE | 28.92 | 28355574 | |
| 41 | Phosphorylation | RGSGQGDSLYPVGYL CCCCCCCCCEECCEE | 36.31 | 23927012 | |
| 43 | Phosphorylation | SGQGDSLYPVGYLDK CCCCCCCEECCEECC | 10.38 | 23927012 | |
| 47 | Phosphorylation | DSLYPVGYLDKQVPD CCCEECCEECCCCCC | 16.38 | 23403867 | |
| 50 | Ubiquitination | YPVGYLDKQVPDTSV EECCEECCCCCCCCC | 51.07 | 22053931 | |
| 50 (in isoform 3) | Ubiquitination | - | 51.07 | 21906983 | |
| 50 (in isoform 1) | Ubiquitination | - | 51.07 | 21906983 | |
| 50 | Acetylation | YPVGYLDKQVPDTSV EECCEECCCCCCCCC | 51.07 | 26051181 | |
| 50 (in isoform 2) | Ubiquitination | - | 51.07 | 21906983 | |
| 50 | Ubiquitination | YPVGYLDKQVPDTSV EECCEECCCCCCCCC | 51.07 | 2190698 | |
| 88 (in isoform 2) | Phosphorylation | - | 4.49 | 22210691 | |
| 93 (in isoform 2) | Phosphorylation | - | 18.38 | 22210691 | |
| 117 | Phosphorylation | IQALMAISATFKMLE HHHHHHHHHHHHHHH | 16.24 | 22210691 | |
| 119 | Phosphorylation | ALMAISATFKMLESS HHHHHHHHHHHHHHH | 19.59 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EMC4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EMC4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EMC4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of EMC4_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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