F186B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F186B_HUMAN
• UniProt AC: Q8IYM0
• Protein Name: Protein FAM186B
• Gene Name: FAM186B
• Organism: Homo sapiens (Human).
• Sequence Length: 893
• Protein Sequence: MEKDDPPQLVTPTSVKAIILRIEAAQLTRAQEDISTQLSDILDNVNCVINRFQEELGYDLKENAKSQQRDPKGKKRFILLEKIASFSKDAMMKEKHLYDILRWLGDWGDTLTYEIGPRKSEEEAAALDEWIEVTEKVLPLSLIATKRGIESLTALCSTLIEGQKKRSQVSKRTFWQGWQGRSPQTSPSHPQPLSPEQMLQDQHTMNTKASEVTSMLQELLDSTMFSKGEVRAIRYMATVVENLNKALILQHKENRSLETKYRHLQMQATKELSSQRLHFQQFMEVLESRRDALLKQVEILGGRYHDLLLMKQALEFQLKKAQNATGQAEDLAEVSVDSPGPSERETLPRKETVMEESQQEPMKEEQLFSPLPPSPMAMIRDSGAIAAGHQPLSTMTVRSRVADVFGSKDTESLEPVLLPLVDRRFPKKWERPVAESLGHKDKDQEDYFQKGGLQIKFHCSKQLSLESSRQVTSESQEEPWEEEFGREMRRQLWLEEEEMWQQRQKKWALLEQEHQEKLRQWNLEDLAREQQRRWVQLEKEQESPRREPEQLGEDVERRIFTPTSRWRDLEKAELSLVPAPSRTQSAHQSRRPHLPMSPSTQQPALGKQRPMSSVEFTYRPRTRRVPTKPKKSASFPVTGTSIRRLTWPSLQISPANIKKKVYHMDMEAQRKNLQLLSEESELRLPHYLRSKALELTTTTMELGALRLQYLCHKYIFYRRLQSLRQEAINHVQIMKETEASYKAQNLYIFLENIDRLQSLRLQAWTDKQKGLEEKHRECLSSMVTMFPKLQLEWNVHLNIPEVTSPKPKKCKLPAASPRHIRPSGPTYKQPFLSRHRACVPLQMARQQGKQMEAVWKTEVASSSYAIEKKTPASLPRDQLRGHPDIPRLLTLDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	ILLEKIASFSKDAMM HHHHHHHHCCHHHHH	33.26	24719451
112	Phosphorylation	GDWGDTLTYEIGPRK CCCCCCEEEECCCCC	22.62	23612710
151	Phosphorylation	ATKRGIESLTALCST HHHHCHHHHHHHHHH	29.15	30622161
153	Phosphorylation	KRGIESLTALCSTLI HHCHHHHHHHHHHHH	27.19	30622161
157	Phosphorylation	ESLTALCSTLIEGQK HHHHHHHHHHHCCCH	27.39	25693802
158	Phosphorylation	SLTALCSTLIEGQKK HHHHHHHHHHCCCHH	30.66	25693802
210	Phosphorylation	HTMNTKASEVTSMLQ HHHHCHHHHHHHHHH	33.87	27732954
213	Phosphorylation	NTKASEVTSMLQELL HCHHHHHHHHHHHHH	12.36	27732954
214	Phosphorylation	TKASEVTSMLQELLD CHHHHHHHHHHHHHH	23.75	28450419
222	Phosphorylation	MLQELLDSTMFSKGE HHHHHHHHCCCCHHH	23.03	25627689
223	Phosphorylation	LQELLDSTMFSKGEV HHHHHHHCCCCHHHH	23.15	25627689
226	Phosphorylation	LLDSTMFSKGEVRAI HHHHCCCCHHHHHHH	29.00	25627689
235	Phosphorylation	GEVRAIRYMATVVEN HHHHHHHHHHHHHHH	5.74	21659604
238	Phosphorylation	RAIRYMATVVENLNK HHHHHHHHHHHHHHH	14.46	21659604
335	Phosphorylation	AEDLAEVSVDSPGPS HHHHEECCCCCCCCC	16.23	30622161
338	Phosphorylation	LAEVSVDSPGPSERE HEECCCCCCCCCHHC	29.60	30622161
342	Phosphorylation	SVDSPGPSERETLPR CCCCCCCCHHCCCCC	56.02	30622161
346	Phosphorylation	PGPSERETLPRKETV CCCCHHCCCCCHHHH	48.56	-
352	Phosphorylation	ETLPRKETVMEESQQ CCCCCHHHHCHHHHC	28.34	25693802
357	Phosphorylation	KETVMEESQQEPMKE HHHHCHHHHCCCCCH	24.69	25693802
436	Phosphorylation	WERPVAESLGHKDKD CCCHHHHHCCCCCCC	29.88	28355574
461	Acetylation	QIKFHCSKQLSLESS EEEEEECCCCCCCHH	61.73	19822279
597	Phosphorylation	RRPHLPMSPSTQQPA CCCCCCCCCCCCCCC	17.48	26657352
622	Phosphorylation	EFTYRPRTRRVPTKP EEEECCCCCCCCCCC	26.05	-
646	Phosphorylation	GTSIRRLTWPSLQIS CCCHHHCCCCCCCCC	33.25	30622161
649	Phosphorylation	IRRLTWPSLQISPAN HHHCCCCCCCCCHHH	25.19	30622161
653	Phosphorylation	TWPSLQISPANIKKK CCCCCCCCHHHHHHH	12.66	30622161
677	Phosphorylation	RKNLQLLSEESELRL HHHHHHHCCHHHCCH	48.16	30622161
680	Phosphorylation	LQLLSEESELRLPHY HHHHCCHHHCCHHHH	37.57	30622161
722	Phosphorylation	IFYRRLQSLRQEAIN HHHHHHHHHHHHHHH	30.06	29496963
758	Phosphorylation	ENIDRLQSLRLQAWT HCHHHHHHHHHHHHC	21.76	29496963
816	Phosphorylation	KCKLPAASPRHIRPS CCCCCCCCCCCCCCC	25.27	23312004
861	Phosphorylation	VWKTEVASSSYAIEK EEEHHCCCCCCCCCC	25.62	22964224
862	Phosphorylation	WKTEVASSSYAIEKK EEHHCCCCCCCCCCC	20.03	-
873	Phosphorylation	IEKKTPASLPRDQLR CCCCCCCCCCHHHHC	39.86	24719451
890	Phosphorylation	PDIPRLLTLDV---- CCCCCCEECCC----	26.04	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F186B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F186B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F186B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of F186B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.