CLP1L_HUMAN - dbPTM
CLP1L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLP1L_HUMAN
UniProt AC Q96KA5
Protein Name Cleft lip and palate transmembrane protein 1-like protein
Gene Name CLPTM1L
Organism Homo sapiens (Human).
Sequence Length 538
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Enhances cisplatin-mediated apoptosis, when overexpressed..
Protein Sequence MWSGRSSFTSLVVGVFVVYVVHTCWVMYGIVYTRPCSGDANCIQPYLARRPKLQLSVYTTTRSHLGAENNIDLVLNVEDFDVESKFERTVNVSVPKKTRNNGTLYAYIFLHHAGVLPWHDGKQVHLVSPLTTYMVPKPEEINLLTGESDTQQIEAEKKPTSALDEPVSHWRPRLALNVMADNFVFDGSSLPADVHRYMKMIQLGKTVHYLPILFIDQLSNRVKDLMVINRSTTELPLTVSYDKVSLGRLRFWIHMQDAVYSLQQFGFSEKDADEVKGIFVDTNLYFLALTFFVAAFHLLFDFLAFKNDISFWKKKKSMIGMSTKAVLWRCFSTVVIFLFLLDEQTSLLVLVPAGVGAAIELWKVKKALKMTIFWRGLMPEFQFGTYSESERKTEEYDTQAMKYLSYLLYPLCVGGAVYSLLNIKYKSWYSWLINSFVNGVYAFGFLFMLPQLFVNYKLKSVAHLPWKAFTYKAFNTFIDDVFAFIITMPTSHRLACFRDDVVFLVYLYQRWLYPVDKRRVNEFGESYEEKATRAPHTD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
60PhosphorylationLQLSVYTTTRSHLGA
EEEEEEECCCHHCCC		11.5220068231
84PhosphorylationVEDFDVESKFERTVN
ECCCCCHHCEEEEEE		42.3628450419
85 (in isoform 2)Ubiquitination-37.4321890473
85 (in isoform 1)Ubiquitination-37.4321890473
85UbiquitinationEDFDVESKFERTVNV
CCCCCHHCEEEEEEE		37.4322817900
89O-linked_GlycosylationVESKFERTVNVSVPK
CHHCEEEEEEEECCC		14.8330059200
91N-linked_GlycosylationSKFERTVNVSVPKKT
HCEEEEEEEECCCCC		21.52UniProtKB CARBOHYD
91N-linked_GlycosylationSKFERTVNVSVPKKT
HCEEEEEEEECCCCC		21.5220068230
101N-linked_GlycosylationVPKKTRNNGTLYAYI
CCCCCCCCCCEEEEE		41.35UniProtKB CARBOHYD
137UbiquitinationLTTYMVPKPEEINLL
CEEEECCCHHHCCEE		54.3629967540
158UbiquitinationQQIEAEKKPTSALDE
HHHHHHHCCCCCCCC		45.0629967540
198UbiquitinationPADVHRYMKMIQLGK
CHHHHHHHHHHHHCC		2.1021890473
199 (in isoform 2)Ubiquitination-24.7421890473
199 (in isoform 1)Ubiquitination-24.7421890473
199UbiquitinationADVHRYMKMIQLGKT
HHHHHHHHHHHHCCC		24.7421890473
205UbiquitinationMKMIQLGKTVHYLPI
HHHHHHCCCEEHHHH		56.84-
206PhosphorylationKMIQLGKTVHYLPIL
HHHHHCCCEEHHHHH		15.66-
209PhosphorylationQLGKTVHYLPILFID
HHCCCEEHHHHHHHH		15.16-
223UbiquitinationDQLSNRVKDLMVINR
HHHCHHCEEEEEECC		41.74-
229N-linked_GlycosylationVKDLMVINRSTTELP
CEEEEEECCCCCCCE		22.0519159218
231PhosphorylationDLMVINRSTTELPLT
EEEEECCCCCCCEEE		34.8820068231
232PhosphorylationLMVINRSTTELPLTV
EEEECCCCCCCEEEE		22.5120068231
233PhosphorylationMVINRSTTELPLTVS
EEECCCCCCCEEEEE		36.4520068231
238PhosphorylationSTTELPLTVSYDKVS
CCCCCEEEEEEEEEC		12.88-
240PhosphorylationTELPLTVSYDKVSLG
CCCEEEEEEEEECCC		23.5220068231
241PhosphorylationELPLTVSYDKVSLGR
CCEEEEEEEEECCCE		18.5620068231
242UbiquitinationLPLTVSYDKVSLGRL
CEEEEEEEEECCCEE		37.0627667366
243 (in isoform 2)Ubiquitination-26.0321890473
243UbiquitinationPLTVSYDKVSLGRLR
EEEEEEEEECCCEEE		26.0327667366
243 (in isoform 1)Ubiquitination-26.0321890473
312UbiquitinationFKNDISFWKKKKSMI
HHCCHHHHHHHHHHC		12.5522817900
313UbiquitinationKNDISFWKKKKSMIG
HCCHHHHHHHHHHCC		53.3422817900
314UbiquitinationNDISFWKKKKSMIGM
CCHHHHHHHHHHCCC		56.9022817900
315UbiquitinationDISFWKKKKSMIGMS
CHHHHHHHHHHCCCC		46.4822817900
316 (in isoform 1)Ubiquitination-54.8821890473
316UbiquitinationISFWKKKKSMIGMST
HHHHHHHHHHCCCCH		54.8822817900
316 (in isoform 2)Ubiquitination-54.8821890473
323UbiquitinationKSMIGMSTKAVLWRC
HHHCCCCHHHHHHHH		17.7121963094
324UbiquitinationSMIGMSTKAVLWRCF
HHCCCCHHHHHHHHH		29.2321963094
387PhosphorylationEFQFGTYSESERKTE
HHCCCCCCHHHHCCH		34.19-
389PhosphorylationQFGTYSESERKTEEY
CCCCCCHHHHCCHHH		36.44-
392UbiquitinationTYSESERKTEEYDTQ
CCCHHHHCCHHHHHH		57.12-
396PhosphorylationSERKTEEYDTQAMKY
HHHCCHHHHHHHHHH		20.32-
403PhosphorylationYDTQAMKYLSYLLYP
HHHHHHHHHHHHHHH		6.44-
406PhosphorylationQAMKYLSYLLYPLCV
HHHHHHHHHHHHHHH		9.72-
423 (in isoform 2)Ubiquitination-5.3521890473
431 (in isoform 2)Ubiquitination-5.8821890473
456UbiquitinationLPQLFVNYKLKSVAH
HHHHHHHCCCCCCCC		16.6422817900
457UbiquitinationPQLFVNYKLKSVAHL
HHHHHHCCCCCCCCC		44.2122817900
458UbiquitinationQLFVNYKLKSVAHLP
HHHHHCCCCCCCCCC		3.3621890473
459 (in isoform 1)Ubiquitination-38.4421890473
4592-HydroxyisobutyrylationLFVNYKLKSVAHLPW
HHHHCCCCCCCCCCH		38.44-
459UbiquitinationLFVNYKLKSVAHLPW
HHHHCCCCCCCCCCH		38.4421963094
466UbiquitinationKSVAHLPWKAFTYKA
CCCCCCCHHHHHHHH		15.8021890473
467UbiquitinationSVAHLPWKAFTYKAF
CCCCCCHHHHHHHHH		31.5123000965
467 (in isoform 1)Ubiquitination-31.5121890473
471UbiquitinationLPWKAFTYKAFNTFI
CCHHHHHHHHHHHHH		8.2123000965
472UbiquitinationPWKAFTYKAFNTFID
CHHHHHHHHHHHHHH		43.3623000965
481 (in isoform 2)Ubiquitination-3.1021890473
488SulfoxidationVFAFIITMPTSHRLA
HHHHHCCCCCCCCCH		2.1028183972
494 (in isoform 2)Ubiquitination-3.9921890473
516UbiquitinationQRWLYPVDKRRVNEF
HHHHCCCCHHHHHHH		33.9521963094
517 (in isoform 1)Ubiquitination-42.1921890473
517UbiquitinationRWLYPVDKRRVNEFG
HHHCCCCHHHHHHHH		42.1921906983
526PhosphorylationRVNEFGESYEEKATR
HHHHHHHHHHHHHCC		37.9225159151
527PhosphorylationVNEFGESYEEKATRA
HHHHHHHHHHHHCCC		24.6523663014
529UbiquitinationEFGESYEEKATRAPH
HHHHHHHHHHCCCCC		39.4927667366
530 (in isoform 1)Ubiquitination-43.0221890473
530UbiquitinationFGESYEEKATRAPHT
HHHHHHHHHCCCCCC		43.0227667366
5302-HydroxyisobutyrylationFGESYEEKATRAPHT
HHHHHHHHHCCCCCC		43.02-
532PhosphorylationESYEEKATRAPHTD-
HHHHHHHCCCCCCC-		38.1323312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLP1L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLP1L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLP1L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPTN1_HUMANSPTAN1physical
22939629
RM47_HUMANMRPL47physical
22939629
QCR8_HUMANUQCRQphysical
22939629
GLPK_HUMANGKphysical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLP1L_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-229, AND MASSSPECTROMETRY.

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