LYRM4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYRM4_HUMAN
• UniProt AC: Q9HD34
• Protein Name: LYR motif-containing protein 4
• Gene Name: LYRM4
• Organism: Homo sapiens (Human).
• Sequence Length: 91
• Subcellular Localization: Mitochondrion. Nucleus.
• Protein Description: Required for nuclear and mitochondrial iron-sulfur protein biosynthesis..
• Protein Sequence: MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQVHIGQLYSTDKLIIENRDMPRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	ESKRFSAYNYRTYAV HCCCCCCCCHHHHHH	16.13	-
28	Phosphorylation	KRFSAYNYRTYAVRR CCCCCCCHHHHHHHH	7.52	-
31	Phosphorylation	SAYNYRTYAVRRIRD CCCCHHHHHHHHHHH	8.29	-
47	Malonylation	FRENKNVKDPVEIQT HHHCCCCCCCHHHHH	66.75	26320211
47	Succinylation	FRENKNVKDPVEIQT HHHCCCCCCCHHHHH	66.75	-
47	Succinylation	FRENKNVKDPVEIQT HHHCCCCCCCHHHHH	66.75	27452117
54	Phosphorylation	KDPVEIQTLVNKAKR CCCHHHHHHHHHHHH	38.03	18452278
58	Ubiquitination	EIQTLVNKAKRDLGV HHHHHHHHHHHHHCC	48.05	2097226
76	Phosphorylation	QVHIGQLYSTDKLII EECHHHCCCCCEEEE	11.13	24719451
77	Phosphorylation	VHIGQLYSTDKLIIE ECHHHCCCCCEEEEC	38.43	24719451
85	Phosphorylation	TDKLIIENRDMPRT- CCEEEECCCCCCCC-	34.54	24719451
93	Phosphorylation	RDMPRT--------- CCCCCC---------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYRM4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYRM4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYRM4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NECT2_HUMAN	PVRL2	physical	21988832
NFS1_HUMAN	NFS1	physical	26344197
ISCU_HUMAN	ISCU	physical	27499296
LYRM4_HUMAN	LYRM4	physical	27499296
FRDA_HUMAN	FXN	physical	27499296
NFS1_HUMAN	NFS1	physical	27499296
IDE_HUMAN	IDE	physical	27499296
NRDC_HUMAN	NRD1	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
HOGA1_HUMAN	HOGA1	physical	27499296
DDAH1_HUMAN	DDAH1	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
ODBA_HUMAN	BCKDHA	physical	27499296
ACPM_HUMAN	NDUFAB1	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• 615595: Combined oxidative phosphorylation deficiency 19 (COXPD19)
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.