| UniProt ID | NECT2_HUMAN | |
|---|---|---|
| UniProt AC | Q92692 | |
| Protein Name | Nectin-2 | |
| Gene Name | NECTIN2 {ECO:0000312|HGNC:HGNC:9707} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 538 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. [PubMed: 26755705 Probable cell adhesion protein] | |
| Protein Sequence | MARAAALLPSRSPPTPLLWPLLLLLLLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVEDVSLDLEDEEGEEEEEYLDKINPIYDALSYSSPSDSYQGKGFVMSRAMYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | RAAALLPSRSPPTPL CHHHCCCCCCCCCCC | 22199227 | ||
| 92 | O-linked_Glycosylation | FHPKMGPSFPSPKPG CCCCCCCCCCCCCCC | OGP | ||
| 95 | O-linked_Glycosylation | KMGPSFPSPKPGSER CCCCCCCCCCCCCCC | 63726889 | ||
| 95 | Phosphorylation | KMGPSFPSPKPGSER CCCCCCCCCCCCCCC | 21712546 | ||
| 100 | Phosphorylation | FPSPKPGSERLSFVS CCCCCCCCCCEEEEE | 21712546 | ||
| 104 | Phosphorylation | KPGSERLSFVSAKQS CCCCCCEEEEEEECC | 21712546 | ||
| 111 | Phosphorylation | SFVSAKQSTGQDTEA EEEEEECCCCCCCHH | 24043423 | ||
| 112 | Phosphorylation | FVSAKQSTGQDTEAE EEEEECCCCCCCHHH | 24043423 | ||
| 116 | Phosphorylation | KQSTGQDTEAELQDA ECCCCCCCHHHHHHH | 24043423 | ||
| 124 | Phosphorylation | EAELQDATLALHGLT HHHHHHHHEHCCCCE | 24043423 | ||
| 131 | Phosphorylation | TLALHGLTVEDEGNY HEHCCCCEEEECCCE | 24043423 | ||
| 137 | N-linked_Glycosylation | LTVEDEGNYTCEFAT CEEEECCCEEEEEEE | UniProtKB CARBOHYD | ||
| 138 | Phosphorylation | TVEDEGNYTCEFATF EEEECCCEEEEEEEE | 24043423 | ||
| 139 | Phosphorylation | VEDEGNYTCEFATFP EEECCCEEEEEEEEC | 24043423 | ||
| 144 | Phosphorylation | NYTCEFATFPKGSVR CEEEEEEEECCCCCC | 24043423 | ||
| 172 | Phosphorylation | QAEAQKVTFSQDPTT HHHHHCCEECCCCCE | 29978859 | ||
| 174 | Phosphorylation | EAQKVTFSQDPTTVA HHHCCEECCCCCEEE | 29978859 | ||
| 178 | Phosphorylation | VTFSQDPTTVALCIS CEECCCCCEEEEEEE | 29978859 | ||
| 179 | Phosphorylation | TFSQDPTTVALCISK EECCCCCEEEEEEEC | 29978859 | ||
| 185 | Phosphorylation | TTVALCISKEGRPPA CEEEEEEECCCCCCC | 29978859 | ||
| 207 | Phosphorylation | LDWEAKETQVSGTLA CCHHEEEEEECEEEE | 30631047 | ||
| 218 | Phosphorylation | GTLAGTVTVTSRFTL EEEEEEEEEEECEEE | 30631047 | ||
| 220 | Phosphorylation | LAGTVTVTSRFTLVP EEEEEEEEECEEECC | 30631047 | ||
| 228 | Phosphorylation | SRFTLVPSGRADGVT ECEEECCCCCCCCEE | - | ||
| 324 | N-linked_Glycosylation | HAVDSLFNTTFVCTV EEHHHHCCCEEEEEE | UniProtKB CARBOHYD | ||
| 352 | Phosphorylation | FVRETPNTAGAGATG EEECCCCCCCCCCCC | - | ||
| 377 | Phosphorylation | IATAVAATGILICRQ HHHHHHHHHHHHHHH | - | ||
| 387 | Ubiquitination | LICRQQRKEQTLQGA HHHHHHHHHHCCCCC | 29901268 | ||
| 390 | Phosphorylation | RQQRKEQTLQGAEED HHHHHHHCCCCCCCC | 25159151 | ||
| 392 | Ubiquitination | QRKEQTLQGAEEDED HHHHHCCCCCCCCCC | 33845483 | ||
| 392 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 393 (in isoform 2) | Phosphorylation | - | 30266825 | ||
| 402 (in isoform 2) | Phosphorylation | - | 30266825 | ||
| 405 | Phosphorylation | EDLEGPPSYKPPTPK CCCCCCCCCCCCCCH | 30266825 | ||
| 406 | Phosphorylation | DLEGPPSYKPPTPKA CCCCCCCCCCCCCHH | 28176443 | ||
| 407 | Ubiquitination | LEGPPSYKPPTPKAK CCCCCCCCCCCCHHH | 33845483 | ||
| 408 (in isoform 2) | Phosphorylation | - | 30266825 | ||
| 410 | Phosphorylation | PPSYKPPTPKAKLEA CCCCCCCCCHHHHHH | 23401153 | ||
| 412 | Ubiquitination | SYKPPTPKAKLEAQE CCCCCCCHHHHHHHC | 29967540 | ||
| 414 | Ubiquitination | KPPTPKAKLEAQEMP CCCCCHHHHHHHCCC | 29967540 | ||
| 422 | Phosphorylation | LEAQEMPSQLFTLGA HHHHCCCHHHCCCCC | 27794612 | ||
| 426 | Phosphorylation | EMPSQLFTLGASEHS CCCHHHCCCCCCCCC | 27794612 | ||
| 430 | Phosphorylation | QLFTLGASEHSPLKT HHCCCCCCCCCCCCC | 29255136 | ||
| 433 | Phosphorylation | TLGASEHSPLKTPYF CCCCCCCCCCCCCCC | 29255136 | ||
| 436 | Ubiquitination | ASEHSPLKTPYFDAG CCCCCCCCCCCCCCC | 29967540 | ||
| 437 | Phosphorylation | SEHSPLKTPYFDAGA CCCCCCCCCCCCCCC | 27251275 | ||
| 439 | Phosphorylation | HSPLKTPYFDAGASC CCCCCCCCCCCCCCC | 27259358 | ||
| 445 | Phosphorylation | PYFDAGASCTEQEMP CCCCCCCCCCCCCCC | 26657352 | ||
| 447 | Phosphorylation | FDAGASCTEQEMPRY CCCCCCCCCCCCCCC | 27259358 | ||
| 454 | Phosphorylation | TEQEMPRYHELPTLE CCCCCCCCCCCCCHH | 28176443 | ||
| 459 | Phosphorylation | PRYHELPTLEERSGP CCCCCCCCHHHHCCC | 29255136 | ||
| 465 (in isoform 2) | Phosphorylation | - | 26657352 | ||
| 470 (in isoform 2) | Phosphorylation | - | 29116813 | ||
| 473 (in isoform 2) | Phosphorylation | - | 22199227 | ||
| 491 | Phosphorylation | PPAVEDVSLDLEDEE CCCEEEEECCCCCCC | 28348404 | ||
| 505 | Phosphorylation | EGEEEEEYLDKINPI CCHHHHHHHHHHCHH | 22817900 | ||
| 513 | Phosphorylation | LDKINPIYDALSYSS HHHHCHHHHHHCCCC | 21945579 | ||
| 517 | Phosphorylation | NPIYDALSYSSPSDS CHHHHHHCCCCCCCC | 21945579 | ||
| 518 | Phosphorylation | PIYDALSYSSPSDSY HHHHHHCCCCCCCCC | 21945579 | ||
| 519 | Phosphorylation | IYDALSYSSPSDSYQ HHHHHCCCCCCCCCC | 21945579 | ||
| 520 | Phosphorylation | YDALSYSSPSDSYQG HHHHCCCCCCCCCCC | 21945579 | ||
| 522 | Phosphorylation | ALSYSSPSDSYQGKG HHCCCCCCCCCCCCC | 23663014 | ||
| 524 | Phosphorylation | SYSSPSDSYQGKGFV CCCCCCCCCCCCCEE | 21945579 | ||
| 525 | Phosphorylation | YSSPSDSYQGKGFVM CCCCCCCCCCCCEEE | 21945579 | ||
| 537 | Phosphorylation | FVMSRAMYV------ EEEEEEEEC------ | 20736484 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NECT2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NECT2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NECT2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NECT2_HUMAN | PVRL2 | physical | 10617658 | |
| AFAD_HUMAN | MLLT4 | physical | 10617658 | |
| NECT2_HUMAN | PVRL2 | physical | 9845526 | |
| NECT3_HUMAN | PVRL3 | physical | 21982860 | |
| NECT2_HUMAN | PVRL2 | physical | 21982860 | |
| UBP53_HUMAN | USP53 | physical | 21988832 | |
| SIAH1_HUMAN | SIAH1 | physical | 25416956 | |
| KR107_HUMAN | KRTAP10-7 | physical | 25416956 | |
| KR101_HUMAN | KRTAP10-1 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| BTBD1_HUMAN | BTBD1 | physical | 28514442 | |
| SPA12_HUMAN | SERPINA12 | physical | 28514442 | |
| LOXE3_HUMAN | ALOXE3 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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