| UniProt ID | NECT3_HUMAN | |
|---|---|---|
| UniProt AC | Q9NQS3 | |
| Protein Name | Nectin-3 | |
| Gene Name | NECTIN3 {ECO:0000312|HGNC:HGNC:17664} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 549 | |
| Subcellular Localization |
Cell membrane Single-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane. |
|
| Protein Description | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.. | |
| Protein Sequence | MARTLRPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 43 | Ubiquitination | PPPLLLLLFPLLLFS CCCHHHHHHHHHHHH | 27667366 | ||
| 73 | N-linked_Glycosylation | VTAVWGKNVSLKCLI EEEEECCCCEEEEEE | 22902367 | ||
| 83 | N-linked_Glycosylation | LKCLIEVNETITQIS EEEEEEECCCCEEEE | UniProtKB CARBOHYD | ||
| 125 | N-linked_Glycosylation | QGRVLFKNYSLNDAT ECEEEEEEEECCCCE | 22902367 | ||
| 139 | Ubiquitination | TITLHNIGFSDSGKY EEEEEECCCCCCCCE | 27667366 | ||
| 173 | Phosphorylation | VLVEPTVSLIKGPDS EEECCCEEEEECCCC | 24719451 | ||
| 186 | N-linked_Glycosylation | DSLIDGGNETVAAIC CCCCCCCCHHEEEEE | 22902367 | ||
| 222 | N-linked_Glycosylation | STTTSFPNETATIIS EECCCCCCCHHEEEE | 22902367 | ||
| 232 | Ubiquitination | ATIISQYKLFPTRFA HEEEEEEEECCCHHC | 27667366 | ||
| 239 | Ubiquitination | KLFPTRFARGRRITC EECCCHHCCCCEEEE | 22817900 | ||
| 240 | Ubiquitination | LFPTRFARGRRITCV ECCCHHCCCCEEEEE | 27667366 | ||
| 255 | Ubiquitination | VKHPALEKDIRYSFI EECHHHCCCCEEEEE | 27667366 | ||
| 259 | Ubiquitination | ALEKDIRYSFILDIQ HHCCCCEEEEEEEEE | 22817900 | ||
| 260 | Ubiquitination | LEKDIRYSFILDIQY HCCCCEEEEEEEEEE | 22817900 | ||
| 263 | Ubiquitination | DIRYSFILDIQYAPE CCEEEEEEEEEECCE | 22817900 | ||
| 280 | Ubiquitination | VTGYDGNWFVGRKGV EECCCCCEEECCCCE | 22817900 | ||
| 286 | Ubiquitination | NWFVGRKGVNLKCNA CEEECCCCEECCCCC | 27667366 | ||
| 303 | Ubiquitination | NPPPFKSVWSRLDGQ CCCCCCHHHHHCCCC | 22817900 | ||
| 307 | Ubiquitination | FKSVWSRLDGQWPDG CCHHHHHCCCCCCCC | 22817900 | ||
| 328 | Ubiquitination | TLHFVHPLTFNYSGV CEEEECEEEECCCEE | 27667366 | ||
| 331 | N-linked_Glycosylation | FVHPLTFNYSGVYIC EECEEEECCCEEEEE | 22902367 | ||
| 336 | Ubiquitination | TFNYSGVYICKVTNS EECCCEEEEEEEECC | 27667366 | ||
| 351 | Ubiquitination | LGQRSDQKVIYISDP CCCCCCCEEEEECCC | 27667366 | ||
| 354 | Phosphorylation | RSDQKVIYISDPPTT CCCCEEEEECCCCCC | 28348404 | ||
| 356 | Phosphorylation | DQKVIYISDPPTTTT CCEEEEECCCCCCCC | 28348404 | ||
| 360 | Phosphorylation | IYISDPPTTTTLQPT EEECCCCCCCCCCCE | 28348404 | ||
| 361 | Phosphorylation | YISDPPTTTTLQPTI EECCCCCCCCCCCEE | 28348404 | ||
| 362 | Phosphorylation | ISDPPTTTTLQPTIQ ECCCCCCCCCCCEEE | 28348404 | ||
| 363 | Phosphorylation | SDPPTTTTLQPTIQW CCCCCCCCCCCEEEC | 28348404 | ||
| 367 | O-linked_Glycosylation | TTTTLQPTIQWHPST CCCCCCCEEECCCCC | OGP | ||
| 367 | Phosphorylation | TTTTLQPTIQWHPST CCCCCCCEEECCCCC | 28348404 | ||
| 373 | Phosphorylation | PTIQWHPSTADIEDL CEEECCCCCCCHHHH | 28348404 | ||
| 373 | O-linked_Glycosylation | PTIQWHPSTADIEDL CEEECCCCCCCHHHH | OGP | ||
| 374 | Phosphorylation | TIQWHPSTADIEDLA EEECCCCCCCHHHHC | 28348404 | ||
| 374 | O-linked_Glycosylation | TIQWHPSTADIEDLA EEECCCCCCCHHHHC | OGP | ||
| 382 | Ubiquitination | ADIEDLATEPKKLPF CCHHHHCCCCCCCCC | 27667366 | ||
| 386 (in isoform 3) | Phosphorylation | - | 29514088 | ||
| 388 | Ubiquitination | ATEPKKLPFPLSTLA CCCCCCCCCCHHHHE | 33845483 | ||
| 403 | Ubiquitination | TIKDDTIATIIASVV ECCCCHHHHHHHHHH | 29967540 | ||
| 418 | Ubiquitination | GGALFIVLVSVLAGI HHHHHHHHHHHHHHH | 29967540 | ||
| 428 | Ubiquitination | VLAGIFCYRRRRTFR HHHHHHHHHHCCCCC | 22817900 | ||
| 436 | Ubiquitination | RRRRTFRGDYFAKNY HHCCCCCCCHHHHCC | 22817900 | ||
| 438 | Phosphorylation | RRTFRGDYFAKNYIP CCCCCCCHHHHCCCC | 19901323 | ||
| 448 | Ubiquitination | KNYIPPSDMQKESQI HCCCCHHHCCCHHHC | 22817900 | ||
| 449 | Ubiquitination | NYIPPSDMQKESQID CCCCHHHCCCHHHCC | 22817900 | ||
| 451 | Ubiquitination | IPPSDMQKESQIDVL CCHHHCCCHHHCCCH | 21906983 | ||
| 451 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 452 | Ubiquitination | PPSDMQKESQIDVLQ CHHHCCCHHHCCCHH | 22817900 | ||
| 453 | Phosphorylation | PSDMQKESQIDVLQQ HHHCCCHHHCCCHHH | 23403867 | ||
| 456 | Ubiquitination | MQKESQIDVLQQDEL CCCHHHCCCHHHHHH | 22817900 | ||
| 457 | Ubiquitination | QKESQIDVLQQDELD CCHHHCCCHHHHHHH | 22817900 | ||
| 460 | Ubiquitination | SQIDVLQQDELDSYP HHCCCHHHHHHHHCC | 22817900 | ||
| 465 | Phosphorylation | LQQDELDSYPDSVKK HHHHHHHHCCHHHCC | 30266825 | ||
| 466 | Phosphorylation | QQDELDSYPDSVKKE HHHHHHHCCHHHCCC | 30266825 | ||
| 469 | Ubiquitination | ELDSYPDSVKKENKN HHHHCCHHHCCCCCC | 22817900 | ||
| 469 | Phosphorylation | ELDSYPDSVKKENKN HHHHCCHHHCCCCCC | 30266825 | ||
| 471 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 471 | Ubiquitination | DSYPDSVKKENKNPV HHCCHHHCCCCCCCC | 21906983 | ||
| 472 | Ubiquitination | SYPDSVKKENKNPVN HCCHHHCCCCCCCCH | 22817900 | ||
| 475 | Ubiquitination | DSVKKENKNPVNNLI HHHCCCCCCCCHHCC | 22817900 | ||
| 477 | Ubiquitination | VKKENKNPVNNLIRK HCCCCCCCCHHCCCH | 22817900 | ||
| 482 | Ubiquitination | KNPVNNLIRKDYLEE CCCCHHCCCHHHCCC | 22817900 | ||
| 486 | Phosphorylation | NNLIRKDYLEEPEKT HHCCCHHHCCCCCHH | 28152594 | ||
| 492 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 492 | Ubiquitination | DYLEEPEKTQWNNVE HHCCCCCHHCCCCHH | 21906983 | ||
| 496 | Ubiquitination | EPEKTQWNNVENLNR CCCHHCCCCHHHCCC | 22817900 | ||
| 500 | Ubiquitination | TQWNNVENLNRFERP HCCCCHHHCCCCCCC | 22817900 | ||
| 502 | Ubiquitination | WNNVENLNRFERPMD CCCHHHCCCCCCCCH | 22817900 | ||
| 503 | Ubiquitination | NNVENLNRFERPMDY CCHHHCCCCCCCCHH | 22817900 | ||
| 504 | Ubiquitination | NVENLNRFERPMDYY CHHHCCCCCCCCHHH | 22817900 | ||
| 506 | Ubiquitination | ENLNRFERPMDYYED HHCCCCCCCCHHHHH | 22817900 | ||
| 510 | Phosphorylation | RFERPMDYYEDLKMG CCCCCCHHHHHHHHH | 25884760 | ||
| 511 | Phosphorylation | FERPMDYYEDLKMGM CCCCCHHHHHHHHHC | 20007894 | ||
| 515 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 515 | Ubiquitination | MDYYEDLKMGMKFVS CHHHHHHHHHCEECC | 22817900 | ||
| 519 | Ubiquitination | EDLKMGMKFVSDEHY HHHHHHCEECCHHHC | 22817900 | ||
| 522 | Phosphorylation | KMGMKFVSDEHYDEN HHHCEECCHHHCCCC | 27642862 | ||
| 523 | Ubiquitination | MGMKFVSDEHYDENE HHCEECCHHHCCCCC | 22817900 | ||
| 526 | Phosphorylation | KFVSDEHYDENEDDL EECCHHHCCCCCCCC | 25884760 | ||
| 535 | Phosphorylation | ENEDDLVSHVDGSVI CCCCCCHHCCCCCEE | 27422710 | ||
| 540 | Phosphorylation | LVSHVDGSVISRREW CHHCCCCCEEECEEC | 27642862 | ||
| 543 | Phosphorylation | HVDGSVISRREWYV- CCCCCEEECEECCC- | 27642862 | ||
| 546 | Ubiquitination | GSVISRREWYV---- CCEEECEECCC---- | 22817900 | ||
| 550 | Ubiquitination | SRREWYV-------- ECEECCC-------- | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NECT3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NECT3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NECT3_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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