FBX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX2_HUMAN
• UniProt AC: Q9UK22
• Protein Name: F-box only protein 2
• Gene Name: FBXO2
• Organism: Homo sapiens (Human).
• Sequence Length: 296
• Subcellular Localization: Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity)..
• Protein Sequence: MDGDGDPESVGQPEEASPEEQPEEASAEEERPEDQQEEEAAAAAAYLDELPEPLLLRVLAALPAAELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGGVEEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWCDVEHGGDGWRVEELPGDSGVEFTHDESVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRSDAGCLYELTVKLLSEHENVLAEFSSGQVAVPQDSDGGGWMEISHTFTDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Ubiquitination	RLVCLRWKELVDGAP HHHHHHHHHHHCCCC	34.43	30230243
155	Phosphorylation	VEELPGDSGVEFTHD EEECCCCCCCEECCC	51.13	-
160	Phosphorylation	GDSGVEFTHDESVKK CCCCCEECCCHHHHH	18.21	24076635
164	Phosphorylation	VEFTHDESVKKYFAS CEECCCHHHHHHHHH	45.34	24076635
166	Ubiquitination	FTHDESVKKYFASSF ECCCHHHHHHHHHHH	51.54	30230243
172	Phosphorylation	VKKYFASSFEWCRKA HHHHHHHHHHHHHHC	24.61	24076635
217	Phosphorylation	RSDAGCLYELTVKLL CCCCCHHHHHHHHHH	16.99	28152594
220	Phosphorylation	AGCLYELTVKLLSEH CCHHHHHHHHHHHHC	12.03	28152594
288	Phosphorylation	GWFGARVTNSSVWVE CEECCEEECCCEEEC	24.67	30622161
290	Phosphorylation	FGARVTNSSVWVEP- ECCEEECCCEEECC-	19.53	30622161
291	Phosphorylation	GARVTNSSVWVEP-- CCEEECCCEEECC--	23.28	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITB1_HUMAN	ITGB1	physical	12140560
FETUA_HUMAN	AHSG	physical	12140560
TERA_HUMAN	VCP	physical	15723043
CHIP_HUMAN	STUB1	physical	16682404
BACE1_HUMAN	BACE1	physical	20854419
SKP1_HUMAN	SKP1	physical	17494702
SKP1_HUMAN	SKP1	physical	15109709
CXB2_HUMAN	GJB2	physical	15109709
CUL1_HUMAN	CUL1	physical	21135578
CUL7_HUMAN	CUL7	physical	21135578
ANC2_HUMAN	ANAPC2	physical	21135578
CUL1_HUMAN	CUL1	physical	18203720
SKP1_HUMAN	SKP1	physical	18203720
RBX1_HUMAN	RBX1	physical	18203720
SKP1_HUMAN	SKP1	physical	18284940
ITB1_HUMAN	ITGB1	physical	16275327
TOR1A_HUMAN	TOR1A	physical	22917612
FETUA_HUMAN	AHSG	physical	17116465
ITB1_HUMAN	ITGB1	physical	17116465
UB2D2_HUMAN	UBE2D2	physical	12140560
UB2D1_HUMAN	UBE2D1	physical	16682404
UB2D2_HUMAN	UBE2D2	physical	16682404
UB2D3_HUMAN	UBE2D3	physical	16682404
UB2E1_HUMAN	UBE2E1	physical	16682404
UB2L3_HUMAN	UBE2L3	physical	16682404
CUL1_HUMAN	CUL1	physical	23319600
A1AT_HUMAN	SERPINA1	physical	26295339

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.