TIGIT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIGIT_HUMAN
• UniProt AC: Q495A1
• Protein Name: T-cell immunoreceptor with Ig and ITIM domains
• Gene Name: TIGIT
• Organism: Homo sapiens (Human).
• Sequence Length: 244
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells..
• Protein Sequence: MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVVVALTRKKKALRIHSVEGDLRRKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGEDCAELHDYFNVLSYRSLGNCSFFTETG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	N-linked_Glycosylation	GTIETTGNISAEKGG EEEEECCCEEECCCC	23.97	UniProtKB CARBOHYD
94	Phosphorylation	PGPGLGLTLQSLTVN CCCCCCEEEEEEEEC	22.43	26074081
97	Phosphorylation	GLGLTLQSLTVNDTG CCCEEEEEEEECCCC	29.17	26074081
99	Phosphorylation	GLTLQSLTVNDTGEY CEEEEEEEECCCCCE	23.62	26074081
101	N-linked_Glycosylation	TLQSLTVNDTGEYFC EEEEEEECCCCCEEE	35.57	UniProtKB CARBOHYD
103	Phosphorylation	QSLTVNDTGEYFCIY EEEEECCCCCEEEEE	27.06	26074081
149	Phosphorylation	LLGAMAATLVVICTA HHHHHHHHHHHHHHH	15.56	-
155	Phosphorylation	ATLVVICTAVIVVVA HHHHHHHHHHHHHHH	16.91	-
164	Phosphorylation	VIVVVALTRKKKALR HHHHHHHHCCCCHHE	30.61	-
174	Phosphorylation	KKALRIHSVEGDLRR CCHHEEEEEECCHHH	21.35	23401153
183	Phosphorylation	EGDLRRKSAGQEEWS ECCHHHCCCCCCCCC	35.50	27080861
190	Phosphorylation	SAGQEEWSPSAPSPP CCCCCCCCCCCCCCC	16.56	27080861
192	Phosphorylation	GQEEWSPSAPSPPGS CCCCCCCCCCCCCCC	47.50	27080861
225	Phosphorylation	DCAELHDYFNVLSYR CHHHHHHHHHEECEE	6.06	29978859
230	Phosphorylation	HDYFNVLSYRSLGNC HHHHHEECEEECCCC	17.76	29978859
231	Phosphorylation	DYFNVLSYRSLGNCS HHHHEECEEECCCCE	10.48	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
225	Y	Phosphorylation	Kinase	FYN	P06241	PSP
225	Y	Phosphorylation	Kinase	LCK	P06239	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIGIT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIGIT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NECT2_HUMAN	PVRL2	physical	21982860
NECT3_HUMAN	PVRL3	physical	21982860
NECT4_HUMAN	PVRL4	physical	21982860
PVR_HUMAN	PVR	physical	21982860

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.