| UniProt ID | NECT4_HUMAN | |
|---|---|---|
| UniProt AC | Q96NY8 | |
| Protein Name | Nectin-4 | |
| Gene Name | NECTIN4 {ECO:0000312|HGNC:HGNC:19688} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 510 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . Cell junction, adherens junction . Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254). Processed poliovirus receptor-related protein 4: Secreted . The secreted form |
|
| Protein Description | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; (Microbial infection) Acts as a receptor for measles virus.. | |
| Protein Sequence | MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 58 | Phosphorylation | PCFYRGDSGEQVGQV CEEEECCCCCEEEEE | 29759185 | ||
| 131 (in isoform 2) | Phosphorylation | - | 25849741 | ||
| 153 (in isoform 2) | Phosphorylation | - | 25849741 | ||
| 156 (in isoform 2) | Phosphorylation | - | 25849741 | ||
| 279 | Phosphorylation | SEGQPPPSYNWTRLD HCCCCCCCCCCEECC | 25690035 | ||
| 281 | N-linked_Glycosylation | GQPPPSYNWTRLDGP CCCCCCCCCEECCCC | UniProtKB CARBOHYD | ||
| 391 | Phosphorylation | QKYEEELTLTRENSI HHHHHHHHCCCHHHH | 25056879 | ||
| 393 | Phosphorylation | YEEELTLTRENSIRR HHHHHHCCCHHHHHH | 25056879 | ||
| 397 | Phosphorylation | LTLTRENSIRRLHSH HHCCCHHHHHHHHHC | 25849741 | ||
| 403 | Phosphorylation | NSIRRLHSHHTDPRS HHHHHHHHCCCCCCC | 28348404 | ||
| 406 | Phosphorylation | RRLHSHHTDPRSQPE HHHHHCCCCCCCCCH | 28102081 | ||
| 415 | Phosphorylation | PRSQPEESVGLRAEG CCCCCHHHHCCCCCC | 28348404 | ||
| 426 | Phosphorylation | RAEGHPDSLKDNSSC CCCCCCCCCCCCCCC | 25849741 | ||
| 431 | Phosphorylation | PDSLKDNSSCSVMSE CCCCCCCCCCCEEEC | 28348404 | ||
| 432 | Phosphorylation | DSLKDNSSCSVMSEE CCCCCCCCCCEEECC | 28348404 | ||
| 434 | Phosphorylation | LKDNSSCSVMSEEPE CCCCCCCCEEECCCC | 24719451 | ||
| 437 | Phosphorylation | NSSCSVMSEEPEGRS CCCCCEEECCCCCCC | 28348404 | ||
| 444 | Phosphorylation | SEEPEGRSYSTLTTV ECCCCCCCCCCEEEE | 25849741 | ||
| 445 | Phosphorylation | EEPEGRSYSTLTTVR CCCCCCCCCCEEEEE | 30278072 | ||
| 446 | Phosphorylation | EPEGRSYSTLTTVRE CCCCCCCCCEEEEEE | 27966365 | ||
| 447 | Phosphorylation | PEGRSYSTLTTVREI CCCCCCCCEEEEEEE | 25849741 | ||
| 449 | Phosphorylation | GRSYSTLTTVREIET CCCCCCEEEEEEEEH | 26074081 | ||
| 450 | Phosphorylation | RSYSTLTTVREIETQ CCCCCEEEEEEEEHH | 26074081 | ||
| 458 | Phosphorylation | VREIETQTELLSPGS EEEEEHHCCCCCCCC | 26657352 | ||
| 462 | Phosphorylation | ETQTELLSPGSGRAE EHHCCCCCCCCCCCC | 24719451 | ||
| 465 | Phosphorylation | TELLSPGSGRAEEEE CCCCCCCCCCCCCHH | 28348404 | ||
| 491 | Phosphorylation | HFVQENGTLRAKPTG HHHHHCCCEEECCCC | 25849741 | ||
| 497 | Phosphorylation | GTLRAKPTGNGIYIN CCEEECCCCCCEEEC | 26356563 | ||
| 502 | Phosphorylation | KPTGNGIYINGRGHL CCCCCCEEECCCCCC | 21082442 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NECT4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NECT4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NECT4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NECT1_HUMAN | PVRL1 | physical | 21982860 | |
| NECT2_HUMAN | PVRL2 | physical | 21982860 | |
| TIGIT_HUMAN | TIGIT | physical | 21982860 | |
| EI2BD_HUMAN | EIF2B4 | physical | 26186194 | |
| DPS1_HUMAN | PDSS1 | physical | 26186194 | |
| FBX10_HUMAN | FBXO10 | physical | 26186194 | |
| EI2BA_HUMAN | EIF2B1 | physical | 26186194 | |
| PIGU_HUMAN | PIGU | physical | 26186194 | |
| CF062_HUMAN | C6orf62 | physical | 26186194 | |
| ENAH_HUMAN | ENAH | physical | 26186194 | |
| EVL_HUMAN | EVL | physical | 26186194 | |
| PPGB_HUMAN | CTSA | physical | 26186194 | |
| EI2BB_HUMAN | EIF2B2 | physical | 26186194 | |
| EI2BG_HUMAN | EIF2B3 | physical | 26186194 | |
| RRP1_HUMAN | RRP1 | physical | 26186194 | |
| DPS1_HUMAN | PDSS1 | physical | 28514442 | |
| CF062_HUMAN | C6orf62 | physical | 28514442 | |
| FBX10_HUMAN | FBXO10 | physical | 28514442 | |
| ENAH_HUMAN | ENAH | physical | 28514442 | |
| EI2BG_HUMAN | EIF2B3 | physical | 28514442 | |
| EVL_HUMAN | EVL | physical | 28514442 | |
| EI2BB_HUMAN | EIF2B2 | physical | 28514442 | |
| EI2BD_HUMAN | EIF2B4 | physical | 28514442 | |
| EI2BA_HUMAN | EIF2B1 | physical | 28514442 | |
| PIGU_HUMAN | PIGU | physical | 28514442 | |
| BGAL_HUMAN | GLB1 | physical | 28514442 | |
| RRP1_HUMAN | RRP1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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