FBX10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX10_HUMAN
• UniProt AC: Q9UK96
• Protein Name: F-box only protein 10
• Gene Name: FBXO10
• Organism: Homo sapiens (Human).
• Sequence Length: 956
• Subcellular Localization: Cytoplasm .
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2..
• Protein Sequence: MEAGGLPLELWRMILAYLHLPDLGRCSLVCRAWYELILSLDSTRWRQLCLGCTECRHPNWPNQPDVEPESWREAFKQHYLASKTWTKNALDLESSICFSLFRRRRERRTLSVGPGREFDSLGSALAMASLYDRIVLFPGVYEEQGEIILKVPVEIVGQGKLGEVALLASIDQHCSTTRLCNLVFTPAWFSPIMYKTTSGHVQFDNCNFENGHIQVHGPGTCQVKFCTFKNTHIFLHNVPLCVLENCEFVGSENNSVTVEGHPSADKNWAYKYLLGLIKSSPTFLPTEDSDFLMSLDLESRDQAWSPKTCDIVIEGSQSPTSPASSSPKPGSKAGSQEAEVGSDGERVAQTPDSSDGGLSPSGEDEDEDQLMYRLSYQVQGPRPVLGGSFLGPPLPGASIQLPSCLVLNSLQQELQKDKEAMALANSVQGCLIRKCLFRDGKGGVFVCSHGRAKMEGNIFRNLTYAVRCIHNSKIIMLRNDIYRCRASGIFLRLEGGGLIAGNNIYHNAEAGVDIRKKSNPLILCNQIHHGLRSGIVVLGNGKGIIRNNQIFSNKEAGIYILYHGNPVVSGNHIFKGRAAGIAVNENGKGLITENVIRENQWGGVDIRRGGIPVLRSNLICFGYSDGVVVGDEGKGLIEGNTIYANKGCGVWMMSSSLPHVTSNHVSYNGLYGVAVFSQKDGSSELPRGHRAQENFSEDGDAILWETELEKEDDPLRRPITIALVESNSINHNGASGLYVQSSEALHVITNVIHANGDRGITVAQSSQPTRVANNSISCNRQSGVKVEAQCKVELRGNGIYDNRGHGIITKGDSTIVIENDIIGNRGSGLQLLPRSDTKVIKNRIHSFRAYGIAVRGRAKALVQENIIFQGKTSKTIFQQISNNRECIMQNNKFLVFKKKSDTWRLVNPPARPHLENSLRRPSAAHNGQKVTAMATRITARVEGGYHSNRSVFCTIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	LPDLGRCSLVCRAWY CCCCCHHHHHHHHHH	23.60	-
43	Phosphorylation	LILSLDSTRWRQLCL HHHCCCCCHHHHHHC	33.64	-
94	Phosphorylation	KNALDLESSICFSLF CCCHHHHHHHHHHHH	32.09	-
109	Phosphorylation	RRRRERRTLSVGPGR HHHHHCCCEECCCCC	29.61	-
305	Phosphorylation	ESRDQAWSPKTCDIV CCCCCCCCCCCCCEE	21.38	24719451
316	Phosphorylation	CDIVIEGSQSPTSPA CCEEEECCCCCCCCC	18.07	21712546
318	Phosphorylation	IVIEGSQSPTSPASS EEEECCCCCCCCCCC	31.66	21712546
320	Phosphorylation	IEGSQSPTSPASSSP EECCCCCCCCCCCCC	53.22	21712546
321	Phosphorylation	EGSQSPTSPASSSPK ECCCCCCCCCCCCCC	23.12	21712546
324	Phosphorylation	QSPTSPASSSPKPGS CCCCCCCCCCCCCCC	34.43	21712546
325	Phosphorylation	SPTSPASSSPKPGSK CCCCCCCCCCCCCCC	53.41	21712546
326	Phosphorylation	PTSPASSSPKPGSKA CCCCCCCCCCCCCCC	34.15	24719451
331	Phosphorylation	SSSPKPGSKAGSQEA CCCCCCCCCCCCCEE	28.05	23312004
342	Phosphorylation	SQEAEVGSDGERVAQ CCEEEECCCCCEEEC	47.84	29255136
463	Phosphorylation	GNIFRNLTYAVRCIH CCHHHHHHHHHHHHH	17.00	-
559	Phosphorylation	SNKEAGIYILYHGNP CCCCCCEEEEECCCC	5.51	27050516
562	Phosphorylation	EAGIYILYHGNPVVS CCCEEEEECCCCEEC	9.72	27050516
775	Phosphorylation	PTRVANNSISCNRQS CCEEECCCEECCCCC	18.71	21712546
777	Phosphorylation	RVANNSISCNRQSGV EEECCCEECCCCCCC	12.74	21712546
855	Methylation	RAYGIAVRGRAKALV HHHEEEECCHHHHHH	21.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	23319600

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.