EI2BG_HUMAN - dbPTM
EI2BG_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EI2BG_HUMAN
UniProt AC Q9NR50
Protein Name Translation initiation factor eIF-2B subunit gamma
Gene Name EIF2B3
Organism Homo sapiens (Human).
Sequence Length 452
Subcellular Localization
Protein Description Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP..
Protein Sequence MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGSNIQGSVICNNAVIEKGADIKDCLIGSGQRIEAKAKRVNEVIVGNDQLMEI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEFQAVVM
-------CCCEEEEE		11.9722223895
55PhosphorylationFEEVIVVTTRDVQKA
CCEEEEEEEHHHHHH		12.7630257219
56PhosphorylationEEVIVVTTRDVQKAL
CEEEEEEEHHHHHHH		17.1730257219
61UbiquitinationVTTRDVQKALCAEFK
EEEHHHHHHHHHHHC		43.08-
68UbiquitinationKALCAEFKMKMKPDI
HHHHHHHCCCCCCCE		29.17-
68AcetylationKALCAEFKMKMKPDI
HHHHHHHCCCCCCCE		29.1725953088
72UbiquitinationAEFKMKMKPDIVCIP
HHHCCCCCCCEEEEC		33.74-
92PhosphorylationGTADSLRYIYPKLKT
CHHHHHHHHHHHCCC		15.31-
96UbiquitinationSLRYIYPKLKTDVLV
HHHHHHHHCCCCEEE		45.72-
134UbiquitinationSLAMLMRKGQDSIEP
HHHHHHHCCCCCCCC		47.1321906983
134 (in isoform 3)Ubiquitination-47.1321890473
134 (in isoform 2)Ubiquitination-47.1321890473
134 (in isoform 1)Ubiquitination-47.1321890473
134MethylationSLAMLMRKGQDSIEP
HHHHHHHCCCCCCCC		47.13-
138PhosphorylationLMRKGQDSIEPVPGQ
HHHCCCCCCCCCCCC		22.4428857561
146UbiquitinationIEPVPGQKGKKKAVE
CCCCCCCCCCCCCHH		77.83-
148MethylationPVPGQKGKKKAVEQR
CCCCCCCCCCCHHCC		59.13-
148UbiquitinationPVPGQKGKKKAVEQR
CCCCCCCCCCCHHCC		59.13-
1652-HydroxyisobutyrylationIGVDSTGKRLLFMAN
ECCCCCCCEEEEECC		39.70-
165UbiquitinationIGVDSTGKRLLFMAN
ECCCCCCCEEEEECC		39.70-
165AcetylationIGVDSTGKRLLFMAN
ECCCCCCCEEEEECC		39.7026051181
189UbiquitinationIKGSILQKHPRIRFH
ECHHHHHHCCCEECC		52.73-
189AcetylationIKGSILQKHPRIRFH
ECHHHHHHCCCEECC		52.7327452117
220PhosphorylationDFLMENGSITSIRSE
HHHHHCCCCEEHHHH		33.98-
235UbiquitinationLIPYLVRKQFSSASS
HHHHHHHHHHHCCCH		48.49-
238PhosphorylationYLVRKQFSSASSQQG
HHHHHHHHCCCHHHC		23.6229978859
239PhosphorylationLVRKQFSSASSQQGQ
HHHHHHHCCCHHHCH		33.2029978859
241PhosphorylationRKQFSSASSQQGQEE
HHHHHCCCHHHCHHH		30.5429978859
242PhosphorylationKQFSSASSQQGQEEK
HHHHCCCHHHCHHHH		26.6629978859
249UbiquitinationSQQGQEEKEEDLKKK
HHHCHHHHHHHHHHH		66.70-
259 (in isoform 1)Ubiquitination-50.4921890473
259 (in isoform 3)Ubiquitination-50.4921890473
259 (in isoform 2)Ubiquitination-50.4921890473
259UbiquitinationDLKKKELKSLDIYSF
HHHHHHHHHCCHHHH		50.4921890473
260PhosphorylationLKKKELKSLDIYSFI
HHHHHHHHCCHHHHH		43.8522199227
264PhosphorylationELKSLDIYSFIKEAN
HHHHCCHHHHHHHHC		9.3725159151
265PhosphorylationLKSLDIYSFIKEANT
HHHCCHHHHHHHHCC		22.3420873877
268UbiquitinationLDIYSFIKEANTLNL
CCHHHHHHHHCCCCC		49.08-
306AcetylationRCYVHIMKEGLCSRV
HHHHHHHHCCCCHHH		48.2926051181
314PhosphorylationEGLCSRVSTLGLYME
CCCCHHHHHHHHHHH		19.4628857561
315PhosphorylationGLCSRVSTLGLYMEA
CCCHHHHHHHHHHHH		23.2228857561
319PhosphorylationRVSTLGLYMEANRQV
HHHHHHHHHHHHHHH		7.3627642862
328UbiquitinationEANRQVPKLLSALCP
HHHHHHHHHHHHHCC		64.30-
349UbiquitinationSSAQIVSKHLVGVDS
CCHHHHHHHHCCCCC		30.02-
367UbiquitinationPETQIGEKSSIKRSV
CCCCCCCCCCCCHHH		44.27-
382UbiquitinationIGSSCLIKDRVTITN
HCCCCCCCCCEEEEC		26.91-
422AcetylationIEKGADIKDCLIGSG
EECCCCHHHHCCCCC		42.8326051181
422UbiquitinationIEKGADIKDCLIGSG
EECCCCHHHHCCCCC		42.83-
428PhosphorylationIKDCLIGSGQRIEAK
HHHHCCCCCCHHHHH		25.4321815630
450SulfoxidationIVGNDQLMEI-----
EECCCHHCCC-----		3.4630846556
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EI2BG_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EI2BG_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EI2BG_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STC2_HUMANSTC2physical
16169070
EI2BE_HUMANEIF2B5physical
10858531
ABCF1_HUMANABCF1physical
22863883
CN166_HUMANC14orf166physical
22863883
RTCB_HUMANRTCBphysical
22863883
NELFB_HUMANNELFBphysical
22863883
YBOX3_HUMANYBX3physical
22863883
DDX1_HUMANDDX1physical
22863883
DHX9_HUMANDHX9physical
22863883
DIM1_HUMANDIMT1physical
22863883
EDC4_HUMANEDC4physical
22863883
EI2BB_HUMANEIF2B2physical
22863883
HNRPM_HUMANHNRNPMphysical
22863883
HNRPU_HUMANHNRNPUphysical
22863883
IF2B3_HUMANIGF2BP3physical
22863883
ILF2_HUMANILF2physical
22863883
MRE11_HUMANMRE11Aphysical
22863883
NMT1_HUMANNMT1physical
22863883
SYQ_HUMANQARSphysical
22863883
RFC4_HUMANRFC4physical
22863883
EI2BA_HUMANEIF2B1physical
26344197
EI2BD_HUMANEIF2B4physical
26344197
EIF3C_HUMANEIF3Cphysical
26344197
EI2BA_HUMANEIF2B1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
603896Leukodystrophy with vanishing white matter (VWM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EI2BG_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory