| UniProt ID | NECT1_HUMAN | |
|---|---|---|
| UniProt AC | Q15223 | |
| Protein Name | Nectin-1 | |
| Gene Name | NECTIN1 {ECO:0000312|HGNC:HGNC:9706} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 517 | |
| Subcellular Localization |
Isoform Alpha: Cell membrane Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Isoform Delta: Cell membrane Single-pass type I membrane protein. Isoform Gamma: Secreted. |
|
| Protein Description | Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.; (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.. | |
| Protein Sequence | MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | N-linked_Glycosylation | HSQVVQVNDSMYGFI CCCEEEECHHHHCCC | UniProtKB CARBOHYD | ||
| 52 | Phosphorylation | TDVVLHCSFANPLPS CEEEEECEECCCCCC | - | ||
| 59 | Phosphorylation | SFANPLPSVKITQVT EECCCCCCCEEEEEE | - | ||
| 70 | Phosphorylation | TQVTWQKSTNGSKQN EEEEEEECCCCCEEE | 29083192 | ||
| 71 | Phosphorylation | QVTWQKSTNGSKQNV EEEEEECCCCCEEEE | 29083192 | ||
| 72 | N-linked_Glycosylation | VTWQKSTNGSKQNVA EEEEECCCCCEEEEE | 21980294 | ||
| 74 | Phosphorylation | WQKSTNGSKQNVAIY EEECCCCCEEEEEEE | 29083192 | ||
| 81 | Phosphorylation | SKQNVAIYNPSMGVS CEEEEEEECCCCCEE | 29083192 | ||
| 84 | Phosphorylation | NVAIYNPSMGVSVLA EEEEECCCCCEEEEE | 29083192 | ||
| 88 | Phosphorylation | YNPSMGVSVLAPYRE ECCCCCEEEEECHHH | 29083192 | ||
| 93 | Phosphorylation | GVSVLAPYRERVEFL CEEEEECHHHHEEEC | 29083192 | ||
| 139 | N-linked_Glycosylation | GNRESQLNLTVMAKP CCCCCEEEEEEEECC | 21980294 | ||
| 145 | Ubiquitination | LNLTVMAKPTNWIEG EEEEEEECCCCHHHH | - | ||
| 171 | Phosphorylation | DDKVLVATCTSANGK CCCEEEEEEECCCCC | 28787133 | ||
| 173 | Phosphorylation | KVLVATCTSANGKPP CEEEEEEECCCCCCC | 28787133 | ||
| 174 | Phosphorylation | VLVATCTSANGKPPS EEEEEEECCCCCCCC | 28787133 | ||
| 181 | Phosphorylation | SANGKPPSVVSWETR CCCCCCCCEEEEEEE | - | ||
| 190 (in isoform 3) | Ubiquitination | - | 21906983 | ||
| 190 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 190 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 190 | Ubiquitination | VSWETRLKGEAEYQE EEEEEEECCCEEEEE | 22817900 | ||
| 202 | N-linked_Glycosylation | YQEIRNPNGTVTVIS EEEECCCCCCEEEEE | 22902367 | ||
| 202 | N-linked_Glycosylation | YQEIRNPNGTVTVIS EEEECCCCCCEEEEE | 22902367 | ||
| 206 | Phosphorylation | RNPNGTVTVISRYRL CCCCCCEEEEECEEE | 24719451 | ||
| 211 | Phosphorylation | TVTVISRYRLVPSRE CEEEEECEEECCCHH | 24719451 | ||
| 286 | N-linked_Glycosylation | EYHWTTLNGSLPKGV EEEEEECCCCCCCCC | UniProtKB CARBOHYD | ||
| 286 | N-linked_Glycosylation | EYHWTTLNGSLPKGV EEEEEECCCCCCCCC | 19349973 | ||
| 297 | N-linked_Glycosylation | PKGVEAQNRTLFFKG CCCCCCCCCEEEEEC | UniProtKB CARBOHYD | ||
| 307 | N-linked_Glycosylation | LFFKGPINYSLAGTY EEEECCCCEEECEEE | UniProtKB CARBOHYD | ||
| 332 | N-linked_Glycosylation | RSGQVEVNITEFPYT CCCEEEEEEEECCCC | 19349973 | ||
| 332 | N-linked_Glycosylation | RSGQVEVNITEFPYT CCCEEEEEEEECCCC | 19349973 | ||
| 339 | O-linked_Glycosylation | NITEFPYTPSPPEHG EEEECCCCCCCCCCC | OGP | ||
| 386 | Ubiquitination | RRRRHTFKGDYSTKK HHCCCCCCCCCCCCE | - | ||
| 389 | Phosphorylation | RHTFKGDYSTKKHVY CCCCCCCCCCCEEEE | 27642862 | ||
| 390 | Phosphorylation | HTFKGDYSTKKHVYG CCCCCCCCCCEEEEC | 27251275 | ||
| 391 | Phosphorylation | TFKGDYSTKKHVYGN CCCCCCCCCEEEECC | - | ||
| 393 | Ubiquitination | KGDYSTKKHVYGNGY CCCCCCCEEEECCCC | - | ||
| 396 | Phosphorylation | YSTKKHVYGNGYSKA CCCCEEEECCCCCCC | 25884760 | ||
| 400 | Phosphorylation | KHVYGNGYSKAGIPQ EEEECCCCCCCCCCC | 22817900 | ||
| 418 | Phosphorylation | PMAQNLQYPDDSDDE CCHHCCCCCCCCCCC | 30266825 | ||
| 422 | Phosphorylation | NLQYPDDSDDEKKAG CCCCCCCCCCCCCCC | 23927012 | ||
| 427 | Ubiquitination | DDSDDEKKAGPLGGS CCCCCCCCCCCCCCC | - | ||
| 430 (in isoform 2) | Phosphorylation | - | 25907765 | ||
| 434 | Phosphorylation | KAGPLGGSSYEEEEE CCCCCCCCCCCHHHH | 23401153 | ||
| 435 | Phosphorylation | AGPLGGSSYEEEEEE CCCCCCCCCCHHHHH | 26503892 | ||
| 435 (in isoform 2) | Phosphorylation | - | 25907765 | ||
| 436 | Phosphorylation | GPLGGSSYEEEEEEE CCCCCCCCCHHHHHH | 22167270 | ||
| 436 (in isoform 2) | Phosphorylation | - | 25907765 | ||
| 441 (in isoform 2) | Phosphorylation | - | 25907765 | ||
| 443 (in isoform 2) | Phosphorylation | - | 25907765 | ||
| 444 (in isoform 2) | Phosphorylation | - | 25907765 | ||
| 447 (in isoform 2) | Phosphorylation | - | 25907765 | ||
| 459 | Ubiquitination | KVGGPHPKYDEDAKR CCCCCCCCCCCCCCC | 23503661 | ||
| 460 | Phosphorylation | VGGPHPKYDEDAKRP CCCCCCCCCCCCCCC | 28796482 | ||
| 465 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 465 | Ubiquitination | PKYDEDAKRPYFTVD CCCCCCCCCCCEECC | 22817900 | ||
| 467 | Phosphorylation | YDEDAKRPYFTVDEA CCCCCCCCCEECCHH | 17389395 | ||
| 468 | Phosphorylation | DEDAKRPYFTVDEAE CCCCCCCCEECCHHH | 20007894 | ||
| 470 | Phosphorylation | DAKRPYFTVDEAEAR CCCCCCEECCHHHHH | 25884760 | ||
| 481 | Phosphorylation | AEARQDGYGDRTLGY HHHHHCCCCCCCCCC | 22817900 | ||
| 488 | Phosphorylation | YGDRTLGYQYDPEQL CCCCCCCCCCCHHHC | 25884760 | ||
| 490 | Phosphorylation | DRTLGYQYDPEQLDL CCCCCCCCCHHHCHH | 27642862 | ||
| 503 | Phosphorylation | DLAENMVSQNDGSFI HHHHHHCCCCCCCCC | 28450419 | ||
| 508 | Phosphorylation | MVSQNDGSFISKKEW HCCCCCCCCCCCEEC | 28464451 | ||
| 511 | Phosphorylation | QNDGSFISKKEWYV- CCCCCCCCCEECCC- | 28450419 | ||
| 512 | Ubiquitination | NDGSFISKKEWYV-- CCCCCCCCEECCC-- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NECT1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NECT1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NECT1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| AFAD_HUMAN | MLLT4 | physical | 10225955 | |
| NECT4_HUMAN | PVRL4 | physical | 21982860 | |
| NECT3_HUMAN | PVRL3 | physical | 21982860 | |
| NECT1_HUMAN | PVRL1 | physical | 21982860 | |
| FGFR1_HUMAN | FGFR1 | physical | 22955284 | |
| FGFR2_HUMAN | FGFR2 | physical | 22955284 | |
| FGFR3_HUMAN | FGFR3 | physical | 22955284 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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