INP5K_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INP5K_HUMAN
• UniProt AC: Q9BT40
• Protein Name: Inositol polyphosphate 5-phosphatase K {ECO:0000305}
• Gene Name: INPP5K {ECO:0000312|HGNC:HGNC:33882}
• Organism: Homo sapiens (Human).
• Sequence Length: 448
• Subcellular Localization: Endoplasmic reticulum . Following stimulation with EGF, translocates to membrane ruffles.
• Protein Description: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. [PubMed: 10753883 Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity]
• Protein Sequence: MSSRKLSGPKGRRLSIHVVTWNVASAAPPLDLSDLLQLNNRNLNLDIYVIGLQELNSGIISLLSDAAFNDSWSSFLMDVLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNILDHDLIIWFGDMNFRIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYIDISNIPTTEDEFLLCYYSNSLRSVVGISRPFQIPPGSLREDPLGEAQPQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSSRKLSGPKGRRL -CCCCCCCCCCCCCE	56.96	29514088
84	Phosphorylation	MDVLSPLSFIKVSHV HHHHCHHHHCCCCCE	28.45	24719451
114	Phosphorylation	LPYIQILSTKSTPTG CCEEEEECCCCCCCC	35.10	24719451
172 (in isoform 2)	Ubiquitination	-	25.21	21890473
220	Ubiquitination	CYGGLWEKDQLSIAK CCCCCCHHHHHHHHH	38.91	-
228	Ubiquitination	DQLSIAKKHDPLLRE HHHHHHHHHCHHHHH	44.19	-
248	Ubiquitination	LLFPPTYKFDRNSND CCCCCCCCCCCCCCC	43.18	21890473
248 (in isoform 1)	Ubiquitination	-	43.18	21890473
294	Phosphorylation	IPPASHFSLSLRGYS CCCCHHEEEEECCCC	16.18	17081983
296	Phosphorylation	PASHFSLSLRGYSSH CCHHEEEEECCCCCC	18.15	17081983
388	Phosphorylation	WVGDSKVSCSDNLNQ EECCCCEECCCCCCE	16.19	22210691
406	Phosphorylation	DISNIPTTEDEFLLC ECCCCCCCCCEEEHH	35.76	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INP5K_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INP5K_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INP5K_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOR2_HUMAN	NCOR2	physical	11509665
TANK_HUMAN	TANK	physical	21988832
FATE1_HUMAN	FATE1	physical	25416956
MD2BP_HUMAN	MAD2L1BP	physical	28514442
KTNA1_HUMAN	KATNA1	physical	28514442
UBP47_HUMAN	USP47	physical	28514442
RFX1_HUMAN	RFX1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
CA131_HUMAN	C1orf131	physical	28514442
PESC_HUMAN	PES1	physical	28514442
PUR2_HUMAN	GART	physical	28514442
ABHDA_HUMAN	ABHD10	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.