ABHDA_HUMAN - dbPTM
ABHDA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABHDA_HUMAN
UniProt AC Q9NUJ1
Protein Name Mycophenolic acid acyl-glucuronide esterase, mitochondrial
Gene Name ABHD10
Organism Homo sapiens (Human).
Sequence Length 306
Subcellular Localization Mitochondrion .
Protein Description Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate..
Protein Sequence MAVARLAAVAAWVPCRSWGWAAVPFGPHRGLSVLLARIPQRAPRWLPACRQKTSLSFLNRPDLPNLAYKKLKGKSPGIIFIPGYLSYMNGTKALAIEEFCKSLGHACIRFDYSGVGSSDGNSEESTLGKWRKDVLSIIDDLADGPQILVGSSLGGWLMLHAAIARPEKVVALIGVATAADTLVTKFNQLPVELKKEVEMKGVWSMPSKYSEEGVYNVQYSFIKEAEHHCLLHSPIPVNCPIRLLHGMKDDIVPWHTSMQVADRVLSTDVDVILRKHSDHRMREKADIQLLVYTIDDLIDKLSTIVN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationAAWVPCRSWGWAAVP
HHHCCCCCCCEEECC		36.3468732107
32PhosphorylationFGPHRGLSVLLARIP
CCCCCCHHHHHHHCC		17.3468732113
37UbiquitinationGLSVLLARIPQRAPR
CHHHHHHHCCCCCCC		40.88-
43UbiquitinationARIPQRAPRWLPACR
HHCCCCCCCCCHHHC		30.12-
68PhosphorylationPDLPNLAYKKLKGKS
CCCCCHHHHHHCCCC		16.3028152594
69AcetylationDLPNLAYKKLKGKSP
CCCCHHHHHHCCCCC		46.12-
69AcetylationDLPNLAYKKLKGKSP
CCCCHHHHHHCCCCC		46.1223954790
69UbiquitinationDLPNLAYKKLKGKSP
CCCCHHHHHHCCCCC		46.12-
69SuccinylationDLPNLAYKKLKGKSP
CCCCHHHHHHCCCCC		46.1223954790
69MalonylationDLPNLAYKKLKGKSP
CCCCHHHHHHCCCCC		46.1226320211
69UbiquitinationDLPNLAYKKLKGKSP
CCCCHHHHHHCCCCC		46.1223503661
692-HydroxyisobutyrylationDLPNLAYKKLKGKSP
CCCCHHHHHHCCCCC		46.12-
70AcetylationLPNLAYKKLKGKSPG
CCCHHHHHHCCCCCC		42.6330586685
70UbiquitinationLPNLAYKKLKGKSPG
CCCHHHHHHCCCCCC		42.6323503661
72UbiquitinationNLAYKKLKGKSPGII
CHHHHHHCCCCCCEE		73.5023503661
74UbiquitinationAYKKLKGKSPGIIFI
HHHHHCCCCCCEEEE		52.4723503661
75PhosphorylationYKKLKGKSPGIIFIP
HHHHCCCCCCEEEEC		36.7121406692
84PhosphorylationGIIFIPGYLSYMNGT
CEEEECCHHHHCCCH		6.2627080861
86PhosphorylationIFIPGYLSYMNGTKA
EEECCHHHHCCCHHH		17.5327080861
87PhosphorylationFIPGYLSYMNGTKAL
EECCHHHHCCCHHHH		7.6321406692
91PhosphorylationYLSYMNGTKALAIEE
HHHHCCCHHHHHHHH		14.2427080861
91AcetylationYLSYMNGTKALAIEE
HHHHCCCHHHHHHHH		14.24-
91UbiquitinationYLSYMNGTKALAIEE
HHHHCCCHHHHHHHH		14.24-
100GlutathionylationALAIEEFCKSLGHAC
HHHHHHHHHHHCCEE		3.1122555962
101MalonylationLAIEEFCKSLGHACI
HHHHHHHHHHCCEEE		54.7826320211
101SuccinylationLAIEEFCKSLGHACI
HHHHHHHHHHCCEEE		54.7827452117
101AcetylationLAIEEFCKSLGHACI
HHHHHHHHHHCCEEE		54.7825825284
101AcetylationLAIEEFCKSLGHACI
HHHHHHHHHHCCEEE		54.78-
112PhosphorylationHACIRFDYSGVGSSD
CEEEEECCCCCCCCC		12.4728152594
113PhosphorylationACIRFDYSGVGSSDG
EEEEECCCCCCCCCC		28.9328152594
117PhosphorylationFDYSGVGSSDGNSEE
ECCCCCCCCCCCCCC		23.8920068231
118PhosphorylationDYSGVGSSDGNSEES
CCCCCCCCCCCCCCC		43.5420068231
122PhosphorylationVGSSDGNSEESTLGK
CCCCCCCCCCCCCHH		48.5520068231
125PhosphorylationSDGNSEESTLGKWRK
CCCCCCCCCCHHHHH		25.5320068231
126PhosphorylationDGNSEESTLGKWRKD
CCCCCCCCCHHHHHH		42.6920068231
129UbiquitinationSEESTLGKWRKDVLS
CCCCCCHHHHHHHHH		47.11-
129UbiquitinationSEESTLGKWRKDVLS
CCCCCCHHHHHHHHH		47.1121906983
129AcetylationSEESTLGKWRKDVLS
CCCCCCHHHHHHHHH		47.1126822725
132UbiquitinationSTLGKWRKDVLSIID
CCCHHHHHHHHHHHH		51.5822817900
177PhosphorylationVALIGVATAADTLVT
HHHEEHHHCHHHHHH		21.7021406692
181PhosphorylationGVATAADTLVTKFNQ
EHHHCHHHHHHHHHC		20.5721406692
184PhosphorylationTAADTLVTKFNQLPV
HCHHHHHHHHHCCCC		32.7921406692
185AcetylationAADTLVTKFNQLPVE
CHHHHHHHHHCCCCC		34.5391057
194UbiquitinationNQLPVELKKEVEMKG
HCCCCCHHHCEECCC		33.1221906983
1942-HydroxyisobutyrylationNQLPVELKKEVEMKG
HCCCCCHHHCEECCC		33.12-
195UbiquitinationQLPVELKKEVEMKGV
CCCCCHHHCEECCCC		78.5722817900
200UbiquitinationLKKEVEMKGVWSMPS
HHHCEECCCCCCCCC		36.4921906983
200UbiquitinationLKKEVEMKGVWSMPS
HHHCEECCCCCCCCC		36.4921890473
208AcetylationGVWSMPSKYSEEGVY
CCCCCCCCCCCCCEE		47.1025038526
209PhosphorylationVWSMPSKYSEEGVYN
CCCCCCCCCCCCEEE		26.1728152594
210PhosphorylationWSMPSKYSEEGVYNV
CCCCCCCCCCCEEEE		32.6728152594
215PhosphorylationKYSEEGVYNVQYSFI
CCCCCCEEEEEEEEH		22.0728152594
219PhosphorylationEGVYNVQYSFIKEAE
CCEEEEEEEEHHHCC		10.9828152594
220PhosphorylationGVYNVQYSFIKEAEH
CEEEEEEEEHHHCCC		11.9124719451
233PhosphorylationEHHCLLHSPIPVNCP
CCCEEECCCCCCCCC		25.2129255136
248UbiquitinationIRLLHGMKDDIVPWH
HHHHCCCCCCCCCCH		57.7622817900
2482-HydroxyisobutyrylationIRLLHGMKDDIVPWH
HHHHCCCCCCCCCCH		57.76-
248AcetylationIRLLHGMKDDIVPWH
HHHHCCCCCCCCCCH		57.7623954790
248MalonylationIRLLHGMKDDIVPWH
HHHHCCCCCCCCCCH		57.7626320211
266PhosphorylationQVADRVLSTDVDVIL
HHHHHHHCCCHHHHH		21.5030622161
267PhosphorylationVADRVLSTDVDVILR
HHHHHHCCCHHHHHH		35.5630622161
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABHDA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABHDA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABHDA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABHDA_HUMAN

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Related Literatures of Post-Translational Modification

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