MAK_HUMAN - dbPTM
MAK_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAK_HUMAN
UniProt AC P20794
Protein Name Serine/threonine-protein kinase MAK
Gene Name MAK
Organism Homo sapiens (Human).
Sequence Length 623
Subcellular Localization Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Localized in both the connecting cilia and the
Protein Description Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells..
Protein Sequence MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTSLKSDSELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAGNLGSYATYNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIVNRAQPIPSVHGRTDWVAKYGGHR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MNRYTTMRQLG
----CCCCCCCCCCC		11.1020068231
5Phosphorylation---MNRYTTMRQLGD
---CCCCCCCCCCCC		15.7520068231
6Phosphorylation--MNRYTTMRQLGDG
--CCCCCCCCCCCCC		11.0420068231
14PhosphorylationMRQLGDGTYGSVLMG
CCCCCCCCCEEEEEE		29.4620068231
15PhosphorylationRQLGDGTYGSVLMGK
CCCCCCCCEEEEEEC		16.9720068231
17PhosphorylationLGDGTYGSVLMGKSN
CCCCCCEEEEEECCC		11.1520068231
53PhosphorylationMNLREVKSLKKLNHA
CCHHHHHHHHHCCCC		51.0724719451
152PhosphorylationGLARELRSQPPYTDY
HHHHHHHCCCCCCCC		60.7123663014
156PhosphorylationELRSQPPYTDYVSTR
HHHCCCCCCCCCCCC		20.9423663014
157PhosphorylationLRSQPPYTDYVSTRW
HHCCCCCCCCCCCCC		26.9923663014
159PhosphorylationSQPPYTDYVSTRWYR
CCCCCCCCCCCCCCC		6.6221082442
161PhosphorylationPPYTDYVSTRWYRAP
CCCCCCCCCCCCCCC		13.1623663014
162PhosphorylationPYTDYVSTRWYRAPE
CCCCCCCCCCCCCCH		18.3823663014
165PhosphorylationDYVSTRWYRAPEVLL
CCCCCCCCCCCHHHH		8.1323663014
218PhosphorylationKICQVLGTPKKSDWP
HHHHHHCCCCCCCCC		27.9824719451
276PhosphorylationPKKRPTASQALKHPY
CCCCCCHHHHHCCCC		20.6123532336
457PhosphorylationHSTGENKSLPAVTSL
CCCCCCCCCCCCCCC		51.6827251275
476PhosphorylationELSTAPTSKQYYLKQ
HHCCCCCCCHHHHHH		19.3924719451
480PhosphorylationAPTSKQYYLKQSRYL
CCCCCHHHHHHCCCC		12.6222461510
510PhosphorylationEINPHTWSNQLFPKS
CCCCCCCHHCCCCHH		18.82-
549PhosphorylationNQSGYIPSFLKKEVQ
CCCCCCCHHHHHHHH		33.3824719451
557PhosphorylationFLKKEVQSAGQRIHL
HHHHHHHHCCCCEEE		39.2722985185
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
157TPhosphorylationKinaseMAKP20794
PSP
159YPhosphorylationKinaseMAKP20794
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAK_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAK_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAK_HUMANMAKphysical
21986944
CDK20_HUMANCDK20physical
21986944
FZR1_HUMANFZR1physical
21986944
A4_HUMANAPPphysical
21832049
SLAF7_HUMANSLAMF7physical
21988832
SERC1_HUMANSERINC1physical
21988832
NDUB7_HUMANNDUFB7physical
21988832
PP2AB_HUMANPPP2CBphysical
21988832
SND1_HUMANSND1physical
21988832
MAK_HUMANMAKphysical
23602568
FILA_HUMANFLGphysical
27173435
ICK_HUMANICKphysical
27173435
K0556_HUMANKIAA0556physical
27173435
PRDX2_HUMANPRDX2physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614181Retinitis pigmentosa 62 (RP62)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAK_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Male germ cell-associated kinase is overexpressed in prostate cancercells and causes mitotic defects via deregulation of APC/C(CDH1).";
Wang L.Y., Kung H.J.;
Oncogene 0:0-0(2011).
Cited for: FUNCTION, INTERACTION WITH CDK20 AND FZR1, SUBCELLULAR LOCATION,AUTOPHOSPHORYLATION AT THR-157 AND TYR-159, AND MUTAGENESIS OF THR-157AND TYR-159.

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