| UniProt ID | TRI11_HUMAN | |
|---|---|---|
| UniProt AC | Q96F44 | |
| Protein Name | E3 ubiquitin-protein ligase TRIM11 | |
| Gene Name | TRIM11 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 468 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.. | |
| Protein Sequence | MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCRENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MAAPDLSTNLQEEA -CCCCCCCHHHHHHH | 23.72 | 24043423 | |
| 8 | Phosphorylation | MAAPDLSTNLQEEAT CCCCCCCHHHHHHHH | 47.44 | 24043423 | |
| 15 | Phosphorylation | TNLQEEATCAICLDY HHHHHHHHHHHHHHH | 13.02 | 24043423 | |
| 22 | Phosphorylation | TCAICLDYFTDPVMT HHHHHHHHHCCCCCC | 8.74 | 24043423 | |
| 24 | Phosphorylation | AICLDYFTDPVMTDC HHHHHHHCCCCCCCC | 32.91 | 24043423 | |
| 29 | Phosphorylation | YFTDPVMTDCGHNFC HHCCCCCCCCCCCHH | 28.50 | 24043423 | |
| 60 | Phosphorylation | CPECRELSPQRNLRP CHHHHHHCCCCCCCC | 17.77 | 26074081 | |
| 73 | Ubiquitination | RPNRPLAKMAEMARR CCCCHHHHHHHHHHH | 46.45 | 32015554 | |
| 85 | Phosphorylation | ARRLHPPSPVPQGVC HHHHCCCCCCCCCCC | 42.87 | 23401153 | |
| 136 (in isoform 2) | Ubiquitination | - | 56.66 | 21906983 | |
| 136 (in isoform 1) | Ubiquitination | - | 56.66 | 21906983 | |
| 136 | Ubiquitination | QDAAEDLKAKLEKSL HHHHHHHHHHHHHHH | 56.66 | 21906983 | |
| 138 | Ubiquitination | AAEDLKAKLEKSLEH HHHHHHHHHHHHHHH | 56.44 | 22817900 | |
| 141 (in isoform 2) | Ubiquitination | - | 71.43 | - | |
| 141 | Ubiquitination | DLKAKLEKSLEHLRK HHHHHHHHHHHHHHH | 71.43 | 29901268 | |
| 142 | Phosphorylation | LKAKLEKSLEHLRKQ HHHHHHHHHHHHHHH | 29.61 | 21406692 | |
| 163 | Phosphorylation | FQAQADETCVLWQKM HHHHCHHHHHHHHHH | 14.41 | 29978859 | |
| 181 | Ubiquitination | QRQNVLGEFERLRRL HHHHHHHHHHHHHHH | 39.93 | 27667366 | |
| 248 (in isoform 2) | Ubiquitination | - | 45.28 | - | |
| 248 | Ubiquitination | LGLLQDIKDALRRVQ HHHHHHHHHHHHHHH | 45.28 | - | |
| 257 | Ubiquitination | ALRRVQDVKLQPPEV HHHHHHCCCCCCCCC | 3.59 | 27667366 | |
| 258 (in isoform 2) | Ubiquitination | - | 50.09 | 21906983 | |
| 258 | Ubiquitination | LRRVQDVKLQPPEVV HHHHHCCCCCCCCCC | 50.09 | 27667366 | |
| 258 (in isoform 1) | Ubiquitination | - | 50.09 | 21906983 | |
| 281 | Phosphorylation | RVPGLVETLRRFRGD CCCCHHHHHHHHCCC | 20.34 | 21406692 | |
| 286 | Methylation | VETLRRFRGDVTLDP HHHHHHHCCCCCCCC | 38.29 | 115918949 | |
| 304 (in isoform 2) | Ubiquitination | - | 52.68 | - | |
| 308 | Phosphorylation | ILSEDRRSVQRGDLR EECCCCCCCCCCCHH | 24.40 | - | |
| 321 | Phosphorylation | LRQALPDSPERFDPG HHHHCCCCCCCCCCC | 27.07 | 21815630 | |
| 458 | Ubiquitination | PMTICRPKGGSGDTL CEEEEECCCCCCCCC | 57.46 | 33845483 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRI11_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRI11_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRI11_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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