RBPS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBPS2_HUMAN
• UniProt AC: Q6ZRY4
• Protein Name: RNA-binding protein with multiple splicing 2
• Gene Name: RBPMS2
• Organism: Homo sapiens (Human).
• Sequence Length: 209
• Subcellular Localization: Cytoplasm .
• Protein Description: Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation..
• Protein Sequence: MSNLKPDGEHGGSTGTGSGAGSGGALEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTARQPVGFVIFDSRAGAEAAKNALNGIRFDPENPQTLRLEFAKANTKMAKSKLMATPNPSNVHPALGAHFIARDPYDLMGAALIPASPEAWAPYPLYTTELTPAISHAAFTYPTATAAAAALHAQVRWYPSSDTTQQGWKYRQFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSNLKPDGE ------CCCCCCCCC	51.36	19413330
2	Phosphorylation	------MSNLKPDGE ------CCCCCCCCC	51.36	21406692
13	Phosphorylation	PDGEHGGSTGTGSGA CCCCCCCCCCCCCCC	28.40	21406692
14	Phosphorylation	DGEHGGSTGTGSGAG CCCCCCCCCCCCCCC	41.88	21406692
16	Phosphorylation	EHGGSTGTGSGAGSG CCCCCCCCCCCCCCC	28.41	21406692
18	Phosphorylation	GGSTGTGSGAGSGGA CCCCCCCCCCCCCCC	25.88	21406692
22	Phosphorylation	GTGSGAGSGGALEEE CCCCCCCCCCCHHHH	33.25	21406692
60	Phosphorylation	PFKGYEGSLIKLTAR CCCCCCCCEEEEEEC	18.25	24719451
93	Ubiquitination	NALNGIRFDPENPQT HHHCCCCCCCCCCCC	20.33	-
107	Ubiquitination	TLRLEFAKANTKMAK CHHHHHHHHCCHHHH	47.71	32015554
204	Ubiquitination	DTTQQGWKYRQFC-- CCCCCCEEEECCC--	37.06	21890473
204	Ubiquitination	DTTQQGWKYRQFC-- CCCCCCEEEECCC--	37.06	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBPS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBPS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBPS2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RBPS2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.