COIA1_HUMAN - dbPTM
COIA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COIA1_HUMAN
UniProt AC P39060
Protein Name Collagen alpha-1(XVIII) chain
Gene Name COL18A1
Organism Homo sapiens (Human).
Sequence Length 1754
Subcellular Localization Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane .
Non-collagenous domain 1: Secreted, extracellular space, extracellular matrix, basement membrane . Secreted .
Endostatin: Secre
Protein Description Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.; Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling.; Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. [PubMed: 9459295 May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity May negatively regulate the activity of homotrimeric non-collagenous domain 1]
Protein Sequence MAPYPCGCHILLLLFCCLAAARANLLNLNWLWFNNEDTSHAATTIPEPQGPLPVQPTADTTTHVTPRNGSTEPATAPGSPEPPSELLEDGQDTPTSAESPDAPEENIAGVGAEILNVAKGIRSFVQLWNDTVPTESLARAETLVLETPVGPLALAGPSSTPQENGTTLWPSRGIPSSPGAHTTEAGTLPAPTPSPPSLGRPWAPLTGPSVPPPSSGRASLSSLLGGAPPWGSLQDPDSQGLSPAAAAPSQQLQRPDVRLRTPLLHPLVMGSLGKHAAPSAFSSGLPGALSQVAVTTLTRDSGAWVSHVANSVGPGLANNSALLGADPEAPAGRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLLVPPCGSVPPPAPPPCCQFCEALQDACWSRLGGGRLPVACASLPTQEDGYCVLIGPAAERISEEVGLLQLLGDPPPQQVTQTDDPDVGLAYVFGPDANSGQVARYHFPSLFFRDFSLLFHIRPATEGPGVLFAITDSAQAMVLLGVKLSGVQDGHQDISLLYTEPGAGQTHTAASFRLPAFVGQWTHLALSVAGGFVALYVDCEEFQRMPLARSSRGLELEPGAGLFVAQAGGADPDKFQGVIAELKVRRDPQVSPMHCLDEEGDDSDGASGDSGSGLGDARELLREETGAALKPRLPAPPPVTTPPLAGGSSTEDSRSEEVEEQTTVASLGAQTLPGSDSVSTWDGSVRTPGGRVKEGGLKGQKGEPGVPGPPGRAGPPGSPCLPGPPGLPCPVSPLGPAGPALQTVPGPQGPPGPPGRDGTPGRDGEPGDPGEDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVGERGPPGPQGPPGPPGPSFRHDKLTFIDMEGSGFGGDLEALRGPRGFPGPPGPPGVPGLPGEPGRFGVNSSDVPGPAGLPGVPGREGPPGFPGLPGPPGPPGREGPPGRTGQKGSLGEAGAPGHKGSKGAPGPAGARGESGLAGAPGPAGPPGPPGPPGPPGPGLPAGFDDMEGSGGPFWSTARSADGPQGPPGLPGLKGDPGVPGLPGAKGEVGADGVPGFPGLPGREGIAGPQGPKGDRGSRGEKGDPGKDGVGQPGLPGPPGPPGPVVYVSEQDGSVLSVPGPEGRPGFAGFPGPAGPKGNLGSKGERGSPGPKGEKGEPGSIFSPDGGALGPAQKGAKGEPGFRGPPGPYGRPGYKGEIGFPGRPGRPGMNGLKGEKGEPGDASLGFGMRGMPGPPGPPGPPGPPGTPVYDSNVFAESSRPGPPGLPGNQGPPGPKGAKGEVGPPGPPGQFPFDFLQLEAEMKGEKGDRGDAGQKGERGEPGGGGFFGSSLPGPPGPPGPPGPRGYPGIPGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTISVPGPPGPPGPPGPPGTMGASSGVRLWATRQAMLGQVHEVPEGWLIFVAEQEELYVRVQNGFRKVQLEARTPLPRGTDNEVAALQPPVVQLHDSNPYPRREHPHPTARPWRADDILASPPRLPEPQPYPGAPHHSSYVHLRPARPTSPPAHSHRDFQPVLHLVALNSPLSGGMRGIRGADFQCFQQARAVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPLKPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQASSLLGGRLLGQSAASCHHAYIVLCIENSFMTASK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43O-linked_GlycosylationEDTSHAATTIPEPQG
CCCCCCCCCCCCCCC		26.49OGP
68N-linked_GlycosylationTTHVTPRNGSTEPAT
CCEECCCCCCCCCCC		50.39UniProtKB CARBOHYD
79O-linked_GlycosylationEPATAPGSPEPPSEL
CCCCCCCCCCCCHHH		25.65OGP
93O-linked_GlycosylationLLEDGQDTPTSAESP
HCCCCCCCCCCCCCC		22.15OGP
93PhosphorylationLLEDGQDTPTSAESP
HCCCCCCCCCCCCCC		22.1524275569
95PhosphorylationEDGQDTPTSAESPDA
CCCCCCCCCCCCCCC		42.5329759185
95O-linked_GlycosylationEDGQDTPTSAESPDA
CCCCCCCCCCCCCCC		42.53OGP
96O-linked_GlycosylationDGQDTPTSAESPDAP
CCCCCCCCCCCCCCC		31.10OGP
96PhosphorylationDGQDTPTSAESPDAP
CCCCCCCCCCCCCCC		31.1029759185
99PhosphorylationDTPTSAESPDAPEEN
CCCCCCCCCCCCHHH		28.0024275569
129N-linked_GlycosylationRSFVQLWNDTVPTES
HHHHHHHCCCCCHHH		43.60UniProtKB CARBOHYD
164N-linked_GlycosylationPSSTPQENGTTLWPS
CCCCCCCCCCCCCCC		48.11UniProtKB CARBOHYD
192O-linked_GlycosylationAGTLPAPTPSPPSLG
CCCCCCCCCCCCCCC		38.21OGP
194O-linked_GlycosylationTLPAPTPSPPSLGRP
CCCCCCCCCCCCCCC		52.50OGP
206PhosphorylationGRPWAPLTGPSVPPP
CCCCCCCCCCCCCCC		46.0928961369
209PhosphorylationWAPLTGPSVPPPSSG
CCCCCCCCCCCCCCC		48.9128961369
214PhosphorylationGPSVPPPSSGRASLS
CCCCCCCCCCCCCHH		51.7228961369
215PhosphorylationPSVPPPSSGRASLSS
CCCCCCCCCCCCHHH		37.7628961369
219PhosphorylationPPSSGRASLSSLLGG
CCCCCCCCHHHHHCC		27.6828961369
221PhosphorylationSSGRASLSSLLGGAP
CCCCCCHHHHHCCCC		19.2228961369
222PhosphorylationSGRASLSSLLGGAPP
CCCCCHHHHHCCCCC		32.6728961369
249PhosphorylationSPAAAAPSQQLQRPD
CHHHHCCHHHHCCCC		26.3228961369
472O-linked_GlycosylationDPPPQQVTQTDDPDV
CCCCHHCCCCCCCCC		22.78OGP
474O-linked_GlycosylationPPQQVTQTDDPDVGL
CCHHCCCCCCCCCCE		32.76OGP
562PhosphorylationTEPGAGQTHTAASFR
ECCCCCCCCCCHHCC		21.9229759185
647PhosphorylationVRRDPQVSPMHCLDE
ECCCCCCCCCEECCC		15.9721406692
659PhosphorylationLDEEGDDSDGASGDS
CCCCCCCCCCCCCCC		42.5621406692
663PhosphorylationGDDSDGASGDSGSGL
CCCCCCCCCCCCCCH		48.9721406692
666PhosphorylationSDGASGDSGSGLGDA
CCCCCCCCCCCHHHH		38.0821406692
668PhosphorylationGASGDSGSGLGDARE
CCCCCCCCCHHHHHH		34.4921406692
696O-linked_GlycosylationLPAPPPVTTPPLAGG
CCCCCCCCCCCCCCC		39.08OGP
696PhosphorylationLPAPPPVTTPPLAGG
CCCCCCCCCCCCCCC		39.0810441114
697O-linked_GlycosylationPAPPPVTTPPLAGGS
CCCCCCCCCCCCCCC		24.12OGP
697PhosphorylationPAPPPVTTPPLAGGS
CCCCCCCCCCCCCCC		24.1224275569
704PhosphorylationTPPLAGGSSTEDSRS
CCCCCCCCCCCCCCC		32.9226657352
705PhosphorylationPPLAGGSSTEDSRSE
CCCCCCCCCCCCCCH		38.8125850435
706PhosphorylationPLAGGSSTEDSRSEE
CCCCCCCCCCCCCHH		45.5725850435
709PhosphorylationGGSSTEDSRSEEVEE
CCCCCCCCCCHHHHH		31.3225850435
711PhosphorylationSSTEDSRSEEVEEQT
CCCCCCCCHHHHHHH		41.9024275569
718O-linked_GlycosylationSEEVEEQTTVASLGA
CHHHHHHHHHHHCCC		26.90OGP
719O-linked_GlycosylationEEVEEQTTVASLGAQ
HHHHHHHHHHHCCCC		17.48OGP
727O-linked_GlycosylationVASLGAQTLPGSDSV
HHHCCCCCCCCCCCC		34.09OGP
731O-linked_GlycosylationGAQTLPGSDSVSTWD
CCCCCCCCCCCCCCC		25.44OGP
733O-linked_GlycosylationQTLPGSDSVSTWDGS
CCCCCCCCCCCCCCC		21.47OGP
735O-linked_GlycosylationLPGSDSVSTWDGSVR
CCCCCCCCCCCCCCC		27.94OGP
736O-linked_GlycosylationPGSDSVSTWDGSVRT
CCCCCCCCCCCCCCC		25.97OGP
799O-linked_GlycosylationPAGPALQTVPGPQGP
CCCCCCCCCCCCCCC		29.53OGP
902MethylationLEALRGPRGFPGPPG
HHHHCCCCCCCCCCC		63.31-
926N-linked_GlycosylationEPGRFGVNSSDVPGP
CCCCCCCCCCCCCCC		35.85UniProtKB CARBOHYD
1185PhosphorylationGEPGSIFSPDGGALG
CCCCCCCCCCCCCCC		22.0223532336
1211PhosphorylationFRGPPGPYGRPGYKG
CCCCCCCCCCCCCCC		31.5122461510
1245PhosphorylationKGEPGDASLGFGMRG
CCCCCCCCCCCCCCC		33.4921406692
1335PhosphorylationGDRGDAGQKGERGEP
CCCCCCCCCCCCCCC		52.9124719451
1443O-linked_GlycosylationPGTMGASSGVRLWAT
CCCCCCCHHCHHHHH		40.5529351928
1450PhosphorylationSGVRLWATRQAMLGQ
HHCHHHHHHHHHCCC		16.25-
1515PhosphorylationPVVQLHDSNPYPRRE
CEEEECCCCCCCCCC		29.0228857561
1518PhosphorylationQLHDSNPYPRREHPH
EECCCCCCCCCCCCC		17.3928857561
1527O-linked_GlycosylationRREHPHPTARPWRAD
CCCCCCCCCCCCCHH		32.06OGP
1539PhosphorylationRADDILASPPRLPEP
CHHHHCCCCCCCCCC		31.8026437602
1539O-linked_GlycosylationRADDILASPPRLPEP
CHHHHCCCCCCCCCC		31.80OGP
1556O-linked_GlycosylationYPGAPHHSSYVHLRP
CCCCCCCCCCEECEE		21.96OGP
1567O-linked_GlycosylationHLRPARPTSPPAHSH
ECEECCCCCCCCCCC		48.6010441114
1573PhosphorylationPTSPPAHSHRDFQPV
CCCCCCCCCCCCHHH		23.4824719451
1588PhosphorylationLHLVALNSPLSGGMR
EEHEECCCCCCCCCC		28.24-
1622PhosphorylationGTFRAFLSSRLQDLY
HHHHHHHHHHHHHHH		13.6327174698
1623PhosphorylationTFRAFLSSRLQDLYS
HHHHHHHHHHHHHHH		38.8727174698
1629PhosphorylationSSRLQDLYSIVRRAD
HHHHHHHHHHHHHHH		12.4927174698
1630PhosphorylationSRLQDLYSIVRRADR
HHHHHHHHHHHHHHH		23.1627174698
1666UbiquitinationSGSEGPLKPGARIFS
CCCCCCCCCCCEEEE		44.53-
1677UbiquitinationRIFSFDGKDVLRHPT
EEEEECCCCCHHCCC		46.65-
1702PhosphorylationDPNGRRLTESYCETW
CCCCCCCCHHHHHHH		22.5230619164
1704PhosphorylationNGRRLTESYCETWRT
CCCCCCHHHHHHHCC		29.8230619164
1705PhosphorylationGRRLTESYCETWRTE
CCCCCHHHHHHHCCC		6.5130619164
1708PhosphorylationLTESYCETWRTEAPS
CCHHHHHHHCCCCCC		19.3830619164
1711O-linked_GlycosylationSYCETWRTEAPSATG
HHHHHHCCCCCCCCC		28.23OGP
1717O-linked_GlycosylationRTEAPSATGQASSLL
CCCCCCCCCCCHHHH		33.88OGP
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COIA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COIA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COIA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VGFR2_HUMANKDRphysical
12029087
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
267750Knobloch syndrome 1 (KNO1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COIA1_HUMAN

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Related Literatures of Post-Translational Modification

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