dbPTM

POGK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	POGK_HUMAN
UniProt AC	Q9P215
Protein Name	Pogo transposable element with KRAB domain
Gene Name	POGK
Organism	Homo sapiens (Human).
Sequence Length	609
Subcellular Localization	Nucleus .
Protein Description
Protein Sequence	MESTAYPLNLSLKEEEEEEEIQSRELEDGPADMQKVRICSEGGWVPALFDEVAIYFSDEEWEVLTEQQKALYREVMRMNYETVLSLEFPFPKPDMITRLEGEEESQNSDEWQLQGGTSAENEESDVKPPDWPNPMNATSQFPQPQHFDSFGLRLPRDITELPEWSEGYPFYMAMGFPGYDLSADDIAGKFQFSRGMRRSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLPEDLTEKLVTYQRSVLALRRAHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPVLVKTPGREKLKITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIRCHRYGWMTEDLMQDWLEVVWRRRTGAVPKQRGMLILNGFRGHATDSVKNSMESMNTDMVIIPGGLTSQLQVLDVVVYKPLNDSVRAQYSNWLLAGNLALSPTGNAKKPPLGLFLEWVMVAWNSISSESIVQGFKKCHISSNLEEEDDVLWEIESELPGGGEPPKDCDTESMAESN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESTAYPLNL -----CCCCCCCCCC	19.62	20068231
4	Phosphorylation	----MESTAYPLNLS ----CCCCCCCCCCC	19.53	20068231
6	Phosphorylation	--MESTAYPLNLSLK --CCCCCCCCCCCCC	14.35	20068231
11	Phosphorylation	TAYPLNLSLKEEEEE CCCCCCCCCCHHHHH	36.00	28450419
13	Sumoylation	YPLNLSLKEEEEEEE CCCCCCCCHHHHHHH	60.75	-
13	Sumoylation	YPLNLSLKEEEEEEE CCCCCCCCHHHHHHH	60.75	28112733
23	Phosphorylation	EEEEEIQSRELEDGP HHHHHHHHCCCCCCC	33.12	-
35	Ubiquitination	DGPADMQKVRICSEG CCCCCHHHEEECCCC	27.18	-
193	Phosphorylation	IAGKFQFSRGMRRSY HCHHCCCCCCCCCCC	19.69	-
199	Phosphorylation	FSRGMRRSYDAGFKL CCCCCCCCCCCCCEE	19.59	21815630
200	Phosphorylation	SRGMRRSYDAGFKLM CCCCCCCCCCCCEEE	14.17	23312004
222	Ubiquitination	TNNCQAAKQFGVLEK CCCHHHHHHHCCCCH	49.53	-
238	Ubiquitination	VRDWRKVKPQLQNAH HCHHHHHHHHHHHHH	30.04	-
272	Phosphorylation	RVAEYVRYMQAKGDP HHHHHHHHHHHCCCC	5.41	26853621
276	Ubiquitination	YVRYMQAKGDPITRE HHHHHHHCCCCCCHH	47.13	-
288	Ubiquitination	TREAMQLKALEIAQE CHHHHHHHHHHHHHH	33.75	-
301	Ubiquitination	QEMNIPEKGFKASLG HHCCCCCCCHHHHHH	65.38	-
304	Ubiquitination	NIPEKGFKASLGWCR CCCCCCHHHHHHHHH	45.81	-
304	Methylation	NIPEKGFKASLGWCR CCCCCCHHHHHHHHH	45.81	115975227
320	Phosphorylation	MMRRYDLSLRHKVPV HHHHCCCHHCCCCCC	22.06	24117733
338	Ubiquitination	LPEDLTEKLVTYQRS CCCCHHHHHHHHHHH	42.92	22053931
384	Sumoylation	TVDNQGEKPVLVKTP EECCCCCCCEEEECC	47.45	28112733
384	Ubiquitination	TVDNQGEKPVLVKTP EECCCCCCCEEEECC	47.45	-
384	Acetylation	TVDNQGEKPVLVKTP EECCCCCCCEEEECC	47.45	26051181
389	Ubiquitination	GEKPVLVKTPGREKL CCCCEEEECCCCHHH	44.86	-
390	Phosphorylation	EKPVLVKTPGREKLK CCCEEEECCCCHHHE	24.40	28555341
438	Phosphorylation	MEIRCHRYGWMTEDL CEEEEECCCCCCHHH	7.47	24043423
442	Phosphorylation	CHRYGWMTEDLMQDW EECCCCCCHHHHHHH	21.60	24043423
534	Phosphorylation	LAGNLALSPTGNAKK EECCEEECCCCCCCC	18.14	16964243
536	Phosphorylation	GNLALSPTGNAKKPP CCEEECCCCCCCCCC	39.43	28122231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of POGK_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of POGK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of POGK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of POGK_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534, AND MASSSPECTROMETRY.	16964243 [Abstract]