dbPTM

RBGP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RBGP1_HUMAN
UniProt AC	Q9Y3P9
Protein Name	Rab GTPase-activating protein 1
Gene Name	RABGAP1
Organism	Homo sapiens (Human).
Sequence Length	1069
Subcellular Localization	Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Predominantly cytosolic but also associated with the centrosome.
Protein Description	May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition..
Protein Sequence	MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQISLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTLSSIKTATGVQGKETC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDDKASVGKISVS --CCCCCCCCEEEEC	36.82	27251275
11	Phosphorylation	KASVGKISVSSDSVS CCCCCEEEECCCCCC	21.31	-
13	Phosphorylation	SVGKISVSSDSVSTL CCCEEEECCCCCCCC	22.95	27251275
14	Phosphorylation	VGKISVSSDSVSTLN CCEEEECCCCCCCCC	31.58	28348404
16	Phosphorylation	KISVSSDSVSTLNSE EEEECCCCCCCCCCC	21.66	28348404
18	Phosphorylation	SVSSDSVSTLNSEDF EECCCCCCCCCCCCE	31.00	24719451
19	Phosphorylation	VSSDSVSTLNSEDFV ECCCCCCCCCCCCEE	28.01	21130716
22	Phosphorylation	DSVSTLNSEDFVLVS CCCCCCCCCCEEEEE	41.47	21130716
29	Phosphorylation	SEDFVLVSRQGDETP CCCEEEEEECCCCCC	18.09	21130716
35	Phosphorylation	VSRQGDETPSTNNGS EEECCCCCCCCCCCC	27.55	23927012
37	Phosphorylation	RQGDETPSTNNGSDD ECCCCCCCCCCCCCC	51.71	22167270
38	Phosphorylation	QGDETPSTNNGSDDE CCCCCCCCCCCCCCC	33.63	22167270
42	Phosphorylation	TPSTNNGSDDEKTGL CCCCCCCCCCCCCCE	43.97	29255136
47	Phosphorylation	NGSDDEKTGLKIVGN CCCCCCCCCEEEECC	45.78	22167270
56	Phosphorylation	LKIVGNGSEQQLQKE EEEECCCCHHHHHHH	35.91	25159151
120	Phosphorylation	GLQKPEMSLPVKPGQ CCCCCCCCCCCCCCC	28.05	20068231
133	Phosphorylation	GQGDSEASSPFTPVA CCCCCCCCCCCCCCC	34.20	25627689
134	Phosphorylation	QGDSEASSPFTPVAD CCCCCCCCCCCCCCC	30.95	25627689
137	Phosphorylation	SEASSPFTPVADEDS CCCCCCCCCCCCCCC	21.90	25159151
192	Phosphorylation	TLSVPNVSEGIVRLL EEECCCCCCCEEHHC	36.42	-
284	Phosphorylation	SATAAPQTPDSDIFT CCCCCCCCCCCCCEE	28.18	26074081
287	Phosphorylation	AAPQTPDSDIFTFSV CCCCCCCCCCEEEEE	33.53	26074081
304	Ubiquitination	EIKEDDGKGYFSAVP EEEECCCCCEEEECC	58.39	29967540
306	Phosphorylation	KEDDGKGYFSAVPKD EECCCCCEEEECCCC	9.61	25159151
352	Phosphorylation	RCFGLLLSPGKDVRN HHHHHHHCCCCCCCC	31.41	24719451
360	Phosphorylation	PGKDVRNSDMHLLDL CCCCCCCCCCEEEEH	26.25	22617229
369	Phosphorylation	MHLLDLESMGKSSDG CEEEEHHHCCCCCCC	39.88	25954137
378	Phosphorylation	GKSSDGKSYVITGSW CCCCCCCEEEEECCC	30.11	29978859
379	Phosphorylation	KSSDGKSYVITGSWN CCCCCCEEEEECCCC	10.19	27642862
382	Phosphorylation	DGKSYVITGSWNPKS CCCEEEEECCCCCCC	18.34	29978859
384	Phosphorylation	KSYVITGSWNPKSPH CEEEEECCCCCCCCC	18.28	29978859
389	Phosphorylation	TGSWNPKSPHFQVVN ECCCCCCCCCEEECC	25.51	27050516
399	Phosphorylation	FQVVNEETPKDKVLF EEECCCCCCCCCEEE	29.47	28555341
401	Ubiquitination	VVNEETPKDKVLFMT ECCCCCCCCCEEEEE	77.06	29967540
416	Phosphorylation	TAVDLVITEVQEPVR EHHHHHHHCCHHHHH	23.71	-
428	Phosphorylation	PVRFLLETKVRVCSP HHHHHHHCCEEEECC	34.51	20068231
429	Ubiquitination	VRFLLETKVRVCSPN HHHHHHCCEEEECCC	20.76	24816145
447	Phosphorylation	FWPFSKRSTTENFFL ECCCCCCCCCCCHHH	43.34	-
455	Ubiquitination	TTENFFLKLKQIKQR CCCCHHHHHHHHHHH	48.78	-
472	Phosphorylation	KNNTDTLYEVVCLES HCCCCCEEEEEECCC	14.58	27642862
488	Phosphorylation	SERERRKTTASPSVR HHHHHHCCCCCCCCC	26.28	26437602
489	Phosphorylation	ERERRKTTASPSVRL HHHHHCCCCCCCCCC	28.33	29396449
491	Phosphorylation	ERRKTTASPSVRLPQ HHHCCCCCCCCCCCC	18.67	27794612
493	Phosphorylation	RKTTASPSVRLPQSG HCCCCCCCCCCCCCC	19.85	29396449
499	Phosphorylation	PSVRLPQSGSQSSVI CCCCCCCCCCCCCCC	38.17	27251275
501	Phosphorylation	VRLPQSGSQSSVIPS CCCCCCCCCCCCCCC	31.94	26657352
503	Phosphorylation	LPQSGSQSSVIPSPP CCCCCCCCCCCCCCC	28.41	30576142
504	Phosphorylation	PQSGSQSSVIPSPPE CCCCCCCCCCCCCCC	19.21	27251275
508	Phosphorylation	SQSSVIPSPPEDDEE CCCCCCCCCCCCCCC	41.80	26657352
536	Ubiquitination	VSKECAEKILETWGE CCHHHHHHHHHHHHH	33.78	29967540
560	Phosphorylation	NVRPKQLSSLVRNGV CCCHHHHHHHHHCCC	21.09	24702127
561	Phosphorylation	VRPKQLSSLVRNGVP CCHHHHHHHHHCCCC	39.20	24719451
598	Ubiquitination	KYRILITKESPQDSA EEEEEEECCCCCCCC	49.56	24816145
604	Phosphorylation	TKESPQDSAITRDIN ECCCCCCCCCCCCCC	19.14	24719451
621	Ubiquitination	FPAHDYFKDTGGDGQ CCHHHHCCCCCCCCH	48.42	29967540
623	Phosphorylation	AHDYFKDTGGDGQDS HHHHCCCCCCCCHHH	43.59	21406692
630	Phosphorylation	TGGDGQDSLYKICKA CCCCCHHHHHHHHHH	26.22	21406692
632	Phosphorylation	GDGQDSLYKICKAYS CCCHHHHHHHHHHHC	11.40	21406692
633	Ubiquitination	DGQDSLYKICKAYSV CCHHHHHHHHHHHCC	47.09	29967540
723	Phosphorylation	ISLEAHMYASQWFLT HHHHHHHHHHHHHHH	8.01	25690035
730	Phosphorylation	YASQWFLTLFTAKFP HHHHHHHHHHHHCCH	15.45	25690035
733	Phosphorylation	QWFLTLFTAKFPLYM HHHHHHHHHCCHHHH	31.86	24260401
774	Phosphorylation	SKDDLLLTDFEGALK CCCCEEEECHHHHHH	38.31	-
787	Ubiquitination	LKFFRVQLPKRYRSE HHHHHCCCCHHHCCH	5.03	24816145
791	Phosphorylation	RVQLPKRYRSEENAK HCCCCHHHCCHHHHH	25.31	28102081
793	Phosphorylation	QLPKRYRSEENAKKL CCCHHHCCHHHHHHH	40.09	28102081
799	Acetylation	RSEENAKKLMELACN CCHHHHHHHHHHHHH	51.13	7683521
808	Acetylation	MELACNMKISQKKLK HHHHHHCCCCHHHHH	25.80	7683531
867	Ubiquitination	AHELVTSKIALRKDL HHHHHHHHHHHHHCC	23.72	29967540
925	Phosphorylation	RELDKAESEIKKNSS HHHHHHHHHHHHCCC	49.86	23828894
931	Phosphorylation	ESEIKKNSSIIGDYK HHHHHHCCCCCCCHH	31.62	21712546
932	Phosphorylation	SEIKKNSSIIGDYKQ HHHHHCCCCCCCHHH	27.84	21712546
937	Phosphorylation	NSSIIGDYKQICSQL CCCCCCCHHHHHHHH	10.28	21712546
953	Phosphorylation	ERLEKQQTANKVEIE HHHHHHHHCCHHHHH	29.69	-
956	Ubiquitination	EKQQTANKVEIEKIR HHHHHCCHHHHHHHH	38.49	24816145
986	Phosphorylation	EGRVKGISSTKEVLD CCCEECCCCCHHHHC	40.39	26074081
987	Phosphorylation	GRVKGISSTKEVLDE CCEECCCCCHHHHCC	41.39	26074081
988	Phosphorylation	RVKGISSTKEVLDED CEECCCCCHHHHCCC	25.16	26074081
996	Phosphorylation	KEVLDEDTDEEKETL HHHHCCCCHHHHHHH	43.17	29255136
1002	Phosphorylation	DTDEEKETLKNQLRE CCHHHHHHHHHHHHH	54.84	23927012
1010	Sulfoxidation	LKNQLREMELELAQT HHHHHHHHHHHHHHH	6.02	21406390
1046	Ubiquitination	LNEVQAAKKTWFNRT HHHHHHHHHHHHHHH	54.47	29967540
1048	Phosphorylation	EVQAAKKTWFNRTLS HHHHHHHHHHHHHHH	34.28	23882029
1053	Phosphorylation	KKTWFNRTLSSIKTA HHHHHHHHHHHHHHH	31.90	29514088
1055	Phosphorylation	TWFNRTLSSIKTATG HHHHHHHHHHHHHCC	29.42	29514088
1056	Phosphorylation	WFNRTLSSIKTATGV HHHHHHHHHHHHCCC	31.08	29514088
1058	Ubiquitination	NRTLSSIKTATGVQG HHHHHHHHHHCCCCC	33.77	33845483
1059	Phosphorylation	RTLSSIKTATGVQGK HHHHHHHHHCCCCCC	27.99	26434776
1061	Phosphorylation	LSSIKTATGVQGKET HHHHHHHCCCCCCCC	43.02	26434776
1066	Ubiquitination	TATGVQGKETC---- HHCCCCCCCCC----	32.53	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RBGP1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RBGP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RBGP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBG10_HUMAN	RABGAP1L	physical	20562859
RBG1L_HUMAN	RABGAP1L	physical	20562859
CARM1_MOUSE	Carm1	physical	17124247
ORC2_HUMAN	ORC2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RBGP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-996, AND MASSSPECTROMETRY.	18669648 [Abstract]