dbPTM

SPAS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPAS2_HUMAN
UniProt AC	Q86XZ4
Protein Name	Spermatogenesis-associated serine-rich protein 2
Gene Name	SPATS2
Organism	Homo sapiens (Human).
Sequence Length	545
Subcellular Localization	Cytoplasm.
Protein Description
Protein Sequence	MSRKQNQKDSSGFIFDLQSNTVLAQGGAFENMKEKINAVRAIVPNKSNNEIILVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTESVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSKKLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQMSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSLTSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIERGQTHSAGTNGTGVSMEPSPPTPSFKKGLPQRKPRTSQTEAVNS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RKQNQKDSSGFIFDL CCCCCCCCCCCEEEC	39.12	30576142
11	Phosphorylation	KQNQKDSSGFIFDLQ CCCCCCCCCCEEECC	48.10	24719451
47	Phosphorylation	RAIVPNKSNNEIILV EEECCCCCCCEEEEE	52.07	27251275
93	Acetylation	KKKNKKKKNKPKPAA CCCCCCCCCCCCCCC	78.18	30592593
97	Acetylation	KKKKNKPKPAAEPSN CCCCCCCCCCCCCCC	49.23	30592599
112	Phosphorylation	GIPDSSKSVSIQEEQ CCCCCCCCCCCCCCC	24.05	23403867
114	Phosphorylation	PDSSKSVSIQEEQSA CCCCCCCCCCCCCCC	26.16	21815630
120	Phosphorylation	VSIQEEQSAPSSEKG CCCCCCCCCCCCCCC	45.48	23403867
123	Phosphorylation	QEEQSAPSSEKGGMN CCCCCCCCCCCCCCC	51.34	23403867
124	Phosphorylation	EEQSAPSSEKGGMNG CCCCCCCCCCCCCCC	42.12	21815630
132	Phosphorylation	EKGGMNGYHVNGAIN CCCCCCCEEECCCCC	9.52	20068231
141	Phosphorylation	VNGAINDTESVDSLS ECCCCCCCCCCHHHH	26.18	20068231
143	Phosphorylation	GAINDTESVDSLSEG CCCCCCCCCHHHHHC	33.06	25137130
146	Phosphorylation	NDTESVDSLSEGLET CCCCCCHHHHHCHHE	31.47	25137130
148	Phosphorylation	TESVDSLSEGLETLS CCCCHHHHHCHHEEE	33.30	20068231
153	Phosphorylation	SLSEGLETLSIDARE HHHHCHHEEECCHHH	30.74	26074081
155	Phosphorylation	SEGLETLSIDARELE HHCHHEEECCHHHCC	26.33	20068231
168	Sulfoxidation	LEDPESAMLDTLDRT CCCHHHHHHHHHHHH	4.91	21406390
175	Phosphorylation	MLDTLDRTGSMLQNG HHHHHHHHHCHHHHC	33.02	28857561
177	Phosphorylation	DTLDRTGSMLQNGVS HHHHHHHCHHHHCCC	18.73	28857561
190	Phosphorylation	VSDFETKSLTMHSIH CCCCCCCCCCHHHHH	36.17	29116813
192	Phosphorylation	DFETKSLTMHSIHNS CCCCCCCCHHHHHCC	21.67	29514088
195	Phosphorylation	TKSLTMHSIHNSQQP CCCCCHHHHHCCCCH	18.08	29514088
199	Phosphorylation	TMHSIHNSQQPRNAA CHHHHHCCCCHHHHH	18.94	28555341
207	Ubiquitination	QQPRNAAKSLSRPTT CCHHHHHHHCCCCCC	49.90	-
208	Phosphorylation	QPRNAAKSLSRPTTE CHHHHHHHCCCCCCC	27.18	28348404
210	Phosphorylation	RNAAKSLSRPTTETQ HHHHHHCCCCCCCHH	43.22	28348404
213	Phosphorylation	AKSLSRPTTETQFSN HHHCCCCCCCHHHCC	35.83	18491316
214	Phosphorylation	KSLSRPTTETQFSNM HHCCCCCCCHHHCCC	39.45	18491316
216	Phosphorylation	LSRPTTETQFSNMGM CCCCCCCHHHCCCCC	32.59	28857561
219	Phosphorylation	PTTETQFSNMGMEDV CCCCHHHCCCCCCCC	18.98	30576142
230	Phosphorylation	MEDVPLATSKKLSSN CCCCCHHHCHHHHHH	49.08	28555341
233	Ubiquitination	VPLATSKKLSSNIEK CCHHHCHHHHHHHHH	54.06	-
240	Ubiquitination	KLSSNIEKSVKDLQR HHHHHHHHHHHHHHH	57.67	-
279	Phosphorylation	QAFAELESCLMDREV HHHHHHHHHHHHHHH	25.77	26270265
294	Ubiquitination	ALLAEMDKVKAEAME HHHHHHHHHHHHHHH	44.30	-
296	Ubiquitination	LAEMDKVKAEAMEIL HHHHHHHHHHHHHHH	46.37	-
336	Acetylation	VELRADIKHFVSERK HHHHHHHHHHHHHCC	31.38	26051181
336	Ubiquitination	VELRADIKHFVSERK HHHHHHHHHHHHHCC	31.38	-
362	Ubiquitination	TCDVETLKKSIDSFG ECCHHHHHHHHHHCC	52.47	-
363	Ubiquitination	CDVETLKKSIDSFGQ CCHHHHHHHHHHCCC	56.61	-
367	Phosphorylation	TLKKSIDSFGQVSHP HHHHHHHHCCCCCCC	29.61	24719451
375	Ubiquitination	FGQVSHPKNSYSTRS CCCCCCCCCCCCCCC	53.77	-
378	Phosphorylation	VSHPKNSYSTRSRCS CCCCCCCCCCCCCCC	24.37	24719451
379	Phosphorylation	SHPKNSYSTRSRCSS CCCCCCCCCCCCCCC	19.71	22210691
380	Phosphorylation	HPKNSYSTRSRCSSV CCCCCCCCCCCCCCC	25.16	24719451
382	Phosphorylation	KNSYSTRSRCSSVTS CCCCCCCCCCCCCEE	37.41	22817900
385	Phosphorylation	YSTRSRCSSVTSVSL CCCCCCCCCCEEEEE	27.08	27273156
386	Phosphorylation	STRSRCSSVTSVSLS CCCCCCCCCEEEEEC	32.80	27273156
388	Phosphorylation	RSRCSSVTSVSLSSP CCCCCCCEEEEECCC	25.92	29978859
389	Phosphorylation	SRCSSVTSVSLSSPS CCCCCCEEEEECCCC	13.93	25159151
391	Phosphorylation	CSSVTSVSLSSPSDA CCCCEEEEECCCCCC	23.46	29978859
393	Phosphorylation	SVTSVSLSSPSDASA CCEEEEECCCCCCCC	32.47	29978859
394	Phosphorylation	VTSVSLSSPSDASAA CEEEEECCCCCCCCC	33.44	25159151
396	Phosphorylation	SVSLSSPSDASAASS EEEECCCCCCCCCCC	47.99	30576142
399	Phosphorylation	LSSPSDASAASSSTC ECCCCCCCCCCCCCC	29.38	23312004
402	Phosphorylation	PSDASAASSSTCASP CCCCCCCCCCCCCCC	25.25	27174698
403	Phosphorylation	SDASAASSSTCASPP CCCCCCCCCCCCCCC	25.58	30576142
404	Phosphorylation	DASAASSSTCASPPS CCCCCCCCCCCCCCC	25.63	27174698
405	Phosphorylation	ASAASSSTCASPPSL CCCCCCCCCCCCCCC	17.65	30576142
408	Phosphorylation	ASSSTCASPPSLTSA CCCCCCCCCCCCCCC	39.22	30576142
411	Phosphorylation	STCASPPSLTSANKK CCCCCCCCCCCCCCC	47.89	27174698
413	Phosphorylation	CASPPSLTSANKKNF CCCCCCCCCCCCCCC	30.08	27174698
414	Phosphorylation	ASPPSLTSANKKNFA CCCCCCCCCCCCCCC	34.83	27174698
418	Ubiquitination	SLTSANKKNFAPGET CCCCCCCCCCCCCCC	58.04	-
425	Phosphorylation	KNFAPGETPAAIANS CCCCCCCCCHHHHCC	24.92	27050516
432	Phosphorylation	TPAAIANSSGQPYQP CCHHHHCCCCCCCCC	27.16	29978859
433	Phosphorylation	PAAIANSSGQPYQPL CHHHHCCCCCCCCCH	41.05	28796482
437	Phosphorylation	ANSSGQPYQPLREVL HCCCCCCCCCHHHHC	18.18	28796482
449	Methylation	EVLPGNRRGGQGYRP HHCCCCCCCCCCCCC	58.56	30761157
455	Methylation	RRGGQGYRPQGQKSN CCCCCCCCCCCCCCC	24.72	115387495
472	Phosphorylation	MNQGRHDSMGRYRNS CCCCCCCCCCCCCCC	19.60	24719451
476	Phosphorylation	RHDSMGRYRNSSWYS CCCCCCCCCCCCCCC	14.39	30576142
479	Phosphorylation	SMGRYRNSSWYSSGS CCCCCCCCCCCCCCC	17.16	22167270
480	Phosphorylation	MGRYRNSSWYSSGSR CCCCCCCCCCCCCCC	33.32	23401153
482	Phosphorylation	RYRNSSWYSSGSRYQ CCCCCCCCCCCCCCC	8.56	28796482
483	Phosphorylation	YRNSSWYSSGSRYQS CCCCCCCCCCCCCCC	23.20	28796482
484	Phosphorylation	RNSSWYSSGSRYQSA CCCCCCCCCCCCCCC	25.70	28796482
486	Phosphorylation	SSWYSSGSRYQSAPS CCCCCCCCCCCCCCC	29.75	28796482
488	Phosphorylation	WYSSGSRYQSAPSQA CCCCCCCCCCCCCCC	14.44	-
490	Phosphorylation	SSGSRYQSAPSQAPG CCCCCCCCCCCCCCC	32.96	22210691
493	Phosphorylation	SRYQSAPSQAPGNTI CCCCCCCCCCCCCCC	38.40	28555341
499	Phosphorylation	PSQAPGNTIERGQTH CCCCCCCCCCCCCCC	30.08	27251275
507	Phosphorylation	IERGQTHSAGTNGTG CCCCCCCCCCCCCCC	31.61	-
516	Phosphorylation	GTNGTGVSMEPSPPT CCCCCCCCCCCCCCC	20.83	28555341
520	Phosphorylation	TGVSMEPSPPTPSFK CCCCCCCCCCCCCHH	30.15	26055452
523	Phosphorylation	SMEPSPPTPSFKKGL CCCCCCCCCCHHCCC	34.64	26055452
525	Phosphorylation	EPSPPTPSFKKGLPQ CCCCCCCCHHCCCCC	52.77	20068231
537	Phosphorylation	LPQRKPRTSQTEAVN CCCCCCCCCCCCCCC	33.44	22199227
538	Phosphorylation	PQRKPRTSQTEAVNS CCCCCCCCCCCCCCC	36.06	30576142
540	Phosphorylation	RKPRTSQTEAVNS-- CCCCCCCCCCCCC--	26.19	30576142
545	O-linked_Glycosylation	SQTEAVNS------- CCCCCCCC-------	34.69	23301498
545	Phosphorylation	SQTEAVNS------- CCCCCCCC-------	34.69	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPAS2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPAS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPAS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPAS2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520 AND THR-523, ANDMASS SPECTROMETRY.	18669648 [Abstract]