FGRL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGRL1_HUMAN
• UniProt AC: Q8N441
• Protein Name: Fibroblast growth factor receptor-like 1
• Gene Name: FGFRL1
• Organism: Homo sapiens (Human).
• Sequence Length: 504
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.
• Protein Description: Has a negative effect on cell proliferation..
• Protein Sequence: MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPPGTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHTHTHTHSHTHSHVEGKVHQHIHYQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	QVARLGRTVRLQCPV HHHHHCCEEEEECCC	14.26	-
85	2-Hydroxyisobutyrylation	RVLPQGLKVKQVERE EECCCCCEEEEEEHH	54.96	-
111	N-linked_Glycosylation	GFGSLSVNYTLVVLD CCCEEEEEEEEEEEC	22.24	UniProtKB CARBOHYD
121	Phosphorylation	LVVLDDISPGKESLG EEEECCCCCCCCCCC	34.30	24719451
131	Phosphorylation	KESLGPDSSSGGQED CCCCCCCCCCCCCCC	29.54	27282143
133	Phosphorylation	SLGPDSSSGGQEDPA CCCCCCCCCCCCCHH	51.39	27282143
141	Phosphorylation	GGQEDPASQQWARPR CCCCCHHHHCCCCCC	28.43	27282143
167	Phosphorylation	IARPVGSSVRLKCVA EEEECCCCEEEEEEE	12.82	-
171	Acetylation	VGSSVRLKCVASGHP CCCCEEEEEEECCCC	18.99	19827587
202	Acetylation	EAAEPRKKKWTLSLK CCCCCCCCCEEEEEC	55.62	7695439
231	N-linked_Glycosylation	SNRAGAINATYKVDV ECCCCCCCCEEEEEE	26.20	UniProtKB CARBOHYD
255	N-linked_Glycosylation	LTGTHPVNTTVDFGG ECCCCCCCCEEECCC	34.19	UniProtKB CARBOHYD
275	Acetylation	CKVRSDVKPVIQWLK EEECCCCHHHHHHHH	38.26	7822385
282	Acetylation	KPVIQWLKRVEYGAE HHHHHHHHHHHCCCC	51.98	7822395
293	N-linked_Glycosylation	YGAEGRHNSTIDVGG CCCCCCCCEEEEECC	39.21	UniProtKB CARBOHYD
427	Phosphorylation	PGTARDRSGDKDLPS CCCCCCCCCCCCCCH	56.48	23312004
434	Phosphorylation	SGDKDLPSLAALSAG CCCCCCCHHHHHHCC	37.63	23312004
439	Phosphorylation	LPSLAALSAGPGVGL CCHHHHHHCCCCCCC	26.84	23312004
452	Phosphorylation	GLCEEHGSPAAPQHL CCCHHHCCCCCCHHH	17.17	27050516
502	Phosphorylation	KVHQHIHYQC----- EEEECCCCCC-----	15.80	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGRL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGRL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGRL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBE2O_HUMAN	UBE2O	physical	28514442
BACH1_HUMAN	BACH1	physical	28514442
TERF2_HUMAN	TERF2	physical	28514442
DCAF1_HUMAN	VPRBP	physical	28514442
CLH2_HUMAN	CLTCL1	physical	28514442
COPG1_HUMAN	COPG1	physical	28514442
ANGE1_HUMAN	ANGEL1	physical	28514442
ZZEF1_HUMAN	ZZEF1	physical	28514442
CELR2_HUMAN	CELSR2	physical	28514442
K0232_HUMAN	KIAA0232	physical	28514442
LRP2_HUMAN	LRP2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.