| UniProt ID | ANGE1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UNK9 | |
| Protein Name | Protein angel homolog 1 | |
| Gene Name | ANGEL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 670 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MIASCLCYLLLPATRLFRALSDAFFTCRKNVLLANSSSPQVEGDFAMAPRGPEQEECEGLLQQWREEGLSQVLSTASEGPLIDKGLAQSSLALLMDNPGEENAASEDRWSSRQLSDLRAAENLDEPFPEMLGEEPLLEVEGVEGSMWAAIPMQSEPQYADCAALPVGALATEQWEEDPAVLAWSIAPEPVPQEEASIWPFEGLGQLQPPAVEIPYHEILWREWEDFSTQPDAQGLKAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQEVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKTDGCAVCYKPTRFRLLCASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLCVANTHILYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFIRDGELQYHGMPAWKVSGQEDFSHQLYQRKLQAPLWPSSLGITDCCQYVTSCHPKRSERRKYGRDFLLRFRFCSIACQRPVGLVLMEGVTDTKPERPAGWAESVLEEDASELEPAFSRTVGTIQHCLHLTSVYTHFLPQRGRPEVTTMPLGLGMTVDYIFFSAESCENGNRTDHRLYRDGTLKLLGRLSLLSEEILWAANGLPNPFCSSDHLCLLASFGMEVTAP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | S-palmitoylation | ---MIASCLCYLLLP ---CHHHHHHHHHHH | 1.94 | 29575903 | |
| 7 | S-palmitoylation | -MIASCLCYLLLPAT -CHHHHHHHHHHHHH | 2.36 | 29575903 | |
| 29 | Ubiquitination | DAFFTCRKNVLLANS HHHHHHHCCEEECCC | 54.26 | 21906983 | |
| 36 | Phosphorylation | KNVLLANSSSPQVEG CCEEECCCCCCCCCC | 26.96 | 26657352 | |
| 37 | Phosphorylation | NVLLANSSSPQVEGD CEEECCCCCCCCCCC | 45.93 | 30108239 | |
| 38 | Phosphorylation | VLLANSSSPQVEGDF EEECCCCCCCCCCCE | 21.12 | 25159151 | |
| 70 | Phosphorylation | QWREEGLSQVLSTAS HHHHHCHHHHHHHCC | 29.15 | 21712546 | |
| 77 | Phosphorylation | SQVLSTASEGPLIDK HHHHHHCCCCCCCCH | 43.08 | - | |
| 105 | Phosphorylation | PGEENAASEDRWSSR CCCCCCCCCCCCCHH | 37.30 | 28348404 | |
| 110 | Phosphorylation | AASEDRWSSRQLSDL CCCCCCCCHHHHHHH | 19.28 | 28348404 | |
| 111 | Phosphorylation | ASEDRWSSRQLSDLR CCCCCCCHHHHHHHH | 19.65 | 28348404 | |
| 115 | Phosphorylation | RWSSRQLSDLRAAEN CCCHHHHHHHHHHHC | 26.68 | 24719451 | |
| 318 | Phosphorylation | SLRMMGFTCFYKRRT HHHHCCCEEEEECCC | 8.93 | 46163179 | |
| 328 | Ubiquitination | YKRRTGCKTDGCAVC EECCCCCCCCCCEEE | 51.50 | - | |
| 336 | Phosphorylation | TDGCAVCYKPTRFRL CCCCEEEECCCCEEE | 17.26 | 11079431 | |
| 337 | Ubiquitination | DGCAVCYKPTRFRLL CCCEEEECCCCEEEE | 34.48 | - | |
| 347 | Phosphorylation | RFRLLCASPVEYFRP CEEEEECCCHHHHCC | 28.60 | 72500113 | |
| 351 | Phosphorylation | LCASPVEYFRPGLEL EECCCHHHHCCCHHH | 12.72 | 72500119 | |
| 416 | Ubiquitination | ILLAEVDKVARLSDG HHHHHHHHHHCCCCC | 42.86 | - | |
| 460 | Ubiquitination | YHGMPAWKVSGQEDF ECCCCCEEECCCCCC | 28.73 | - | |
| 472 | Phosphorylation | EDFSHQLYQRKLQAP CCCHHHHHHHHCCCC | 10.33 | 25159151 | |
| 475 | Ubiquitination | SHQLYQRKLQAPLWP HHHHHHHHCCCCCCC | 29.44 | - | |
| 591 | Phosphorylation | QRGRPEVTTMPLGLG CCCCCCCCCCCCCCC | 18.73 | 22210691 | |
| 592 | Phosphorylation | RGRPEVTTMPLGLGM CCCCCCCCCCCCCCC | 23.20 | 22210691 | |
| 622 | Phosphorylation | NRTDHRLYRDGTLKL CCCCCEEHHHHHHHH | 13.45 | 22817900 | |
| 628 | Ubiquitination | LYRDGTLKLLGRLSL EHHHHHHHHHHHHHH | 41.31 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ANGE1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ANGE1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ANGE1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ANGE1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347 AND TYR-351, ANDMASS SPECTROMETRY. | |
