TRI17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI17_HUMAN
• UniProt AC: Q9Y577
• Protein Name: E3 ubiquitin-protein ligase TRIM17
• Gene Name: TRIM17
• Organism: Homo sapiens (Human).
• Sequence Length: 477
• Protein Description: May function as a ubiquitin E3 ligase..
• Protein Sequence: MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMSPQRNLLPNRLLTKVAEMAQQHPGLQKQDLCQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVPDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	GRRKRKGSFPCPECR CCCCCCCCCCCHHHH	29.11	27251275
69	Phosphorylation	CPECREMSPQRNLLP CHHHHHCCCCCCCCC	17.09	22617229
158	Phosphorylation	EYLREQITRTGNLQA HHHHHHHHHHCCHHH	23.13	30576142
160	Phosphorylation	LREQITRTGNLQARE HHHHHHHHCCHHHHH	23.05	30576142
279	Phosphorylation	APPTRPRTVCRVPGQ CCCCCCCEEEECCCC	27.00	27251275
279 (in isoform 2)	Phosphorylation	-	27.00	27251275
382	Ubiquitination	SRKDRVPKCPENGFW CCCCCCCCCCCCCEE	60.61	-
407	Phosphorylation	LSTFSALTPVMLMEP EEECCCCCCEECCCC	17.35	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM17	Q9Y577	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI39_HUMAN	TRIM39	physical	16189514
TRI44_HUMAN	TRIM44	physical	19358823
ZWINT_HUMAN	ZWINT	physical	22023800
UB2D1_HUMAN	UBE2D1	physical	21143188
UB2D2_HUMAN	UBE2D2	physical	21143188
UB2D3_HUMAN	UBE2D3	physical	21143188
UB2E1_HUMAN	UBE2E1	physical	21143188
UBC_HUMAN	UBC	physical	22493164
UB2D1_HUMAN	UBE2D1	physical	22493164
UB2D2_HUMAN	UBE2D2	physical	22493164
UBE2N_HUMAN	UBE2N	physical	22493164
TRI41_HUMAN	TRIM41	physical	22493164
TRI39_HUMAN	TRIM39	physical	22493164
LRSM1_HUMAN	LRSAM1	physical	22493164
TRAF6_HUMAN	TRAF6	physical	22493164
TRI39_HUMAN	TRIM39	physical	25416956
TRI44_HUMAN	TRIM44	physical	28514442
SNX2_HUMAN	SNX2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.