ZNF91_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNF91_HUMAN
• UniProt AC: Q05481
• Protein Name: Zinc finger protein 91
• Gene Name: ZNF91
• Organism: Homo sapiens (Human).
• Sequence Length: 1191
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1. [PubMed: 25274305 May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo]
• Protein Sequence: MPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTGICPHFPQDFWPEQSMEDSFQKVLLRKYEKCGHENLQLRKGCKSVDECKVHKEGYNKLNQCLTTAQSKVFQCGKYLKVFYKFLNSNRHTIRHTGKKCFKCKKCVKSFCIRLHKTQHKCVYITEKSCKCKECEKTFHWSSTLTNHKEIHTEDKPYKCEECGKAFKQLSTLTTHKIICAKEKIYKCEECGKAFLWSSTLTRHKRIHTGEKPYKCEECGKAFSHSSTLAKHKRIHTGEKPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKAFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRFHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTGEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKAFKQFSTLTTHKIIHAGKKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKCEECGKAFLWSSTLRRHKRIHTGEKPYKCEECGKAFSHSSALAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKTFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRIHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTGEKPYKCKECGKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHKIIHTKEKPSKSEECDKAFIWSSTLTEHKRIHTREKTYKCEECGKAFSQPSHLTTHKRMHTGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKPYKCEECGKAFRKSSTLTEHKIIHTGEKPYKCEECGKAFSQSSTLTRHTRMHTGEKPYKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHKRIHTREKPYKCEECGKAFSQSSTLTRHKRLHTGEKPYKCGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQSSILTNHKKIHTITPVIPLLWEAEAGGSRGQEMETILANTVKPLLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Ubiquitination	DSFQKVLLRKYEKCG HHHHHHHHHHHHHHC	5.06	29967540
114	Ubiquitination	VLLRKYEKCGHENLQ HHHHHHHHHCCCCHH	42.29	-
120	Ubiquitination	EKCGHENLQLRKGCK HHHCCCCHHHCCCCC	4.64	29967540
127	Acetylation	LQLRKGCKSVDECKV HHHCCCCCCHHHHHC	63.28	19818007
140	Ubiquitination	KVHKEGYNKLNQCLT HCCHHHHHHHHHHHH	53.87	27667366
141	Ubiquitination	VHKEGYNKLNQCLTT CCHHHHHHHHHHHHH	40.09	29967540
152	Ubiquitination	CLTTAQSKVFQCGKY HHHHHHHHHHHHHHH	34.68	29967540
166	Ubiquitination	YLKVFYKFLNSNRHT HHHHHHHHHHCCCCE	5.49	27667366
198	Ubiquitination	FCIRLHKTQHKCVYI HHHHHHCCCCEEEEE	25.76	27667366
207	Ubiquitination	HKCVYITEKSCKCKE CEEEEEECCCCCCCC	33.15	27667366
239	Sumoylation	HTEDKPYKCEECGKA CCCCCCCCHHHHHHH	43.63	-
239	Sumoylation	HTEDKPYKCEECGKA CCCCCCCCHHHHHHH	43.63	-
239	Ubiquitination	HTEDKPYKCEECGKA CCCCCCCCHHHHHHH	43.63	27667366
289	Phosphorylation	TRHKRIHTGEKPYKC CCCCCCCCCCCCCCC	44.67	29496963
292	Ubiquitination	KRIHTGEKPYKCEEC CCCCCCCCCCCCHHH	55.80	-
294	Phosphorylation	IHTGEKPYKCEECGK CCCCCCCCCCHHHCC	39.06	-
295	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCCHHHCCC	43.63	-
295	Ubiquitination	HTGEKPYKCEECGKA CCCCCCCCCHHHCCC	43.63	-
295	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCCHHHCCC	43.63	-
317	Phosphorylation	AKHKRIHTGEKPYKC HHCCCCCCCCCCCCH	44.67	29496963
320	Ubiquitination	KRIHTGEKPYKCEEC CCCCCCCCCCCHHHH	55.80	-
322	Phosphorylation	IHTGEKPYKCEECGK CCCCCCCCCHHHHHC	39.06	-
323	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCHHHHHCC	43.63	-
323	Ubiquitination	HTGEKPYKCEECGKA CCCCCCCCHHHHHCC	43.63	-
323	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCHHHHHCC	43.63	-
337	Ubiquitination	AFSRSSTLAKHKRIH CCCCCCHHHHCCCCC	6.89	29967540
345	Phosphorylation	AKHKRIHTGEKPYKC HHCCCCCCCCCCEEC	44.67	29496963
350	Phosphorylation	IHTGEKPYKCKECGK CCCCCCCEECCCCCC	39.83	-
369	Ubiquitination	SSTLANHKITHTEEK CHHHHCCCCCCCCCC	49.46	29967540
378	Phosphorylation	THTEEKPYKCKECDK CCCCCCCCCHHHHHH	39.83	-
391	Phosphorylation	DKAFKRLSTLTKHKI HHHHHHHHHHCHHCC	25.96	21060948
407	Sumoylation	HAGEKLYKCEECGKA CCCCCEEECHHHHHC	45.68	-
407	Sumoylation	HAGEKLYKCEECGKA CCCCCEEECHHHHHC	45.68	-
407	Ubiquitination	HAGEKLYKCEECGKA CCCCCEEECHHHHHC	45.68	-
413	Ubiquitination	YKCEECGKAFNRSSN EECHHHHHCCCCCCC	62.56	-
429	Phosphorylation	TIHKFIHTGEKPYKC EEEEEEECCCCCEEC	42.07	29496963
432	Ubiquitination	KFIHTGEKPYKCEEC EEEECCCCCEECCCC	55.80	-
434	Phosphorylation	IHTGEKPYKCEECGK EECCCCCEECCCCCC	39.06	-
435	Sumoylation	HTGEKPYKCEECGKA ECCCCCEECCCCCCC	43.63	-
435	Ubiquitination	HTGEKPYKCEECGKA ECCCCCEECCCCCCC	43.63	-
435	Sumoylation	HTGEKPYKCEECGKA ECCCCCEECCCCCCC	43.63	-
485	Phosphorylation	TRHKRIHTGEKPYKC CCCCCCCCCCCCCCH	44.67	29496963
488	Ubiquitination	KRIHTGEKPYKCEEC CCCCCCCCCCCHHHH	55.80	-
490	Phosphorylation	IHTGEKPYKCEECGK CCCCCCCCCHHHHHH	39.06	-
491	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCHHHHHHH	43.63	-
491	Ubiquitination	HTGEKPYKCEECGKA CCCCCCCCHHHHHHH	43.63	-
491	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCHHHHHHH	43.63	-
507	Ubiquitination	RQSSTLTKHKIIHTG HHCCCCCCCEEEECC	46.11	-
509	Ubiquitination	SSTLTKHKIIHTGEK CCCCCCCEEEECCCC	44.93	-
513	Phosphorylation	TKHKIIHTGEKPYKF CCCEEEECCCCCCCH	36.31	29496963
516	Ubiquitination	KIIHTGEKPYKFEEC EEEECCCCCCCHHHH	55.80	-
530	Phosphorylation	CGKAFRQSLTLNKHK HHHHHHHHHCCCCCC	21.04	22210691
560	Phosphorylation	KAFKQFSTLTTHKII HHHHHHHHHHHHHHH	29.43	18767875
575	Sumoylation	HAGKKLYKCEECGKA HCCCCEEECHHHHHC	45.68	-
575	Sumoylation	HAGKKLYKCEECGKA HCCCCEEECHHHHHC	45.68	-
575	Ubiquitination	HAGKKLYKCEECGKA HCCCCEEECHHHHHC	45.68	-
597	Phosphorylation	STHKIIHTGEKSYKC CCCCEEECCCCEEEC	36.31	27251275
600	Ubiquitination	KIIHTGEKSYKCEEC CEEECCCCEEECCHH	61.50	-
601	Phosphorylation	IIHTGEKSYKCEECG EEECCCCEEECCHHH	26.06	30631047
603	Sumoylation	HTGEKSYKCEECGKA ECCCCEEECCHHHCC	42.11	-
603	Sumoylation	HTGEKSYKCEECGKA ECCCCEEECCHHHCC	42.11	-
625	Phosphorylation	RRHKRIHTGEKPYKC HHCCCCCCCCCCCCC	44.67	29496963
628	Ubiquitination	KRIHTGEKPYKCEEC CCCCCCCCCCCCHHH	55.80	-
630	Phosphorylation	IHTGEKPYKCEECGK CCCCCCCCCCHHHHH	39.06	-
631	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCCHHHHHC	43.63	-
631	Ubiquitination	HTGEKPYKCEECGKA CCCCCCCCCHHHHHC	43.63	-
631	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCCHHHHHC	43.63	-
645	Ubiquitination	AFSHSSALAKHKRIH CCCCHHHHHHCCCCC	7.63	29967540
653	Phosphorylation	AKHKRIHTGEKPYKC HHCCCCCCCCCCCCC	44.67	29496963
658	Phosphorylation	IHTGEKPYKCKECGK CCCCCCCCCCCCCCC	39.83	-
677	Ubiquitination	SSTLANHKITHTEEK CHHHHCCCCCCCCCC	49.46	29967540
686	Phosphorylation	THTEEKPYKCKECDK CCCCCCCCCCCCCHH	39.83	-
694	Phosphorylation	KCKECDKTFKRLSTL CCCCCHHHHHHHHHH	22.57	26074081
699	Phosphorylation	DKTFKRLSTLTKHKI HHHHHHHHHHCHHCE	25.96	26074081
700	Phosphorylation	KTFKRLSTLTKHKII HHHHHHHHHCHHCEE	42.93	22210691
702	Phosphorylation	FKRLSTLTKHKIIHA HHHHHHHCHHCEEEC	31.06	26074081
715	Sumoylation	HAGEKLYKCEECGKA ECCCCEEECHHHHHC	45.68	-
715	Sumoylation	HAGEKLYKCEECGKA ECCCCEEECHHHHHC	45.68	-
715	Ubiquitination	HAGEKLYKCEECGKA ECCCCEEECHHHHHC	45.68	-
721	Ubiquitination	YKCEECGKAFNRSSN EECHHHHHCCCCCCC	62.56	-
737	Phosphorylation	TIHKFIHTGEKPYKC EEEEEEECCCCCEEC	42.07	29496963
740	Ubiquitination	KFIHTGEKPYKCEEC EEEECCCCCEECCCC	55.80	-
742	Phosphorylation	IHTGEKPYKCEECGK EECCCCCEECCCCCC	39.06	-
743	Sumoylation	HTGEKPYKCEECGKA ECCCCCEECCCCCCC	43.63	-
743	Ubiquitination	HTGEKPYKCEECGKA ECCCCCEECCCCCCC	43.63	-
743	Sumoylation	HTGEKPYKCEECGKA ECCCCCEECCCCCCC	43.63	-
793	Phosphorylation	TRHKRIHTGEKPYKC CCCCCCCCCCCCCCC	44.67	29496963
796	Ubiquitination	KRIHTGEKPYKCEEC CCCCCCCCCCCCHHH	55.80	-
798	Phosphorylation	IHTGEKPYKCEECGK CCCCCCCCCCHHHCC	39.06	-
799	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCCHHHCCC	43.63	-
799	Ubiquitination	HTGEKPYKCEECGKA CCCCCCCCCHHHCCC	43.63	-
799	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCCHHHCCC	43.63	-
815	Ubiquitination	SRSSTLTKHKTIHTG CCCCCCCCCCEEECC	46.33	-
821	Phosphorylation	TKHKTIHTGEKPYKC CCCCEEECCCCCCCC	43.09	29496963
824	Sumoylation	KTIHTGEKPYKCKEC CEEECCCCCCCCCHH	55.80	-
824	Sumoylation	KTIHTGEKPYKCKEC CEEECCCCCCCCCHH	55.80	-
826	Phosphorylation	IHTGEKPYKCKECGK EECCCCCCCCCHHHH	39.83	-
855	Sumoylation	HAGEKLYKCEECGKA CCCCCEEEHHHHHHH	45.68	-
855	Sumoylation	HAGEKLYKCEECGKA CCCCCEEEHHHHHHH	45.68	-
855	Ubiquitination	HAGEKLYKCEECGKA CCCCCEEEHHHHHHH	45.68	-
866	Phosphorylation	CGKAFNQSSNLTTHK HHHHCCCCCCCCEEE	23.46	-
882	Phosphorylation	IHTKEKPSKSEECDK EECCCCCCCCCCCCC	60.94	-
884	Phosphorylation	TKEKPSKSEECDKAF CCCCCCCCCCCCCCC	42.86	-
894	Phosphorylation	CDKAFIWSSTLTEHK CCCCCEECCCCCCCC	14.50	-
895	Phosphorylation	DKAFIWSSTLTEHKR CCCCEECCCCCCCCC	16.67	-
927	Phosphorylation	SQPSHLTTHKRMHTG CCCCCCCCCCCCCCC	31.59	24719451
939	Sumoylation	HTGEKPYKCEECGKA CCCCCCEEHHHHHHC	43.63	-
939	Sumoylation	HTGEKPYKCEECGKA CCCCCCEEHHHHHHC	43.63	-
939	Ubiquitination	HTGEKPYKCEECGKA CCCCCCEEHHHHHHC	43.63	-
950	Phosphorylation	CGKAFSQSSTLTTHK HHHCCCCCCCCEEEE	24.88	-
951	Phosphorylation	GKAFSQSSTLTTHKI HHCCCCCCCCEEEEE	21.57	-
954	Phosphorylation	FSQSSTLTTHKIIHT CCCCCCCEEEEEEEC	27.26	-
957	Sumoylation	SSTLTTHKIIHTGEK CCCCEEEEEEECCCC	41.06	-
957	Sumoylation	SSTLTTHKIIHTGEK CCCCEEEEEEECCCC	41.06	-
957	Ubiquitination	SSTLTTHKIIHTGEK CCCCEEEEEEECCCC	41.06	-
961	Phosphorylation	TTHKIIHTGEKPYKC EEEEEEECCCCCEEH	36.31	29496963
964	Ubiquitination	KIIHTGEKPYKCEEC EEEECCCCCEEHHHH	55.80	-
966	Phosphorylation	IHTGEKPYKCEECGK EECCCCCEEHHHHHH	39.06	-
967	Acetylation	HTGEKPYKCEECGKA ECCCCCEEHHHHHHH	43.63	19825661
967	Sumoylation	HTGEKPYKCEECGKA ECCCCCEEHHHHHHH	43.63	-
967	Ubiquitination	HTGEKPYKCEECGKA ECCCCCEEHHHHHHH	43.63	-
967	Sumoylation	HTGEKPYKCEECGKA ECCCCCEEHHHHHHH	43.63	-
978	Phosphorylation	CGKAFRKSSTLTEHK HHHHHHHCCCCCCCE	25.05	-
979	Phosphorylation	GKAFRKSSTLTEHKI HHHHHHCCCCCCCEE	30.39	-
985	Ubiquitination	SSTLTEHKIIHTGEK CCCCCCCEEEECCCC	36.80	-
989	Phosphorylation	TEHKIIHTGEKPYKC CCCEEEECCCCCEEC	36.31	29496963
992	Ubiquitination	KIIHTGEKPYKCEEC EEEECCCCCEECHHH	55.80	-
994	Phosphorylation	IHTGEKPYKCEECGK EECCCCCEECHHHHH	39.06	-
995	Acetylation	HTGEKPYKCEECGKA ECCCCCEECHHHHHC	43.63	19825669
995	Sumoylation	HTGEKPYKCEECGKA ECCCCCEECHHHHHC	43.63	-
995	Ubiquitination	HTGEKPYKCEECGKA ECCCCCEECHHHHHC	43.63	-
995	Sumoylation	HTGEKPYKCEECGKA ECCCCCEECHHHHHC	43.63	-
1005	Ubiquitination	ECGKAFSQSSTLTRH HHHHCHHCCCCCCCC	34.64	21890473
1006	Phosphorylation	CGKAFSQSSTLTRHT HHHCHHCCCCCCCCC	24.88	-
1023	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCHHHHHHC	43.63	-
1023	Sumoylation	HTGEKPYKCEECGKA CCCCCCCCHHHHHHC	43.63	-
1023	Ubiquitination	HTGEKPYKCEECGKA CCCCCCCCHHHHHHC	43.63	-
1029	Ubiquitination	YKCEECGKAFNRSSK CCHHHHHHCCCCCCC	62.56	-
1031	Ubiquitination	CEECGKAFNRSSKLT HHHHHHCCCCCCCCC	9.95	21890473
1034	Phosphorylation	CGKAFNRSSKLTTHK HHHCCCCCCCCCCCC	32.69	18767875
1035	Phosphorylation	GKAFNRSSKLTTHKI HHCCCCCCCCCCCCE	28.57	18767875
1038	Phosphorylation	FNRSSKLTTHKIIHT CCCCCCCCCCCEEEC	30.50	18767875
1039	Phosphorylation	NRSSKLTTHKIIHTG CCCCCCCCCCEEECC	31.44	18767875
1041	Ubiquitination	SSKLTTHKIIHTGEK CCCCCCCCEEECCCC	41.06	-
1045	Phosphorylation	TTHKIIHTGEKPYKC CCCCEEECCCCCEEC	36.31	29496963
1048	Ubiquitination	KIIHTGEKPYKCEEC CEEECCCCCEECCCC	55.80	-
1050	Phosphorylation	IHTGEKPYKCEECGK EECCCCCEECCCCCC	39.06	-
1051	Acetylation	HTGEKPYKCEECGKA ECCCCCEECCCCCCE	43.63	19825677
1051	Sumoylation	HTGEKPYKCEECGKA ECCCCCEECCCCCCE	43.63	-
1051	Ubiquitination	HTGEKPYKCEECGKA ECCCCCEECCCCCCE	43.63	-
1051	Sumoylation	HTGEKPYKCEECGKA ECCCCCEECCCCCCE	43.63	-
1063	Ubiquitination	GKAFISSSTLNGHKR CCEEEECHHCCCCCC	30.07	21890473
1072	Ubiquitination	LNGHKRIHTREKPYK CCCCCCCCCCCCCCC	23.93	21890473
1079	Sumoylation	HTREKPYKCEECGKA CCCCCCCCCHHHHHH	43.63	-
1079	Sumoylation	HTREKPYKCEECGKA CCCCCCCCCHHHHHH	43.63	-
1079	Ubiquitination	HTREKPYKCEECGKA CCCCCCCCCHHHHHH	43.63	-
1090	Phosphorylation	CGKAFSQSSTLTRHK HHHHCCCCCCCCCCC	24.88	-
1101	Phosphorylation	TRHKRLHTGEKPYKC CCCCCCCCCCCCCCC	52.18	27422710
1104	Sumoylation	KRLHTGEKPYKCGEC CCCCCCCCCCCCCCC	55.80	-
1104	Ubiquitination	KRLHTGEKPYKCGEC CCCCCCCCCCCCCCC	55.80	21890473
1104	Sumoylation	KRLHTGEKPYKCGEC CCCCCCCCCCCCCCC	55.80	-
1107	Sumoylation	HTGEKPYKCGECGKA CCCCCCCCCCCCHHH	44.27	-
1107	Sumoylation	HTGEKPYKCGECGKA CCCCCCCCCCCCHHH	44.27	-
1125	Ubiquitination	SSALTKHKIIHTGEK CCCCCCCEEEECCCC	44.93	-
1129	Phosphorylation	TKHKIIHTGEKPYKC CCCEEEECCCCCCCC	36.31	29496963
1132	Ubiquitination	KIIHTGEKPYKCEKC EEEECCCCCCCCCCC	55.80	-
1134	Phosphorylation	IHTGEKPYKCEKCGK EECCCCCCCCCCCCC	39.06	-
1135	Acetylation	HTGEKPYKCEKCGKA ECCCCCCCCCCCCCC	44.43	19825685
1157	Phosphorylation	TNHKKIHTITPVIPL CCCCCCCEECCCHHH	29.98	-
1159	Phosphorylation	HKKIHTITPVIPLLW CCCCCEECCCHHHHE	16.80	22210691
1180	Phosphorylation	SRGQEMETILANTVK CCCHHHHHHHHHCCC	21.71	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNF91_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNF91_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNF91_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZNF91_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.