CCD15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD15_HUMAN
• UniProt AC: Q0P6D6
• Protein Name: Coiled-coil domain-containing protein 15
• Gene Name: CCDC15
• Organism: Homo sapiens (Human).
• Sequence Length: 951
• Protein Sequence: MLGSMARKKPRNTSRLPLALNPLKSKDVLAVLAERNEAIVPVGAWVEPASPGSSEIPAYTSAYLIEEELKEQLRKKQEALKHFQKQVKYRVNQQIRLRKKQQLQKSYERAQKEGSIAMQSSATHLTSKRTSVFPNNLNVAIGSSRLPPSLMPGDGIEDEENQNELFQQQAQALSETMKQARHRLASFKTVIKKKGSVFPDDGRKSFLTREEVLSRKPASTGINTGIRGELPIKVHQGLLAAVPYQNYMENQELDYEEPDYEESSSLVTDEKGKEDLFGRGQQDQQAIHSEDKNKPFSRVQKVKFKNPLFVLMEEEEQKQLHFEGLQDILPEAQDYFLEAQGDLLETQGDLTGIQSVKPDTQAVEMKVQVTEPEGQAIEPEGQPIKTETQGIMLKAQSIELEEGSIVLKTQDFLPTNQALLTKNQDVLLKDHCVLPKDQSILLKYQDQDFLPRDQHVLHKDQDILPKYQDQNFLPKDQNFLSRDQHVLPKDQDILPKYQDQNFLPKDQNFLSRDQHVLPKDQNILPKYQGQDFLPKDQDFLSRDQHVLPKDWNILPKCQDQDFLPRDQGVLPKDQNILPICQDQDFLPRDQGYLPKDQNILPICQDRDFLPRDLHVLSNDQNILPKCQDQDFLPKYQKVHFKEPYSDMTDEKGREDFSLADYQCLPPKSQDQDDIKNQQPASFMREERVREELPLDYHQYVVPKIQDQDSPREQNKHIKLPSSFEKWEIARGNTPGVPLAYDRYQSGLSTEFQAPLAFQSDVDKEEDKKERQKQYLRHRRLFMDIEREQVKEQQRQKEQKKKIEKIKKKREQECYAAEQRILRMNFHEDPYSGEKLSEILAQLQLQEIKGTREKQQREKEYLRYVEALRAQIQEKMQLYNITLPPLCCCGPDFWDAHPDTCANNCIFYKNHRAYTRALHSFINSCDVPGGNSTLRVAIHNFASAHRRTLKNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	ARKKPRNTSRLPLAL CCCCCCCCCCCCCCC	19.26	28348404
14	Phosphorylation	RKKPRNTSRLPLALN CCCCCCCCCCCCCCC	35.06	24719451
24	Ubiquitination	PLALNPLKSKDVLAV CCCCCCCCCCHHHHH	57.63	27667366
26	Ubiquitination	ALNPLKSKDVLAVLA CCCCCCCCHHHHHHH	50.71	29967540
27	Ubiquitination	LNPLKSKDVLAVLAE CCCCCCCHHHHHHHH	47.99	21853274
50	Phosphorylation	GAWVEPASPGSSEIP CEEECCCCCCCCCCC	40.27	27251275
53	Phosphorylation	VEPASPGSSEIPAYT ECCCCCCCCCCCHHH	28.34	27251275
54	Phosphorylation	EPASPGSSEIPAYTS CCCCCCCCCCCHHHH	45.52	27251275
56	Ubiquitination	ASPGSSEIPAYTSAY CCCCCCCCCHHHHHH	2.27	25015289
59	Phosphorylation	GSSEIPAYTSAYLIE CCCCCCHHHHHHHHH	8.89	24275569
60	Phosphorylation	SSEIPAYTSAYLIEE CCCCCHHHHHHHHHH	14.69	24275569
61	Phosphorylation	SEIPAYTSAYLIEEE CCCCHHHHHHHHHHH	11.40	24275569
63	Ubiquitination	IPAYTSAYLIEEELK CCHHHHHHHHHHHHH	14.15	25015289
76	Ubiquitination	LKEQLRKKQEALKHF HHHHHHHHHHHHHHH	47.11	21853274
79	Ubiquitination	QLRKKQEALKHFQKQ HHHHHHHHHHHHHHH	21.29	25015289
81	Ubiquitination	RKKQEALKHFQKQVK HHHHHHHHHHHHHHH	49.80	29967540
105	Ubiquitination	RKKQQLQKSYERAQK HHHHHHHHHHHHHHH	64.69	25015289
106	Phosphorylation	KKQQLQKSYERAQKE HHHHHHHHHHHHHHH	21.18	24719451
107	Phosphorylation	KQQLQKSYERAQKEG HHHHHHHHHHHHHHC	19.23	24719451
112	Ubiquitination	KSYERAQKEGSIAMQ HHHHHHHHHCCCEEC	64.16	25015289
121	Phosphorylation	GSIAMQSSATHLTSK CCCEECCCCCCCCCC	21.94	22210691
123	Phosphorylation	IAMQSSATHLTSKRT CEECCCCCCCCCCCC	21.26	-
128	Ubiquitination	SATHLTSKRTSVFPN CCCCCCCCCCCCCCC	55.23	25015289
144	Phosphorylation	LNVAIGSSRLPPSLM EEEEEECCCCCCCCC	32.40	22210691
186	Phosphorylation	QARHRLASFKTVIKK HHHHHHHHHHHHHHH	31.69	22673903
188	Ubiquitination	RHRLASFKTVIKKKG HHHHHHHHHHHHHCC	39.11	-
189	Phosphorylation	HRLASFKTVIKKKGS HHHHHHHHHHHHCCC	26.00	22673903
205	Phosphorylation	FPDDGRKSFLTREEV CCCCCCCCCCCHHHH	24.91	24945436
208	Phosphorylation	DGRKSFLTREEVLSR CCCCCCCCHHHHHCC	33.74	29449344
214	Phosphorylation	LTREEVLSRKPASTG CCHHHHHCCCCCCCC	43.35	29449344
216	Ubiquitination	REEVLSRKPASTGIN HHHHHCCCCCCCCCC	41.37	29967540
255	Phosphorylation	MENQELDYEEPDYEE HHCCCCCCCCCCCHH	34.51	-
260	Phosphorylation	LDYEEPDYEESSSLV CCCCCCCCHHHCCCC	32.10	-
273	Ubiquitination	LVTDEKGKEDLFGRG CCCCCCCCCCCCCCC	60.15	29967540
292	Ubiquitination	QAIHSEDKNKPFSRV HHHHCCCCCCCCCCC	63.92	29967540
305	Ubiquitination	RVQKVKFKNPLFVLM CCEECEECCCEEEEE	52.52	29967540
358	Ubiquitination	TGIQSVKPDTQAVEM CCCEECCCCCCEEEE	47.96	21890473
385	Ubiquitination	EPEGQPIKTETQGIM CCCCCCCCCCCCCEE	47.17	-
388	Ubiquitination	GQPIKTETQGIMLKA CCCCCCCCCCEEEEE	37.01	21890473
397	Phosphorylation	GIMLKAQSIELEEGS CEEEEEEEEEECCCC	23.92	27251275
408	Ubiquitination	EEGSIVLKTQDFLPT CCCCEEEEECCCCCC	32.99	29967540
409	Phosphorylation	EGSIVLKTQDFLPTN CCCEEEEECCCCCCC	29.25	22210691
421	Phosphorylation	PTNQALLTKNQDVLL CCCHHHHHCCCCEEE	28.88	-
422	Ubiquitination	TNQALLTKNQDVLLK CCHHHHHCCCCEEEC	53.21	29967540
426	Ubiquitination	LLTKNQDVLLKDHCV HHHCCCCEEECCEEE	4.93	21890473
429	Ubiquitination	KNQDVLLKDHCVLPK CCCCEEECCEEECCC	41.06	29967540
436	Ubiquitination	KDHCVLPKDQSILLK CCEEECCCCCEEEEC	65.33	29967540
443	Ubiquitination	KDQSILLKYQDQDFL CCCEEEECCCCCCCC	37.10	29967540
456	Ubiquitination	FLPRDQHVLHKDQDI CCCCCHHCCCCCCCC	5.07	21890473
459	Ubiquitination	RDQHVLHKDQDILPK CCHHCCCCCCCCCHH	53.58	29967540
466	Ubiquitination	KDQDILPKYQDQNFL CCCCCCHHHCCCCCC	52.69	29967540
475	Ubiquitination	QDQNFLPKDQNFLSR CCCCCCCCCCCCHHC	74.27	22817900
489	Ubiquitination	RDQHVLPKDQDILPK CCCCCCCCCCCCCHH	64.95	29967540
496	Ubiquitination	KDQDILPKYQDQNFL CCCCCCHHHCCCCCC	52.69	-
505	Ubiquitination	QDQNFLPKDQNFLSR CCCCCCCCCCCCHHC	74.27	21890473
519	Ubiquitination	RDQHVLPKDQNILPK CCCCCCCCCCCCCHH	68.72	29967540
535	Ubiquitination	QGQDFLPKDQDFLSR CCCCCCCCCHHHHCC	70.89	29967540
549	Ubiquitination	RDQHVLPKDWNILPK CCCCCCCCCCCCCCC	71.82	29967540
556	Ubiquitination	KDWNILPKCQDQDFL CCCCCCCCCCCCCCC	40.87	29967540
572	Ubiquitination	RDQGVLPKDQNILPI CCCCCCCCCCCCCCC	68.72	29967540
595	Ubiquitination	RDQGYLPKDQNILPI CCCCCCCCCCCCCCC	70.16	29967540
625	Ubiquitination	NDQNILPKCQDQDFL CCCCCCHHCCCCCCC	40.87	29967540
634	Ubiquitination	QDQDFLPKYQKVHFK CCCCCCHHHCEEEEC	63.56	29967540
644	Phosphorylation	KVHFKEPYSDMTDEK EEEECCCCCCCCCCC	20.56	29083192
645	Phosphorylation	VHFKEPYSDMTDEKG EEECCCCCCCCCCCC	31.46	22210691
648	Phosphorylation	KEPYSDMTDEKGRED CCCCCCCCCCCCCCC	46.10	29083192
675	Ubiquitination	SQDQDDIKNQQPASF CCCHHHHHHCCCCHH	56.55	29967540
681	Phosphorylation	IKNQQPASFMREERV HHHCCCCHHHHHHHH	26.68	29083192
696	Phosphorylation	REELPLDYHQYVVPK HHHCCCCCHHHCCCC	9.86	28796482
699	Phosphorylation	LPLDYHQYVVPKIQD CCCCCHHHCCCCCCC	7.07	28796482
703	Ubiquitination	YHQYVVPKIQDQDSP CHHHCCCCCCCCCCH	41.19	29967540
725	Ubiquitination	KLPSSFEKWEIARGN CCCCHHHHHHHHCCC	48.38	29967540
834	Ubiquitination	EDPYSGEKLSEILAQ CCCCCHHHHHHHHHH	61.92	-
848	Ubiquitination	QLQLQEIKGTREKQQ HHHHHHHHCHHHHHH	54.18	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.