DACH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DACH2_HUMAN
• UniProt AC: Q96NX9
• Protein Name: Dachshund homolog 2
• Gene Name: DACH2
• Organism: Homo sapiens (Human).
• Sequence Length: 599
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain..
• Protein Sequence: MAVSASPVISATSSGAGVPGGLFRAEPLYSTPREPPRLTPNMINSFVVNNHSNSAGGGGRGNTNTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMTRKQAVNSSRPGRPPKRSLGVLQENARLLTHAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSNTGGSESSWDKDKMQSPFAAPGPQHGIAHAALAGQPGIGGAPTLNPLQQNHLLTNRLDLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLSRAGTSVIKERIPESPSPAPSLEENHRPGSQTSSHTSSSVSSSPSQMDHHLERMEEVPVQIPIMKSPLDKIQLTPGQALPAGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRREQVEQALKQATTSDSGLRMLKDTGIPDIEIENNGTPHDSAAMQGGNYYCLEMAQQLYSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	LTPNMINSFVVNNHS CCHHHCCEEEECCCC	14.43	25072903
52	Phosphorylation	SFVVNNHSNSAGGGG EEEECCCCCCCCCCC	34.30	25072903
54	Phosphorylation	VVNNHSNSAGGGGRG EECCCCCCCCCCCCC	31.16	25072903
108	Phosphorylation	HLVGGLHTVYTKLKR HHHCCHHHHHHHHHC	21.91	20049867
110	Phosphorylation	VGGLHTVYTKLKRLD HCCHHHHHHHHHCCC	10.18	20049867
111	Phosphorylation	GGLHTVYTKLKRLDI CCHHHHHHHHHCCCC	26.09	20049867
148	Phosphorylation	VNRCKLITRKDFETL CCHHEEEEHHHHHHH	41.94	28555341
186	Phosphorylation	PGRPPKRSLGVLQEN CCCCCCCCHHHHHHH	35.28	22210691
236	Phosphorylation	MKLMAMNTLQGNGSQ CHHHHHHHCCCCCCC	13.84	-
242	Phosphorylation	NTLQGNGSQNGTESE HHCCCCCCCCCCCCC	25.19	-
327	Phosphorylation	PHPLLPVSLPPASVA CCCCCCCCCCHHHHH	32.97	22210691
357	Phosphorylation	AAAAQIHSPLSRAGT HHHHHCCCCHHHCCC	29.21	-
360	Phosphorylation	AQIHSPLSRAGTSVI HHCCCCHHHCCCHHH	24.38	22210691
433	Phosphorylation	PLDKIQLTPGQALPA CCCCCCCCCCCCCCC	14.70	22210691
453	Phosphorylation	FIFADSLSSVETLLT EEECCCHHHHHHHHH	35.97	22210691
454	Phosphorylation	IFADSLSSVETLLTN EECCCHHHHHHHHHH	29.30	22210691
537	Phosphorylation	QEALEFESKRREQVE HHHHHHHHHHHHHHH	36.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DACH2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DACH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DACH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLYG2_HUMAN	GYG2	physical	28514442
DACH1_HUMAN	DACH1	physical	28514442
TRI26_HUMAN	TRIM26	physical	28514442
CD2AP_HUMAN	CD2AP	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.