| UniProt ID | TAF1A_HUMAN | |
|---|---|---|
| UniProt AC | Q15573 | |
| Protein Name | TATA box-binding protein-associated factor RNA polymerase I subunit A | |
| Gene Name | TAF1A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 450 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.. | |
| Protein Sequence | MSDFSEELKGPVTDDEEVETSVLSGAGMHFPWLQTYVETVAIGGKRRKDFAQTTSACLSFIQEALLKHQWQQAAEYMYSYFQTLEDSDSYKRQAAPEIIWKLGSEILFYHPKSNMESFNTFANRMKNIGVMNYLKISLQHALYLLHHGMLKDAKRNLSEAETWRHGENTSSREILINLIQAYKGLLQYYTWSEKKMELSKLDKDDYAYNAVAQDVFNHSWKTSANISALIKIPGVWDPFVKSYVEMLEFYGDRDGAQEVLTNYAYDEKFPSNPNAHIYLYNFLKRQKAPRSKLISVLKILYQIVPSHKLMLEFHTLLRKSEKEEHRKLGLEVLFGVLDFAGCTKNITAWKYLAKYLKNILMGNHLAWVQEEWNSRKNWWPGFHFSYFWAKSDWKEDTALACEKAFVAGLLLGKGCRYFRYILKQDHQILGKKIKRMKRSVKKYSIVNPRL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSDFSEELK ------CCCCHHHHC | 47.57 | 25849741 | |
| 5 | Phosphorylation | ---MSDFSEELKGPV ---CCCCHHHHCCCC | 34.84 | 25849741 | |
| 189 | Phosphorylation | YKGLLQYYTWSEKKM HHHHHHHHCCCHHHH | 6.70 | 25884760 | |
| 203 | Ubiquitination | MELSKLDKDDYAYNA HCHHHCCHHHHHHHH | 64.04 | - | |
| 219 | Phosphorylation | AQDVFNHSWKTSANI HHHHHCCCCCCCCCH | 31.22 | - | |
| 315 | Phosphorylation | KLMLEFHTLLRKSEK HHHHHHHHHHHHCCH | 32.58 | 24260401 | |
| 327 | Acetylation | SEKEEHRKLGLEVLF CCHHHHHHHHHHHHH | 49.14 | 7696547 | |
| 413 | Ubiquitination | VAGLLLGKGCRYFRY HHHHHHCCCHHHHHH | 55.60 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TAF1A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TAF1A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TAF1A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TBP_HUMAN | TBP | physical | 7801123 | |
| TAF1B_HUMAN | TAF1B | physical | 7801123 | |
| TAF1C_HUMAN | TAF1C | physical | 7801123 | |
| UBF1_HUMAN | UBTF | physical | 10913176 | |
| AN32A_HUMAN | ANP32A | physical | 11163245 | |
| TAF1D_HUMAN | TAF1D | physical | 17318177 | |
| TBP_HUMAN | TBP | physical | 15315821 | |
| JMJD6_HUMAN | JMJD6 | physical | 23455924 | |
| CK057_HUMAN | C11orf57 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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