UniProt ID | NPAT_HUMAN | |
---|---|---|
UniProt AC | Q14207 | |
Protein Name | Protein NPAT | |
Gene Name | NPAT | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1427 | |
Subcellular Localization | Nucleus. Nucleus, Cajal body. Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 spec | |
Protein Description | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.. | |
Protein Sequence | MLLPSDVARLVLGYLQQENLISTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKTKETSNNVPAIMSSLWKKLDHTLSQIRSMQSSPRFAGSQRARTRTGIAEIKRQRKLASQTAPASAELLTLPYLSGQFTTPPSTGTQVTRPSGQISDPSRSYFVVVNHSQSQDTVTTGEALNVIPGAQEKKAHASLMSPGRRKSESQRKSTTLSGPHSTIRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNNIAQVPKQTDNNPTEPETSIDEFLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSISSQPMESNPSIVLADETNLAVKGSFETEESDGQSGQPAFCTSYQNDDPLNALKNSNNHDVLRQEDQENFSQISTSIQKKAFKTAVPTEQKCDIDITFESVPNLNDFNQRGNSNAECNPHCAELYTNQMSTETEMAIGIEKNSLSSNVPSESQLQPDQPDIPITSFVSLGCEANNENLILSGKSSQLLSQDTSLTGKPSKKSQFCENSNDTVKLKINFHGSKSSDSSEVHKSKIEINVLEPVMSQLSNCQDNSCLQSEILPVSVESSHLNVSGQVEIHLGDSLSSTKQPSNDSASVELNHTENEAQASKSENSQEPSSSVKEENTIFLSLGGNANCEKVALTPPEGTPVENSHSLPPESVCSSVGDSHPESQNTDDKPSSNNSAEIDASNIVSLKVIISDDPFVSSDTELTSAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAEVGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFSANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQGLRNKPCIGKQVNNLVDSSGHSVGCHAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKPCHRRVLCFDSTTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLKPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQSEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNVLSVGTAVKDLKQEQTKSASSLITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRASSRSTTKKRKIEELDERERNSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
5 | Phosphorylation | ---MLLPSDVARLVL ---CCCHHHHHHHHH | 44.69 | 29759185 | |
53 | Ubiquitination | FIPACLLSLFGKNLT CHHHHHHHHHCCCHH | 14.54 | 21963094 | |
57 | Ubiquitination | CLLSLFGKNLTTILN HHHHHHCCCHHHHHH | 41.26 | 22817900 | |
61 | Phosphorylation | LFGKNLTTILNEYVA HHCCCHHHHHHHHHH | 27.00 | 23403867 | |
72 | Ubiquitination | EYVAMKTKETSNNVP HHHHHHCCCCCCCHH | 54.17 | 29967540 | |
87 | Ubiquitination | AIMSSLWKKLDHTLS HHHHHHHHHHHHHHH | 49.07 | 29967540 | |
88 | Acetylation | IMSSLWKKLDHTLSQ HHHHHHHHHHHHHHH | 47.79 | 7306245 | |
88 | Ubiquitination | IMSSLWKKLDHTLSQ HHHHHHHHHHHHHHH | 47.79 | 29967540 | |
98 | Phosphorylation | HTLSQIRSMQSSPRF HHHHHHHHCCCCCCC | 23.85 | 27174698 | |
101 | Phosphorylation | SQIRSMQSSPRFAGS HHHHHCCCCCCCCCC | 33.40 | 27174698 | |
102 | Phosphorylation | QIRSMQSSPRFAGSQ HHHHCCCCCCCCCCH | 11.82 | 27174698 | |
108 | Phosphorylation | SSPRFAGSQRARTRT CCCCCCCCHHHHHHH | 17.05 | 27174698 | |
113 | Phosphorylation | AGSQRARTRTGIAEI CCCHHHHHHHCHHHH | 31.43 | 20068231 | |
115 | Phosphorylation | SQRARTRTGIAEIKR CHHHHHHHCHHHHHH | 32.12 | 20068231 | |
121 | Acetylation | RTGIAEIKRQRKLAS HHCHHHHHHHHHHHH | 33.70 | 25953088 | |
121 | Ubiquitination | RTGIAEIKRQRKLAS HHCHHHHHHHHHHHH | 33.70 | 21963094 | |
125 | Ubiquitination | AEIKRQRKLASQTAP HHHHHHHHHHHCCCC | 39.81 | 22817900 | |
139 | Phosphorylation | PASAELLTLPYLSGQ CCCHHHHHHCCCCCC | 38.01 | 26074081 | |
142 | Phosphorylation | AELLTLPYLSGQFTT HHHHHHCCCCCCCCC | 19.33 | 26074081 | |
144 | Phosphorylation | LLTLPYLSGQFTTPP HHHHCCCCCCCCCCC | 25.38 | 26074081 | |
148 | Phosphorylation | PYLSGQFTTPPSTGT CCCCCCCCCCCCCCC | 30.42 | 26074081 | |
149 | Phosphorylation | YLSGQFTTPPSTGTQ CCCCCCCCCCCCCCC | 34.19 | 26074081 | |
152 | Phosphorylation | GQFTTPPSTGTQVTR CCCCCCCCCCCCEEC | 40.44 | 26074081 | |
153 | Phosphorylation | QFTTPPSTGTQVTRP CCCCCCCCCCCEECC | 50.45 | 26074081 | |
155 | Phosphorylation | TTPPSTGTQVTRPSG CCCCCCCCCEECCCC | 21.69 | 26074081 | |
161 | Phosphorylation | GTQVTRPSGQISDPS CCCEECCCCCCCCCC | 39.79 | 17081983 | |
165 | Phosphorylation | TRPSGQISDPSRSYF ECCCCCCCCCCCCEE | 35.26 | 22817900 | |
168 | Phosphorylation | SGQISDPSRSYFVVV CCCCCCCCCCEEEEE | 38.56 | 17081983 | |
174 | Ubiquitination | PSRSYFVVVNHSQSQ CCCCEEEEEECCCCC | 2.27 | 22817900 | |
189 | Ubiquitination | DTVTTGEALNVIPGA CEECCCHHHCCCCCH | 13.04 | 22817900 | |
194 | Ubiquitination | GEALNVIPGAQEKKA CHHHCCCCCHHHHHH | 27.99 | 22817900 | |
200 | Ubiquitination | IPGAQEKKAHASLMS CCCHHHHHHHHHHCC | 44.65 | 29967540 | |
204 | Phosphorylation | QEKKAHASLMSPGRR HHHHHHHHHCCCCCC | 18.10 | 28176443 | |
207 | Phosphorylation | KAHASLMSPGRRKSE HHHHHHCCCCCCCCH | 29.51 | 23401153 | |
218 | Ubiquitination | RKSESQRKSTTLSGP CCCHHHHHCCCCCCC | 44.51 | 29967540 | |
219 | Phosphorylation | KSESQRKSTTLSGPH CCHHHHHCCCCCCCC | 28.90 | 28555341 | |
220 | Phosphorylation | SESQRKSTTLSGPHS CHHHHHCCCCCCCCH | 34.49 | 20860994 | |
227 | Phosphorylation | TTLSGPHSTIRNFQD CCCCCCCHHHCCCCC | 28.76 | - | |
228 | Phosphorylation | TLSGPHSTIRNFQDP CCCCCCHHHCCCCCC | 22.41 | - | |
242 | Acetylation | PNAFAVEKQMVIENA CCCCHHHHHHHHHHH | 36.78 | 23749302 | |
242 | Ubiquitination | PNAFAVEKQMVIENA CCCCHHHHHHHHHHH | 36.78 | 21906983 | |
252 | Acetylation | VIENAREKILSNKSL HHHHHHHHHHCCHHH | 43.31 | 25953088 | |
257 | Acetylation | REKILSNKSLQEKLA HHHHHCCHHHHHHHH | 49.52 | 25953088 | |
257 | Ubiquitination | REKILSNKSLQEKLA HHHHHCCHHHHHHHH | 49.52 | 22817900 | |
262 | Acetylation | SNKSLQEKLAENINK CCHHHHHHHHHHHHH | 39.78 | 25953088 | |
262 | Ubiquitination | SNKSLQEKLAENINK CCHHHHHHHHHHHHH | 39.78 | 21906983 | |
269 | Acetylation | KLAENINKFLTSDNN HHHHHHHHHHHCCCC | 37.64 | 23749302 | |
269 | Ubiquitination | KLAENINKFLTSDNN HHHHHHHHHHHCCCC | 37.64 | 29967540 | |
337 | Phosphorylation | DLFDYGKTKNNKNIS HHHHHCCCCCCCCCC | 34.34 | 29978859 | |
341 | Acetylation | YGKTKNNKNISQSIS HCCCCCCCCCCCCCC | 66.12 | 25953088 | |
344 | Phosphorylation | TKNNKNISQSISSQP CCCCCCCCCCCCCCC | 27.54 | 29978859 | |
346 | Phosphorylation | NNKNISQSISSQPME CCCCCCCCCCCCCCC | 20.04 | 29978859 | |
348 | Phosphorylation | KNISQSISSQPMESN CCCCCCCCCCCCCCC | 28.32 | 29978859 | |
349 | Phosphorylation | NISQSISSQPMESNP CCCCCCCCCCCCCCC | 36.31 | 29978859 | |
354 | Phosphorylation | ISSQPMESNPSIVLA CCCCCCCCCCCEEEE | 48.03 | 29978859 | |
357 | Phosphorylation | QPMESNPSIVLADET CCCCCCCCEEEECCC | 29.58 | 29978859 | |
364 | Phosphorylation | SIVLADETNLAVKGS CEEEECCCCEEEECE | 35.76 | 29978859 | |
374 | Phosphorylation | AVKGSFETEESDGQS EEECEEECCCCCCCC | 42.94 | 25627689 | |
377 | Phosphorylation | GSFETEESDGQSGQP CEEECCCCCCCCCCC | 40.59 | 25627689 | |
381 | Phosphorylation | TEESDGQSGQPAFCT CCCCCCCCCCCEEEE | 44.95 | 28348404 | |
388 | Phosphorylation | SGQPAFCTSYQNDDP CCCCEEEECCCCCCH | 24.82 | 28348404 | |
389 | Phosphorylation | GQPAFCTSYQNDDPL CCCEEEECCCCCCHH | 26.38 | 28348404 | |
400 | Ubiquitination | DDPLNALKNSNNHDV CCHHHHHHCCCCCHH | 56.79 | 29967540 | |
421 | Phosphorylation | ENFSQISTSIQKKAF HCHHHHHHHHHHHHH | 31.32 | - | |
422 | Phosphorylation | NFSQISTSIQKKAFK CHHHHHHHHHHHHHH | 19.07 | 21815630 | |
425 | Acetylation | QISTSIQKKAFKTAV HHHHHHHHHHHHCCC | 44.38 | 25953088 | |
425 | Ubiquitination | QISTSIQKKAFKTAV HHHHHHHHHHHHCCC | 44.38 | 29967540 | |
429 | Acetylation | SIQKKAFKTAVPTEQ HHHHHHHHCCCCCCC | 40.20 | 25953088 | |
430 | Phosphorylation | IQKKAFKTAVPTEQK HHHHHHHCCCCCCCC | 26.83 | 21406692 | |
434 | Phosphorylation | AFKTAVPTEQKCDID HHHCCCCCCCCCCEE | 44.44 | 21406692 | |
530 | Phosphorylation | NLILSGKSSQLLSQD CEEECCCHHHHHCCC | 27.17 | 22210691 | |
531 | Phosphorylation | LILSGKSSQLLSQDT EEECCCHHHHHCCCC | 28.47 | 22210691 | |
535 | Phosphorylation | GKSSQLLSQDTSLTG CCHHHHHCCCCCCCC | 34.30 | 17525332 | |
538 | Phosphorylation | SQLLSQDTSLTGKPS HHHHCCCCCCCCCCC | 20.28 | 23312004 | |
539 | Phosphorylation | QLLSQDTSLTGKPSK HHHCCCCCCCCCCCC | 32.02 | 25159151 | |
541 | Phosphorylation | LSQDTSLTGKPSKKS HCCCCCCCCCCCCHH | 42.82 | 25159151 | |
543 | Acetylation | QDTSLTGKPSKKSQF CCCCCCCCCCCHHHH | 40.66 | 25953088 | |
545 | Phosphorylation | TSLTGKPSKKSQFCE CCCCCCCCCHHHHCC | 57.09 | 22210691 | |
546 | Acetylation | SLTGKPSKKSQFCEN CCCCCCCCHHHHCCC | 66.04 | 25953088 | |
547 | Ubiquitination | LTGKPSKKSQFCENS CCCCCCCHHHHCCCC | 54.55 | - | |
548 | Phosphorylation | TGKPSKKSQFCENSN CCCCCCHHHHCCCCC | 32.02 | 26552605 | |
554 | Phosphorylation | KSQFCENSNDTVKLK HHHHCCCCCCEEEEE | 17.50 | 23401153 | |
557 | Phosphorylation | FCENSNDTVKLKINF HCCCCCCEEEEEEEE | 24.64 | 23898821 | |
559 | Acetylation | ENSNDTVKLKINFHG CCCCCEEEEEEEECC | 46.27 | 25953088 | |
567 | Phosphorylation | LKINFHGSKSSDSSE EEEEECCCCCCCCCH | 22.31 | 27251275 | |
568 | Ubiquitination | KINFHGSKSSDSSEV EEEECCCCCCCCCHH | 59.58 | 29967540 | |
573 | Phosphorylation | GSKSSDSSEVHKSKI CCCCCCCCHHHHHHE | 48.94 | - | |
599 | Phosphorylation | LSNCQDNSCLQSEIL HHCCCCCCCCCCCEE | 25.21 | - | |
659 | Phosphorylation | QASKSENSQEPSSSV HHHHCCCCCCCCCCC | 31.69 | 28985074 | |
688 | Phosphorylation | NCEKVALTPPEGTPV CEEEEEECCCCCCCC | 27.36 | 26074081 | |
693 | Phosphorylation | ALTPPEGTPVENSHS EECCCCCCCCCCCCC | 23.62 | 26074081 | |
698 | Phosphorylation | EGTPVENSHSLPPES CCCCCCCCCCCCCHH | 10.84 | 26074081 | |
700 | Phosphorylation | TPVENSHSLPPESVC CCCCCCCCCCCHHHH | 42.25 | 26074081 | |
745 | Phosphorylation | VSLKVIISDDPFVSS EEEEEEECCCCCCCC | 25.49 | 20873877 | |
751 | Phosphorylation | ISDDPFVSSDTELTS ECCCCCCCCCHHHHH | 23.91 | 20873877 | |
752 | Phosphorylation | SDDPFVSSDTELTSA CCCCCCCCCHHHHHH | 43.16 | 20873877 | |
754 | Phosphorylation | DPFVSSDTELTSAVS CCCCCCCHHHHHHHH | 34.54 | 20873877 | |
757 | Phosphorylation | VSSDTELTSAVSSIN CCCCHHHHHHHHHCC | 14.38 | 20873877 | |
758 | Phosphorylation | SSDTELTSAVSSING CCCHHHHHHHHHCCC | 39.02 | 20873877 | |
761 | Phosphorylation | TELTSAVSSINGENL HHHHHHHHHCCCCCC | 25.80 | 28450419 | |
762 | Phosphorylation | ELTSAVSSINGENLP HHHHHHHHCCCCCCC | 17.30 | 28450419 | |
770 | Phosphorylation | INGENLPTIILSSPT CCCCCCCEEEECCCC | 24.66 | 28450419 | |
774 | Phosphorylation | NLPTIILSSPTKSPT CCCEEEECCCCCCCC | 24.70 | 30278072 | |
775 | Phosphorylation | LPTIILSSPTKSPTK CCEEEECCCCCCCCC | 32.89 | 30278072 | |
777 | Phosphorylation | TIILSSPTKSPTKNA EEEECCCCCCCCCCC | 46.21 | 25159151 | |
779 | Phosphorylation | ILSSPTKSPTKNAEL EECCCCCCCCCCCHH | 40.04 | 22115753 | |
781 | Phosphorylation | SSPTKSPTKNAELVK CCCCCCCCCCCHHHH | 43.98 | 28387310 | |
908 | Phosphorylation | PLPPQLQTPPRSNSV CCCCCCCCCCCCCCE | 43.80 | 26074081 | |
914 | Phosphorylation | QTPPRSNSVFAVNQA CCCCCCCCEEEEEEE | 21.62 | 26074081 | |
952 | Phosphorylation | MVGMIPVSVVGQNGN CCCCEEEEEECCCCC | 13.01 | 26074081 | |
962 | Phosphorylation | GQNGNNFSTPPRQVL CCCCCCCCCCCHHEE | 41.97 | 26074081 | |
963 | Phosphorylation | QNGNNFSTPPRQVLH CCCCCCCCCCHHEEE | 32.92 | 26074081 | |
993 | Ubiquitination | PVPPKSQKAQGLRNK CCCCHHHCCCCCCCC | 50.17 | 29967540 | |
1000 | Acetylation | KAQGLRNKPCIGKQV CCCCCCCCCCCHHHH | 34.53 | 26051181 | |
1005 | Acetylation | RNKPCIGKQVNNLVD CCCCCCHHHHHHHHH | 31.03 | 26051181 | |
1024 | Acetylation | SVGCHAQKTEVSDKS CCCCCCCCCCCCCHH | 47.65 | 25953088 | |
1030 | Acetylation | QKTEVSDKSIATDLG CCCCCCCHHHHHHCC | 35.93 | 25953088 | |
1030 | Ubiquitination | QKTEVSDKSIATDLG CCCCCCCHHHHHHCC | 35.93 | 29967540 | |
1031 | Phosphorylation | KTEVSDKSIATDLGK CCCCCCHHHHHHCCC | 23.57 | 22210691 | |
1034 | Phosphorylation | VSDKSIATDLGKKSE CCCHHHHHHCCCCCC | 30.04 | 20068231 | |
1038 | Ubiquitination | SIATDLGKKSEETTV HHHHHCCCCCCCCCC | 61.49 | 29967540 | |
1039 | Ubiquitination | IATDLGKKSEETTVP HHHHCCCCCCCCCCC | 62.39 | 29967540 | |
1057 | Acetylation | ESIVPAAKPCHRRVL HHCCCCCCCCCCEEE | 50.73 | 25953088 | |
1082 | Acetylation | NTQGPNHKMVSQNKE CCCCCCCCCCCCCCC | 47.87 | 25953088 | |
1094 | Phosphorylation | NKERNAVSFPNLDSP CCCCCCCCCCCCCCC | 32.35 | - | |
1100 | Phosphorylation | VSFPNLDSPNVSSTL CCCCCCCCCCCCCCC | 22.88 | 25159151 | |
1108 | Acetylation | PNVSSTLKPPSNNAI CCCCCCCCCCCCCCC | 55.78 | 25953088 | |
1116 | Acetylation | PPSNNAIKREKEKPP CCCCCCCHHHCCCCC | 52.69 | 25953088 | |
1116 | Sumoylation | PPSNNAIKREKEKPP CCCCCCCHHHCCCCC | 52.69 | 28112733 | |
1129 | Phosphorylation | PPLPKILSKSESAIS CCCCHHHCCCHHHHH | 37.29 | 25262027 | |
1130 | Acetylation | PLPKILSKSESAISR CCCHHHCCCHHHHHH | 55.59 | 25953088 | |
1130 | Ubiquitination | PLPKILSKSESAISR CCCHHHCCCHHHHHH | 55.59 | 29967540 | |
1131 | Phosphorylation | LPKILSKSESAISRH CCHHHCCCHHHHHHC | 33.15 | 25262027 | |
1133 | Phosphorylation | KILSKSESAISRHTT HHHCCCHHHHHHCCC | 37.68 | 25262027 | |
1136 | Phosphorylation | SKSESAISRHTTIRE CCCHHHHHHCCCHHH | 20.09 | 25262027 | |
1137 | Ubiquitination | KSESAISRHTTIRET CCHHHHHHCCCHHHC | 25.67 | 29967540 | |
1139 | Phosphorylation | ESAISRHTTIRETQS HHHHHHCCCHHHCCC | 23.86 | 29083192 | |
1140 | Phosphorylation | SAISRHTTIRETQSE HHHHHCCCHHHCCCC | 16.35 | 29083192 | |
1144 | Phosphorylation | RHTTIRETQSEKKVS HCCCHHHCCCCCCCC | 27.78 | 30624053 | |
1146 | Phosphorylation | TTIRETQSEKKVSPT CCHHHCCCCCCCCHH | 59.82 | 23312004 | |
1149 | Sumoylation | RETQSEKKVSPTEIV HHCCCCCCCCHHHHH | 43.84 | - | |
1149 | Sumoylation | RETQSEKKVSPTEIV HHCCCCCCCCHHHHH | 43.84 | 28112733 | |
1151 | Phosphorylation | TQSEKKVSPTEIVLE CCCCCCCCHHHHHHH | 34.68 | 29255136 | |
1153 | Phosphorylation | SEKKVSPTEIVLESF CCCCCCHHHHHHHHH | 30.73 | 29255136 | |
1158 | Phosphorylation | SPTEIVLESFHKATA CHHHHHHHHHHHHHC | 40.23 | 32142685 | |
1159 | Phosphorylation | PTEIVLESFHKATAN HHHHHHHHHHHHHCC | 28.61 | 23927012 | |
1167 | Acetylation | FHKATANKENELCSD HHHHHCCCCCCCCHH | 60.49 | 26051181 | |
1173 | Phosphorylation | NKENELCSDVERQKN CCCCCCCHHHHHHHC | 58.26 | 25159151 | |
1185 | Acetylation | QKNPENSKLSIGQQN HHCCCCCCCCCCCCC | 58.81 | 25953088 | |
1199 | Acetylation | NGGLRSEKSIASLQE CCCCCCHHHHHHHHH | 48.70 | 23749302 | |
1200 | Phosphorylation | GGLRSEKSIASLQEM CCCCCHHHHHHHHHH | 21.24 | 21406692 | |
1203 | Phosphorylation | RSEKSIASLQEMTKK CCHHHHHHHHHHHHH | 28.99 | 21406692 | |
1208 | Phosphorylation | IASLQEMTKKQGTSS HHHHHHHHHHCCCCC | 34.05 | 21406692 | |
1213 | Phosphorylation | EMTKKQGTSSNNKNV HHHHHCCCCCCCCCE | 26.87 | 29759185 | |
1214 | Phosphorylation | MTKKQGTSSNNKNVL HHHHCCCCCCCCCEE | 37.58 | 20058876 | |
1215 | Phosphorylation | TKKQGTSSNNKNVLS HHHCCCCCCCCCEEE | 44.23 | - | |
1222 | Phosphorylation | SNNKNVLSVGTAVKD CCCCCEEEHHHHHHH | 17.76 | 28555341 | |
1225 | Phosphorylation | KNVLSVGTAVKDLKQ CCEEEHHHHHHHHHH | 26.56 | 25599653 | |
1228 | Acetylation | LSVGTAVKDLKQEQT EEHHHHHHHHHHHHH | 55.68 | 19608861 | |
1231 | Sumoylation | GTAVKDLKQEQTKSA HHHHHHHHHHHHCCH | 63.02 | - | |
1231 | Sumoylation | GTAVKDLKQEQTKSA HHHHHHHHHHHHCCH | 63.02 | - | |
1235 | Phosphorylation | KDLKQEQTKSASSLI HHHHHHHHCCHHHHH | 26.64 | 28102081 | |
1239 | Phosphorylation | QEQTKSASSLITTEM HHHHCCHHHHHHHHH | 32.54 | 30576142 | |
1243 | Phosphorylation | KSASSLITTEMLQDI CCHHHHHHHHHHHHH | 23.23 | 30576142 | |
1244 | Phosphorylation | SASSLITTEMLQDIQ CHHHHHHHHHHHHHH | 16.65 | 30576142 | |
1254 | Phosphorylation | LQDIQRHSSVSRLAD HHHHHHHHCHHHHCC | 34.32 | - | |
1255 | Phosphorylation | QDIQRHSSVSRLADS HHHHHHHCHHHHCCC | 20.27 | 30576142 | |
1262 | Phosphorylation | SVSRLADSSDLPVPR CHHHHCCCCCCCCCC | 21.83 | - | |
1263 | Phosphorylation | VSRLADSSDLPVPRT HHHHCCCCCCCCCCC | 43.65 | - | |
1270 | Phosphorylation | SDLPVPRTPGSGAGE CCCCCCCCCCCCCCH | 26.40 | 30576142 | |
1273 | Phosphorylation | PVPRTPGSGAGEKHK CCCCCCCCCCCHHCC | 27.03 | 23401153 | |
1280 | Sumoylation | SGAGEKHKEEPIDII CCCCHHCCCCCCCEE | 74.88 | - | |
1280 | Sumoylation | SGAGEKHKEEPIDII CCCCHHCCCCCCCEE | 74.88 | 28112733 | |
1296 | Phosphorylation | APSSRRFSEDSSTSK CCCCCCCCCCCCCCC | 38.39 | 25159151 | |
1299 | Phosphorylation | SRRFSEDSSTSKVMV CCCCCCCCCCCCEEC | 31.31 | 30108239 | |
1300 | Phosphorylation | RRFSEDSSTSKVMVP CCCCCCCCCCCEECC | 49.36 | 30108239 | |
1301 | Phosphorylation | RFSEDSSTSKVMVPP CCCCCCCCCCEECCC | 36.20 | 23927012 | |
1302 | Phosphorylation | FSEDSSTSKVMVPPV CCCCCCCCCEECCCC | 25.79 | 23927012 | |
1303 | Phosphorylation | SEDSSTSKVMVPPVT CCCCCCCCEECCCCC | 34.14 | 33259812 | |
1317 | Phosphorylation | TPDLPACSPASETGS CCCCCCCCCCCCCCC | 26.13 | 28348404 | |
1346 | Phosphorylation | SRAAISRTTSATPLK HHHHHHCCCCCCCCC | 20.50 | 23927012 | |
1347 | Phosphorylation | RAAISRTTSATPLKD HHHHHCCCCCCCCCC | 18.43 | 23927012 | |
1348 | Phosphorylation | AAISRTTSATPLKDN HHHHCCCCCCCCCCC | 29.54 | 23927012 | |
1350 | Phosphorylation | ISRTTSATPLKDNTQ HHCCCCCCCCCCCHH | 28.99 | 9205109 | |
1353 | Ubiquitination | TTSATPLKDNTQQFR CCCCCCCCCCHHHHH | 50.57 | - | |
1387 | Acetylation | RNSRPSSKNLTNSSI HHCCCCCCCCCCCCC | 61.38 | 7704263 | |
1397 | Acetylation | TNSSIPMKKKKIKKK CCCCCCCCHHHCCCC | 56.96 | 25953088 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
775 | S | Phosphorylation | Kinase | CDK2 | P24941 | Uniprot |
779 | S | Phosphorylation | Kinase | CDK2 | P24941 | Uniprot |
1100 | S | Phosphorylation | Kinase | CDK2 | P24941 | Uniprot |
1270 | T | Phosphorylation | Kinase | CDK2 | P24941 | Uniprot |
1350 | T | Phosphorylation | Kinase | CDK2 | P24941 | Uniprot |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NPAT_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
STIP1_HUMAN | STIP1 | physical | 12887926 | |
PO2F1_HUMAN | POU2F1 | physical | 12887926 | |
G3P_HUMAN | GAPDH | physical | 12887926 | |
TRRAP_HUMAN | TRRAP | physical | 17967892 | |
HINFP_HUMAN | HINFP | physical | 15988025 | |
CCNE1_HUMAN | CCNE1 | physical | 10995387 | |
CDK2_HUMAN | CDK2 | physical | 10995387 | |
CCNA1_HUMAN | CCNA1 | physical | 10995387 | |
HINFP_HUMAN | HINFP | physical | 22288532 | |
TRRAP_HUMAN | TRRAP | physical | 22288532 | |
SRBP2_HUMAN | SREBF2 | physical | 22288532 | |
CCNE1_HUMAN | CCNE1 | physical | 9472014 | |
CDK2_HUMAN | CDK2 | physical | 9472014 | |
H2B1_YEAST | HTB1 | physical | 22885324 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Acetylation | |
Reference | PubMed |
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1228, AND MASS SPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-554, AND MASSSPECTROMETRY. | |
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, AND MASSSPECTROMETRY. | |
"Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2in Cajal bodies promotes histone gene transcription."; Ma T., Van Tine B.A., Wei Y., Garrett M.D., Nelson D., Adams P.D.,Wang J., Qin J., Chow L.T., Harper J.W.; Genes Dev. 14:2298-2313(2000). Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CCNA1;CCNE1 AND CDK2, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-775;SER-779; SER-1100; THR-1270 AND THR-1350 BY CDK2, AND MUTAGENESIS OFSER-775; SER-779; SER-1100; THR-1270 AND THR-1350. |