NPAT_HUMAN - dbPTM
NPAT_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NPAT_HUMAN
UniProt AC Q14207
Protein Name Protein NPAT
Gene Name NPAT
Organism Homo sapiens (Human).
Sequence Length 1427
Subcellular Localization Nucleus. Nucleus, Cajal body. Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 spec
Protein Description Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters..
Protein Sequence MLLPSDVARLVLGYLQQENLISTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKTKETSNNVPAIMSSLWKKLDHTLSQIRSMQSSPRFAGSQRARTRTGIAEIKRQRKLASQTAPASAELLTLPYLSGQFTTPPSTGTQVTRPSGQISDPSRSYFVVVNHSQSQDTVTTGEALNVIPGAQEKKAHASLMSPGRRKSESQRKSTTLSGPHSTIRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNNIAQVPKQTDNNPTEPETSIDEFLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSISSQPMESNPSIVLADETNLAVKGSFETEESDGQSGQPAFCTSYQNDDPLNALKNSNNHDVLRQEDQENFSQISTSIQKKAFKTAVPTEQKCDIDITFESVPNLNDFNQRGNSNAECNPHCAELYTNQMSTETEMAIGIEKNSLSSNVPSESQLQPDQPDIPITSFVSLGCEANNENLILSGKSSQLLSQDTSLTGKPSKKSQFCENSNDTVKLKINFHGSKSSDSSEVHKSKIEINVLEPVMSQLSNCQDNSCLQSEILPVSVESSHLNVSGQVEIHLGDSLSSTKQPSNDSASVELNHTENEAQASKSENSQEPSSSVKEENTIFLSLGGNANCEKVALTPPEGTPVENSHSLPPESVCSSVGDSHPESQNTDDKPSSNNSAEIDASNIVSLKVIISDDPFVSSDTELTSAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAEVGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFSANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQGLRNKPCIGKQVNNLVDSSGHSVGCHAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKPCHRRVLCFDSTTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLKPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQSEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNVLSVGTAVKDLKQEQTKSASSLITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRASSRSTTKKRKIEELDERERNSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MLLPSDVARLVL
---CCCHHHHHHHHH
44.6929759185
53UbiquitinationFIPACLLSLFGKNLT
CHHHHHHHHHCCCHH
14.5421963094
57UbiquitinationCLLSLFGKNLTTILN
HHHHHHCCCHHHHHH
41.2622817900
61PhosphorylationLFGKNLTTILNEYVA
HHCCCHHHHHHHHHH
27.0023403867
72UbiquitinationEYVAMKTKETSNNVP
HHHHHHCCCCCCCHH
54.1729967540
87UbiquitinationAIMSSLWKKLDHTLS
HHHHHHHHHHHHHHH
49.0729967540
88AcetylationIMSSLWKKLDHTLSQ
HHHHHHHHHHHHHHH
47.797306245
88UbiquitinationIMSSLWKKLDHTLSQ
HHHHHHHHHHHHHHH
47.7929967540
98PhosphorylationHTLSQIRSMQSSPRF
HHHHHHHHCCCCCCC
23.8527174698
101PhosphorylationSQIRSMQSSPRFAGS
HHHHHCCCCCCCCCC
33.4027174698
102PhosphorylationQIRSMQSSPRFAGSQ
HHHHCCCCCCCCCCH
11.8227174698
108PhosphorylationSSPRFAGSQRARTRT
CCCCCCCCHHHHHHH
17.0527174698
113PhosphorylationAGSQRARTRTGIAEI
CCCHHHHHHHCHHHH
31.4320068231
115PhosphorylationSQRARTRTGIAEIKR
CHHHHHHHCHHHHHH
32.1220068231
121AcetylationRTGIAEIKRQRKLAS
HHCHHHHHHHHHHHH
33.7025953088
121UbiquitinationRTGIAEIKRQRKLAS
HHCHHHHHHHHHHHH
33.7021963094
125UbiquitinationAEIKRQRKLASQTAP
HHHHHHHHHHHCCCC
39.8122817900
139PhosphorylationPASAELLTLPYLSGQ
CCCHHHHHHCCCCCC
38.0126074081
142PhosphorylationAELLTLPYLSGQFTT
HHHHHHCCCCCCCCC
19.3326074081
144PhosphorylationLLTLPYLSGQFTTPP
HHHHCCCCCCCCCCC
25.3826074081
148PhosphorylationPYLSGQFTTPPSTGT
CCCCCCCCCCCCCCC
30.4226074081
149PhosphorylationYLSGQFTTPPSTGTQ
CCCCCCCCCCCCCCC
34.1926074081
152PhosphorylationGQFTTPPSTGTQVTR
CCCCCCCCCCCCEEC
40.4426074081
153PhosphorylationQFTTPPSTGTQVTRP
CCCCCCCCCCCEECC
50.4526074081
155PhosphorylationTTPPSTGTQVTRPSG
CCCCCCCCCEECCCC
21.6926074081
161PhosphorylationGTQVTRPSGQISDPS
CCCEECCCCCCCCCC
39.7917081983
165PhosphorylationTRPSGQISDPSRSYF
ECCCCCCCCCCCCEE
35.2622817900
168PhosphorylationSGQISDPSRSYFVVV
CCCCCCCCCCEEEEE
38.5617081983
174UbiquitinationPSRSYFVVVNHSQSQ
CCCCEEEEEECCCCC
2.2722817900
189UbiquitinationDTVTTGEALNVIPGA
CEECCCHHHCCCCCH
13.0422817900
194UbiquitinationGEALNVIPGAQEKKA
CHHHCCCCCHHHHHH
27.9922817900
200UbiquitinationIPGAQEKKAHASLMS
CCCHHHHHHHHHHCC
44.6529967540
204PhosphorylationQEKKAHASLMSPGRR
HHHHHHHHHCCCCCC
18.1028176443
207PhosphorylationKAHASLMSPGRRKSE
HHHHHHCCCCCCCCH
29.5123401153
218UbiquitinationRKSESQRKSTTLSGP
CCCHHHHHCCCCCCC
44.5129967540
219PhosphorylationKSESQRKSTTLSGPH
CCHHHHHCCCCCCCC
28.9028555341
220PhosphorylationSESQRKSTTLSGPHS
CHHHHHCCCCCCCCH
34.4920860994
227PhosphorylationTTLSGPHSTIRNFQD
CCCCCCCHHHCCCCC
28.76-
228PhosphorylationTLSGPHSTIRNFQDP
CCCCCCHHHCCCCCC
22.41-
242AcetylationPNAFAVEKQMVIENA
CCCCHHHHHHHHHHH
36.7823749302
242UbiquitinationPNAFAVEKQMVIENA
CCCCHHHHHHHHHHH
36.7821906983
252AcetylationVIENAREKILSNKSL
HHHHHHHHHHCCHHH
43.3125953088
257AcetylationREKILSNKSLQEKLA
HHHHHCCHHHHHHHH
49.5225953088
257UbiquitinationREKILSNKSLQEKLA
HHHHHCCHHHHHHHH
49.5222817900
262AcetylationSNKSLQEKLAENINK
CCHHHHHHHHHHHHH
39.7825953088
262UbiquitinationSNKSLQEKLAENINK
CCHHHHHHHHHHHHH
39.7821906983
269AcetylationKLAENINKFLTSDNN
HHHHHHHHHHHCCCC
37.6423749302
269UbiquitinationKLAENINKFLTSDNN
HHHHHHHHHHHCCCC
37.6429967540
337PhosphorylationDLFDYGKTKNNKNIS
HHHHHCCCCCCCCCC
34.3429978859
341AcetylationYGKTKNNKNISQSIS
HCCCCCCCCCCCCCC
66.1225953088
344PhosphorylationTKNNKNISQSISSQP
CCCCCCCCCCCCCCC
27.5429978859
346PhosphorylationNNKNISQSISSQPME
CCCCCCCCCCCCCCC
20.0429978859
348PhosphorylationKNISQSISSQPMESN
CCCCCCCCCCCCCCC
28.3229978859
349PhosphorylationNISQSISSQPMESNP
CCCCCCCCCCCCCCC
36.3129978859
354PhosphorylationISSQPMESNPSIVLA
CCCCCCCCCCCEEEE
48.0329978859
357PhosphorylationQPMESNPSIVLADET
CCCCCCCCEEEECCC
29.5829978859
364PhosphorylationSIVLADETNLAVKGS
CEEEECCCCEEEECE
35.7629978859
374PhosphorylationAVKGSFETEESDGQS
EEECEEECCCCCCCC
42.9425627689
377PhosphorylationGSFETEESDGQSGQP
CEEECCCCCCCCCCC
40.5925627689
381PhosphorylationTEESDGQSGQPAFCT
CCCCCCCCCCCEEEE
44.9528348404
388PhosphorylationSGQPAFCTSYQNDDP
CCCCEEEECCCCCCH
24.8228348404
389PhosphorylationGQPAFCTSYQNDDPL
CCCEEEECCCCCCHH
26.3828348404
400UbiquitinationDDPLNALKNSNNHDV
CCHHHHHHCCCCCHH
56.7929967540
421PhosphorylationENFSQISTSIQKKAF
HCHHHHHHHHHHHHH
31.32-
422PhosphorylationNFSQISTSIQKKAFK
CHHHHHHHHHHHHHH
19.0721815630
425AcetylationQISTSIQKKAFKTAV
HHHHHHHHHHHHCCC
44.3825953088
425UbiquitinationQISTSIQKKAFKTAV
HHHHHHHHHHHHCCC
44.3829967540
429AcetylationSIQKKAFKTAVPTEQ
HHHHHHHHCCCCCCC
40.2025953088
430PhosphorylationIQKKAFKTAVPTEQK
HHHHHHHCCCCCCCC
26.8321406692
434PhosphorylationAFKTAVPTEQKCDID
HHHCCCCCCCCCCEE
44.4421406692
530PhosphorylationNLILSGKSSQLLSQD
CEEECCCHHHHHCCC
27.1722210691
531PhosphorylationLILSGKSSQLLSQDT
EEECCCHHHHHCCCC
28.4722210691
535PhosphorylationGKSSQLLSQDTSLTG
CCHHHHHCCCCCCCC
34.3017525332
538PhosphorylationSQLLSQDTSLTGKPS
HHHHCCCCCCCCCCC
20.2823312004
539PhosphorylationQLLSQDTSLTGKPSK
HHHCCCCCCCCCCCC
32.0225159151
541PhosphorylationLSQDTSLTGKPSKKS
HCCCCCCCCCCCCHH
42.8225159151
543AcetylationQDTSLTGKPSKKSQF
CCCCCCCCCCCHHHH
40.6625953088
545PhosphorylationTSLTGKPSKKSQFCE
CCCCCCCCCHHHHCC
57.0922210691
546AcetylationSLTGKPSKKSQFCEN
CCCCCCCCHHHHCCC
66.0425953088
547UbiquitinationLTGKPSKKSQFCENS
CCCCCCCHHHHCCCC
54.55-
548PhosphorylationTGKPSKKSQFCENSN
CCCCCCHHHHCCCCC
32.0226552605
554PhosphorylationKSQFCENSNDTVKLK
HHHHCCCCCCEEEEE
17.5023401153
557PhosphorylationFCENSNDTVKLKINF
HCCCCCCEEEEEEEE
24.6423898821
559AcetylationENSNDTVKLKINFHG
CCCCCEEEEEEEECC
46.2725953088
567PhosphorylationLKINFHGSKSSDSSE
EEEEECCCCCCCCCH
22.3127251275
568UbiquitinationKINFHGSKSSDSSEV
EEEECCCCCCCCCHH
59.5829967540
573PhosphorylationGSKSSDSSEVHKSKI
CCCCCCCCHHHHHHE
48.94-
599PhosphorylationLSNCQDNSCLQSEIL
HHCCCCCCCCCCCEE
25.21-
659PhosphorylationQASKSENSQEPSSSV
HHHHCCCCCCCCCCC
31.6928985074
688PhosphorylationNCEKVALTPPEGTPV
CEEEEEECCCCCCCC
27.3626074081
693PhosphorylationALTPPEGTPVENSHS
EECCCCCCCCCCCCC
23.6226074081
698PhosphorylationEGTPVENSHSLPPES
CCCCCCCCCCCCCHH
10.8426074081
700PhosphorylationTPVENSHSLPPESVC
CCCCCCCCCCCHHHH
42.2526074081
745PhosphorylationVSLKVIISDDPFVSS
EEEEEEECCCCCCCC
25.4920873877
751PhosphorylationISDDPFVSSDTELTS
ECCCCCCCCCHHHHH
23.9120873877
752PhosphorylationSDDPFVSSDTELTSA
CCCCCCCCCHHHHHH
43.1620873877
754PhosphorylationDPFVSSDTELTSAVS
CCCCCCCHHHHHHHH
34.5420873877
757PhosphorylationVSSDTELTSAVSSIN
CCCCHHHHHHHHHCC
14.3820873877
758PhosphorylationSSDTELTSAVSSING
CCCHHHHHHHHHCCC
39.0220873877
761PhosphorylationTELTSAVSSINGENL
HHHHHHHHHCCCCCC
25.8028450419
762PhosphorylationELTSAVSSINGENLP
HHHHHHHHCCCCCCC
17.3028450419
770PhosphorylationINGENLPTIILSSPT
CCCCCCCEEEECCCC
24.6628450419
774PhosphorylationNLPTIILSSPTKSPT
CCCEEEECCCCCCCC
24.7030278072
775PhosphorylationLPTIILSSPTKSPTK
CCEEEECCCCCCCCC
32.8930278072
777PhosphorylationTIILSSPTKSPTKNA
EEEECCCCCCCCCCC
46.2125159151
779PhosphorylationILSSPTKSPTKNAEL
EECCCCCCCCCCCHH
40.0422115753
781PhosphorylationSSPTKSPTKNAELVK
CCCCCCCCCCCHHHH
43.9828387310
908PhosphorylationPLPPQLQTPPRSNSV
CCCCCCCCCCCCCCE
43.8026074081
914PhosphorylationQTPPRSNSVFAVNQA
CCCCCCCCEEEEEEE
21.6226074081
952PhosphorylationMVGMIPVSVVGQNGN
CCCCEEEEEECCCCC
13.0126074081
962PhosphorylationGQNGNNFSTPPRQVL
CCCCCCCCCCCHHEE
41.9726074081
963PhosphorylationQNGNNFSTPPRQVLH
CCCCCCCCCCHHEEE
32.9226074081
993UbiquitinationPVPPKSQKAQGLRNK
CCCCHHHCCCCCCCC
50.1729967540
1000AcetylationKAQGLRNKPCIGKQV
CCCCCCCCCCCHHHH
34.5326051181
1005AcetylationRNKPCIGKQVNNLVD
CCCCCCHHHHHHHHH
31.0326051181
1024AcetylationSVGCHAQKTEVSDKS
CCCCCCCCCCCCCHH
47.6525953088
1030AcetylationQKTEVSDKSIATDLG
CCCCCCCHHHHHHCC
35.9325953088
1030UbiquitinationQKTEVSDKSIATDLG
CCCCCCCHHHHHHCC
35.9329967540
1031PhosphorylationKTEVSDKSIATDLGK
CCCCCCHHHHHHCCC
23.5722210691
1034PhosphorylationVSDKSIATDLGKKSE
CCCHHHHHHCCCCCC
30.0420068231
1038UbiquitinationSIATDLGKKSEETTV
HHHHHCCCCCCCCCC
61.4929967540
1039UbiquitinationIATDLGKKSEETTVP
HHHHCCCCCCCCCCC
62.3929967540
1057AcetylationESIVPAAKPCHRRVL
HHCCCCCCCCCCEEE
50.7325953088
1082AcetylationNTQGPNHKMVSQNKE
CCCCCCCCCCCCCCC
47.8725953088
1094PhosphorylationNKERNAVSFPNLDSP
CCCCCCCCCCCCCCC
32.35-
1100PhosphorylationVSFPNLDSPNVSSTL
CCCCCCCCCCCCCCC
22.8825159151
1108AcetylationPNVSSTLKPPSNNAI
CCCCCCCCCCCCCCC
55.7825953088
1116AcetylationPPSNNAIKREKEKPP
CCCCCCCHHHCCCCC
52.6925953088
1116SumoylationPPSNNAIKREKEKPP
CCCCCCCHHHCCCCC
52.6928112733
1129PhosphorylationPPLPKILSKSESAIS
CCCCHHHCCCHHHHH
37.2925262027
1130AcetylationPLPKILSKSESAISR
CCCHHHCCCHHHHHH
55.5925953088
1130UbiquitinationPLPKILSKSESAISR
CCCHHHCCCHHHHHH
55.5929967540
1131PhosphorylationLPKILSKSESAISRH
CCHHHCCCHHHHHHC
33.1525262027
1133PhosphorylationKILSKSESAISRHTT
HHHCCCHHHHHHCCC
37.6825262027
1136PhosphorylationSKSESAISRHTTIRE
CCCHHHHHHCCCHHH
20.0925262027
1137UbiquitinationKSESAISRHTTIRET
CCHHHHHHCCCHHHC
25.6729967540
1139PhosphorylationESAISRHTTIRETQS
HHHHHHCCCHHHCCC
23.8629083192
1140PhosphorylationSAISRHTTIRETQSE
HHHHHCCCHHHCCCC
16.3529083192
1144PhosphorylationRHTTIRETQSEKKVS
HCCCHHHCCCCCCCC
27.7830624053
1146PhosphorylationTTIRETQSEKKVSPT
CCHHHCCCCCCCCHH
59.8223312004
1149SumoylationRETQSEKKVSPTEIV
HHCCCCCCCCHHHHH
43.84-
1149SumoylationRETQSEKKVSPTEIV
HHCCCCCCCCHHHHH
43.8428112733
1151PhosphorylationTQSEKKVSPTEIVLE
CCCCCCCCHHHHHHH
34.6829255136
1153PhosphorylationSEKKVSPTEIVLESF
CCCCCCHHHHHHHHH
30.7329255136
1158PhosphorylationSPTEIVLESFHKATA
CHHHHHHHHHHHHHC
40.2332142685
1159PhosphorylationPTEIVLESFHKATAN
HHHHHHHHHHHHHCC
28.6123927012
1167AcetylationFHKATANKENELCSD
HHHHHCCCCCCCCHH
60.4926051181
1173PhosphorylationNKENELCSDVERQKN
CCCCCCCHHHHHHHC
58.2625159151
1185AcetylationQKNPENSKLSIGQQN
HHCCCCCCCCCCCCC
58.8125953088
1199AcetylationNGGLRSEKSIASLQE
CCCCCCHHHHHHHHH
48.7023749302
1200PhosphorylationGGLRSEKSIASLQEM
CCCCCHHHHHHHHHH
21.2421406692
1203PhosphorylationRSEKSIASLQEMTKK
CCHHHHHHHHHHHHH
28.9921406692
1208PhosphorylationIASLQEMTKKQGTSS
HHHHHHHHHHCCCCC
34.0521406692
1213PhosphorylationEMTKKQGTSSNNKNV
HHHHHCCCCCCCCCE
26.8729759185
1214PhosphorylationMTKKQGTSSNNKNVL
HHHHCCCCCCCCCEE
37.5820058876
1215PhosphorylationTKKQGTSSNNKNVLS
HHHCCCCCCCCCEEE
44.23-
1222PhosphorylationSNNKNVLSVGTAVKD
CCCCCEEEHHHHHHH
17.7628555341
1225PhosphorylationKNVLSVGTAVKDLKQ
CCEEEHHHHHHHHHH
26.5625599653
1228AcetylationLSVGTAVKDLKQEQT
EEHHHHHHHHHHHHH
55.6819608861
1231SumoylationGTAVKDLKQEQTKSA
HHHHHHHHHHHHCCH
63.02-
1231SumoylationGTAVKDLKQEQTKSA
HHHHHHHHHHHHCCH
63.02-
1235PhosphorylationKDLKQEQTKSASSLI
HHHHHHHHCCHHHHH
26.6428102081
1239PhosphorylationQEQTKSASSLITTEM
HHHHCCHHHHHHHHH
32.5430576142
1243PhosphorylationKSASSLITTEMLQDI
CCHHHHHHHHHHHHH
23.2330576142
1244PhosphorylationSASSLITTEMLQDIQ
CHHHHHHHHHHHHHH
16.6530576142
1254PhosphorylationLQDIQRHSSVSRLAD
HHHHHHHHCHHHHCC
34.32-
1255PhosphorylationQDIQRHSSVSRLADS
HHHHHHHCHHHHCCC
20.2730576142
1262PhosphorylationSVSRLADSSDLPVPR
CHHHHCCCCCCCCCC
21.83-
1263PhosphorylationVSRLADSSDLPVPRT
HHHHCCCCCCCCCCC
43.65-
1270PhosphorylationSDLPVPRTPGSGAGE
CCCCCCCCCCCCCCH
26.4030576142
1273PhosphorylationPVPRTPGSGAGEKHK
CCCCCCCCCCCHHCC
27.0323401153
1280SumoylationSGAGEKHKEEPIDII
CCCCHHCCCCCCCEE
74.88-
1280SumoylationSGAGEKHKEEPIDII
CCCCHHCCCCCCCEE
74.8828112733
1296PhosphorylationAPSSRRFSEDSSTSK
CCCCCCCCCCCCCCC
38.3925159151
1299PhosphorylationSRRFSEDSSTSKVMV
CCCCCCCCCCCCEEC
31.3130108239
1300PhosphorylationRRFSEDSSTSKVMVP
CCCCCCCCCCCEECC
49.3630108239
1301PhosphorylationRFSEDSSTSKVMVPP
CCCCCCCCCCEECCC
36.2023927012
1302PhosphorylationFSEDSSTSKVMVPPV
CCCCCCCCCEECCCC
25.7923927012
1303PhosphorylationSEDSSTSKVMVPPVT
CCCCCCCCEECCCCC
34.1433259812
1317PhosphorylationTPDLPACSPASETGS
CCCCCCCCCCCCCCC
26.1328348404
1346PhosphorylationSRAAISRTTSATPLK
HHHHHHCCCCCCCCC
20.5023927012
1347PhosphorylationRAAISRTTSATPLKD
HHHHHCCCCCCCCCC
18.4323927012
1348PhosphorylationAAISRTTSATPLKDN
HHHHCCCCCCCCCCC
29.5423927012
1350PhosphorylationISRTTSATPLKDNTQ
HHCCCCCCCCCCCHH
28.999205109
1353UbiquitinationTTSATPLKDNTQQFR
CCCCCCCCCCHHHHH
50.57-
1387AcetylationRNSRPSSKNLTNSSI
HHCCCCCCCCCCCCC
61.387704263
1397AcetylationTNSSIPMKKKKIKKK
CCCCCCCCHHHCCCC
56.9625953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
775SPhosphorylationKinaseCDK2P24941
Uniprot
779SPhosphorylationKinaseCDK2P24941
Uniprot
1100SPhosphorylationKinaseCDK2P24941
Uniprot
1270TPhosphorylationKinaseCDK2P24941
Uniprot
1350TPhosphorylationKinaseCDK2P24941
Uniprot

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
775SPhosphorylation

10995387
779SPhosphorylation

10995387
1100SPhosphorylation

10995387
1270TPhosphorylation

10995387
1350TPhosphorylation

10995387

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NPAT_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STIP1_HUMANSTIP1physical
12887926
PO2F1_HUMANPOU2F1physical
12887926
G3P_HUMANGAPDHphysical
12887926
TRRAP_HUMANTRRAPphysical
17967892
HINFP_HUMANHINFPphysical
15988025
CCNE1_HUMANCCNE1physical
10995387
CDK2_HUMANCDK2physical
10995387
CCNA1_HUMANCCNA1physical
10995387
HINFP_HUMANHINFPphysical
22288532
TRRAP_HUMANTRRAPphysical
22288532
SRBP2_HUMANSREBF2physical
22288532
CCNE1_HUMANCCNE1physical
9472014
CDK2_HUMANCDK2physical
9472014
H2B1_YEASTHTB1physical
22885324

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NPAT_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1228, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-554, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, AND MASSSPECTROMETRY.
"Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2in Cajal bodies promotes histone gene transcription.";
Ma T., Van Tine B.A., Wei Y., Garrett M.D., Nelson D., Adams P.D.,Wang J., Qin J., Chow L.T., Harper J.W.;
Genes Dev. 14:2298-2313(2000).
Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CCNA1;CCNE1 AND CDK2, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-775;SER-779; SER-1100; THR-1270 AND THR-1350 BY CDK2, AND MUTAGENESIS OFSER-775; SER-779; SER-1100; THR-1270 AND THR-1350.

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