NIPBL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NIPBL_HUMAN
• UniProt AC: Q6KC79
• Protein Name: Nipped-B-like protein
• Gene Name: NIPBL
• Organism: Homo sapiens (Human).
• Sequence Length: 2804
• Subcellular Localization: Nucleus . Chromosome .
• Protein Description: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. [PubMed: 22628566]
• Protein Sequence: MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTAVFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAAKDGTSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	ELKDNLGSDDPEGDI EEHHCCCCCCCCCCH	41.84	28348404
103	Phosphorylation	LQAVLARSPNVFREK HHHHHHCCCCCHHCH	18.41	25159151
111	Phosphorylation	PNVFREKSMQNRYVQ CCCHHCHHHHCHHHH	22.35	29978859
116	Phosphorylation	EKSMQNRYVQSGMMM CHHHHCHHHHHHHHH	15.47	29978859
119	Phosphorylation	MQNRYVQSGMMMSQY HHCHHHHHHHHHHHH	20.72	29978859
124	Phosphorylation	VQSGMMMSQYKLSQN HHHHHHHHHHHCCCC	16.68	29978859
126	Phosphorylation	SGMMMSQYKLSQNSM HHHHHHHHHCCCCCC	13.44	29978859
129	Phosphorylation	MMSQYKLSQNSMHSS HHHHHHCCCCCCCCC	24.14	28450419
132	Phosphorylation	QYKLSQNSMHSSPAS HHHCCCCCCCCCCCC	15.38	28450419
135	Phosphorylation	LSQNSMHSSPASSNY CCCCCCCCCCCCCCC	29.40	25159151
136	Phosphorylation	SQNSMHSSPASSNYQ CCCCCCCCCCCCCCC	15.14	23927012
136 (in isoform 2)	Phosphorylation	-	15.14	18669648
139	Phosphorylation	SMHSSPASSNYQQTT CCCCCCCCCCCCCCC	23.62	23927012
139 (in isoform 2)	Phosphorylation	-	23.62	18669648
140	O-linked_Glycosylation	MHSSPASSNYQQTTI CCCCCCCCCCCCCCC	41.48	30059200
140	Phosphorylation	MHSSPASSNYQQTTI CCCCCCCCCCCCCCC	41.48	23927012
142	Phosphorylation	SSPASSNYQQTTISH CCCCCCCCCCCCCCC	12.16	23927012
145	Phosphorylation	ASSNYQQTTISHSPS CCCCCCCCCCCCCCC	15.57	23927012
146	O-linked_Glycosylation	SSNYQQTTISHSPSS CCCCCCCCCCCCCCC	19.02	30059200
146	Phosphorylation	SSNYQQTTISHSPSS CCCCCCCCCCCCCCC	19.02	23927012
148	O-linked_Glycosylation	NYQQTTISHSPSSRF CCCCCCCCCCCCCCC	18.80	30059200
148	Phosphorylation	NYQQTTISHSPSSRF CCCCCCCCCCCCCCC	18.80	23401153
150	Phosphorylation	QQTTISHSPSSRFVP CCCCCCCCCCCCCCC	21.49	23401153
150 (in isoform 2)	Phosphorylation	-	21.49	18669648
152	Phosphorylation	TTISHSPSSRFVPPQ CCCCCCCCCCCCCCC	36.84	23927012
153	Phosphorylation	TISHSPSSRFVPPQT CCCCCCCCCCCCCCC	32.87	23927012
154	Methylation	ISHSPSSRFVPPQTS CCCCCCCCCCCCCCC	40.70	115387105
160	O-linked_Glycosylation	SRFVPPQTSSGNRFM CCCCCCCCCCCCCCC	30.54	30059200
160	Phosphorylation	SRFVPPQTSSGNRFM CCCCCCCCCCCCCCC	30.54	21815630
161	O-linked_Glycosylation	RFVPPQTSSGNRFMP CCCCCCCCCCCCCCC	30.88	30059200
161	Phosphorylation	RFVPPQTSSGNRFMP CCCCCCCCCCCCCCC	30.88	20068231
162	O-linked_Glycosylation	FVPPQTSSGNRFMPQ CCCCCCCCCCCCCCC	43.40	30059200
162	Phosphorylation	FVPPQTSSGNRFMPQ CCCCCCCCCCCCCCC	43.40	25159151
162 (in isoform 2)	Phosphorylation	-	43.40	18669648
165	Methylation	PQTSSGNRFMPQQNS CCCCCCCCCCCCCCC	32.53	115485025
172	Phosphorylation	RFMPQQNSPVPSPYA CCCCCCCCCCCCCCC	23.96	18669648
172 (in isoform 2)	Phosphorylation	-	23.96	18669648
182	Phosphorylation	PSPYAPQSPAGYMPY CCCCCCCCCCCCCCC	18.69	18669648
182 (in isoform 2)	Phosphorylation	-	18.69	18669648
207	Phosphorylation	QMQQASVSSPIVAGG HHHHCCCCCCEEECC	28.09	26074081
208	O-linked_Glycosylation	MQQASVSSPIVAGGL HHHCCCCCCEEECCC	19.25	30059200
208	Phosphorylation	MQQASVSSPIVAGGL HHHCCCCCCEEECCC	19.25	18669648
208 (in isoform 2)	Phosphorylation	-	19.25	18669648
222	Ubiquitination	LRNIHDNKVSGPLSG CCCCCCCCCCCCCCC	43.78	-
224	Phosphorylation	NIHDNKVSGPLSGNS CCCCCCCCCCCCCCC	35.98	25002506
228	Phosphorylation	NKVSGPLSGNSANHH CCCCCCCCCCCCCCC	38.78	25159151
231	Phosphorylation	SGPLSGNSANHHADN CCCCCCCCCCCCCCC	33.69	25159151
243	Phosphorylation	ADNPRHGSSEDYLHM CCCCCCCCHHHHHHH	25.16	30108239
244	Phosphorylation	DNPRHGSSEDYLHMV CCCCCCCHHHHHHHH	38.79	30108239
247	Phosphorylation	RHGSSEDYLHMVHRL CCCCHHHHHHHHHHH	8.41	30108239
255	Phosphorylation	LHMVHRLSSDDGDSS HHHHHHHCCCCCCCH	31.51	23898821
256	Phosphorylation	HMVHRLSSDDGDSST HHHHHHCCCCCCCHH	44.29	23911959
256 (in isoform 2)	Phosphorylation	-	44.29	18669648
261	Phosphorylation	LSSDDGDSSTMRNAA HCCCCCCCHHHHCHH	32.98	28450419
262	Phosphorylation	SSDDGDSSTMRNAAS CCCCCCCHHHHCHHC	30.84	28450419
263	Phosphorylation	SDDGDSSTMRNAASF CCCCCCHHHHCHHCC	24.89	28450419
269	Phosphorylation	STMRNAASFPLRSPQ HHHHCHHCCCCCCCC	25.61	25159151
273	Methylation	NAASFPLRSPQPVCS CHHCCCCCCCCCCCC	46.67	115485033
274	Phosphorylation	AASFPLRSPQPVCSP HHCCCCCCCCCCCCC	35.25	29255136
274 (in isoform 2)	Phosphorylation	-	35.25	18669648
280	Phosphorylation	RSPQPVCSPAGSEGT CCCCCCCCCCCCCCC	20.30	29255136
280 (in isoform 2)	Phosphorylation	-	20.30	18669648
284	Phosphorylation	PVCSPAGSEGTPKGS CCCCCCCCCCCCCCC	34.65	29255136
284 (in isoform 2)	Phosphorylation	-	34.65	18669648
287	Phosphorylation	SPAGSEGTPKGSRPP CCCCCCCCCCCCCCC	20.13	23401153
287 (in isoform 2)	Phosphorylation	-	20.13	18669648
289	Acetylation	AGSEGTPKGSRPPLI CCCCCCCCCCCCCEE	70.16	26051181
291	Phosphorylation	SEGTPKGSRPPLILQ CCCCCCCCCCCEEEE	47.98	23927012
299	Phosphorylation	RPPLILQSQSLPCSS CCCEEEECCCCCCCC	20.49	23927012
301	Phosphorylation	PLILQSQSLPCSSPR CEEEECCCCCCCCCC	39.25	23927012
305	Phosphorylation	QSQSLPCSSPRDVPP ECCCCCCCCCCCCCC	41.24	22167270
305 (in isoform 2)	Phosphorylation	-	41.24	18669648
306	Phosphorylation	SQSLPCSSPRDVPPD CCCCCCCCCCCCCCC	30.58	22167270
306 (in isoform 2)	Phosphorylation	-	30.58	18669648
318	Phosphorylation	PPDILLDSPERKQKK CCCCCCCCHHHHHHH	28.73	19664994
318 (in isoform 2)	Phosphorylation	-	28.73	18669648
328	Acetylation	RKQKKQKKMKLGKDE HHHHHHHHHCCCCCH	38.48	21466224
330	Acetylation	QKKQKKMKLGKDEKE HHHHHHHCCCCCHHH	64.07	21466224
333	Acetylation	QKKMKLGKDEKEQSE HHHHCCCCCHHHHHH	73.48	26051181
345	Phosphorylation	QSEKAAMYDIISSPS HHHHHHHHHHHHCCC	10.16	21945579
349	Phosphorylation	AAMYDIISSPSKDST HHHHHHHHCCCCCCC	36.21	29255136
350	Phosphorylation	AMYDIISSPSKDSTK HHHHHHHCCCCCCCH	23.84	29255136
350 (in isoform 2)	Phosphorylation	-	23.84	18669648
352	Phosphorylation	YDIISSPSKDSTKLT HHHHHCCCCCCCHHE	51.55	29255136
355	Phosphorylation	ISSPSKDSTKLTLRL HHCCCCCCCHHEEEH	31.04	30266825
356	Phosphorylation	SSPSKDSTKLTLRLS HCCCCCCCHHEEEHH	39.96	30266825
357	Ubiquitination	SPSKDSTKLTLRLSR CCCCCCCHHEEEHHH	43.35	-
359	Phosphorylation	SKDSTKLTLRLSRVR CCCCCHHEEEHHHHH	16.04	23312004
363	Phosphorylation	TKLTLRLSRVRSSDM CHHEEEHHHHHCCCC	23.46	28102081
367	Phosphorylation	LRLSRVRSSDMDQQE EEHHHHHCCCCCHHH	28.03	23898821
367 (in isoform 2)	Phosphorylation	-	28.03	18669648
368	Phosphorylation	RLSRVRSSDMDQQED EHHHHHCCCCCHHHH	26.79	28348404
378	Phosphorylation	DQQEDMISGVENSNV CHHHHHHHCCCCCCC	30.10	17081983
383	Phosphorylation	MISGVENSNVSENDI HHHCCCCCCCCCCCC	25.71	29978859
386	Phosphorylation	GVENSNVSENDIPFN CCCCCCCCCCCCCCC	34.63	29978859
396	Phosphorylation	DIPFNVQYPGQTSKT CCCCCEECCCCCCCC	12.68	27080861
400	Phosphorylation	NVQYPGQTSKTPITP CEECCCCCCCCCCCH	37.80	27080861
401	Phosphorylation	VQYPGQTSKTPITPQ EECCCCCCCCCCCHH	27.01	23090842
403	Phosphorylation	YPGQTSKTPITPQDI CCCCCCCCCCCHHHC	21.49	26074081
406	Phosphorylation	QTSKTPITPQDINRP CCCCCCCCHHHCCCC	18.99	26074081
421	Phosphorylation	LNAAQCLSQQEQTAF CCHHHHCCHHHHHHC	37.13	29496963
426	Phosphorylation	CLSQQEQTAFLPANQ HCCHHHHHHCCCHHH	20.72	28464451
466	Phosphorylation	ISQQGPIYDEVELDA HHHCCCCCCHHHHHH	14.80	27642862
498	Acetylation	FSKEVQDKDKPLKKR HHHHHCCCCCCCHHH	51.03	25953088
500	Acetylation	KEVQDKDKPLKKRKQ HHHCCCCCCCHHHCC	58.97	23749302
518	Phosphorylation	PQEAGGATGGNRPAS CCCCCCCCCCCCCCC	49.23	23663014
525	Phosphorylation	TGGNRPASQETGSTG CCCCCCCCCCCCCCC	31.09	23663014
528	Phosphorylation	NRPASQETGSTGNGS CCCCCCCCCCCCCCC	28.88	23663014
530	Phosphorylation	PASQETGSTGNGSRP CCCCCCCCCCCCCCC	40.33	23663014
531	Phosphorylation	ASQETGSTGNGSRPA CCCCCCCCCCCCCCE	35.69	23663014
535	Phosphorylation	TGSTGNGSRPALMVS CCCCCCCCCCEEEEE	38.81	27794612
542	Phosphorylation	SRPALMVSIDLHQAG CCCEEEEEEEHHHCC	9.09	30576142
553	Phosphorylation	HQAGRVDSQASITQD HHCCCCCCCCCCCCC	25.45	20164059
556	Phosphorylation	GRVDSQASITQDSDS CCCCCCCCCCCCCCC	20.66	20164059
558	Phosphorylation	VDSQASITQDSDSIK CCCCCCCCCCCCCCC	24.67	30576142
561	Phosphorylation	QASITQDSDSIKKPE CCCCCCCCCCCCCHH	24.36	20068231
563	Phosphorylation	SITQDSDSIKKPEEI CCCCCCCCCCCHHHH	40.01	20860994
579	Phosphorylation	QCNDAPVSVLQEDIV CCCCCCCHHHHHHHH	18.95	29449344
588	Phosphorylation	LQEDIVGSLKSTPEN HHHHHHHCCCCCCCC	23.02	28450419
591	Phosphorylation	DIVGSLKSTPENHPE HHHHCCCCCCCCCCC	55.26	25159151
592	Phosphorylation	IVGSLKSTPENHPET HHHCCCCCCCCCCCC	32.79	25159151
599	Phosphorylation	TPENHPETPKKKSDP CCCCCCCCCCCCCCC	44.88	23401153
604	Phosphorylation	PETPKKKSDPELSKS CCCCCCCCCCCCCHH	68.24	24850871
609	Phosphorylation	KKSDPELSKSEMKQS CCCCCCCCHHHHHHH	32.26	20058876
610	Acetylation	KSDPELSKSEMKQSE CCCCCCCHHHHHHHH	64.16	25953088
611	Phosphorylation	SDPELSKSEMKQSES CCCCCCHHHHHHHHH	39.28	29449344
616	Phosphorylation	SKSEMKQSESRLAES CHHHHHHHHHHHHHC	31.83	20058876
624	Acetylation	ESRLAESKPNENRLV HHHHHHCCCCCCCCE	43.28	26051181
646	Phosphorylation	KLETKVETQTEELKQ HHCHHHHHHHHHHHH	43.72	17525332
648	Phosphorylation	ETKVETQTEELKQNE CHHHHHHHHHHHHHH	38.56	29214152
666	Phosphorylation	TECKQNESTIVEPKQ CCHHCCCCCCCCCCC	30.86	28509920
667	Phosphorylation	ECKQNESTIVEPKQN CHHCCCCCCCCCCCC	23.90	28509920
679	Phosphorylation	KQNENRLSDTKPNDN CCCCCCCCCCCCCCC	39.74	24961811
681	Phosphorylation	NENRLSDTKPNDNKQ CCCCCCCCCCCCCCC	45.05	28102081
682	Acetylation	ENRLSDTKPNDNKQN CCCCCCCCCCCCCCC	46.98	26051181
698	Phosphorylation	GRSETTKSRPETPKQ CCCCCCCCCCCCCCC	51.48	27794612
702	Phosphorylation	TTKSRPETPKQKGES CCCCCCCCCCCCCCC	38.17	26074081
706	Acetylation	RPETPKQKGESRPET CCCCCCCCCCCCCCC	71.43	20167786
709	Phosphorylation	TPKQKGESRPETPKQ CCCCCCCCCCCCCCC	62.90	23401153
713	Phosphorylation	KGESRPETPKQKSDG CCCCCCCCCCCCCCC	38.17	30266825
724	Phosphorylation	KSDGHPETPKQKGDG CCCCCCCCCCCCCCC	39.99	27273156
735	Phosphorylation	KGDGRPETPKQKGES CCCCCCCCCCCCCCC	38.17	30266825
739	Acetylation	RPETPKQKGESRPET CCCCCCCCCCCCCCC	71.43	-
742	Phosphorylation	TPKQKGESRPETPKQ CCCCCCCCCCCCCCC	62.90	23401153
746	Phosphorylation	KGESRPETPKQKNEG CCCCCCCCCCCCCCC	38.17	30266825
757	Phosphorylation	KNEGRPETPKHRHDN CCCCCCCCCCCCCCC	40.08	25159151
768	Phosphorylation	RHDNRRDSGKPSTEK CCCCCCCCCCCCCCC	47.07	26657352
770	Acetylation	DNRRDSGKPSTEKKP CCCCCCCCCCCCCCC	39.48	26051181
772	Phosphorylation	RRDSGKPSTEKKPEV CCCCCCCCCCCCCCH	53.32	25159151
773	Phosphorylation	RDSGKPSTEKKPEVS CCCCCCCCCCCCCHH	61.42	29496963
775	Acetylation	SGKPSTEKKPEVSKH CCCCCCCCCCCHHHC	73.96	26051181
788	Phosphorylation	KHKQDTKSDSPRLKS HCCCCCCCCCHHHHH	45.47	21406692
790	Phosphorylation	KQDTKSDSPRLKSER CCCCCCCCHHHHHHH	21.00	30576142
809	Phosphorylation	KQRPDGRSVSESLRR HHCCCCCCHHHHHHH	35.21	23312004
811	Phosphorylation	RPDGRSVSESLRRDH CCCCCCHHHHHHHCC	23.78	25159151
813	Phosphorylation	DGRSVSESLRRDHDN CCCCHHHHHHHCCCC	21.48	23312004
845	Phosphorylation	SRVRRPETLRSSSRN HHCCCHHHHHCCCCC	30.10	24719451
848	Phosphorylation	RRPETLRSSSRNEHG CCHHHHHCCCCCCCC	35.46	28857561
849	Phosphorylation	RPETLRSSSRNEHGI CHHHHHCCCCCCCCC	27.21	26657352
850	Phosphorylation	PETLRSSSRNEHGIK HHHHHCCCCCCCCCC	40.13	28857561
862	Acetylation	GIKSDSSKTDKLERK CCCCCCCCHHHHHHH	65.77	19809903
874	Phosphorylation	ERKHRHESGDSRERP HHHHCCCCCCCCCCC	41.60	26055452
877	Phosphorylation	HRHESGDSRERPSSG HCCCCCCCCCCCCCC	39.30	20873877
882	Phosphorylation	GDSRERPSSGEQKSR CCCCCCCCCCCCCCC	58.14	20873877
883	Phosphorylation	DSRERPSSGEQKSRP CCCCCCCCCCCCCCC	49.37	20873877
888	Phosphorylation	PSSGEQKSRPDSPRV CCCCCCCCCCCCCCC	49.06	29396449
892	Phosphorylation	EQKSRPDSPRVKQGD CCCCCCCCCCCCCCC	19.79	25159151
907	Acetylation	SNKSRSDKLGFKSPT CCCCHHHCCCCCCCC	52.32	25953088
911	Acetylation	RSDKLGFKSPTSKDD HHHCCCCCCCCCCCC	54.44	25953088
912	Phosphorylation	SDKLGFKSPTSKDDK HHCCCCCCCCCCCCC	31.02	25159151
912 (in isoform 2)	Phosphorylation	-	31.02	18669648
914	Phosphorylation	KLGFKSPTSKDDKRT CCCCCCCCCCCCCCC	56.34	21712546
915	Phosphorylation	LGFKSPTSKDDKRTE CCCCCCCCCCCCCCC	37.15	24732914
950	Phosphorylation	SYLLGGRSGALKNFV HHHCCCCCCHHHCCC	31.52	28555341
954	Methylation	GGRSGALKNFVIPKI CCCCCHHHCCCCCCE	48.05	-
965	Acetylation	IPKIKRDKDGNVTQE CCCEECCCCCCCCHH	72.13	25953088
970	Phosphorylation	RDKDGNVTQETKKME CCCCCCCCHHHHHHH	25.37	29978859
973	Phosphorylation	DGNVTQETKKMEMKG CCCCCHHHHHHHCCC	26.58	29978859
997	Acetylation	GLVEDLNKGAKPVVV CHHHHHCCCCCCEEE	68.49	26051181
1000	Acetylation	EDLNKGAKPVVVLQK HHHCCCCCCEEEEEE	47.19	26051181
1000	Ubiquitination	EDLNKGAKPVVVLQK HHHCCCCCCEEEEEE	47.19	-
1007	Acetylation	KPVVVLQKLSLDDVQ CCEEEEEECCHHHHH	35.56	7266313
1009	Phosphorylation	VVVLQKLSLDDVQKL EEEEEECCHHHHHHH	36.47	-
1026	Phosphorylation	DREDKSRSSLKPIKN CCCHHCCCCCCCCCC	47.30	22210691
1029	Acetylation	DKSRSSLKPIKNKPS HHCCCCCCCCCCCCC	46.79	23749302
1038	Phosphorylation	IKNKPSKSNKGSIDQ CCCCCCCCCCCCCCH	48.38	29214152
1040	Ubiquitination	NKPSKSNKGSIDQSV CCCCCCCCCCCCHHH	62.21	-
1042	Phosphorylation	PSKSNKGSIDQSVLK CCCCCCCCCCHHHHH	25.30	25159151
1046	Phosphorylation	NKGSIDQSVLKELPP CCCCCCHHHHHHCCH	26.18	30108239
1077	Phosphorylation	KMNKRKRSTVNEKPK HCCCCCCCCCCCCCC	39.48	26657352
1078	Phosphorylation	MNKRKRSTVNEKPKY CCCCCCCCCCCCCCC	31.23	21406692
1082	Acetylation	KRSTVNEKPKYAEIS CCCCCCCCCCCCCCC	41.42	23749302
1085	Phosphorylation	TVNEKPKYAEISSDE CCCCCCCCCCCCCCC	20.28	21955146
1089	Phosphorylation	KPKYAEISSDEDNDS CCCCCCCCCCCCCCC	24.20	28355574
1089 (in isoform 2)	Phosphorylation	-	24.20	18669648
1090	Phosphorylation	PKYAEISSDEDNDSD CCCCCCCCCCCCCCH	51.16	28355574
1090 (in isoform 2)	Phosphorylation	-	51.16	18669648
1096	Phosphorylation	SSDEDNDSDEAFESS CCCCCCCCHHHHHHH	43.54	25159151
1096 (in isoform 2)	Phosphorylation	-	43.54	18669648
1102	Phosphorylation	DSDEAFESSRKRHKK CCHHHHHHHHHHHCC	29.05	30108239
1103	Phosphorylation	SDEAFESSRKRHKKD CHHHHHHHHHHHCCC	34.32	30108239
1125	Phosphorylation	EERDRRSSGDHRRSG HHHHHHCCCCCCCCC	46.56	-
1146	Phosphorylation	RSSGGGRYRNRSPSD CCCCCCCCCCCCCCC	18.60	-
1150	Phosphorylation	GGRYRNRSPSDSDME CCCCCCCCCCCCCCC	32.10	26055452
1150 (in isoform 2)	Phosphorylation	-	32.10	18669648
1152	O-linked_Glycosylation	RYRNRSPSDSDMEDY CCCCCCCCCCCCCCC	51.50	30059200
1152	Phosphorylation	RYRNRSPSDSDMEDY CCCCCCCCCCCCCCC	51.50	26055452
1152 (in isoform 2)	Phosphorylation	-	51.50	18669648
1154	Phosphorylation	RNRSPSDSDMEDYSP CCCCCCCCCCCCCCC	43.10	26055452
1154 (in isoform 2)	Phosphorylation	-	43.10	18669648
1159	Phosphorylation	SDSDMEDYSPPPSLS CCCCCCCCCCCCCHH	15.12	22115753
1159 (in isoform 2)	Phosphorylation	-	15.12	18669648
1160	Phosphorylation	DSDMEDYSPPPSLSE CCCCCCCCCCCCHHH	43.16	26055452
1160 (in isoform 2)	Phosphorylation	-	43.16	18669648
1164	Phosphorylation	EDYSPPPSLSEVARK CCCCCCCCHHHHHHH	50.75	20873877
1166	Phosphorylation	YSPPPSLSEVARKMK CCCCCCHHHHHHHHH	34.07	20873877
1184	Phosphorylation	KQKKRKAYEPKLTPE HHHHHHHCCCCCCHH	35.48	-
1189	Phosphorylation	KAYEPKLTPEEMMDS HHCCCCCCHHHHCCH	34.48	21815630
1196	Phosphorylation	TPEEMMDSSTFKRFT CHHHHCCHHHHHHHH	17.24	25159151
1197	Phosphorylation	PEEMMDSSTFKRFTA HHHHCCHHHHHHHHH	33.33	21815630
1198	Phosphorylation	EEMMDSSTFKRFTAS HHHCCHHHHHHHHHH	36.81	25159151
1243	Phosphorylation	HQLNELGSESAKIKA HHHHHCCCHHHHHHH	40.79	25159151
1247	Acetylation	ELGSESAKIKAMGIM HCCCHHHHHHHHCCH	54.76	23954790
1247	Ubiquitination	ELGSESAKIKAMGIM HCCCHHHHHHHHCCH	54.76	19608861
1271	Ubiquitination	KVLNILEKNIQDGSK HHHHHHHHHCCCCHH	56.77	-
1278	Acetylation	KNIQDGSKLSTLLNH HHCCCCHHHHHHHHC	52.57	26051181
1278	Ubiquitination	KNIQDGSKLSTLLNH HHCCCCHHHHHHHHC	52.57	-
1280	Phosphorylation	IQDGSKLSTLLNHNN CCCCHHHHHHHHCCC	22.27	22798277
1281	Phosphorylation	QDGSKLSTLLNHNND CCCHHHHHHHHCCCC	45.78	22798277
1289	Phosphorylation	LLNHNNDTEEEERLW HHHCCCCHHHHHHHH	47.63	22798277
1305	Phosphorylation	DLIMERVTKSADACL HHHHHHHHHHHCHHC	26.04	25954137
1307	Phosphorylation	IMERVTKSADACLTT HHHHHHHHHCHHCHH	23.24	25954137
1314	Phosphorylation	SADACLTTINIMTSP HHCHHCHHHHHHCCC	10.08	25954137
1319	Phosphorylation	LTTINIMTSPNMPKA CHHHHHHCCCCCCCC	36.92	25954137
1341	Acetylation	ERVIQYTKFHLQNTL HHHHHHHHHHHHCCC	26.33	26051181
1367	Phosphorylation	PHGGGLLSSKAKRAK CCCCCCCCHHHHHHC	34.53	25627689
1368	Phosphorylation	HGGGLLSSKAKRAKC CCCCCCCHHHHHHCC	36.28	25159151
1369	Acetylation	GGGLLSSKAKRAKCS CCCCCCHHHHHHCCC	55.33	25953088
1369	Ubiquitination	GGGLLSSKAKRAKCS CCCCCCHHHHHHCCC	55.33	-
1439	Phosphorylation	LCAIKLVTAVFSRYE HHHHHHHHHHHHHHH	27.78	20058876
1443	O-linked_Glycosylation	KLVTAVFSRYEKHRQ HHHHHHHHHHHHHHH	27.62	30059200
1458	Phosphorylation	LILEEIFTSLARLPT HHHHHHHHHHHCCCC	28.61	21082442
1459	Phosphorylation	ILEEIFTSLARLPTS HHHHHHHHHHCCCCC	14.85	21082442
1528	Phosphorylation	IDQDVVITNSYETAM CCCCEEECCHHHHHH	13.40	20068231
1530	Phosphorylation	QDVVITNSYETAMRT CCEEECCHHHHHHHH	18.72	20068231
1531	Phosphorylation	DVVITNSYETAMRTA CEEECCHHHHHHHHH	21.26	20068231
1533	Phosphorylation	VITNSYETAMRTAQN EECCHHHHHHHHHHH	19.95	20068231
1547	Acetylation	NFLSIFLKKCGSKQG HHHHHHHHHHCCCCC	34.96	26051181
1547	Ubiquitination	NFLSIFLKKCGSKQG HHHHHHHHHHCCCCC	34.96	-
1548	Ubiquitination	FLSIFLKKCGSKQGE HHHHHHHHHCCCCCC	46.07	-
1609	Phosphorylation	EMALRVASLDYLGTV HHHHHHHCHHHHHHH	20.93	21406692
1612	Phosphorylation	LRVASLDYLGTVAAR HHHHCHHHHHHHHHH	16.60	21406692
1615	Phosphorylation	ASLDYLGTVAARLRK HCHHHHHHHHHHHHH	12.36	21406692
1628	Acetylation	RKDAVTSKMDQGSIE HHHHHHCCCCHHHHH	36.81	26051181
1628	Ubiquitination	RKDAVTSKMDQGSIE HHHHHHCCCCHHHHH	36.81	-
1639	Ubiquitination	GSIERILKQVSGGED HHHHHHHHHHHCCHH	46.40	-
1642	Phosphorylation	ERILKQVSGGEDEIQ HHHHHHHHCCHHHHH	38.29	-
1674	Ubiquitination	PSLVFSRKFYIAQWF HHHHHCHHHHHHHHH	41.12	-
1690	Acetylation	DTTLETEKAMKSQKD HCCHHHHHHHHHHCC	62.29	26051181
1700	Phosphorylation	KSQKDEESSEGTHHA HHHCCCCCCCCCCCC	31.48	29083192
1701	Phosphorylation	SQKDEESSEGTHHAK HHCCCCCCCCCCCCH	43.24	29083192
1704	Phosphorylation	DEESSEGTHHAKEIE CCCCCCCCCCCHHHH	13.36	29083192
1708	Acetylation	SEGTHHAKEIETTGQ CCCCCCCHHHHHHHH	55.67	26051181
1729	Phosphorylation	NRKKFLRSIIKTTPS HHHHHHHHHHHCCHH	30.71	24719451
1733	Phosphorylation	FLRSIIKTTPSQFST HHHHHHHCCHHHHCC	33.27	19691289
1734	Phosphorylation	LRSIIKTTPSQFSTL HHHHHHCCHHHHCCC	18.88	19691289
1736	Phosphorylation	SIIKTTPSQFSTLKM HHHHCCHHHHCCCCC	41.59	19691289
1739	Phosphorylation	KTTPSQFSTLKMNSD HCCHHHHCCCCCCCC	25.78	23312004
1740	Phosphorylation	TTPSQFSTLKMNSDT CCHHHHCCCCCCCCC	31.52	23186163
1745	Phosphorylation	FSTLKMNSDTVDYDD HCCCCCCCCCCCHHH	31.03	-
1747	Phosphorylation	TLKMNSDTVDYDDAC CCCCCCCCCCHHHHH	18.33	-
1750	Phosphorylation	MNSDTVDYDDACLIV CCCCCCCHHHHHHHH	16.04	-
1881	Phosphorylation	DICIEQPTFPKITEM HHHCCCCCCHHHHHH	52.87	20068231
1904	Ubiquitination	NDEEGIKKLVNETFQ CCHHHHHHHHHHHHH	56.60	-
1958	Phosphorylation	LLQNLLKSEEDSSYK HHHHHHCCCCCCCCH	46.30	28102081
1962	Phosphorylation	LLKSEEDSSYKPVKK HHCCCCCCCCHHHHH	38.56	29496907
1963	Phosphorylation	LKSEEDSSYKPVKKA HCCCCCCCCHHHHHH	49.88	28102081
1964	Phosphorylation	KSEEDSSYKPVKKAC CCCCCCCCHHHHHHH	24.22	28102081
1984	Ubiquitination	NLVEHILKYEESLAD HHHHHHHHHHHHHCC	50.44	-
1985	Phosphorylation	LVEHILKYEESLADS HHHHHHHHHHHHCCC	22.83	-
1988	Phosphorylation	HILKYEESLADSDNK HHHHHHHHHCCCCCC	19.54	-
1992	Phosphorylation	YEESLADSDNKGVNS HHHHHCCCCCCCCCH	37.16	-
2013	Phosphorylation	ITTLFLFSKIRPQLM HHHHHHHHHCCHHHH	29.35	24719451
2026	Phosphorylation	LMVKHAMTMQPYLTT HHHHHCHHCCCEEEC	17.28	26552605
2030	Phosphorylation	HAMTMQPYLTTKCST HCHHCCCEEECCCCC	10.37	26552605
2032	Phosphorylation	MTMQPYLTTKCSTQN HHCCCEEECCCCCCC	20.54	26552605
2033	Phosphorylation	TMQPYLTTKCSTQND HCCCEEECCCCCCCC	27.71	26552605
2121	Methylation	YGAISKLKSQHQEDP HHHHHHHHHHCCCCC	52.37	115974027
2122	Phosphorylation	GAISKLKSQHQEDPN HHHHHHHHHCCCCCC	43.24	20873877
2131	Phosphorylation	HQEDPNNTSLLTNKP CCCCCCCCCHHCCHH	27.65	20873877
2132	Phosphorylation	QEDPNNTSLLTNKPA CCCCCCCCHHCCHHH	24.41	20873877
2135	Phosphorylation	PNNTSLLTNKPALLR CCCCCHHCCHHHHHH	46.63	20873877
2137	Ubiquitination	NTSLLTNKPALLRSL CCCHHCCHHHHHHHH	26.82	-
2162	Acetylation	DFDLEDFKGNSKVNI CCCHHHCCCCCCCCH	70.29	26051181
2162	Ubiquitination	DFDLEDFKGNSKVNI CCCHHHCCCCCCCCH	70.29	-
2170	Acetylation	GNSKVNIKDKVLELL CCCCCCHHHHHHHHH	46.42	7308111
2190	Phosphorylation	HSDEEVQTKAIIGLG CCCHHHHHHHHHHHC	27.85	-
2223	Ubiquitination	YNNILSDKNSSVNLK HHHHHCCCCCCHHHH	56.18	-
2235	Ubiquitination	NLKIQVLKNLQTYLQ HHHHHHHHHHHHHHH	57.67	-
2239	Phosphorylation	QVLKNLQTYLQEEDT HHHHHHHHHHHHHHH	29.39	24043423
2240	Phosphorylation	VLKNLQTYLQEEDTR HHHHHHHHHHHHHHH	8.07	28258704
2246	Phosphorylation	TYLQEEDTRMQQADR HHHHHHHHHHHHHHH	31.18	24043423
2337	Ubiquitination	PEPAMRNKADQQLVE CCHHHCCHHHHHHHH	42.87	-
2347	Ubiquitination	QQLVEIDKKYAGFIH HHHHHHHHHHCCEEH	54.03	-
2348	Ubiquitination	QLVEIDKKYAGFIHM HHHHHHHHHCCEEHH	36.26	-
2362	Acetylation	MKAVAGMKMSYQVQQ HHHHHCCCCHHHHHH	24.63	19813341
2397	Phosphorylation	ALCSHLYSMIRGNRQ HHHHHHHHHHHCCHH	17.69	-
2482	Phosphorylation	DKRKERKSSPSKENE HHHHHHCCCCCCCCC	54.42	28634120
2483	Phosphorylation	KRKERKSSPSKENES HHHHHCCCCCCCCCC	35.91	29214152
2485	Phosphorylation	KERKSSPSKENESSD HHHCCCCCCCCCCCC	55.33	26278961
2490	Phosphorylation	SPSKENESSDSEEEV CCCCCCCCCCCHHHH	51.53	25159151
2491	Phosphorylation	PSKENESSDSEEEVS CCCCCCCCCCHHHHC	38.69	25159151
2493	Phosphorylation	KENESSDSEEEVSRP CCCCCCCCHHHHCCC	49.18	25159151
2498	Phosphorylation	SDSEEEVSRPRKSRK CCCHHHHCCCCHHCC	39.59	20873877
2509	Phosphorylation	KSRKRVDSDSDSDSE HHCCCCCCCCCCCCH	35.84	26055452
2509 (in isoform 2)	Phosphorylation	-	35.84	18669648
2511	Phosphorylation	RKRVDSDSDSDSEDD CCCCCCCCCCCCHHH	42.86	26055452
2511 (in isoform 2)	Phosphorylation	-	42.86	18669648
2513	Phosphorylation	RVDSDSDSDSEDDIN CCCCCCCCCCHHHHH	47.16	25159151
2513 (in isoform 2)	Phosphorylation	-	47.16	18669648
2515	Phosphorylation	DSDSDSDSEDDINSV CCCCCCCCHHHHHHH	47.04	22115753
2515 (in isoform 2)	Phosphorylation	-	47.04	18669648
2521	Phosphorylation	DSEDDINSVMKCLPE CCHHHHHHHHHHCCC	24.75	29514088
2554	Ubiquitination	LMLKQHLKNLCGFSD HHHHHHHHHHHCCCC	45.83	-
2563	Ubiquitination	LCGFSDSKIQKYSPS HHCCCCHHHHHCCHH	54.89	-
2566	Ubiquitination	FSDSKIQKYSPSESA CCCHHHHHCCHHHHH	51.69	-
2567	Phosphorylation	SDSKIQKYSPSESAK CCHHHHHCCHHHHHH	14.94	30576142
2568	Phosphorylation	DSKIQKYSPSESAKV CHHHHHCCHHHHHHH	29.05	25159151
2570	Phosphorylation	KIQKYSPSESAKVYD HHHHCCHHHHHHHHH	37.94	30576142
2578	Ubiquitination	ESAKVYDKAINRKTG HHHHHHHHHHHCCCC	33.22	-
2583	Ubiquitination	YDKAINRKTGVHFHP HHHHHHCCCCCCCCC	45.18	-
2591	Ubiquitination	TGVHFHPKQTLDFLR CCCCCCCHHHHHHHH	47.55	-
2613	Phosphorylation	ITEEVKRSIVKQYLD CCHHHHHHHHHHHHH	26.47	-
2651	Phosphorylation	NARNKAITSLLGGGS HHHHHHHHHHHCCCC	20.41	23927012
2651 (in isoform 2)	Phosphorylation	-	20.41	30177828
2652	Phosphorylation	ARNKAITSLLGGGSP HHHHHHHHHHCCCCC	18.58	23401153
2652 (in isoform 2)	Phosphorylation	-	18.58	30177828
2658	Phosphorylation	TSLLGGGSPKNNTAA HHHHCCCCCCCCCCC	35.66	19664994
2658 (in isoform 2)	Phosphorylation	-	35.66	18669648
2663	Phosphorylation	GGSPKNNTAAETEDD CCCCCCCCCCCCCCC	36.32	23927012
2663 (in isoform 2)	Phosphorylation	-	36.32	20873877
2667	Phosphorylation	KNNTAAETEDDESDG CCCCCCCCCCCCCCC	39.73	22167270
2667 (in isoform 2)	Phosphorylation	-	39.73	26503892
2672	Phosphorylation	AETEDDESDGEDRGG CCCCCCCCCCCCCCC	58.89	22167270
2672 (in isoform 2)	Phosphorylation	-	58.89	26503892
2681	Phosphorylation	GEDRGGGTSGSLRRS CCCCCCCCCHHHCCH	32.94	22167270
2681 (in isoform 2)	Phosphorylation	-	32.94	22167270
2682	Phosphorylation	EDRGGGTSGSLRRSK CCCCCCCCHHHCCHH	29.65	22167270
2682 (in isoform 2)	Phosphorylation	-	29.65	22167270
2684	Phosphorylation	RGGGTSGSLRRSKRN CCCCCCHHHCCHHCC	20.62	22167270
2688	Phosphorylation	TSGSLRRSKRNSDST CCHHHCCHHCCCCHH	29.54	22210691
2692	Phosphorylation	LRRSKRNSDSTELAA HCCHHCCCCHHHHHH	36.65	22210691
2704	Phosphorylation	LAAQMNESVDVMDVI HHHHHCCCCCHHHHH	20.72	22210691
2731	Phosphorylation	IARVVQKTSSGFSVQ HHHHHHHCCCCCEEE	15.84	30576142
2744	Phosphorylation	VQWMAGSYSGSWTEA EEEECCCCCCCCCCC	19.01	30576142
2745	Phosphorylation	QWMAGSYSGSWTEAK EEECCCCCCCCCCCH	28.22	30576142
2765	Phosphorylation	KLVPWVDTIKESDII CCCCHHHCCCHHHHH	25.08	-
2775	Ubiquitination	ESDIIYKKIALTSAN HHHHHHHHHHHCCHH	19.08	-
2783	Acetylation	IALTSANKLTNKVVQ HHHCCHHHHHHHHHH	57.30	25953088
2787	Acetylation	SANKLTNKVVQTLRS CHHHHHHHHHHHHHH	38.25	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NIPBL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NIPBL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NIPBL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SP100_HUMAN	SP100	physical	15882967
CBX3_HUMAN	CBX3	physical	15882967
SMC1A_HUMAN	SMC1A	physical	20720539
SMC3_HUMAN	SMC3	physical	20720539
MED23_HUMAN	MED23	physical	20720539
TOM40_HUMAN	TOMM40	physical	22939629
PPT1_HUMAN	PPT1	physical	22939629
SF3A2_HUMAN	SF3A2	physical	22939629
RAD21_HUMAN	RAD21	physical	22939629
SCC4_HUMAN	MAU2	physical	16802858
SCC4_HUMAN	MAU2	physical	26344197
SCC4_HUMAN	MAU2	physical	28167679
CBX3_HUMAN	CBX3	physical	28167679

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 122470: Cornelia de Lange syndrome 1 (CDLS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318; SER-1089; SER-1090;SER-1096; SER-1150; SER-1152; SER-1154; SER-1160; SER-2658; THR-2667AND SER-2672, AND MASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2658, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274; SER-280; SER-284;SER-2658; THR-2667 AND SER-2672, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139; SER-150; SER-162;SER-306; SER-318; SER-350; SER-912; SER-1089; SER-1090; SER-1096;SER-1150; SER-1152; SER-1154; SER-1160; SER-2509; SER-2511; SER-2513;SER-2515 AND SER-2658, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2658, AND MASSSPECTROMETRY.
PubMed: 18691976

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-912 AND THR-914, ANDMASS SPECTROMETRY.
PubMed: 17924679

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2658, AND MASSSPECTROMETRY.
PubMed: 16565220

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2658, AND MASSSPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318; THR-746; SER-849;SER-850; SER-1089; SER-1090; SER-1096; SER-1150; SER-1152; SER-1154;TYR-1159 AND SER-2658, AND MASS SPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2658 AND SER-2672, ANDMASS SPECTROMETRY.
PubMed: 15302935

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, AND MASSSPECTROMETRY.
PubMed: 17525332