| UniProt ID | SCC4_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y6X3 | |
| Protein Name | MAU2 chromatid cohesion factor homolog | |
| Gene Name | MAU2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 613 | |
| Subcellular Localization | Nucleus, nucleoplasm . Nucleus . Chromosome . Binds to chromatin from the end of mitosis until prophase. | |
| Protein Description | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin. [PubMed: 28167679] | |
| Protein Sequence | MAAQAAAAAQAAAAQAAQAEAADSWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQIPQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 58 | Ubiquitination | LQAVFPFKPPQRIEA HHHHCCCCCCCHHEE | 56.90 | - | |
| 76 | Phosphorylation | LQLGSVLYHHTKNSE HHHHCHHHHHCCCHH | 6.87 | - | |
| 80 | Ubiquitination | SVLYHHTKNSEQARS CHHHHHCCCHHHHHH | 54.87 | - | |
| 91 (in isoform 1) | Ubiquitination | - | 51.74 | 21890473 | |
| 91 | Ubiquitination | QARSHLEKAWLISQQ HHHHHHHHHHHHHCC | 51.74 | 22817900 | |
| 130 | Ubiquitination | VDAAKPLLRKAIQIS CCCHHHHHHHHHHHH | 7.77 | 21890473 | |
| 132 | Acetylation | AAKPLLRKAIQISQQ CHHHHHHHHHHHHCC | 50.22 | 26051181 | |
| 132 | Ubiquitination | AAKPLLRKAIQISQQ CHHHHHHHHHHHHCC | 50.22 | 22817900 | |
| 240 | Phosphorylation | LVLQVTHYLDAGQVK HHHHHHHHCCCCCCC | 9.27 | 20058876 | |
| 250 | Ubiquitination | AGQVKSVKPCLKQLQ CCCCCCHHHHHHHHH | 36.78 | - | |
| 262 | Phosphorylation | QLQQCIQTISTLHDD HHHHHHHHHHHCCCC | 9.29 | 29978859 | |
| 264 | Phosphorylation | QQCIQTISTLHDDEI HHHHHHHHHCCCCCC | 28.44 | 29978859 | |
| 265 | Phosphorylation | QCIQTISTLHDDEIL HHHHHHHHCCCCCCC | 25.02 | 29978859 | |
| 274 | Phosphorylation | HDDEILPSNPADLFH CCCCCCCCCHHHHHH | 52.58 | 29978859 | |
| 305 | Phosphorylation | MHSMQAGYLEKAQKY HHHHHCCHHHHHHHH | 18.07 | 24719451 | |
| 312 | Phosphorylation | YLEKAQKYTDKALMQ HHHHHHHHCHHHHHH | 14.21 | 29083192 | |
| 313 | Phosphorylation | LEKAQKYTDKALMQL HHHHHHHCHHHHHHH | 37.75 | 29083192 | |
| 315 | Ubiquitination | KAQKYTDKALMQLEK HHHHHCHHHHHHHHH | 35.30 | 29967540 | |
| 315 | Acetylation | KAQKYTDKALMQLEK HHHHHCHHHHHHHHH | 35.30 | 25953088 | |
| 322 (in isoform 1) | Ubiquitination | - | 63.10 | 21890473 | |
| 322 | Ubiquitination | KALMQLEKLKMLDCS HHHHHHHHHCCCCCH | 63.10 | 21890473 | |
| 324 | Ubiquitination | LMQLEKLKMLDCSPI HHHHHHHCCCCCHHH | 48.78 | 22817900 | |
| 333 | Ubiquitination | LDCSPILSSFQVILL CCCHHHHHHHHHHHH | 29.81 | 21890473 | |
| 335 | Ubiquitination | CSPILSSFQVILLEH CHHHHHHHHHHHHHH | 6.38 | 22817900 | |
| 353 | Ubiquitination | CRLVTGHKATALQEI HHHHHCCHHHHHHHH | 49.10 | - | |
| 409 | Phosphorylation | FTTALRLTNHQELWA HHHHHHHCCHHHHHH | 24.99 | - | |
| 449 | Phosphorylation | ERINPDHSFPVSSHC HHHCCCCCCCCCHHH | 38.33 | 25627689 | |
| 453 | Phosphorylation | PDHSFPVSSHCLRAA CCCCCCCCHHHHHHH | 18.01 | 30242111 | |
| 454 | Phosphorylation | DHSFPVSSHCLRAAA CCCCCCCHHHHHHHH | 20.60 | 30242111 | |
| 463 | Phosphorylation | CLRAAAFYVRGLFSF HHHHHHHHHHHHHHH | 5.63 | 30242111 | |
| 475 | Phosphorylation | FSFFQGRYNEAKRFL HHHHHCCHHHHHHHH | 24.95 | 26657352 | |
| 479 | Ubiquitination | QGRYNEAKRFLRETL HCCHHHHHHHHHHHH | 37.19 | - | |
| 485 | Phosphorylation | AKRFLRETLKMSNAE HHHHHHHHHHCCCHH | 25.83 | 26657352 | |
| 487 | Ubiquitination | RFLRETLKMSNAEDL HHHHHHHHCCCHHHH | 47.94 | - | |
| 489 | Phosphorylation | LRETLKMSNAEDLNR HHHHHHCCCHHHHHH | 31.16 | - | |
| 530 | Phosphorylation | VPAMQLASKIPDMSV HHHHHHHHCCCCHHH | 39.44 | 20068231 | |
| 608 | O-linked_Glycosylation | AQNGPNTSLASLL-- CCCCCCCCHHHCC-- | 28.69 | 23301498 | |
| 611 | O-linked_Glycosylation | GPNTSLASLL----- CCCCCHHHCC----- | 35.18 | 23301498 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SCC4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SCC4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SCC4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SRCAP_HUMAN | SRCAP | physical | 26496610 | |
| CBX1_HUMAN | CBX1 | physical | 26496610 | |
| CBX5_HUMAN | CBX5 | physical | 26496610 | |
| NIPBL_HUMAN | NIPBL | physical | 26496610 | |
| MOB3C_HUMAN | MOB3C | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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